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  1. Book ; Online ; E-Book: Imaging technologies and transdermal delivery in skin disorders

    Xu, Chenjie / Wang, Xiaomeng / Pramanik, Manojit

    2020  

    Author's details edited by Chenjie Xu, Xiaomeng Wang, Manojit Pramanik
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xviii, 480 Seiten), Illustrationen, Diagramme
    Publisher Wiley-VCH
    Publishing place Newark
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020403827
    ISBN 978-3-527-81466-4 ; 978-3-527-81464-0 ; 978-3-527-81463-3 ; 9783527344604 ; 3-527-81466-3 ; 3-527-81464-7 ; 3-527-81463-9 ; 3527344608
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Advanced technologies for biomedical applications by emerging researchers in Asia-Pacific.

    Wang, Weiping / Xu, Chenjie / Yoo, Jin-Wook

    Bioengineering & translational medicine

    2023  Volume 8, Issue 6, Page(s) e10621

    Language English
    Publishing date 2023-11-19
    Publishing country United States
    Document type Editorial
    ISSN 2380-6761
    ISSN 2380-6761
    DOI 10.1002/btm2.10621
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial of Special Column on Delivery Nanotechnologies to Modulate the Immune System and Combat Inflammation and Infection.

    He, Wei / Sosnik, Alejandro / Xu, Chenjie

    Acta pharmaceutica Sinica. B

    2023  Volume 13, Issue 6, Page(s) 2296–2297

    Language English
    Publishing date 2023-06-28
    Publishing country Netherlands
    Document type Editorial
    ISSN 2211-3835
    ISSN 2211-3835
    DOI 10.1016/j.apsb.2023.05.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Recyclable detection of gefitinib in clinical sample mediated by multifunctional Ag-anchored g-C

    Xu, Tao / Wang, Rongyan / Gu, Chenjie / Jiang, Tao

    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

    2023  Volume 299, Page(s) 122801

    Abstract: Surface-enhanced Raman scattering (SERS) technology enables to satisfy the increasing demand of clinical drug monitoring due to the superiority of fingerprint recognition, real-time response, and nondestructive collection. Here, a novel graphitic carbon ... ...

    Abstract Surface-enhanced Raman scattering (SERS) technology enables to satisfy the increasing demand of clinical drug monitoring due to the superiority of fingerprint recognition, real-time response, and nondestructive collection. Here, a novel graphitic carbon nitride (g-C
    MeSH term(s) Gefitinib ; Molybdenum/chemistry ; Surface Plasmon Resonance ; Spectrum Analysis, Raman/methods ; Metal Nanoparticles/chemistry
    Chemical Substances Gefitinib (S65743JHBS) ; Molybdenum (81AH48963U)
    Language English
    Publishing date 2023-05-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 210413-1
    ISSN 1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
    ISSN (online) 1873-3557
    ISSN 0370-8322 ; 0584-8539 ; 1386-1425
    DOI 10.1016/j.saa.2023.122801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 51/98: Show issues
    Z 1611 a: Show issues
    924/340: Show issues

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  5. Article: Wearable patches for transdermal drug delivery.

    He, Jiahui / Zhang, Yuyue / Yu, Xinge / Xu, Chenjie

    Acta pharmaceutica Sinica. B

    2023  Volume 13, Issue 6, Page(s) 2298–2309

    Abstract: Transdermal drug delivery systems (TDDs) avoid gastrointestinal degradation and hepatic first-pass metabolism, providing good drug bioavailability and patient compliance. One emerging type of TDDs is the wearable patch worn on the skin surface to deliver ...

    Abstract Transdermal drug delivery systems (TDDs) avoid gastrointestinal degradation and hepatic first-pass metabolism, providing good drug bioavailability and patient compliance. One emerging type of TDDs is the wearable patch worn on the skin surface to deliver medication through the skin. They can generally be grouped into passive and active types, depending on the properties of materials, design principles and integrated devices. This review describes the latest advancement in the development of wearable patches, focusing on the integration of stimulus-responsive materials and electronics. This development is deemed to provide a dosage, temporal, and spatial control of therapeutics delivery.
    Language English
    Publishing date 2023-05-15
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2211-3835
    ISSN 2211-3835
    DOI 10.1016/j.apsb.2023.05.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Topical Delivery of microRNA-125b by Framework Nucleic Acids for Psoriasis Treatment.

