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  1. Article ; Online: Therapeutic effects and mechanisms of Zhen-Wu-Bu-Qi Decoction on dextran sulfate sodium-induced chronic colitis in mice assessed by multi-omics approaches.

    Zhai, Lixiang / Peng, Jiao / Zhuang, Min / Chang, Yao-Yao / Cheng, Ka Wing / Ning, Zi-Wan / Huang, Tao / Lin, Chengyuan / Wong, Hoi Leong Xavier / Lam, Yan Y / Tan, Hor Yue / Xiao, Hai-Tao / Bian, Zhao-Xiang

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2022  Volume 99, Page(s) 154001

    Abstract: Background: Zhen-Wu-Bu-Qi Decoction (ZWBQD), a traditional Chinese medicine formula comprising ...

    Abstract Background: Zhen-Wu-Bu-Qi Decoction (ZWBQD), a traditional Chinese medicine formula comprising Poria, Radix Paeoniae Alba, Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis Recens, Radix Codonopsis and Rhizoma Coptidis, is used for treating ulcerative colitis (UC). In a previous study, we have reported ZWBQD mitigates the severity of dextran sulfate sodium (DSS)-induced colitis in mice.
    Hypothesis: In this study, we aimed to understand the systemic actions and underlying mechanisms of ZWBQD on experimental colitis in mice.
    Methods: We used multi-omics techniques and immunoblotting approach to study the pharmacological actions and mechanisms of ZWBQD in DSS-induced chronic colitic mice.
    Results: We showed that ZWBQD exhibited potent anti-inflammatory properties and significantly protected DSS-induced colitic mice against colon injury by regulating the PI3K-AKT, MAPK signaling pathway and NF-κB signaling pathways. We also revealed that ZWBQD significantly ameliorated gut microbiota dysbiosis and abnormalities of tryptophan catabolites induced by DSS.
    Conclusions: We demonstrated that the therapeutic effects of ZWBQD on experimental colitis are mediated by regulating multiple signaling pathways and modulation of gut microbiota. Our study employed an integrative strategy to elucidate novel mechanisms of ZWBQD, which provides new insights into the development of Chinese herbal medicine-based therapeutics for UC.
    Language English
    Publishing date 2022-02-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2022.154001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4115: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Therapeutic effects and mechanisms of Zhen-Wu-Bu-Qi Decoction on dextran sulfate sodium-induced chronic colitis in mice assessed by multi-omics approaches

    Zhai, Lixiang / Peng, Jiao / Zhuang, Min / Chang, Yao-yao / Cheng, Ka Wing / Ning, Zi-wan / Huang, Tao / Lin, Chengyuan / Wong, Hoi Leong Xavier / Lam, Yan Y. / Tan, Hor Yue / Xiao, Hai-tao / Bian, Zhao-xiang

    Phytomedicine. 2022 May, v. 99

    2022  

    Abstract: Zhen-Wu-Bu-Qi Decoction (ZWBQD), a traditional Chinese medicine formula comprising Poria ...

    Abstract Zhen-Wu-Bu-Qi Decoction (ZWBQD), a traditional Chinese medicine formula comprising Poria, Radix Paeoniae Alba, Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis Recens, Radix Codonopsis and Rhizoma Coptidis, is used for treating ulcerative colitis (UC). In a previous study, we have reported ZWBQD mitigates the severity of dextran sulfate sodium (DSS)-induced colitis in mice. In this study, we aimed to understand the systemic actions and underlying mechanisms of ZWBQD on experimental colitis in mice. We used multi-omics techniques and immunoblotting approach to study the pharmacological actions and mechanisms of ZWBQD in DSS-induced chronic colitic mice. We showed that ZWBQD exhibited potent anti-inflammatory properties and significantly protected DSS-induced colitic mice against colon injury by regulating the PI3K-AKT, MAPK signaling pathway and NF-κB signaling pathways. We also revealed that ZWBQD significantly ameliorated gut microbiota dysbiosis and abnormalities of tryptophan catabolites induced by DSS. We demonstrated that the therapeutic effects of ZWBQD on experimental colitis are mediated by regulating multiple signaling pathways and modulation of gut microbiota. Our study employed an integrative strategy to elucidate novel mechanisms of ZWBQD, which provides new insights into the development of Chinese herbal medicine-based therapeutics for UC.
    Keywords Codonopsis ; Oriental traditional medicine ; Paeonia ; Poria ; colon ; dextran sulfate ; dysbiosis ; immunoblotting ; intestinal microorganisms ; metabolites ; multiomics ; rhizomes ; therapeutics ; tryptophan ; ulcerative colitis
    Language English
    Dates of publication 2022-05
    Publishing place Elsevier GmbH
    Document type Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2022.154001
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4115: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Book: Zhong yi zhen duan ji ben gong yu lin chuang

