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Article: An Improved and Practical Method for Synthesizing of α-Sanshools and Spilanthol.

Nakamura, Akira / Mimaki, Kazuki / Tanigami, Ken-Ichi / Maegawa, Tomohiro

2020 Volume 8, Page(s) 187

Abstract: An efficient and practical route for the synthesis of α-sanshools and spilanthol is described herein. Several modifications of an existing method enabled the preparation of the ( ... ...

Abstract	An efficient and practical route for the synthesis of α-sanshools and spilanthol is described herein. Several modifications of an existing method enabled the preparation of the (2
Language	English
Publishing date	2020-03-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711776-5
ISSN	2296-2646
ISSN	2296-2646
DOI	10.3389/fchem.2020.00187
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Article: [Effect of information about normative difficulty of questions on level of confidence judgments and feeling of knowing judgments].

Tanigami, Aki

Shinrigaku kenkyu : The Japanese journal of psychology

2002 Volume 73, Issue 3, Page(s) 243–250

Abstract: This study investigated whether people's levels of confidence (CL) judgments and feeling of knowing (FOK) judgements in answering questions about general knowledge were influenced by information about normative difficulty of the questions--that is, the ... ...

Abstract	This study investigated whether people's levels of confidence (CL) judgments and feeling of knowing (FOK) judgements in answering questions about general knowledge were influenced by information about normative difficulty of the questions--that is, the percentage of people who could recall the correct answer to the question--. In easy-information condition, participants were told that questions were easier--that is, more people could answer the questions--than they really were. In difficult-information condition, participants were told that the same questions were more difficult--that is, less people could answer the questions--than they really were. Results showed that the participants gave higher CL judgments and higher FOK judgments for their answers in the easy-information condition than for their answers in the difficult-information condition. These results confirm the hypothesis that people's CL judgments and FOK judgments were influenced by the information about normative difficulty of questions.
MeSH term(s)	Adult ; Humans ; Judgment/physiology ; Knowledge of Results (Psychology) ; Memory/physiology ; Mental Recall/physiology ; Set (Psychology)
Language	Japanese
Publishing date	2002-11-18
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	203421-9
ISSN	1884-1082 ; 0021-5236
ISSN (online)	1884-1082
ISSN	0021-5236
DOI	10.4992/jjpsy.73.243
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Article: Successful weaning of a patient with severe COVID-19 pneumonia under prolonged midazolam sedation using morphine.

Kunimasa, Kei / Ohashi, Yoshifumi / Okawa, Megumi / Iida, Hiroshi / Sonoda, Shunji / Hiuge, Yuki / Hachimine, Masaaki / Yamamura, Ai / Kawamura, Takahisa / Inoue, Takako / Tamiya, Motohiro / Kuhara, Hanako / Nishino, Kazumi / Nakamoto, Naoki / Kumagai, Toru / Tanigami, Hironobu

Oxford medical case reports

2022 Volume 2022, Issue 6, Page(s) omac051

Abstract: The coronavirus disease 2019 (COVID-19) pandemic continues to spread around the world. In April 2021, Japan experienced a fourth wave of COVID-19 infections, which led to the breakdown of the medical system. Osaka, Japan, was particularly affected, with ... ...

Abstract	The coronavirus disease 2019 (COVID-19) pandemic continues to spread around the world. In April 2021, Japan experienced a fourth wave of COVID-19 infections, which led to the breakdown of the medical system. Osaka, Japan, was particularly affected, with many severe cases and the highest number of COVID-19-associated deaths in Japan. Herein, we present a patient with severe COVID-19 infection who received prolonged midazolam (MDZ) treatment since propofol was not available due to shortage of medical resources. Moreover, the duration of mechanical ventilation was extended due to the development of a pneumothorax. When MDZ tapering was initiated, tachypnea was observed, which resulted failure in ventilator weaning. However, the use of continuous morphine infusion led a successful weaning off the ventilator. We suggest that the administration of morphine may allow for a smoother weaning process for some patients with severe COVID-19 infection.
Language	English
Publishing date	2022-06-23
Publishing country	England
Document type	Case Reports
ZDB-ID	2766251-2
ISSN	2053-8855
ISSN	2053-8855
DOI	10.1093/omcr/omac051
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Article ; Online: Theobromine up-regulates cerebral brain-derived neurotrophic factor and facilitates motor learning in mice.

