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Article ; Online: Relevancia de marcadores de daño miocárdico en la evolución de los pacientes con COVID-19. Respuesta.

Calvo-Fernández, Alicia / Marrugat, Jaume / Vaquerizo, Beatriz

2021 Volume 75, Issue 1, Page(s) 106

Title translation	Relevance of myocardial injury biomarkers to the prognosis of COVID-19 patients. Response.
Language	Spanish
Publishing date	2021-09-27
Publishing country	Spain
Document type	Journal Article
ZDB-ID	128925-1
ISSN	1579-2242 ; 0300-8932
ISSN (online)	1579-2242
ISSN	0300-8932
DOI	10.1016/j.recesp.2021.08.012
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Article ; Online: Relevance of myocardial injury biomarkers to the prognosis of COVID-19 patients. Response.

Calvo-Fernández, Alicia / Marrugat, Jaume / Vaquerizo, Beatriz

Revista espanola de cardiologia (English ed.)

2021 Volume 75, Issue 1, Page(s) 106

MeSH term(s)	Biomarkers ; COVID-19 ; Humans ; Prognosis ; SARS-CoV-2
Chemical Substances	Biomarkers
Language	Spanish
Publishing date	2021-10-19
Publishing country	Spain
Document type	Letter ; Comment
ZDB-ID	2592481-3
ISSN	1885-5857 ; 1885-5857
ISSN (online)	1885-5857
ISSN	1885-5857
DOI	10.1016/j.rec.2021.08.019
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Article ; Online: Baseline NT-proBNP levels as a predictor of short-and long-term prognosis in COVID-19 patients: a prospective observational study.

Mojón-Álvarez, Diana / Giralt, Teresa / Carreras-Mora, José / Calvo-Fernández, Alicia / Izquierdo, Andrea / Soler, Cristina / Cabero, Paula / Pérez-Fernández, Silvia / Vaquerizo, Beatriz / Ribas Barquet, Núria

BMC infectious diseases

2024 Volume 24, Issue 1, Page(s) 58

Abstract: Background: Up to 20% of COVID-19 patients can suffer COVID-19-related myocardial injury. Elevated cardiac biomarkers, such as hs-cTnT and NT-proBNP, have been related to worse short-term prognosis. However, data on NT-proBNP and long-term prognosis are ...

Abstract	Background: Up to 20% of COVID-19 patients can suffer COVID-19-related myocardial injury. Elevated cardiac biomarkers, such as hs-cTnT and NT-proBNP, have been related to worse short-term prognosis. However, data on NT-proBNP and long-term prognosis are scarce. We have evaluated the potential association of baseline age-adjusted NT-proBNP levels and outcomes at one-year follow-up in COVID-19 patients. Methods: This was a single-center prospective study of 499 COVID-19 patients in whom NT-proBNP was assessed at hospital admission. NT-proBNP levels were age-adjusted and patients were classified as high or low NT-proBNP. Clinical and demographic characteristics, comorbidities, laboratory results, and in-hospital complications and mortality were compared between the two groups. Survivors of the acute phase of COVID-19 were followed up for one year from admission to detect readmissions and mortality. Results: The 68 patients with high NT-proBNP levels at hospital admission were older, with more cardiovascular risk factors, cardiovascular disease, comorbidities, myocardial injury, and higher levels of inflammatory markers than patients with low NT-proBNP levels. They also had more in-hospital complications and a higher acute-phase mortality rate (60.3% vs. 10.2%, p < 0.001). High NT-proBNP levels were an independent marker of death during hospitalization (HR 1.95; CI 1.07-3.52). At one-year follow-up, high NT-proBNP levels were independently associated with mortality (HR 2.69; CI 1.47-4.89). Among survivors of the acute phase of COVID-19, there were no differences in hospital readmissions between those with high vs. low NT-proBNP levels, but survivors with high baseline NT-proBNP levels showed a higher 1-year mortality rate (7.4% vs. 1.3%, p = 0.018). Conclusions: High age-adjusted NT-proBNP levels at the time of hospital admission for COVID-19 are associated with poor short and long-term prognosis. High NT-proBNP seems also to be related to worse prognosis in survivors of the acute phase of COVID-19. A closer follow-up on these patients may be crucial.
MeSH term(s)	Humans ; Prospective Studies ; COVID-19 ; Natriuretic Peptide, Brain ; Prognosis
Chemical Substances	pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0)
Language	English
Publishing date	2024-01-08
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-024-08980-3
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Article: The natural history of QTc interval and its clinical impact in coronavirus disease 2019 survivors after 1 year.