    Zhuang, Zecheng

    2013  

    Author's details Zhuang Zecheng, Zhuang Xin, Yue Chen bian zhu
    MeSH term(s) Medicine, Chinese Traditional ; Diagnostic Techniques and Procedures
    Language Chinese
    Size 16, 403 pages :, portrait
    Edition Di 1 ban.
    Document type Book
    ISBN 9787117170192 ; 7117170190
    Database Catalogue of the US National Library of Medicine (NLM)

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  4. Book: Zhen kong jia xiang

    Zhuang, Jifa

    qing dai min jian mi mi zong jiao shi yan jiu

    (Wen shi zhe xue ji cheng ; 459 ; 文史哲學集成 ; 459)

    2002  

    Author's details Zhuang ji fa
    Series title Wen shi zhe xue ji cheng ; 459
    文史哲學集成 ; 459
    Language Chinese
    Size 2, 556 S, Ill, Tab
    Edition Chu ban
    Publisher Wen shi zhe chu ban she
    Publishing place Tai bei
    Document type Book
    ISBN 9575494350 ; 9789575494353
    Database Former special subject collection: coastal and deep sea fishing

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  5. Book: Nan hua zhen jing

    Zhuang, Zhou / Guo, Xiang / Lu, Deming

    (Song Yuan Ming Qing shan ben cong kan ; Zhongguo zi xue ming zhu ji cheng : 中國子學名著集成 ; / Zhongguo zi xue ming zhu ji cheng bian xiu wei yuan hui bian xiu; Xiao Tianshi zong zhu bian[...] ; 宋元明清善本叢刊)

    1978  

    Author's details Zhuang Zhou zhuan; Guo Xiang zhu; Lu Deming yin yi
    Series title Song Yuan Ming Qing shan ben cong kan
    Zhongguo zi xue ming zhu ji cheng : 中國子學名著集成
    / Zhongguo zi xue ming zhu ji cheng bian xiu wei yuan hui bian xiu; Xiao Tianshi zong zhu bian[...]
    宋元明清善本叢刊
    Language Chinese
    Size 15, 10, 4, 586 p
    Edition Chu ban
    Publisher Zhongguo zi xue ming zhu ji cheng bian yin ji jin hui
    Publishing place Taibei
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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  6. Article ; Online: Antibody targeting TSLP suppresses DSS-induced colitis and activation of the JAK2/STAT5 pathway in mice.

    Zhuang, Wei / Li, Zhen

    European cytokine network

    2024  Volume 34, Issue 4, Page(s) 46–53

    Abstract: There is currently no safe or effective treatment for inflammatory bowel disease (IBD), which is defined as recurrent and persistent intestinal inflammation. Thymic stromal lymphopoietin (TSLP) has been shown to be associated with the pathogenesis of IBD, ...

    Abstract There is currently no safe or effective treatment for inflammatory bowel disease (IBD), which is defined as recurrent and persistent intestinal inflammation. Thymic stromal lymphopoietin (TSLP) has been shown to be associated with the pathogenesis of IBD, and the JAK2/STAT5 signalling pathway has demonstrated much promise as a novel therapeutic target for IBD. In this study, we first evaluated levels of TSLP in dextran sodium sulphate (DSS)-induced IBD mice. Second, we applied tezepelumab, an anti-TSLP monoclonal antibody (20 μg per mouse, intraperitoneally), to DSS-induced IBD mice and quantified the signs of histopathological change, intestinal inflammation, and integrity of the mucosal barrier. In addition, the effect of DSS and/or tezepelumab on the phosphorylation of the JAK/STAT pathway was investigated. TSLP expression levels were elevated in DSS-induced IBD mice, whereas TSLP antibody treatment suppressed the pathological features associated with IBD and alleviated intestinal inflammation and mucosal barrier disruption. Moreover, level of phosphorylated JAK2/STAT5 were increased in DSS-induced IBD mice, but were strongly decreased in the presence of tezepelumab. Our findings suggest that targeting TSLP via the JAK2/STAT5 signalling pathway may be an effective approach for the treatment of IBD.
    MeSH term(s) Animals ; Mice ; Thymic Stromal Lymphopoietin ; STAT5 Transcription Factor ; Janus Kinases ; STAT Transcription Factors ; Signal Transduction ; Cytokines ; Colitis/chemically induced ; Colitis/drug therapy ; Inflammatory Bowel Diseases ; Inflammation
    Chemical Substances Thymic Stromal Lymphopoietin (GT0IL38SP4) ; STAT5 Transcription Factor ; Janus Kinases (EC 2.7.10.2) ; STAT Transcription Factors ; Cytokines
    Language English
    Publishing date 2024-03-08
    Publishing country France
    Document type Journal Article
    ZDB-ID 1118857-1
    ISSN 1952-4005 ; 1148-5493
    ISSN (online) 1952-4005
    ISSN 1148-5493
    DOI 10.1684/ecn.2023.0489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3447: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Book: Zhongguo zhen jiu fa zhan shi