Yoneda, Mitsugu / Sugimoto, Naotoshi / Katakura, Masanori / Matsuzaki, Kentaro / Tanigami, Hayate / Yachie, Akihiro / Ohno-Shosaku, Takako / Shido, Osamu

The Journal of nutritional biochemistry

2016 Volume 39, Page(s) 110–116

Abstract: Theobromine, which is a caffeine derivative, is the primary methylxanthine produced by Theobroma cacao. Theobromine works as a phosphodiesterase (PDE) inhibitor to increase intracellular cyclic adenosine monophosphate (cAMP). cAMP activates the cAMP- ... ...

Abstract	Theobromine, which is a caffeine derivative, is the primary methylxanthine produced by Theobroma cacao. Theobromine works as a phosphodiesterase (PDE) inhibitor to increase intracellular cyclic adenosine monophosphate (cAMP). cAMP activates the cAMP-response element-binding protein (CREB), which is involved in a large variety of brain processes, including the induction of the brain-derived neurotrophic factor (BDNF). BDNF supports cell survival and neuronal functions, including learning and memory. Thus, cAMP/CREB/BDNF pathways play an important role in learning and memory. Here, we investigated whether orally administered theobromine could act as a PDE inhibitor centrally and affect cAMP/CREB/BDNF pathways and learning behavior in mice. The mice were divided into two groups. The control group (CN) was fed a normal diet, whereas the theobromine group (TB) was fed a diet supplemented with 0.05% theobromine for 30 days. We measured the levels of theobromine, phosphorylated vasodilator-stimulated phosphoprotein (p-VASP), phosphorylated CREB (p-CREB), and BDNF in the brain. p-VASP was used as an index of cAMP increases. Moreover, we analyzed the performance of the mice on a three-lever motor learning task. Theobromine was detectable in the brains of TB mice. The brain levels of p-VASP, p-CREB, and BDNF were higher in the TB mice compared with those in the CN mice. In addition, the TB mice performed better on the three-lever task than the CN mice did. These results strongly suggested that orally administered theobromine acted as a PDE inhibitor in the brain, and it augmented the cAMP/CREB/BDNF pathways and motor learning in mice.
MeSH term(s)	Animals ; Blood Glucose/metabolism ; Body Weight ; Brain-Derived Neurotrophic Factor/genetics ; Brain-Derived Neurotrophic Factor/metabolism ; Cacao/chemistry ; Cell Adhesion Molecules/genetics ; Cell Adhesion Molecules/metabolism ; Cyclic AMP/genetics ; Cyclic AMP/metabolism ; Cyclic AMP Response Element-Binding Protein/genetics ; Cyclic AMP Response Element-Binding Protein/metabolism ; Learning ; Male ; Memory ; Mice ; Mice, Inbred C57BL ; Microfilament Proteins/genetics ; Microfilament Proteins/metabolism ; Phosphodiesterase Inhibitors/pharmacology ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Phosphorylation ; Plant Extracts/pharmacology ; Theobromine/blood ; Theobromine/pharmacology ; Up-Regulation
Chemical Substances	Blood Glucose ; Brain-Derived Neurotrophic Factor ; Cell Adhesion Molecules ; Creb1 protein, mouse ; Cyclic AMP Response Element-Binding Protein ; Microfilament Proteins ; Phosphodiesterase Inhibitors ; Phosphoproteins ; Plant Extracts ; vasodilator-stimulated phosphoprotein ; BDNF protein, human (7171WSG8A2) ; Cyclic AMP (E0399OZS9N) ; Theobromine (OBD445WZ5P)
Language	English
Publishing date	2016-10-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1014929-6
ISSN	1873-4847 ; 0955-2863
ISSN (online)	1873-4847
ISSN	0955-2863
DOI	10.1016/j.jnutbio.2016.10.002
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Article ; Online: In vivo mechanical condition plays an important role for appearance of cartilage tissue in ES cell transplanted joint.

Nakajima, Masaaki / Wakitani, Shigeyuki / Harada, Yasuji / Tanigami, Akira / Tomita, Naohide

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

2008 Volume 26, Issue 1, Page(s) 10–17

Abstract: The objective of this study was to evaluate the effects of the mechanical environment on the formation of cartilage tissue in transplanted embryonic stem (ES) cells. Full-thickness osteochondral defects were created on the patella groove of SD rats, and ... ...