Mojón-Álvarez, Diana / Izquierdo, Andrea / Cubero-Gallego, Héctor / Calvo-Fernández, Alicia / Marrugat, Jaume / Pérez-Fernández, Silvia / Cabero, Paula / Solà-Richarte, Claudia / Soler, Cristina / Farré, Núria / Vaquerizo, Beatriz

Frontiers in cardiovascular medicine

2023 Volume 10, Page(s) 1140276

Abstract: Background and objective: Prolonged QTc interval on admission and a higher risk of death in SARS-CoV-2 patients have been reported. The long-term clinical impact of prolonged QTc interval is unknown. This study examined the relationship in COVID-19 ... ...

Abstract	Background and objective: Prolonged QTc interval on admission and a higher risk of death in SARS-CoV-2 patients have been reported. The long-term clinical impact of prolonged QTc interval is unknown. This study examined the relationship in COVID-19 survivors of a prolonged QTc on admission with long-term adverse events, changes in QTc duration and its impact on 1-year prognosis, and factors associated with a prolonged QTc at follow-up. Methods: We conducted a single-center prospective cohort study of 523 SARS-CoV-2-positive patients who were alive on discharge. An electrocardiogram was taken on these patients within the first 48 h after diagnosis and before the administration of any medication with a known effect on QT interval and repeated in 421 patients 7 months after discharge. Mortality, hospital readmission, and new arrhythmia rates 1 year after discharge were reviewed. Results: Thirty-one (6.3%) survivors had a baseline prolonged QTc. They were older, had more cardiovascular risk factors, cardiac disease, and comorbidities, and higher levels of terminal pro-brain natriuretic peptide. There was no relationship between prolonged QTc on admission and the 1-year endpoint (9.8% vs. 5.5%, Conclusions: Prolonged QTc in the acute phase normalized in most COVID-19 survivors and had no clinical long-term impact. Prolonged QTc at follow-up was related to the presence of obesity and previously acquired chronic diseases and was not related to 1-year prognosis.
Language	English
Publishing date	2023-04-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2023.1140276
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Article ; Online: Single antiplatelet therapy after left atrial appendage closure in patients with AF: safety and effectiveness.

Llagostera-Martín, Marc / Cainzos, Miguel / Salvatella, Neus / Cubero-Gallego, Héctor / Mas-Stachurska, Aleksandra / Sánchez-Carpintero, Andrea / Tizón-Marcos, Helena / Calvo-Fernández, Alicia / Molina, Luis / Vaquerizo, Beatriz

Revista espanola de cardiologia (English ed.)

2023 Volume 77, Issue 2, Page(s) 150–157

Abstract: Introduction and objectives: The optimal antithrombotic strategy following left atrial appendage closure (LAAC) is poorly defined in patients with nonvalvular atrial fibrillation. We assessed the safety and effectiveness of a single antiplatelet ... ...

Abstract	Introduction and objectives: The optimal antithrombotic strategy following left atrial appendage closure (LAAC) is poorly defined in patients with nonvalvular atrial fibrillation. We assessed the safety and effectiveness of a single antiplatelet treatment (SAPT) strategy after LAAC in a population at high risk of ischemic and bleeding events. Methods: This single-center, observational, prospective study included a consecutive cohort of patients who underwent LAAC using the LAmbre device (Lifetech Scientific, China) and who were discharged with SAPT. The primary outcome was a composite of stroke, systemic embolism, and device-related thrombosis during follow-up. Secondary endpoints were cardiovascular mortality and major bleeding events (BARC ≥3a). Clinical follow-up was performed at 1, 6, and 12 months and subsequently on an annual basis. Transesophageal echocardiography was performed at 1 and 12 months of follow-up. Results: The study comprised 74 patients. The median age was 77 [72-83] years and 43% were women. The cohort exhibited a high prevalence of comorbidities and cardiovascular risk factors. The median CHA Conclusions: SAPT appears to be a safe and effective treatment following LAAC in patients at high ischemic and hemorrhagic risk. Further studies are needed to confirm our findings.
MeSH term(s)	Aged ; Female ; Humans ; Male ; Atrial Appendage/diagnostic imaging ; Atrial Appendage/surgery ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/surgery ; Hemorrhage/chemically induced ; Hemorrhage/epidemiology ; Left Atrial Appendage Closure ; Platelet Aggregation Inhibitors/adverse effects ; Platelet Aggregation Inhibitors/therapeutic use ; Prospective Studies ; Stroke/epidemiology ; Thrombosis/epidemiology ; Treatment Outcome ; Aged, 80 and over
Chemical Substances	Platelet Aggregation Inhibitors
Language	Spanish
Publishing date	2023-10-23
Publishing country	Spain
Document type	Observational Study ; Journal Article
ZDB-ID	2592481-3
ISSN	1885-5857 ; 1885-5857
ISSN (online)	1885-5857
ISSN	1885-5857
DOI	10.1016/j.rec.2023.06.020
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Article ; Online: The conventional isoproterenol-induced heart failure model does not consistently mimic the diaphragmatic dysfunction observed in patients.