    Zhuang, Yumin

    Historical review of the development of the Chinese acupuncture

    1978  

    Title variant Historical review of the development of the Chinese acupuncture
    Author's details Zhuang Yumin bian zhu
    MeSH term(s) Acupuncture/history
    Language Chinese ; English
    Size 8, 145 p. :, port.
    Publisher Y. Zhuang
    Publishing place Taibei
    Document type Book
    Note Text in Chinese and English.
    Database Catalogue of the US National Library of Medicine (NLM)

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  8. Book: Nan hua zhen jing ping zhu

    Zhuang, Zhou / Xiang, Xiu

    (Song Yuan Ming Qing shan ben cong kan ; Zhongguo zi xue ming zhu ji cheng : 中國子學名著集成 ; / Zhongguo zi xue ming zhu ji cheng bian xiu wei yuan hui bian xiu; Xiao Tianshi zong zhu bian[...] ; 宋元明清善本叢刊)

    1978  

    Author's details Zhuang Zhou zhuan, Xiang Xiu zhu
    Series title Song Yuan Ming Qing shan ben cong kan
    Zhongguo zi xue ming zhu ji cheng : 中國子學名著集成
    / Zhongguo zi xue ming zhu ji cheng bian xiu wei yuan hui bian xiu; Xiao Tianshi zong zhu bian[...]
    宋元明清善本叢刊
    Language Chinese
    Size 4, 4, 702 p
    Edition Chu ban
    Publisher Zhongguo zi xue ming zhu ji cheng bian yin ji jin hui
    Publishing place Taibei
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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  9. Article ; Online: Difunctionalization of

    Zhong, Yuanchen / Zhuang, Zhen / Zhang, Xiaofei / Xu, Bin / Yang, Chunhao

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 36, Page(s) 4830–4833

    Abstract: ... ...

    Abstract gem
    Language English
    Publishing date 2024-04-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d4cc00528g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Genome-wide identification and comprehensive analysis of the phytochrome-interacting factor (PIF) gene family in wheat.

    Zhuang, Hua / Guo, Zhen / Wang, Jian / Chen, Tianqing

    PloS one

    2024  Volume 19, Issue 1, Page(s) e0296269

    Abstract: Phytochrome-interacting factors (PIFs) are essential transcription factors for plant growth, development, and stress responses. Although PIF genes have been extensively studied in many plant species, they have not been thoroughly investigated in wheat. ... ...

    Abstract Phytochrome-interacting factors (PIFs) are essential transcription factors for plant growth, development, and stress responses. Although PIF genes have been extensively studied in many plant species, they have not been thoroughly investigated in wheat. Here, we identified 18 PIF genes in cultivated hexaploid wheat (Triticum aestivum L). Phylogenetic analysis, exon-intron structures, and motif compositions revealed the presence of four distinct groups of TaPIFs. Genome-wide collinearity analysis of PIF genes revealed the evolutionary history of PIFs in wheat, Oryza sativa, and Brachypodium distachyon. Cis-regulatory element analysis suggested that TaPIF genes indicated participated in plant development and stress responses. Subcellular localization assays indicated that TaPIF2-1B and TaPIF4-5B were transcriptionally active. Both were found to be localized to the nucleus. Gene expression analyses demonstrated that TaPIFs were primarily expressed in the leaves and were induced by various biotic and abiotic stresses and phytohormone treatments. This study provides new insights into PIF-mediated stress responses and lays a strong foundation for future investigation of PIF genes in wheat.
    MeSH term(s) Triticum/genetics ; Phylogeny ; Biological Assay ; Biological Evolution ; Phytochrome/genetics
    Chemical Substances Phytochrome (11121-56-5)
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0296269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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