Abstract	The objective of this study was to evaluate the effects of the mechanical environment on the formation of cartilage tissue in transplanted embryonic stem (ES) cells. Full-thickness osteochondral defects were created on the patella groove of SD rats, and ES cells (CCE ES cells obtained from 129/Sv/Ev mice and Green ES FM260 ES cells obtained from 129SV [D3] - Tg [NCAG-EGFP] CZ-001-FM260Osb mice) were transplanted into the defects embedded in collagen gel. The animals were randomly divided into either the joint-free group (JF group) or the joint-immobilized group (JI group) for 3 weeks after a week postoperatively. The results showed that cartilage-like tissue formed in the defects of the JF group whereas large teratomatous masses developed in the defects of the JI group. Some parts of the cartilage-like tissue and the teratomatous masses were positively stained with immunostain for GFP when the Green ES FM260 ES cells were transplanted. It is suggested that the environment plays an important role for ES cells in the process of repairing cartilage tissue in vivo.
MeSH term(s)	Animals ; Cartilage/cytology ; Cartilage/physiology ; Cell Differentiation/physiology ; Chondrocytes/cytology ; Embryonic Stem Cells/cytology ; Embryonic Stem Cells/transplantation ; Graft Survival/physiology ; Immobilization ; Knee Joint/physiology ; Knee Joint/surgery ; Male ; Mice ; Postoperative Complications/pathology ; Rats ; Rats, Sprague-Dawley ; Soft Tissue Neoplasms/pathology ; Stem Cell Transplantation/adverse effects ; Stem Cell Transplantation/methods ; Stress, Mechanical ; Tail ; Teratoma/pathology
Language	English
Publishing date	2008-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605542-4
ISSN	1554-527X ; 0736-0266
ISSN (online)	1554-527X
ISSN	0736-0266
DOI	10.1002/jor.20462
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Article: [Self-evaluation on the ability to retrieve Kanji words: a comparison between an aphasiac and normal subjects].

Tanigami, A / Abe, J

Shinrigaku kenkyu : The Japanese journal of psychology

1997 Volume 68, Issue 1, Page(s) 17–24

Abstract: The present study investigated the accuracy of an aphasiac's self-evaluation on his ability to retrieve words. The aphasiac and six normal subjects were shown a list of words and that of drawings. The words were written in Kanji and the drawings could be ...

Abstract	The present study investigated the accuracy of an aphasiac's self-evaluation on his ability to retrieve words. The aphasiac and six normal subjects were shown a list of words and that of drawings. The words were written in Kanji and the drawings could be translated into the Kanji words. For each word, the subjects rated the likelihood that they could write it, and for each drawing, they rated the likelihood that they could translate it into the Kanji word. A week later, they were asked to translate drawings into Kanji words, and the performance and self-ratings were compared. Although the aphasiac could write far less Kanji words than the normals, his self-rating was as high as the normals. It was suggested that metamnemonic judgments are based on the indirect inferential processes, not on the direct access to the memory-traces. In other words, the aphasiac might raise his rating scores when Kanji words or drawings seemed easy to understand.
MeSH term(s)	Adult ; Aphasia/psychology ; Cognition/physiology ; Female ; Humans ; Japan ; Language ; Male ; Memory/physiology ; Mental Processes ; Middle Aged ; Self-Assessment
Language	Japanese
Publishing date	1997-04
Publishing country	Japan
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	203421-9
ISSN	1884-1082 ; 0021-5236
ISSN (online)	1884-1082
ISSN	0021-5236
DOI	10.4992/jjpsy.68.17
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Article: [A case of previously undiagnosed methemoglobinemia exhibiting sustained low SpO2 value at the induction of general anesthesia].

Ono, Rie / Tanigami, Hironobu / Kagawa, Kiyokazu / Shimaoka, Motomu / Sonoda, Shunji / Iura, Akira / Yasue, Yuichi / Hamabe, Naho / Ishii, Asami

Masui. The Japanese journal of anesthesiology

2013 Volume 62, Issue 6, Page(s) 710–713

Abstract: A 70-year-old woman was scheduled to undergo surgery for removal of thyroid tumor under general anesthesia. A routine preoperative evaluation confirmed that the patient was stable with no signs of cyanosis and dyspnea. However, during pre-oxygenation as ... ...