    Han, Yunfeng / Xi, Long / Leng, Fang / Xu, Chenjie / Zheng, Ying

    International journal of nanomedicine

    2024  Volume 19, Page(s) 2625–2638

    Abstract: Purpose: Psoriasis is a chronic and recurrent inflammatory dermatitis characterized by T cell imbalance and abnormal keratinocyte proliferation. MicroRNAs (miRNAs) hold promise as therapeutic agents for this disease; however, their clinical application ... ...

    Abstract Purpose: Psoriasis is a chronic and recurrent inflammatory dermatitis characterized by T cell imbalance and abnormal keratinocyte proliferation. MicroRNAs (miRNAs) hold promise as therapeutic agents for this disease; however, their clinical application is hindered by poor stability and limited skin penetration. This study demonstrates the utilization of Framework Nucleic Acid (FNA) for the topical delivery of miRNAs in psoriasis treatment.
    Methods: By utilizing miRNA-125b as the model drug, FNA-miR-125b was synthesized via self-assembly. The successful synthesis and stability of FNA-miR-125b in bovine fetal serum (FBS) were verified through gel electrophoresis. Subsequently, flow cytometry was employed to investigate the cell internalization on HaCaT cells, while qPCR determined the effects of FNA-miR-125b on cellular functions. Additionally, the skin penetration ability of FNA-miR-125b was assessed. Finally, a topical administration study involving FNA-miR-125b cream on imiquimod (IMQ)-induced psoriasis mice was conducted to evaluate its therapeutic efficacy.
    Results: The FNA-miR-125b exhibited excellent stability, efficient cellular internalization, and potent inhibition of keratinocyte proliferation. In the psoriasis mouse model, FNA-miR-125b effectively penetrated the skin tissue, resulting in reduced epidermal thickness and PASI score, as well as decreased levels of inflammatory cytokines.
    MeSH term(s) Animals ; Cattle ; Mice ; MicroRNAs/genetics ; Keratinocytes ; Skin ; Psoriasis/drug therapy ; Psoriasis/chemically induced ; Imiquimod/therapeutic use ; Disease Models, Animal ; Mice, Inbred BALB C
    Chemical Substances MicroRNAs ; Imiquimod (P1QW714R7M)
    Language English
    Publishing date 2024-03-15
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2364941-0
    ISSN 1178-2013 ; 1176-9114
    ISSN (online) 1178-2013
    ISSN 1176-9114
    DOI 10.2147/IJN.S441353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6606: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Immune-mediated diseases are associated with a higher risk of ALS incidence: a prospective cohort study from the UK Biobank.

    Cao, Wen / Cao, Zhi / Tang, Lu / Xu, Chenjie / Fan, Dongsheng

    Frontiers in immunology

    2024  Volume 15, Page(s) 1356132

    Abstract: Objective: The occurrence of immune-mediated diseases (IMDs) in amyotrophic lateral sclerosis (ALS) patients is widely reported. However, whether IMDs and ALS is a simple coexistence or if there exists causal relationships between the two has been a ... ...

