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  1. Article ; Online: Ketamine in the Real World: Where Do We Go From Here?

    Wilkinson, Samuel T

    The Journal of clinical psychiatry

    2022  Volume 83, Issue 6

    MeSH term(s) Excitatory Amino Acid Antagonists ; Humans ; Ketamine/adverse effects
    Chemical Substances Excitatory Amino Acid Antagonists ; Ketamine (690G0D6V8H)
    Language English
    Publishing date 2022-09-14
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    DOI 10.4088/JCP.22com14648
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  2. Article ; Online: The Rapidly Shifting Ketamine Landscape in the US.

    Wilkinson, Samuel T / Palamar, Joseph J / Sanacora, Gerard

    JAMA psychiatry

    2024  Volume 81, Issue 3, Page(s) 221–222

    MeSH term(s) Humans ; Ketamine/pharmacology ; Ketamine/therapeutic use ; Substance-Related Disorders ; Illicit Drugs
    Chemical Substances Ketamine (690G0D6V8H) ; Illicit Drugs
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701203-7
    ISSN 2168-6238 ; 2168-622X
    ISSN (online) 2168-6238
    ISSN 2168-622X
    DOI 10.1001/jamapsychiatry.2023.4945
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  3. Article ; Online: The Role of Psychotherapy in the Management of Treatment-Resistant Depression.

    Rogan, Taylor / Wilkinson, Samuel T

    The Psychiatric clinics of North America

    2023  Volume 46, Issue 2, Page(s) 349–358

    Abstract: This article reviews the role of psychotherapy in management of treatment-resistant depression (TRD). Meta-analyses of randomized trials show that psychotherapy has a positive therapeutic benefit in TRD. There is less evidence that one type of ... ...

    Abstract This article reviews the role of psychotherapy in management of treatment-resistant depression (TRD). Meta-analyses of randomized trials show that psychotherapy has a positive therapeutic benefit in TRD. There is less evidence that one type of psychotherapy approach is superior to another. However, more trials have examined cognitive-based therapies than other forms of psychotherapy. Also reviewed is the potential combination of psychotherapy modalities and medication/somatic therapies as an approach to TRD. There is significant interest in ways that psychotherapy modalities could be combined with medication/somatic therapies to harness a state of enhanced neural plasticity and improve longer-term outcomes in mood disorders.
    MeSH term(s) Humans ; Depression/therapy ; Antidepressive Agents/therapeutic use ; Psychotherapy ; Cognitive Behavioral Therapy ; Depressive Disorder, Treatment-Resistant/therapy
    Chemical Substances Antidepressive Agents
    Language English
    Publishing date 2023-03-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 431518-2
    ISSN 1558-3147 ; 0193-953X
    ISSN (online) 1558-3147
    ISSN 0193-953X
    DOI 10.1016/j.psc.2023.02.006
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  4. Article ; Online: At-home ketamine; still a lot to learn.

    Wilkinson, Samuel T / Sanacora, Gerard

    Journal of affective disorders

    2022  Volume 318, Page(s) 150–151

    MeSH term(s) Humans ; Ketamine/adverse effects ; Learning
    Chemical Substances Ketamine (690G0D6V8H)
    Language English
    Publishing date 2022-09-05
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2022.08.090
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  5. Article ; Online: An Update on Community Ketamine Practices.

    O'Brien, Brittany / Wilkinson, Samuel T / Mathew, Sanjay J

    The American journal of psychiatry

    2022  Volume 179, Issue 5, Page(s) 393–394

    MeSH term(s) Humans ; Ketamine/therapeutic use
    Chemical Substances Ketamine (690G0D6V8H)
    Language English
    Publishing date 2022-05-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    DOI 10.1176/appi.ajp.21111086
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  6. Article ; Online: Effects of Electroconvulsive Therapy on Functional Outcomes Among Medicare Patients With Comorbid Depression and Dementia: A Nationwide 1-Year Follow-Up Study.

    Wilkinson, Samuel T / Sint, Kyaw / Forester, Brent P / Rhee, Taeho Greg

    The Journal of clinical psychiatry

    2023  Volume 84, Issue 2

    Abstract: Objective:: Methods:: Results:: ... ...

    Abstract Objective:
    Methods:
    Results:
    Discussion
    MeSH term(s) Humans ; Aged ; United States/epidemiology ; Electroconvulsive Therapy/adverse effects ; Follow-Up Studies ; Depression/epidemiology ; Depression/therapy ; Activities of Daily Living ; Treatment Outcome ; Medicare ; Dementia/epidemiology ; Dementia/therapy ; Dementia/psychology
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    DOI 10.4088/JCP.22m14583
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  7. Article ; Online: Psychedelic renaissance: Revitalized potential therapies for psychiatric disorders.

    Rhee, Taeho Greg / Davoudian, Pasha A / Sanacora, Gerard / Wilkinson, Samuel T

    Drug discovery today

    2023  Volume 28, Issue 12, Page(s) 103818

    Abstract: Psychiatric disorders represent the largest cause of disability worldwide. Global interests in psychedelic substances as potentially therapeutic agents for psychiatric disorders has recently re-emerged. Here, we review progress in the development of ... ...