Cabrera-Aguilera, Ignacio / Falcones, Bryan / Calvo-Fernández, Alicia / Benito, Begoña / Barreiro, Esther / Gea, Joaquim / Farré, Ramon / Almendros, Isaac / Farré, Núria

PloS one

2020 Volume 15, Issue 7, Page(s) e0236923

Abstract: Heart failure (HF) impairs diaphragm function. Animal models realistically mimicking HF should feature both the cardiac alterations and the diaphragmatic dysfunction characterizing this disease. The isoproterenol-induced HF model is widely used, but ... ...

Abstract	Heart failure (HF) impairs diaphragm function. Animal models realistically mimicking HF should feature both the cardiac alterations and the diaphragmatic dysfunction characterizing this disease. The isoproterenol-induced HF model is widely used, but whether it presents diaphragmatic dysfunction is unknown. However, indirect data from research in other fields suggest that isoproterenol could increase diaphragm function. The aim of this study was to test the hypothesis that the widespread rodent model of isoproterenol-induced HF results in increased diaphragmatic contractility. Forty C57BL/6J male mice were randomized into 2 groups: HF and healthy controls. After 30 days of isoproterenol infusion to establish HF, in vivo diaphragmatic excursion and ex vivo isolated diaphragm contractibility were measured. As compared with healthy controls, mice with isoproterenol-induced HF showed the expected changes in structural and functional echocardiographic parameters and lung edema. isoproterenol-induced HF increased in vivo diaphragm excursion (by ≈30%, p<0.01) and increased by ≈50% both ex vivo peak specific force (p<0.05) and tetanic force (p<0.05) at almost all 10-100 Hz frequencies (p<0.05), with reduced fatigue resistance (p<0.01) when compared with healthy controls. Expression of myosin genes encoding the main muscle fiber types revealed that Myh4 was higher in isoproterenol-induced HF than in healthy controls (p<0.05), suggesting greater distribution of type IIb fibers. These results show that the conventional isoproterenol-induced HF model increases diaphragm contraction, a finding contrary to what is observed in patients with HF. Therefore, this specific model seems limited for translational an integrative HF research, especially when cardio-respiratory interactions are investigated.
MeSH term(s)	Adrenergic beta-Agonists/toxicity ; Animals ; Diaphragm/drug effects ; Diaphragm/physiopathology ; Disease Models, Animal ; Heart Failure/chemically induced ; Heart Failure/physiopathology ; Humans ; Isoproterenol/toxicity ; Male ; Mice ; Mice, Inbred C57BL ; Muscle Fibers, Skeletal/drug effects ; Muscle Fibers, Skeletal/pathology ; Muscle Proteins/metabolism ; Pulmonary Edema/chemically induced ; Pulmonary Edema/pathology
Chemical Substances	Adrenergic beta-Agonists ; Muscle Proteins ; Isoproterenol (L628TT009W)
Language	English
Publishing date	2020-07-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0236923
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Article ; Online: Alta tasa de struts no cubiertos en [i]stents[/i] de última generación con polímero persistente, absorbible o sin polímero a un mes del implante

