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Article ; Online: Association between pesticide exposure and colorectal cancer risk and incidence: A systematic review.

Matich, Eryn K / Laryea, Jonathan A / Seely, Kathryn A / Stahr, Shelbie / Su, L Joseph / Hsu, Ping-Ching

2021 Volume 219, Page(s) 112327

Abstract: Background: Studies investigating the association between pesticide exposure and colorectal cancer (CRC) risk have been inconclusive.: Objectives: Investigate the association between pesticide exposure and CRC risk through a systematic literature ... ...

Abstract	Background: Studies investigating the association between pesticide exposure and colorectal cancer (CRC) risk have been inconclusive. Objectives: Investigate the association between pesticide exposure and CRC risk through a systematic literature review. Methods: CRC has the fourth-highest rate of cancer-caused death in the US after lung cancer, breast cancer in women, and prostate cancer in men. Here we have conducted a systematic literature search on studies examining the association between any pesticide exposure and CRC risk using PubMed, MEDLINE via EBSCO host, and Embase according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. Results: Following the review, 139 articles were included for qualitative evaluation. Study participants were farmers, pesticide applicators, pesticide manufacturers, spouses of pesticide applicators, farm residents, Korean veterans of the Vietnam War, rural communities, and those who consumed food with pesticide residues. The studies' results were split between those with significant positive (39 significant results) and inverse (41 significant results) associations when comparing pesticide exposure and CRC risk. Discussion: From our literature review, we have identified a similar number of significant positive and inverse associations of pesticide exposure with CRC risk and therefore cannot conclude whether pesticide exposure has a positive or inverse association with CRC risk overall. However, certain pesticides such as terbufos, dicamba, trifluralin, S-ethyl dipropylthiocarbamate (EPTC), imazethapyr, chlorpyrifos, carbaryl, pendimethalin, and acetochlor are of great concern not only for their associated elevated risk of CRC, but also for the current legal usage in the United States (US). Aldicarb and dieldrin are of moderate concern for the positive associations with CRC risk, and also for the illegal usage or the detection on imported food products even though they have been banned in the US. Pesticides can linger in the soil, water, and air for weeks to years and, therefore, can lead to exposure to farmers, manufacturing workers, and those living in rural communities near these farms and factories. Approximately 60 million people in the US live in rural areas and all of the CRC mortality hotspots are within the rural communities. The CRC mortality rate is still increasing in the rural regions despite the overall decreasing of incidence and mortality of CRC elsewhere. Therefore, the results from this study on the relationship between pesticide exposure and CRC risk will help us to understand CRC health disparities.
MeSH term(s)	Adult ; Colorectal Neoplasms/epidemiology ; Farmers/statistics & numerical data ; Female ; Herbicides/analysis ; Humans ; Incidence ; Male ; Middle Aged ; Occupational Exposure/analysis ; Occupational Exposure/statistics & numerical data ; Pesticide Residues/analysis ; Pesticides/analysis
Chemical Substances	Herbicides ; Pesticide Residues ; Pesticides
Language	English
Publishing date	2021-05-21
Publishing country	Netherlands
Document type	Journal Article ; Systematic Review
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2021.112327
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Article ; Online: Association between pesticide exposure and colorectal cancer risk and incidence

Eryn K. Matich / Jonathan A. Laryea / Kathryn A. Seely / Shelbie Stahr / L. Joseph Su / Ping-Ching Hsu

Ecotoxicology and Environmental Safety, Vol 219, Iss , Pp 112327- (2021)

A systematic review

2021

Abstract: Background: Studies investigating the association between pesticide exposure and colorectal cancer (CRC) risk have been inconclusive. Objectives: Investigate the association between pesticide exposure and CRC risk through a systematic literature review. ... ...

