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  1. Book ; Online: Marine Algal Antioxidants

    Brunet, Christophe / Sansone, Clementina

    2020  

    Keywords Technology: general issues ; algae ; Chlorella ; Fucus ; detoxification ; environmental pollution ; antioxidants ; heavy metals ; selenium ; SOD-1 ; neurotoxicology ; aminoazuphrates ; clinical medicine ; nutrition ; neuropathology ; Dunaliella salina ; microalgae ; red LED ; blue LED ; growth ; carotenoids ; plastoquinol:oxygen oxidoreductase ; photosynthesis ; antioxidant activities ; Box-Behnken design ; microwave-assisted extraction ; polysaccharide ; Ulva pertusa ; seaweed ; 9-cis β-carotene ; all-trans β-carotene ; light intensity ; isomerisation ; light ; ascorbic acid ; phenolic compounds ; flavonoids ; photoprotection ; Phaeodactylum tricornutum ; fucoxanthin ; antioxidative ; antiproliferative ; antioxidant ; biodiversity ; genome-scale metabolic networks (GSMNs), data integration ; brown algae ; oxygenated carotenoid biosynthesis ; abscisic acid ; Saccharina japonica ; Cladosiphon okamuranus ; lipophilic antioxidant ; solvent blending ; macroalgae ; LC-ESI-MS/MS ; carotenoid pigment ; anthocyanin ; chlorophyll derivative ; phototrophic ; heterotrophic ; Scenedesmus ; chlorophylls ; hydroxy-chlorophyll ; oxidative metabolism ; ROS ; lactone-chlorophyll ; photoacclimation ; seaweeds ; green algae ; marine algae ; Ulva intestinalis ; Enteromorpha intestinalis ; quantification ; polyphenols ; apigenin ; accelerated solvent extraction ; ASE ; HPLC-LRMS ; HPLC-HRMS ; HPLC ; TPC ; Folin-Ciocalteu ; TFC ; qNMR ; n/a
    Size 1 electronic resource (192 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021046840
    ISBN 9783039368792 ; 3039368796
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Insights into the biosynthesis pathway of phenolic compounds in microalgae.

    Del Mondo, Angelo / Sansone, Clementina / Brunet, Christophe

    Computational and structural biotechnology journal

    2022  Volume 20, Page(s) 1901–1913

    Abstract: Among the most relevant bioactive molecules family, phenolic compounds (PCs) are well known in higher plants, while their knowledge in microalgae is still scarce. Microalgae represent a novel and promising source of human health benefit compounds to be ... ...

    Abstract Among the most relevant bioactive molecules family, phenolic compounds (PCs) are well known in higher plants, while their knowledge in microalgae is still scarce. Microalgae represent a novel and promising source of human health benefit compounds to be involved, for instance, in nutraceutical composition. This study aims to investigate the PCs biosynthetic pathway in the microalgal realm, exploring its potential variability over the microalgal biodiversity axis. A multistep
    Language English
    Publishing date 2022-04-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2694435-2
    ISSN 2001-0370
    ISSN 2001-0370
    DOI 10.1016/j.csbj.2022.04.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  3. Article: Marine Algal Antioxidants.

    Sansone, Clementina / Brunet, Christophe

    Antioxidants (Basel, Switzerland)

    2020  Volume 9, Issue 3

    Abstract: Sea and marine biodiversity exploration represents a new frontier for the discovery of new natural products with human health benefits ("the exploitable biology", [ ... ]. ...

    Abstract Sea and marine biodiversity exploration represents a new frontier for the discovery of new natural products with human health benefits ("the exploitable biology", [...].
    Language English
    Publishing date 2020-03-02
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox9030206
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Marine Algal Antioxidants

    Sansone, Clementina / Brunet, Christophe

    Antioxidants. 2020 Mar. 02, v. 9, no. 3

    2020  

    Abstract: Sea and marine biodiversity exploration represents a new frontier for the discovery of new natural products with human health benefits (“the exploitable biology”, [ ... ] ...

    Abstract Sea and marine biodiversity exploration represents a new frontier for the discovery of new natural products with human health benefits (“the exploitable biology”, [...]
    Keywords algae ; antioxidants ; biodiversity ; human health
    Language English
    Dates of publication 2020-0302
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox9030206
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: On the human health benefits of microalgal phytohormones: An explorative

    Del Mondo, Angelo / Vinaccia, Annamaria / Pistelli, Luigi / Brunet, Christophe / Sansone, Clementina

    Computational and structural biotechnology journal

    2023  Volume 21, Page(s) 1092–1101

    Abstract: Phytohormones represent a group of secondary metabolites with different chemical structures, in which belong auxins, cytokinins, gibberellins, or brassinosteroids. In higher plants, they cover active roles in growth or defense function, while their ... ...