    Abstract Objective: The occurrence of immune-mediated diseases (IMDs) in amyotrophic lateral sclerosis (ALS) patients is widely reported. However, whether IMDs and ALS is a simple coexistence or if there exists causal relationships between the two has been a subject of great interest to researchers.
    Methods: A total of 454,444 participants from the prospective cohort of UK Biobank were recruited to investigate the longitudinal association between IMDs and ALS. Previously any IMDs and organ specific IMDs were analyzed in relation to the following incident ALS by Cox-proportional hazard models. Subgroup analyses were performed to explore the covariates of these relationships.
    Results: After adjusting for potential covariates, the multivariate analysis showed that any IMDs were associated with an increased risk of ALS incidence (HR:1.42, 95%CI:1.03-1.94). IMDs of the endocrine-system and the intestinal-system were associated with increased risk of ALS incidence (endocrine-system IMDs: HR:3.01, 95%CI:1.49-6.06; intestinal system IMDs: HR:2.07, 95%CI: 1.14-3.77). Subgroup analyses revealed that immune burden, including IMD duration and the severity of inflammation had specific effects on the IMD-ALS association. In participants with IMD duration≥10 years or CRP≥1.3mg/L or females, previous IMDs increased the risk of incident ALS; however, in participants with IMD duration <10 years or CRP<1.3mg/L or males, IMDs had no effect on incident ALS.
    Interpretation: Our study provides evidence that previous any IMDs and endocrine-system and the intestinal-system specific IMDs are associated with an increased risk of developing ALS in females, but not in males.
    MeSH term(s) Male ; Female ; Humans ; Prospective Studies ; UK Biobank ; Amyotrophic Lateral Sclerosis/epidemiology ; Biological Specimen Banks ; Incidence ; Immune System Diseases
    Language English
    Publishing date 2024-03-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1356132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cardiometabolic diseases, total mortality, and benefits of adherence to a healthy lifestyle

    Chenjie Xu / Zhi Cao

    Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-

    a 13-year prospective UK Biobank study

    2022  Volume 9

    Abstract: Abstract Background Cardiometabolic disease (CMD) increases the risk of mortality, but the extent to which this can be offset by adherence to a healthy lifestyle is unknown. We aimed to investigate whether and to what extent a combination of healthy ... ...

    Abstract Abstract Background Cardiometabolic disease (CMD) increases the risk of mortality, but the extent to which this can be offset by adherence to a healthy lifestyle is unknown. We aimed to investigate whether and to what extent a combination of healthy lifestyle is associated with lower risk of total mortality that related to CMD. Methods Data for this prospective analysis was sourced from the UK Biobank with 356,967 participants aged 37 to 73 years between 2006 and 2010. Adherence to a healthy lifestyle was determined on the basis of four factors: no smoking, healthy diet, body mass index < 30 kg/m2, and regular physical activity. CMD was defined as any of incidence of diabetes, coronary heart disease and stroke at baseline. Cox proportional hazards models were used to calculate hazard ratios (HRs) and confidence intervals (CIs) of the associations of CMDs and lifestyle factors with total mortality. Results During a median follow-up of 13 years, a total of 21,473 death events occurred. The multivariable-adjusted HRs of mortality were 1.49 (95% CI 1.53–1.56) for one, 2.17 (95% CI 2.01–2.34) for two, and 3.75 (95% CI 3.04–4.61) for three CMDs. In joint exposure analysis, compared with CMDs-free and a favorable lifestyle, the HRs of mortality were 2.57 (95% CI 2.38–2.78) for patients with CMDs plus an unfavorable lifestyle and 1.58 (95% CI 1.50–1.66) for those with CMDs plus a favorable lifestyle. A favorable lifestyle attenuates the CMDs-related risk of mortality by approximately 63%. The mortality risk of CMDs-free people but have unfavorable lifestyle was higher than those who have over one CMDs but have favorable lifestyle. Conclusion The potential effect of an increasing number of CMDs on total mortality appears additive, adherence to a healthy lifestyle may attenuate the CMDs-related mortality risk by more than 60%. These findings highlight the potential importance of lifestyle interventions to reduce risk of mortality across entire populations, even in patients with CMDs.
    Keywords Cardiometabolic disease ; Diabetes ; Cardiovascular disease ; Healthy lifestyle ; Mortality ; Medicine ; R
    Subject code 310 ; 610
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Cardiometabolic diseases, total mortality, and benefits of adherence to a healthy lifestyle: a 13-year prospective UK Biobank study.

    Xu, Chenjie / Cao, Zhi

    Journal of translational medicine

    2022  Volume 20, Issue 1, Page(s) 234

    Abstract: Background: Cardiometabolic disease (CMD) increases the risk of mortality, but the extent to which this can be offset by adherence to a healthy lifestyle is unknown. We aimed to investigate whether and to what extent a combination of healthy lifestyle ... ...

