LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 3 of total 3

Search options

  1. Article ; Online: Mapping the zoonotic niche of Lassa fever in Africa.

    Mylne, Adrian Q N / Pigott, David M / Longbottom, Joshua / Shearer, Freya / Duda, Kirsten A / Messina, Jane P / Weiss, Daniel J / Moyes, Catherine L / Golding, Nick / Hay, Simon I

    Transactions of the Royal Society of Tropical Medicine and Hygiene

    2015  Volume 109, Issue 8, Page(s) 483–492

    Abstract: Background: Lassa fever is a viral haemorrhagic illness responsible for disease outbreaks across West Africa. It is a zoonosis, with the primary reservoir species identified as the Natal multimammate mouse, Mastomys natalensis. The host is distributed ... ...

    Abstract Background: Lassa fever is a viral haemorrhagic illness responsible for disease outbreaks across West Africa. It is a zoonosis, with the primary reservoir species identified as the Natal multimammate mouse, Mastomys natalensis. The host is distributed across sub-Saharan Africa while the virus' range appears to be restricted to West Africa. The majority of infections result from interactions between the animal reservoir and human populations, although secondary transmission between humans can occur, particularly in hospital settings.
    Methods: Using a species distribution model, the locations of confirmed human and animal infections with Lassa virus (LASV) were used to generate a probabilistic surface of zoonotic transmission potential across sub-Saharan Africa.
    Results: Our results predict that 37.7 million people in 14 countries, across much of West Africa, live in areas where conditions are suitable for zoonotic transmission of LASV. Four of these countries, where at-risk populations are predicted, have yet to report any cases of Lassa fever.
    Conclusions: These maps act as a spatial guide for future surveillance activities to better characterise the geographical distribution of the disease and understand the anthropological, virological and zoological interactions necessary for viral transmission. Combining this zoonotic niche map with detailed patient travel histories can aid differential diagnoses of febrile illnesses, enabling a more rapid response in providing care and reducing the risk of onward transmission.
    MeSH term(s) Animals ; Cluster Analysis ; Disease Outbreaks/prevention & control ; Disease Reservoirs ; Humans ; Lassa Fever/epidemiology ; Lassa Fever/transmission ; Lassa virus/isolation & purification ; Murinae ; Population Surveillance/methods ; Rodent Diseases/epidemiology ; Rodent Diseases/virology ; Topography, Medical ; Zoonoses
    Language English
    Publishing date 2015-06-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 441375-1
    ISSN 1878-3503 ; 0035-9203
    ISSN (online) 1878-3503
    ISSN 0035-9203
    DOI 10.1093/trstmh/trv047
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Un I Zs.257: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: The global distribution of the arbovirus vectors Aedes aegypti and Ae. albopictus.

    Kraemer, Moritz U G / Sinka, Marianne E / Duda, Kirsten A / Mylne, Adrian Q N / Shearer, Freya M / Barker, Christopher M / Moore, Chester G / Carvalho, Roberta G / Coelho, Giovanini E / Van Bortel, Wim / Hendrickx, Guy / Schaffner, Francis / Elyazar, Iqbal R F / Teng, Hwa-Jen / Brady, Oliver J / Messina, Jane P / Pigott, David M / Scott, Thomas W / Smith, David L /
    Wint, G R William / Golding, Nick / Hay, Simon I

    eLife

    2015  Volume 4, Page(s) e08347

    Abstract: Dengue and chikungunya are increasing global public health concerns due to their rapid geographical spread and increasing disease burden. Knowledge of the contemporary distribution of their shared vectors, Aedes aegypti and Aedes albopictus remains ... ...

    Abstract Dengue and chikungunya are increasing global public health concerns due to their rapid geographical spread and increasing disease burden. Knowledge of the contemporary distribution of their shared vectors, Aedes aegypti and Aedes albopictus remains incomplete and is complicated by an ongoing range expansion fuelled by increased global trade and travel. Mapping the global distribution of these vectors and the geographical determinants of their ranges is essential for public health planning. Here we compile the largest contemporary database for both species and pair it with relevant environmental variables predicting their global distribution. We show Aedes distributions to be the widest ever recorded; now extensive in all continents, including North America and Europe. These maps will help define the spatial limits of current autochthonous transmission of dengue and chikungunya viruses. It is only with this kind of rigorous entomological baseline that we can hope to project future health impacts of these viruses.
    MeSH term(s) Aedes/growth & development ; Animals ; Arbovirus Infections/transmission ; Global Health ; Humans ; Insect Vectors ; Phylogeography
    Language English
    Publishing date 2015-06-30
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.08347
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Local, national, and regional viral haemorrhagic fever pandemic potential in Africa: a multistage analysis.