Abstract	Background: Studies investigating the association between pesticide exposure and colorectal cancer (CRC) risk have been inconclusive. Objectives: Investigate the association between pesticide exposure and CRC risk through a systematic literature review. Methods: CRC has the fourth-highest rate of cancer-caused death in the US after lung cancer, breast cancer in women, and prostate cancer in men. Here we have conducted a systematic literature search on studies examining the association between any pesticide exposure and CRC risk using PubMed, MEDLINE via EBSCO host, and Embase according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. Results: Following the review, 139 articles were included for qualitative evaluation. Study participants were farmers, pesticide applicators, pesticide manufacturers, spouses of pesticide applicators, farm residents, Korean veterans of the Vietnam War, rural communities, and those who consumed food with pesticide residues. The studies' results were split between those with significant positive (39 significant results) and inverse (41 significant results) associations when comparing pesticide exposure and CRC risk. Discussion: From our literature review, we have identified a similar number of significant positive and inverse associations of pesticide exposure with CRC risk and therefore cannot conclude whether pesticide exposure has a positive or inverse association with CRC risk overall. However, certain pesticides such as terbufos, dicamba, trifluralin, S-ethyl dipropylthiocarbamate (EPTC), imazethapyr, chlorpyrifos, carbaryl, pendimethalin, and acetochlor are of great concern not only for their associated elevated risk of CRC, but also for the current legal usage in the United States (US). Aldicarb and dieldrin are of moderate concern for the positive associations with CRC risk, and also for the illegal usage or the detection on imported food products even though they have been banned in the US. Pesticides can linger in the soil, water, and air ...
Keywords	Colorectal cancer ; Pesticides ; Environmental exposure ; Occupational exposure ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
Subject code	910
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Why Plants Harbor Complex Endophytic Fungal Communities

Wenndt, Anthony J. / Evans, Sarah E. / van Diepeningen, A.D. / Logan, J.R. / Jacobson, Peter J. / Seely, Mary K. / Jacobson, Kathryn M.

Frontiers in Microbiology

Insights From Perennial Bunchgrass Stipagrostis sabulicola in the Namib Sand Sea

2021 Volume 12

Abstract: All perennial plants harbor diverse endophytic fungal communities, but why they tolerate these complex asymptomatic symbioses is unknown. Using a multi-pronged approach, we conclusively found that a dryland grass supports endophyte communities comprised ... ...

Abstract	All perennial plants harbor diverse endophytic fungal communities, but why they tolerate these complex asymptomatic symbioses is unknown. Using a multi-pronged approach, we conclusively found that a dryland grass supports endophyte communities comprised predominantly of latent saprophytes that can enhance localized nutrient recycling after senescence. A perennial bunchgrass, Stipagrostis sabulicola, which persists along a gradient of extreme abiotic stress in the hyper-arid Namib Sand Sea, was the focal point of our study. Living tillers yielded 20 fungal endophyte taxa, 80% of which decomposed host litter during a 28-day laboratory decomposition assay. During a 6-month field experiment, tillers with endophytes decomposed twice as fast as sterilized tillers, consistent with the laboratory assay. Furthermore, profiling the community active during decomposition using next-generation sequencing revealed that 59–70% of the S. sabulicola endophyte community is comprised of latent saprophytes, and these dual-niche fungi still constitute a large proportion (58–62%) of the litter community more than a year after senescence. This study provides multiple lines of evidence that the fungal communities that initiate decomposition of standing litter develop in living plants, thus providing a plausible explanation for why plants harbor complex endophyte communities. Using frequent overnight non-rainfall moisture events (fog, dew, high humidity), these latent saprophytes can initiate decomposition of standing litter immediately after tiller senescence, thus maximizing the likelihood that plant-bound nutrients are recycled in situ and contribute to the nutrient island effect that is prevalent in drylands.
Keywords	decomposition ; drylands ; endophyte ; fungal community ; latent saprophyte ; nutrient islands
Subject code	580
Language	English
Publishing country	nl
Document type	Article ; Online
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
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Article ; Online: Notice of retraction.

Prather, Paul L / Seely, Kathryn A / Levi, Mark S

The Journal of pharmacology and experimental therapeutics

2009 Volume 331, Issue 3, Page(s) 1147

Language	English
Publishing date	2009-08-09
Publishing country	United States
Document type	Retraction of Publication
ZDB-ID	3106-9
ISSN	1521-0103 ; 0022-3565
ISSN (online)	1521-0103
ISSN	0022-3565
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Article ; Online: Spice drugs are more than harmless herbal blends: a review of the pharmacology and toxicology of synthetic cannabinoids.