Abstract	A 70-year-old woman was scheduled to undergo surgery for removal of thyroid tumor under general anesthesia. A routine preoperative evaluation confirmed that the patient was stable with no signs of cyanosis and dyspnea. However, during pre-oxygenation as well as mechanical ventilation with 100% oxygen, she showed sustained low SpO2 values (i.e., 91%). Arterial blood gas analysis at FIO2 of 1.0 showed an oxygen partial pressure (PaO2) of 297 mmHg. Unexpectedly, the analysis revealed methemoglobinemia (MetHb concentration: 15%) causing a discrepancy between the low SpO2 and normal PaO2 values in this patient. Methemoglobinemia is an uncommon cause of cyanosis; however, anesthesiologists should be aware that some drugs used during perioperative period (e.g., local anesthetics) can cause methemoglobinemia. While our case was a mild one and the patient recovered with no complications, methemoglobinemia levels above 30% could cause tissue hypoxemia and, thereby, requiring a treatment with methylene blue or ascorbic acid.
MeSH term(s)	Aged ; Anesthesia, General ; Female ; Humans ; Methemoglobinemia/diagnosis ; Oximetry ; Oxygen/analysis ; Thyroid Neoplasms/surgery
Chemical Substances	Oxygen (S88TT14065)
Language	Japanese
Publishing date	2013-06
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	391878-6
ISSN	0021-4892
ISSN	0021-4892
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Article ; Online: Endogenous prostaglandin E2 accelerates healing of indomethacin-induced small intestinal lesions through upregulation of vascular endothelial growth factor expression by activation of EP4 receptors.

Takeuchi, Koji / Tanigami, Mayu / Amagase, Kikuko / Ochi, Akimu / Okuda, Sayaka / Hatazawa, Ryo

Journal of gastroenterology and hepatology

2010 Volume 25 Suppl 1, Page(s) S67–74

Abstract: Background and aims: The effects of an EP4 agonist/antagonist on the healing of lesions produced by indomethacin in the small intestine were examined in rats, especially in relation to the expression of vascular endothelial growth factor (VEGF) and ... ...

Abstract	Background and aims: The effects of an EP4 agonist/antagonist on the healing of lesions produced by indomethacin in the small intestine were examined in rats, especially in relation to the expression of vascular endothelial growth factor (VEGF) and angiogenesis. Methods: Animals were given indomethacin (10 mg/kg s.c.) and killed at various time points. To impair the healing of these lesions, a small dose of indomethacin (2 mg/kg p.o.) or AE3-208 (EP4 antagonist: 3 mg/kg i.p.) was given once daily for 6 days after the ulceration was induced, with or without the co-administration of AE1-329 (EP4 agonist: 0.1 mg/kg i.p.). Results: Indomethacin (10 mg/kg) caused severe damage in the small intestine, but the lesions healed rapidly decreasing to approximately one-fifth of their initial size within 7 days. The healing process was significantly impaired by indomethacin (2 mg/kg) given once daily for 6 days after the ulceration. This effect of indomethacin was mimicked by the EP4 antagonist and reversed by co-administration of the EP4 agonist. Mucosal VEGF expression was upregulated after the ulceration, reaching a peak on day 3 followed by a decrease. The changes in VEGF expression paralleled those in mucosal cyclooxygenase-2 expression, as well as prostaglandin E(2) (PGE(2)) content. Indomethacin (2 mg/kg) downregulated both VEGF expression and angiogenesis in the mucosa during the healing process, and these effects were significantly reversed by co-treatment with the EP4 agonist. Conclusion: The results suggest that endogenous PGE(2) promotes the healing of small intestinal lesions by stimulating angiogenesis through the upregulation of VEGF expression mediated by the activation of EP4 receptors.
MeSH term(s)	16,16-Dimethylprostaglandin E2/pharmacology ; Animals ; Cyclooxygenase 1/genetics ; Cyclooxygenase 1/metabolism ; Cyclooxygenase 2/genetics ; Cyclooxygenase 2/metabolism ; Dinoprostone/metabolism ; Disease Models, Animal ; Gene Expression Regulation, Enzymologic ; Indomethacin ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Intestine, Small/drug effects ; Intestine, Small/metabolism ; Intestine, Small/pathology ; Male ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Naphthalenes/pharmacology ; Neovascularization, Physiologic/drug effects ; Peptic Ulcer/chemically induced ; Peptic Ulcer/drug therapy ; Peptic Ulcer/metabolism ; Peptic Ulcer/pathology ; Phenylbutyrates/pharmacology ; RNA, Messenger/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Prostaglandin E/agonists ; Receptors, Prostaglandin E/antagonists & inhibitors ; Receptors, Prostaglandin E/metabolism ; Receptors, Prostaglandin E, EP4 Subtype ; Severity of Illness Index ; Time Factors ; Up-Regulation ; Vascular Endothelial Growth Factor A/metabolism ; Wound Healing/drug effects
Chemical Substances	4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propionylamino)phenyl)butyric acid ; Membrane Proteins ; Naphthalenes ; Phenylbutyrates ; Ptger4 protein, rat ; RNA, Messenger ; Receptors, Prostaglandin E ; Receptors, Prostaglandin E, EP4 Subtype ; Vascular Endothelial Growth Factor A ; vascular endothelial growth factor A, rat ; Cyclooxygenase 1 (EC 1.14.99.1) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Ptgs1 protein, rat (EC 1.14.99.1) ; Ptgs2 protein, rat (EC 1.14.99.1) ; Dinoprostone (K7Q1JQR04M) ; 16,16-Dimethylprostaglandin E2 (M790V82VAC) ; Indomethacin (XXE1CET956)
Language	English
Publishing date	2010-05
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632882-9
ISSN	1440-1746 ; 0815-9319
ISSN (online)	1440-1746
ISSN	0815-9319
DOI	10.1111/j.1440-1746.2010.06222.x
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Zs.A 2180: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Roles of endogenous prostaglandins and cyclooxygenase isozymes in healing of indomethacin-induced small intestinal lesions in rats.