    Abstract Psychiatric disorders represent the largest cause of disability worldwide. Global interests in psychedelic substances as potentially therapeutic agents for psychiatric disorders has recently re-emerged. Here, we review progress in the development of psychedelic compounds that have potential therapeutic effects as well as the safety concerns. We include psilocybin, N,N-dimethyltryptamine (DMT), lysergic acid diethylamide (LSD), and the entactogen 3,4-methyl-enedioxy-methamphetamine (MDMA). We also review the potential interactive effects these compounds can have with psychotherapeutic approaches. We provide a cutting-edge review of active and recently completed clinical trials based on the published literature (from MEDLINE), published abstracts at citable conferences, clinical trials from the US Clinical Trials registry (clinicaltrials.gov) and media press releases.
    MeSH term(s) Humans ; Hallucinogens/pharmacology ; Hallucinogens/therapeutic use ; Lysergic Acid Diethylamide/therapeutic use ; Mental Disorders/drug therapy ; Psilocybin/therapeutic use ; N,N-Dimethyltryptamine/therapeutic use
    Chemical Substances Hallucinogens ; Lysergic Acid Diethylamide (8NA5SWF92O) ; Psilocybin (2RV7212BP0) ; N,N-Dimethyltryptamine (WUB601BHAA)
    Language English
    Publishing date 2023-11-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1324988-5
    ISSN 1878-5832 ; 1359-6446
    ISSN (online) 1878-5832
    ISSN 1359-6446
    DOI 10.1016/j.drudis.2023.103818
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  8. Article ; Online: Trends in Illicit Ketamine Seizures in the US From 2017 to 2022.

    Palamar, Joseph J / Wilkinson, Samuel T / Carr, Thomas H / Rutherford, Caroline / Cottler, Linda B

    JAMA psychiatry

    2023  Volume 80, Issue 7, Page(s) 750–751

    MeSH term(s) Humans ; Ketamine/adverse effects ; Illicit Drugs/adverse effects ; Seizures/diagnosis ; Substance-Related Disorders/diagnosis ; Substance-Related Disorders/epidemiology
    Chemical Substances Ketamine (690G0D6V8H) ; Illicit Drugs
    Language English
    Publishing date 2023-06-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2701203-7
    ISSN 2168-6238 ; 2168-622X
    ISSN (online) 2168-6238
    ISSN 2168-622X
    DOI 10.1001/jamapsychiatry.2023.1423
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  9. Article ; Online: Authorship Credit for Large Clinical Trials.

    Wilkinson, Samuel T / Sanacora, Gerard

    JAMA

    2018  Volume 319, Issue 7, Page(s) 722–723

    MeSH term(s) Authorship ; Humans ; Publishing
    Language English
    Publishing date 2018--20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2017.20939
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  10. Article ; Online: Clinical overview of NMDA-R antagonists and clinical practice.

    Davoudian, Pasha A / Wilkinson, Samuel T

    Advances in pharmacology (San Diego, Calif.)

    2020  Volume 89, Page(s) 103–129

    Abstract: Depression represents one of the most common and debilitating mental illnesses in the world today. Despite this pressing issue, the majority treatments for depression give patients therapeutic response only approximately half of the time, with many not ... ...

    Abstract Depression represents one of the most common and debilitating mental illnesses in the world today. Despite this pressing issue, the majority treatments for depression give patients therapeutic response only approximately half of the time, with many not responding at all. In part, this stagnation has been due to the dominance of the monoamine hypothesis that guides the current approach to understanding and treating depression. While therapies that increase levels of monoamines have been useful, clearly a more complete understanding of the neural circuits and treatments is needed to better help patients. Recent work that exploits the glutamatergic system within the brain has demonstrated a functional role for glutamate in combatting depression. While more research is required to understand the specific glutamatergic pathophysiological mechanisms within depression, emerging clinical work has already demonstrated promising results. Current treatments that target the glutamatergic system, especially NMDA receptor antagonists have already shown efficacy in several clinical trials. In this chapter we briefly introduce a mechanistic basis for a role of glutamate in the pathophysiology of depression. We further review basic and translational studies that describes potential mechanisms and roles for glutamate. A discussion of the first promising NMDA receptor antagonist for depression, ketamine, follows afterward. The development of NMDA receptor antagonists for treatment of depression is chronicled, from initial studies up through the recent FDA approval of intranasal esketamine as well as other newer compounds that have shown recent promise in clinical trials.
    MeSH term(s) Antidepressive Agents/pharmacology ; Depressive Disorder, Major/drug therapy ; Depressive Disorder, Major/physiopathology ; Glutamic Acid/therapeutic use ; Humans ; Ketamine/therapeutic use ; Practice Patterns, Physicians' ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate/metabolism
    Chemical Substances Antidepressive Agents ; Receptors, N-Methyl-D-Aspartate ; Glutamic Acid (3KX376GY7L) ; Ketamine (690G0D6V8H)
    Language English
    Publishing date 2020-06-01
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1557-8925
    ISSN (online) 1557-8925
    DOI 10.1016/bs.apha.2020.04.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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