    Pigott, David M / Deshpande, Aniruddha / Letourneau, Ian / Morozoff, Chloe / Reiner, Robert C / Kraemer, Moritz U G / Brent, Shannon E / Bogoch, Isaac I / Khan, Kamran / Biehl, Molly H / Burstein, Roy / Earl, Lucas / Fullman, Nancy / Messina, Jane P / Mylne, Adrian Q N / Moyes, Catherine L / Shearer, Freya M / Bhatt, Samir / Brady, Oliver J /
    Gething, Peter W / Weiss, Daniel J / Tatem, Andrew J / Caley, Luke / De Groeve, Tom / Vernaccini, Luca / Golding, Nick / Horby, Peter / Kuhn, Jens H / Laney, Sandra J / Ng, Edmond / Piot, Peter / Sankoh, Osman / Murray, Christopher J L / Hay, Simon I

    Lancet (London, England)

    2017  Volume 390, Issue 10113, Page(s) 2662–2672

    Abstract: Background: Predicting when and where pathogens will emerge is difficult, yet, as shown by the recent Ebola and Zika epidemics, effective and timely responses are key. It is therefore crucial to transition from reactive to proactive responses for these ... ...

    Abstract Background: Predicting when and where pathogens will emerge is difficult, yet, as shown by the recent Ebola and Zika epidemics, effective and timely responses are key. It is therefore crucial to transition from reactive to proactive responses for these pathogens. To better identify priorities for outbreak mitigation and prevention, we developed a cohesive framework combining disparate methods and data sources, and assessed subnational pandemic potential for four viral haemorrhagic fevers in Africa, Crimean-Congo haemorrhagic fever, Ebola virus disease, Lassa fever, and Marburg virus disease.
    Methods: In this multistage analysis, we quantified three stages underlying the potential of widespread viral haemorrhagic fever epidemics. Environmental suitability maps were used to define stage 1, index-case potential, which assesses populations at risk of infection due to spillover from zoonotic hosts or vectors, identifying where index cases could present. Stage 2, outbreak potential, iterates upon an existing framework, the Index for Risk Management, to measure potential for secondary spread in people within specific communities. For stage 3, epidemic potential, we combined local and international scale connectivity assessments with stage 2 to evaluate possible spread of local outbreaks nationally, regionally, and internationally.
    Findings: We found epidemic potential to vary within Africa, with regions where viral haemorrhagic fever outbreaks have previously occurred (eg, western Africa) and areas currently considered non-endemic (eg, Cameroon and Ethiopia) both ranking highly. Tracking transitions between stages showed how an index case can escalate into a widespread epidemic in the absence of intervention (eg, Nigeria and Guinea). Our analysis showed Chad, Somalia, and South Sudan to be highly susceptible to any outbreak at subnational levels.
    Interpretation: Our analysis provides a unified assessment of potential epidemic trajectories, with the aim of allowing national and international agencies to pre-emptively evaluate needs and target resources. Within each country, our framework identifies at-risk subnational locations in which to improve surveillance, diagnostic capabilities, and health systems in parallel with the design of policies for optimal responses at each stage. In conjunction with pandemic preparedness activities, assessments such as ours can identify regions where needs and provisions do not align, and thus should be targeted for future strengthening and support.
    Funding: Paul G Allen Family Foundation, Bill & Melinda Gates Foundation, Wellcome Trust, UK Department for International Development.
    MeSH term(s) Africa/epidemiology ; Disease Outbreaks/statistics & numerical data ; Epidemics/statistics & numerical data ; Hemorrhagic Fevers, Viral/epidemiology ; Humans ; Pandemics/statistics & numerical data ; Risk Assessment
    Language English
    Publishing date 2017-10-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(17)32092-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.5: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 94: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top