Hatazawa, Ryo / Ohno, Ryoko / Tanigami, Mayu / Tanaka, Akiko / Takeuchi, Koji

The Journal of pharmacology and experimental therapeutics

2006 Volume 318, Issue 2, Page(s) 691–699

Abstract: The role of prostaglandins (PGs)/cyclooxygenase (COX) in the healing of indomethacin-induced small intestinal ulcers was examined in rats. Animals were given indomethacin (10 mg/kg s.c.) and killed 1, 2, 3, 5, and 7 days later. Indomethacin (2 mg/kg), 5-( ...

Abstract	The role of prostaglandins (PGs)/cyclooxygenase (COX) in the healing of indomethacin-induced small intestinal ulcers was examined in rats. Animals were given indomethacin (10 mg/kg s.c.) and killed 1, 2, 3, 5, and 7 days later. Indomethacin (2 mg/kg), 5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazole (SC560; COX-1 inhibitor; 3 mg/kg), and rofecoxib (COX-2 inhibitor; 3 mg/kg) were given p.o. once daily for 6 days, during the first 3 days or last 3 days of the experimental period. All COX inhibitors given for 6 days significantly impaired the healing of these ulcers. Healing was also impaired by rofecoxib given for the first 3 days or by SC560 given for the last 3 days. The expression of COX-2 mRNA in the intestine was up-regulated after ulceration, persisting for 3 days and dissipating thereafter. Mucosal PGE2 contents decreased within 3 h after ulceration, recovered 24 h later, and increased above normal 1 approximately 3 days later. The PGE2 content at 4 days after ulceration was decreased by rofecoxib but not SC560, whereas that at 7 days was suppressed by SC560 but not rofecoxib. Vascular content in the ulcerated mucosa decreased when the healing was impaired by COX inhibitors. The deleterious effect of indomethacin on healing was mimicked by a prostacyclin E receptor (EP) 4 antagonist and reversed by coadministration of PGE2 as well as an EP4 agonist. In conclusion, endogenous PGs play a role in the healing of intestinal ulcers through EP4 receptors, yet the COX isozyme involved differs depending on the stage of healing; COX-2 in the early stage and COX-1 in the late stage.
MeSH term(s)	Animals ; Blood Vessels/metabolism ; Carmine/metabolism ; Cyclooxygenase 1/metabolism ; Cyclooxygenase 2/biosynthesis ; Cyclooxygenase 2 Inhibitors/pharmacology ; Cyclooxygenase Inhibitors ; Dinoprostone/metabolism ; Indomethacin ; Intestinal Diseases/chemically induced ; Intestinal Diseases/metabolism ; Intestinal Diseases/pathology ; Intestinal Mucosa/metabolism ; Isoenzymes/physiology ; Male ; Prostaglandin Antagonists/pharmacology ; Prostaglandin-Endoperoxide Synthases/metabolism ; Prostaglandin-Endoperoxide Synthases/physiology ; Prostaglandins/agonists ; Prostaglandins/metabolism ; Prostaglandins/physiology ; Prostaglandins E/pharmacology ; RNA, Messenger/biosynthesis ; Rats ; Rats, Sprague-Dawley ; Receptors, Prostaglandin E/drug effects ; Receptors, Prostaglandin E, EP4 Subtype ; Reverse Transcriptase Polymerase Chain Reaction ; Ulcer/chemically induced ; Ulcer/pathology
Chemical Substances	Cyclooxygenase 2 Inhibitors ; Cyclooxygenase Inhibitors ; Isoenzymes ; Prostaglandin Antagonists ; Prostaglandins ; Prostaglandins E ; RNA, Messenger ; Receptors, Prostaglandin E ; Receptors, Prostaglandin E, EP4 Subtype ; Carmine (CID8Z8N95N) ; Cyclooxygenase 1 (EC 1.14.99.1) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Prostaglandin-Endoperoxide Synthases (EC 1.14.99.1) ; Dinoprostone (K7Q1JQR04M) ; Indomethacin (XXE1CET956)
Language	English
Publishing date	2006-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3106-9
ISSN	1521-0103 ; 0022-3565
ISSN (online)	1521-0103
ISSN	0022-3565
DOI	10.1124/jpet.106.103994
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Article ; Online: Oral gastric tube-guided insertion of the ProSeal™ laryngeal mask is an easy and noninvasive method for less experienced users.