Alicia Calvo-Fernández / Josep Gómez-Lara / Roberto Elosua / Xavier Durán / Héctor Cubero-Gallego / Helena Tizón-Marcos / Neus Salvatella / Alejandro Negrete / Raúl Millán / Consol Ivern / José Luis Díez / Andrea Sánchez-Carpintero / Núria Farré / José M. de la Torre Hernández / Beatriz Vaquerizo

REC: Interventional Cardiology, Vol 5, Iss 1, Pp 20-

2023 Volume 28

Abstract: RESUMEN Introducción y objetivos: A pesar del desarrollo de los stents farmacoactivos, el retraso en la endotelización puede causar trombosis tardía. La tomografía de coherencia óptica puede evaluar la cobertura intimal. El objetivo de este estudio fue ... ...

Abstract	RESUMEN Introducción y objetivos: A pesar del desarrollo de los stents farmacoactivos, el retraso en la endotelización puede causar trombosis tardía. La tomografía de coherencia óptica puede evaluar la cobertura intimal. El objetivo de este estudio fue comparar la cobertura y la aposición en lesiones coronarias no complejas de 3 tipos de stent: stent de everolimus con polímero persistente, stent de everolimus con polímero bioabsorbible y stent de biolimus sin polímero, a 1 y 6 meses del implante. Métodos: Se diseñó un estudio prospectivo, multicéntrico, no aleatorizado, que comparó 3 stents farmacoactivos. Se realizaron angiografía y tomografía de coherencia óptica a 1 o 6 meses. El objetivo primario fue comparar la cobertura. Resultados: Se incluyeron 104 pacientes con lesiones coronarias de novo no complejas. Se implantó stent sin polímero a 44 pacientes, stent con polímero bioabsorbible a 35 pacientes y stent con polímero persistente a 25 pacientes. Al mes, se observó una alta tasa de struts no cubiertos, sin diferencias significativas entre los grupos (80,2% sin polímero, 88,1% con polímero bioabsorbible y 82,5% con polímero persistente; p = 0,209). La cobertura mejoró a los 6 meses en los 3 stents, sin diferencias significativas entre ellos (97, 95 y 93,7%, respectivamente; p = 0,172). Conclusiones: En los pacientes con lesiones coronarias no complejas tratados con stent con polímero persistente, con polímero bsorbible o sin polímero, la cobertura y la aposición fueron subóptimas a 1 mes del implante, con mejoría significativa a los 6 meses.
Keywords	Tomografía de coherencia óptica ; Stent farmacoactivo ; Endotelización ; Aposición ; Reestenosis ; Internal medicine ; RC31-1245
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Permanyer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: High rate of uncovered struts in latest generation drug-eluting stents with durable, biodegradable polymer or lack of it 1 month after implantation

REC: Interventional Cardiology (English Ed.), Vol 5, Iss 1, Pp 20-

2023 Volume 28

Abstract: ABSTRACT Introduction and objectives: Delayed vascular healing may induce late stent thrombosis. Optical coherence tomography (OCT) is useful to evaluate endothelial coverage. The objective of this study was to compare stent coverage and apposition in ... ...

Abstract	ABSTRACT Introduction and objectives: Delayed vascular healing may induce late stent thrombosis. Optical coherence tomography (OCT) is useful to evaluate endothelial coverage. The objective of this study was to compare stent coverage and apposition in non-complex coronary artery lesions treated with durable polymer-coated everolimus-eluting stents (durable-polymer EES) vs biodegradable polymer-coated everolimus-eluting stents (biodegradable-polymer EES) vs polymer-free biolimus-eluting stents (BES) 1 and 6 months after stent implantation. Methods: Prospective, multicenter, non-randomized study that compared the 3 types of DES. Follow-up angiography and OCT were performed 1 and 6 months later. The primary endpoint was the rate of uncovered struts as assessed by the OCT at 1 month. Results: A total of 104 patients with de novo non-complex coronary artery lesions were enrolled. A total of 44 patients were treated with polymer-free BES, 35 with biodegradable-polymer EES, and 25 with durable-polymer EES. A high rate of uncovered struts was found at 1 month with no significant differences reported among the stents (80.2%, polymer-free BES; 88.1%, biodegradable-polymer EES; 82.5%, durable-polymer EES; P = .209). Coverage improved after 6 months in the 3 groups without significant differences being reported (97%, 95%, and 93.7%, respectively; P = .172). Conclusions: In patients with de novo non-complex coronary artery lesions treated with durable vs biodegradable vs polymer-free DES, strut coverage and apposition were suboptimal at 1 month with significant improvement at 6 months.
Keywords	Optical coherence tomography ; Drug-eluting stents ; Endothelization ; Apposition ; Restenosis ; Medicine ; R
Subject code	660
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Permanyer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Prognostic Implications of Chronic Heart Failure and Utility of NT-proBNP Levels in Heart Failure Patients with SARS-CoV-2 Infection.