    Abstract Background: Cardiometabolic disease (CMD) increases the risk of mortality, but the extent to which this can be offset by adherence to a healthy lifestyle is unknown. We aimed to investigate whether and to what extent a combination of healthy lifestyle is associated with lower risk of total mortality that related to CMD.
    Methods: Data for this prospective analysis was sourced from the UK Biobank with 356,967 participants aged 37 to 73 years between 2006 and 2010. Adherence to a healthy lifestyle was determined on the basis of four factors: no smoking, healthy diet, body mass index < 30 kg/m
    Results: During a median follow-up of 13 years, a total of 21,473 death events occurred. The multivariable-adjusted HRs of mortality were 1.49 (95% CI 1.53-1.56) for one, 2.17 (95% CI 2.01-2.34) for two, and 3.75 (95% CI 3.04-4.61) for three CMDs. In joint exposure analysis, compared with CMDs-free and a favorable lifestyle, the HRs of mortality were 2.57 (95% CI 2.38-2.78) for patients with CMDs plus an unfavorable lifestyle and 1.58 (95% CI 1.50-1.66) for those with CMDs plus a favorable lifestyle. A favorable lifestyle attenuates the CMDs-related risk of mortality by approximately 63%. The mortality risk of CMDs-free people but have unfavorable lifestyle was higher than those who have over one CMDs but have favorable lifestyle.
    Conclusion: The potential effect of an increasing number of CMDs on total mortality appears additive, adherence to a healthy lifestyle may attenuate the CMDs-related mortality risk by more than 60%. These findings highlight the potential importance of lifestyle interventions to reduce risk of mortality across entire populations, even in patients with CMDs.
    MeSH term(s) Biological Specimen Banks ; Cardiovascular Diseases ; Healthy Lifestyle ; Humans ; Life Style ; Risk Factors ; Stroke/complications ; United Kingdom/epidemiology
    Language English
    Publishing date 2022-05-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2118570-0
    ISSN 1479-5876 ; 1479-5876
    ISSN (online) 1479-5876
    ISSN 1479-5876
    DOI 10.1186/s12967-022-03439-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Optimized Unilateral Magnetic Resonance Sensor with Constant Gradient and Its Applications in Composite Insulators.

    Guo, Pan / Yang, Chenjie / Wu, Jiamin / Xu, Zheng

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 12

    Abstract: In this study, an optimized unilateral magnetic resonance sensor with a three-magnet array is presented for assessing the aging of composite insulators in power grids. The sensor's optimization involved enhancing the static magnetic field strength and ... ...

    Abstract In this study, an optimized unilateral magnetic resonance sensor with a three-magnet array is presented for assessing the aging of composite insulators in power grids. The sensor's optimization involved enhancing the static magnetic field strength and the homogeneity of the RF field while maintaining a constant gradient in the direction of the vertical sensor surface and maximizing homogeneity in the horizontal direction. The center layer of the target area was positioned 4 mm from the coil's upper surface, resulting in a magnetic field strength of 139.74 mT at the center point of the area, with a gradient of 2.318 T/m and a corresponding hydrogen atomic nuclear magnetic resonance frequency of 5.95 MHz. The magnetic field uniformity over a 10 mm × 10 mm range on the plane was 0.75%. The sensor measured 120 mm × 130.5 mm × 76 mm and weighed 7.5 kg. Employing the optimized sensor, magnetic resonance assessment experiments were conducted on composite insulator samples utilizing the CPMG (Carr-Purcell-Meiboom-Gill) pulse sequence. The T
    MeSH term(s) Magnetic Resonance Spectroscopy/methods ; Magnetic Resonance Imaging/methods ; Magnetic Fields ; Hydrogen
    Chemical Substances Hydrogen (7YNJ3PO35Z)
    Language English
    Publishing date 2023-06-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23125476
    Database MEDical Literature Analysis and Retrieval System OnLINE

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