Nagata, Takako / Kishi, Yoshihiko / Tanigami, Hironobu / Hiuge, Yuki / Sonoda, Shunji / Ohashi, Yoshifumi / Kagawa, Kiyokazu / Ushioda, Azusa

Journal of anesthesia

2012 Volume 26, Issue 4, Page(s) 531–535

Abstract: Purpose: The ProSeal™ laryngeal mask airway (PLMA) can be more difficult to insert than the classic laryngeal mask, especially in patients who have a thin palate with a steep oropharyngeal curve. Here, an oral gastric (OG) tube-guided technique is ... ...

Abstract	Purpose: The ProSeal™ laryngeal mask airway (PLMA) can be more difficult to insert than the classic laryngeal mask, especially in patients who have a thin palate with a steep oropharyngeal curve. Here, an oral gastric (OG) tube-guided technique is considered as a method that makes it easier to successfully insert a PLMA. Methods: Sixty patients who were scheduled to undergo general anesthesia without neuromuscular blocking were randomly allocated into two groups: 30 patients with PLMA inserted by the standard digital technique, and 30 with the PLMA inserted by an OG tube-guided technique. Most PLMA insertions were performed by less experienced users. The success rate at the first attempt, the time taken to insert the PLMA, the difficulty of the procedure, and the incidence of oropharyngeal trauma and postoperative sore throat were compared between the two groups. Results: PLMA insertion was successfully achieved at the first attempt using the OG tube-guided technique in all 30 patients. The OG tube-guided insertion required fewer attempts (P = 0.04) and led to a less difficult insertion procedure (P = 0.02) than the standard digital insertion. Effective ventilation during anesthesia was achieved in all patients, with a lower mean cuff pressure in the OG tube-guided technique group (P = 0.02). The frequency of blood sticking to the PLMA tube (P < 0.001) and the incidence of postoperative sore throat (P = 0.003) were lower in the OG tube-guided group than the standard digital technique group. Conclusions: OG tube-guided PLMA insertion is easier for less experienced users, trainees, and experts as well as less invasive for patients than the standard digital insertion.
MeSH term(s)	Adult ; Aged ; Anesthesia, General ; Breast/surgery ; Clinical Competence ; Female ; Gynecologic Surgical Procedures/methods ; Humans ; Intubation, Gastrointestinal/adverse effects ; Intubation, Gastrointestinal/instrumentation ; Intubation, Gastrointestinal/methods ; Laryngeal Masks/adverse effects ; Male ; Middle Aged ; Palpation ; Pharyngitis/epidemiology ; Pharyngitis/etiology ; Postoperative Complications/epidemiology ; Treatment Outcome ; Urologic Surgical Procedures/methods
Language	English
Publishing date	2012-03-10
Publishing country	Japan
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial
ZDB-ID	1107821-2
ISSN	1438-8359 ; 0913-8668
ISSN (online)	1438-8359
ISSN	0913-8668
DOI	10.1007/s00540-012-1361-2
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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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