Belarte-Tornero, Laia C / Valdivielso-Moré, Sandra / Vicente Elcano, Miren / Solé-González, Eduard / Ruíz-Bustillo, Sonia / Calvo-Fernández, Alicia / Subinara, Isaac / Cabero, Paula / Soler, Cristina / Cubero-Gallego, Héctor / Vaquerizo, Beatriz / Farré, Núria

Journal of clinical medicine

2021 Volume 10, Issue 2

Abstract: Background: The prevalence and prognostic value of chronic heart failure (CHF) in the setting of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection has seldom been studied. The aim of this study was to analyze the prevalence and ... ...

Abstract	Background: The prevalence and prognostic value of chronic heart failure (CHF) in the setting of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection has seldom been studied. The aim of this study was to analyze the prevalence and prognosis of CHF in this setting. Methods: This single-center study included 829 consecutive patients with SARS-CoV-2 infection from February to April 2020. Patients with a previous history of CHF were matched 1:2 for age and sex. We analyze the prognostic value of pre-existing CHF. Prognostic implications of N terminal pro brain natriuretic peptide (NT-proBNP) levels on admission in the CHF cohort were explored. Results: A total of 129 patients (43 CHF and 86 non-CHF) where finally included. All-cause mortality was higher in CHF patients compared to non-CHF patients (51.2% vs. 29.1%, Conclusions: All-cause mortality in CHF patients hospitalized due to SARS-CoV-2 infection was 51.2%. CHF was independently associated with all-cause mortality (HR 2.3, CI 95% 1.26-4.2). NT-proBNP levels could be used for stratification risk purposes to guide medical decisions if larger studies confirm this finding.
Language	English
Publishing date	2021-01-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10020323
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Article ; Online: The conventional isoproterenol-induced heart failure model does not consistently mimic the diaphragmatic dysfunction observed in patients.

Ignacio Cabrera-Aguilera / Bryan Falcones / Alicia Calvo-Fernández / Begoña Benito / Esther Barreiro / Joaquim Gea / Ramon Farré / Isaac Almendros / Núria Farré

PLoS ONE, Vol 15, Iss 7, p e

2020 Volume 0236923

Abstract	Heart failure (HF) impairs diaphragm function. Animal models realistically mimicking HF should feature both the cardiac alterations and the diaphragmatic dysfunction characterizing this disease. The isoproterenol-induced HF model is widely used, but whether it presents diaphragmatic dysfunction is unknown. However, indirect data from research in other fields suggest that isoproterenol could increase diaphragm function. The aim of this study was to test the hypothesis that the widespread rodent model of isoproterenol-induced HF results in increased diaphragmatic contractility. Forty C57BL/6J male mice were randomized into 2 groups: HF and healthy controls. After 30 days of isoproterenol infusion to establish HF, in vivo diaphragmatic excursion and ex vivo isolated diaphragm contractibility were measured. As compared with healthy controls, mice with isoproterenol-induced HF showed the expected changes in structural and functional echocardiographic parameters and lung edema. isoproterenol-induced HF increased in vivo diaphragm excursion (by ≈30%, p<0.01) and increased by ≈50% both ex vivo peak specific force (p<0.05) and tetanic force (p<0.05) at almost all 10-100 Hz frequencies (p<0.05), with reduced fatigue resistance (p<0.01) when compared with healthy controls. Expression of myosin genes encoding the main muscle fiber types revealed that Myh4 was higher in isoproterenol-induced HF than in healthy controls (p<0.05), suggesting greater distribution of type IIb fibers. These results show that the conventional isoproterenol-induced HF model increases diaphragm contraction, a finding contrary to what is observed in patients with HF. Therefore, this specific model seems limited for translational an integrative HF research, especially when cardio-respiratory interactions are investigated.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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