Seely, Kathryn A / Lapoint, Jeff / Moran, Jeffery H / Fattore, Liana

Progress in neuro-psychopharmacology & biological psychiatry

2012 Volume 39, Issue 2, Page(s) 234–243

Abstract: K2" and "Spice" drugs (collectively hereafter referred to as Spice) represent a relatively new class of designer drugs that have recently emerged as popular alternatives to marijuana, otherwise characterized as "legal highs". These drugs are readily ... ...

Abstract	"K2" and "Spice" drugs (collectively hereafter referred to as Spice) represent a relatively new class of designer drugs that have recently emerged as popular alternatives to marijuana, otherwise characterized as "legal highs". These drugs are readily available on the Internet and sold in many head shops and convenience stores under the disguise of innocuous products like herbal blends, incense, or air fresheners. Although package labels indicate "not for human consumption", the number of intoxicated people presenting to emergency departments is dramatically increasing. The lack of validated and standardized human testing procedures and an endless supply of potential drugs of abuse are primary reasons why researchers find it difficult to fully characterize clinical consequences associated with Spice. While the exact chemical composition and toxicology of Spice remains to be determined, there is mounting evidence identifying several synthetic cannabinoids as causative agents responsible for psychoactive and adverse physical effects. This review provides updates of the legal status of common synthetic cannabinoids detected in Spice and analytical procedures used to test Spice products and human specimens collected under a variety of clinical circumstances. The pharmacological and toxicological consequences of synthetic cannabinoid abuse are also reviewed to provide a future perspective on potential short- and long-term implications.
MeSH term(s)	Animals ; Cannabinoids/analysis ; Cannabinoids/pharmacology ; Cannabinoids/toxicity ; Designer Drugs/analysis ; Designer Drugs/pharmacology ; Designer Drugs/toxicity ; Drug Users/psychology ; Drug Users/statistics & numerical data ; Drug and Narcotic Control/legislation & jurisprudence ; Humans ; Indoles/analysis ; Indoles/pharmacology ; Indoles/toxicity ; Naphthalenes/analysis ; Naphthalenes/pharmacology ; Naphthalenes/toxicity
Chemical Substances	Cannabinoids ; Designer Drugs ; Indoles ; Naphthalenes ; 1-pentyl-3-(1-naphthoyl)indole (G391998J57)
Language	English
Publishing date	2012-04-26
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	781181-0
ISSN	1878-4216 ; 0278-5846
ISSN (online)	1878-4216
ISSN	0278-5846
DOI	10.1016/j.pnpbp.2012.04.017
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Article ; Online: A Comparison of Less Invasive Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Diagnostic Specimens in Nursing Home Residents-Arkansas, June-August 2020.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2021 Volume 73, Issue Suppl 1, Page(s) S58–S64

Abstract: Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing remains essential for early identification and clinical management of cases. We compared the diagnostic performance of 3 specimen types for characterizing SARS-CoV-2 in ... ...

Abstract	Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing remains essential for early identification and clinical management of cases. We compared the diagnostic performance of 3 specimen types for characterizing SARS-CoV-2 in infected nursing home residents. Methods: A convenience sample of 17 residents were enrolled within 15 days of first positive SARS-CoV-2 result by real-time reverse transcription polymerase chain reaction (RT-PCR) and prospectively followed for 42 days. Anterior nasal swabs (AN), oropharyngeal swabs (OP), and saliva specimens (SA) were collected on the day of enrollment, every 3 days for the first 21 days, and then weekly for 21 days. Specimens were tested for presence of SARS-CoV-2 RNA using RT-PCR and replication-competent virus by viral culture. Results: Comparing the 3 specimen types collected from each participant at each time point, the concordance of paired RT-PCR results ranged from 80% to 88%. After the first positive result, SA and OP were RT-PCR-positive for ≤48 days; AN were RT-PCR-positive for ≤33 days. AN had the highest percentage of RT-PCR-positive results (21/26 [81%]) when collected ≤10 days of participants' first positive result. Eleven specimens were positive by viral culture: 9 AN collected ≤19 days following first positive result and 2 OP collected ≤5 days following first positive result. Conclusions: AN, OP, and SA were effective methods for repeated testing in this population. More AN than OP were positive by viral culture. SA and OP remained RT-PCR-positive longer than AN, which could lead to unnecessary interventions if RT-PCR detection occurred after viral shedding has likely ceased.
MeSH term(s)	Arkansas ; COVID-19 ; Humans ; Nursing Homes ; RNA, Viral/genetics ; SARS-CoV-2
Chemical Substances	RNA, Viral
Language	English
Publishing date	2021-04-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciab310
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Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Altered metabolism of synthetic cannabinoid JWH-018 by human cytochrome P450 2C9 and variants.