    Abstract Phytohormones represent a group of secondary metabolites with different chemical structures, in which belong auxins, cytokinins, gibberellins, or brassinosteroids. In higher plants, they cover active roles in growth or defense function, while their potential benefits for human health protection were noted for some phytohormones and little explored for many others. In this study, we developed a target fishing strategy on fifty-three selected naturally occurring phytohormones covering different families towards proteins involved in key cellular functions related to human metabolism and health protection/disease. This
    Language English
    Publishing date 2023-01-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2694435-2
    ISSN 2001-0370
    ISSN 2001-0370
    DOI 10.1016/j.csbj.2023.01.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Biotechnological response curve of the cyanobacterium Spirulina subsalsa to light energy gradient.

    Pistelli, Luigi / Del Mondo, Angelo / Smerilli, Arianna / Corato, Federico / Sansone, Clementina / Brunet, Christophe

    Biotechnology for biofuels and bioproducts

    2023  Volume 16, Issue 1, Page(s) 28

    Abstract: Background: Microalgae represent a suitable and eco-sustainable resource for human needs thanks to their fast growth ability, together with the great diversity in species and intracellular secondary bioactive metabolites. These high-added-value ... ...

    Abstract Background: Microalgae represent a suitable and eco-sustainable resource for human needs thanks to their fast growth ability, together with the great diversity in species and intracellular secondary bioactive metabolites. These high-added-value compounds are of great interest for human health or animal feed. The intracellular content of these valuable compound families is tightly associated with the microalgal biological state and responds to environmental cues, e.g., light. Our study develops a Biotechnological response curve strategy exploring the bioactive metabolites synthesis in the marine cyanobacterium Spirulina subsalsa over a light energy gradient. The Relative Light energy index generated in our study integrates the red, green and blue photon flux density with their relative photon energy. The Biotechnological response curve combined biochemical analysis of the macromolecular composition (total protein, lipid, and carbohydrate content), total sterols, polyphenols and flavonoids, carotenoids, phenolic compounds, vitamins (A, B
    Results: Results demonstrated that light energy significantly modulate the biochemical status of the microalga Spirulina subsalsa revealing the relevance of the light energy index to explain the light-induced biological variability. The sharp decrease of the photosynthetic rate at high light energy was accompanied with an increase of the antioxidant network response, such as carotenoids, total polyphenols, and the antioxidant capacity. Conversely, low light energy favorized the intracellular content of lipids and vitamins (B
    Conclusions: Results of the Biotechnological response curves were discussed in their functional and physiological relevance as well as for the essence of their potential biotechnological applications. This study emphasized the light energy as a relevant tool to explain the biological responses of microalgae towards light climate variability, and, therefore, to design metabolic manipulation of microalgae.
    Language English
    Publishing date 2023-02-19
    Publishing country England
    Document type Journal Article
    ISSN 2731-3654
    ISSN (online) 2731-3654
    DOI 10.1186/s13068-023-02277-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Promises and Challenges of Microalgal Antioxidant Production.

    Sansone, Clementina / Brunet, Christophe

    Antioxidants (Basel, Switzerland)

    2019  Volume 8, Issue 7

    Abstract: The exploration of natural antioxidants for nutraceuticals and pharmaceuticals industries has recently increased. This communication aims to grasp the relevance of microalgae in the panorama of natural antioxidant molecules supply to industrial ... ...

    Abstract The exploration of natural antioxidants for nutraceuticals and pharmaceuticals industries has recently increased. This communication aims to grasp the relevance of microalgae in the panorama of natural antioxidant molecules supply to industrial applications as alternatives and/or complements to those typically used from higher plants. Microalgal richness in antioxidant compounds and scavenging ability compared to higher plants is discussed in the context of microalgal biodiversity. We mainly focus on families of powerful antioxidant compounds that have been scarcely investigated in microalgae, such as phenolic compounds, sterols, or vitamins, discussing the promise and challenges of microalgae as providers of health benefits, for instance, through their use as functional food ingredients.
    Language English
    Publishing date 2019-06-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox8070199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Insights into the biosynthesis pathway of phenolic compounds in microalgae

    Del Mondo, Angelo / Sansone, Clementina / Brunet, Christophe

    Computational and Structural Biotechnology Journal. 2022, v. 20

    2022  

    Abstract: Among the most relevant bioactive molecules family, phenolic compounds (PCs) are well known in higher plants, while their knowledge in microalgae is still scarce. Microalgae represent a novel and promising source of human health benefit compounds to be ... ...