Patton, Amy L / Seely, Kathryn A / Yarbrough, Azure L / Fantegrossi, William / James, Laura P / McCain, Keith R / Fujiwara, Ryoichi / Prather, Paul L / Moran, Jeffery H / Radominska-Pandya, Anna

Biochemical and biophysical research communications

2018 Volume 498, Issue 3, Page(s) 597–602

Abstract: Synthetic cannabinoids (SCBs), synonymous with 'K2', 'Spice' or 'synthetic marijuana', are psychoactive drugs of abuse that frequently result in clinical effects and toxicity more severe than those classically associated with ... ...

Abstract	Synthetic cannabinoids (SCBs), synonymous with 'K2', 'Spice' or 'synthetic marijuana', are psychoactive drugs of abuse that frequently result in clinical effects and toxicity more severe than those classically associated with Δ
MeSH term(s)	Cytochrome P-450 CYP2C9/genetics ; Cytochrome P-450 CYP2C9/metabolism ; Humans ; Indoles/metabolism ; Kinetics ; Metabolic Networks and Pathways ; Naphthalenes/metabolism ; Oxidation-Reduction ; Polymorphism, Genetic ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Street Drugs/metabolism ; Substance-Related Disorders/genetics ; Substance-Related Disorders/metabolism
Chemical Substances	Indoles ; Naphthalenes ; Recombinant Proteins ; Street Drugs ; CYP2C9 protein, human (EC 1.14.13.-) ; Cytochrome P-450 CYP2C9 (EC 1.14.13.-) ; 1-pentyl-3-(1-naphthoyl)indole (G391998J57)
Language	English
Publishing date	2018-03-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2018.03.028
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Article: Why Plants Harbor Complex Endophytic Fungal Communities: Insights From Perennial Bunchgrass

Wenndt, Anthony J / Evans, Sarah E / van Diepeningen, Anne D / Logan, J Robert / Jacobson, Peter J / Seely, Mary K / Jacobson, Kathryn M

Frontiers in microbiology

2021 Volume 12, Page(s) 691584

Abstract	All perennial plants harbor diverse endophytic fungal communities, but why they tolerate these complex asymptomatic symbioses is unknown. Using a multi-pronged approach, we conclusively found that a dryland grass supports endophyte communities comprised predominantly of latent saprophytes that can enhance localized nutrient recycling after senescence. A perennial bunchgrass,
Language	English
Publishing date	2021-06-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2021.691584
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Article ; Online: Marijuana-based drugs: innovative therapeutics or designer drugs of abuse?

Seely, Kathryn A / Prather, Paul L / James, Laura P / Moran, Jeffery H

Molecular interventions

2011 Volume 11, Issue 1, Page(s) 36–51

Abstract: The principal psychoactive component of marijuana, Δ(9)-tetrahydrocannabinol (THC), activates CB1 cannabinoid receptors (CB1Rs). Unfortunately, pharmacological research into the design of effective THC analogs has been hampered by psychiatric side ... ...

Abstract	The principal psychoactive component of marijuana, Δ(9)-tetrahydrocannabinol (THC), activates CB1 cannabinoid receptors (CB1Rs). Unfortunately, pharmacological research into the design of effective THC analogs has been hampered by psychiatric side effects. THC-based drug design of a less academic nature, however, has led to the marketing of "synthetic marijuana," labeled as K2 or "Spice," among other terms, which elicits psychotropic actions via CB1R activation. Because of structural dissimilarity to THC, the active ingredients of K2/Spice preparations are widely unregulated. The K2/Spice "phenomenon" provides a context for considering whether marijuana-based drugs will truly provide innovative therapeutics or merely perpetuate drug abuse.
MeSH term(s)	Animals ; Cannabinoids/adverse effects ; Cannabinoids/chemistry ; Cannabinoids/pharmacology ; Cannabinoids/therapeutic use ; Cannabis/adverse effects ; Cannabis/chemistry ; Clinical Trials as Topic ; Designer Drugs/adverse effects ; Designer Drugs/chemistry ; Designer Drugs/pharmacology ; Designer Drugs/therapeutic use ; Humans ; Illicit Drugs/adverse effects ; Illicit Drugs/chemistry ; Illicit Drugs/pharmacology ; Models, Biological
Chemical Substances	Cannabinoids ; Designer Drugs ; Illicit Drugs
Language	English
Publishing date	2011-03-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	2108819-6
ISSN	1543-2548 ; 1534-0384
ISSN (online)	1543-2548
ISSN	1534-0384
DOI	10.1124/mi.11.1.6
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Article ; Online: The dietary polyphenols trans-resveratrol and curcumin selectively bind human CB1 cannabinoid receptors with nanomolar affinities and function as antagonists/inverse agonists.

Seely, Kathryn A / Levi, Mark S / Prather, Paul L

publication RETRACTED

The Journal of pharmacology and experimental therapeutics

2009 Volume 330, Issue 1, Page(s) 31–39

Abstract: The dietary polyphenols trans-resveratrol [5-[(1E)-2-(4-hydroxyphenyl)ethenyl]-1,3-benzenediol; found in red wine] and curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1E,6E-heptadiene-3,5-dione] (found in curry powders) exert anti-inflammatory and ... ...

Abstract	The dietary polyphenols trans-resveratrol [5-[(1E)-2-(4-hydroxyphenyl)ethenyl]-1,3-benzenediol; found in red wine] and curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1E,6E-heptadiene-3,5-dione] (found in curry powders) exert anti-inflammatory and antioxidant effects via poorly defined mechanisms. It is interesting that cannabinoids, derived from the marijuana plant (Cannabis sativa), produce similar protective effects via CB1 and CB2 receptors. We examined whether trans-resveratrol, curcumin, and ASC-J9 [1,7-bis(3,4-dimethoxyphenyl)-5-hydroxy-1E,4E,6E-heptatriene-3-one] (a curcumin analog) act as ligands at cannabinoid receptors. All three bind to human (h) CB1 and mouse CB1 receptors with nanomolar affinities, displaying only micromolar affinities for hCB2 receptors. Characteristic of inverse agonists, the polyphenols inhibit basal G-protein activity in membranes prepared from Chinese hamster ovary (CHO)-hCB1 cells or mouse brain that is reversed by a neutral CB1 antagonist. Furthermore, they competitively antagonize G-protein activation produced by a CB1 agonist. In intact CHO-hCB1 cells, the polyphenols act as neutral antagonists, producing no effect when tested alone, whereas competitively antagonizing CB1 agonist mediated inhibition of adenylyl cyclase activity. Confirming their neutral antagonist profile in cells, the polyphenols similarly attenuate stimulation of adenylyl cyclase activity produced by a CB1 inverse agonist. In mice, the polyphenols dose-dependently reverse acute hypothermia produced by a CB1 agonist. Upon repeated administration, the polyphenols also reduce body weight in mice similar to that produced by a CB1 antagonist/inverse agonist. Finally, trans-resveratrol and curcumin share common structural motifs with other known cannabinoid receptor ligands. Collectively, we suggest that trans-resveratrol and curcumin act as antagonists/inverse agonists at CB1 receptors at dietary relevant concentrations. Therefore, these polyphenols and their derivatives might be developed as novel, nontoxic CB1 therapeutics for obesity and/or drug dependence.
MeSH term(s)	Animals ; CHO Cells ; Cricetinae ; Cricetulus ; Curcumin/metabolism ; Female ; Flavonoids/metabolism ; Humans ; Male ; Mice ; Phenols/metabolism ; Polyphenols ; Protein Binding/physiology ; Receptor, Cannabinoid, CB1/agonists ; Receptor, Cannabinoid, CB1/antagonists & inhibitors ; Receptor, Cannabinoid, CB1/metabolism ; Stilbenes/metabolism
Chemical Substances	Flavonoids ; Phenols ; Polyphenols ; Receptor, Cannabinoid, CB1 ; Stilbenes ; Curcumin (IT942ZTH98) ; resveratrol (Q369O8926L)
Language	English
Publishing date	2009-07
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Retracted Publication
ZDB-ID	3106-9
ISSN	1521-0103 ; 0022-3565
ISSN (online)	1521-0103
ISSN	0022-3565
DOI	10.1124/jpet.109.151654
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