    Abstract Among the most relevant bioactive molecules family, phenolic compounds (PCs) are well known in higher plants, while their knowledge in microalgae is still scarce. Microalgae represent a novel and promising source of human health benefit compounds to be involved, for instance, in nutraceutical composition. This study aims to investigate the PCs biosynthetic pathway in the microalgal realm, exploring its potential variability over the microalgal biodiversity axis. A multistep in silico analysis was carried out using a selection of core enzymes from the pathway described in land plants. This study explores their presence in ten groups of prokaryotic and eukaryotic microalgae.. Analyses were carried out taking into account a wide selection of algal protein homologs, functional annotation of conserved domains and motifs, and maximum-likelihood tree construction. Results showed that a conserved core of the pathway for PCs biosynthesis is shared horizontally in all microalgae. Conversely, the ability to synthesize some subclasses of phenolics may be restricted to only some microalgal groups (i.e., Chlorophyta) depending on featured enzymes, such as the flavanone naringenin and other related chalcone isomerase dependent compounds.
    Keywords Chlorophyta ; algal proteins ; biochemical pathways ; biodiversity ; biosynthesis ; biotechnology ; chalcone isomerase ; computer simulation ; dietary supplements ; human health ; microalgae ; naringenin ; phenolic compounds ; phylogeny
    Language English
    Size p. 1901-1913.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2694435-2
    ISSN 2001-0370
    ISSN 2001-0370
    DOI 10.1016/j.csbj.2022.04.019
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Promises and Challenges of Microalgal Antioxidant Production

    Sansone, Clementina / Brunet, Christophe

    Antioxidants. 2019 June 27, v. 8, no. 7

    2019  

    Abstract: The exploration of natural antioxidants for nutraceuticals and pharmaceuticals industries has recently increased. This communication aims to grasp the relevance of microalgae in the panorama of natural antioxidant molecules supply to industrial ... ...

    Abstract The exploration of natural antioxidants for nutraceuticals and pharmaceuticals industries has recently increased. This communication aims to grasp the relevance of microalgae in the panorama of natural antioxidant molecules supply to industrial applications as alternatives and/or complements to those typically used from higher plants. Microalgal richness in antioxidant compounds and scavenging ability compared to higher plants is discussed in the context of microalgal biodiversity. We mainly focus on families of powerful antioxidant compounds that have been scarcely investigated in microalgae, such as phenolic compounds, sterols, or vitamins, discussing the promise and challenges of microalgae as providers of health benefits, for instance, through their use as functional food ingredients.
    Keywords antioxidants ; biodiversity ; drugs ; functional foods ; industrial applications ; ingredients ; microalgae ; phenolic compounds ; sterols ; vitamins
    Language English
    Dates of publication 2019-0627
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox8070199
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: The Recent Advanced in Microalgal Phytosterols: Bioactive Ingredients Along With Human-Health Driven Potential Applications

    Sañé, Elisabet / Del Mondo, Angelo / Ambrosino, Luca / Smerilli, Arianna / Sansone, Clementina / Brunet, Christophe

    Food Reviews International. 2023 May 19, v. 39, no. 4 p.1859-1878

    2023  

    Abstract: It is noteworthy that phytosterol bioactivities are benefit for human health, promoting their interest to be used in the formulation of enriched and/or functional food ingredients. With the growing phytosterols market for food, pharmaceuticals or ... ...

    Abstract It is noteworthy that phytosterol bioactivities are benefit for human health, promoting their interest to be used in the formulation of enriched and/or functional food ingredients. With the growing phytosterols market for food, pharmaceuticals or cosmetics, new sources than higher plants-related ones are needed, also to allow a sustainable and eco-friendly production. Microalgae fill the requisite to become a new asset for the development of food complements or nutraceuticals. The aim of this study is to update and integrate the knowledge on microalgal phytosterols – content, chemodiversity, bioactivity, biosynthetic pathway – and discussing the interests and challenges offered by microalgae-derived phytosterols for biotechnological applications as bioactive ingredients for functional foods. Generally, the content of phytosterols in microalgae is higher than in higher plants, enhancing the interest of these organisms as cell bio-factories of bioactive compounds for human consumption. However, it is important to fill the gap of knowledge on the phytosterol chemical diversity and distribution of microalgae. A first attempt in comparing the distribution of key enzymes involved in phytosterol biosynthetic pathways in the microalgal realm highlighted some phylogenetic differences and a notable discrimination between cyanophytes and eukaryotic microalgae.
    Keywords assets ; bioactive properties ; biochemical pathways ; biosynthesis ; cosmetics ; dietary supplements ; drugs ; functional foods ; human health ; humans ; markets ; microalgae ; phylogeny ; phytosterols ; bioactive compounds ; biosynthesis-related enzymes ; human health benefits
    Language English
    Dates of publication 2023-0519
    Size p. 1859-1878.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 53834-6
    ISSN 1525-6103 ; 8755-9129
    ISSN (online) 1525-6103
    ISSN 8755-9129
    DOI 10.1080/87559129.2021.1938115
    Database NAL-Catalogue (AGRICOLA)

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