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  1. Book: Modern alkaloids

    Fattorusso, Ernesto

    structure, isolation, synthesis and biology

    2008  

    Author's details ed. by Ernesto Fattorusso
    Keywords Alkaloide
    Subject Pflanzenalkaloide
    Language English
    Size XXIV, 665 S. : Ill., graph. Darst.
    Publisher Wiley-VCH
    Publishing place Weinheim
    Publishing country Germany
    Document type Book
    HBZ-ID HT015337311
    ISBN 978-3-527-31521-5 ; 3-527-31521-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 A 1757 order for loan Magazin

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  2. Book ; Online: Handbook of marine natural products

    Fattorusso, Ernesto

    (Springer reference)

    2012  

    Author's details Ernesto Fattorusso ... ed
    Series title Springer reference
    Keywords Aquatic biology ; Biochemistry ; Chemistry, Organic ; Life sciences ; Oceanography ; Pharmacy ; Toxicology
    Language English
    Size Online-Ressource (xxiv, 1452 p)
    Publisher Springer
    Publishing place Dordrecht ;London
    Document type Book ; Online
    Note Includes bibliographical references and index
    ISBN 9789048138333 ; 9789048138340 ; 9048138337 ; 9048138345
    DOI 10.1007/978-90-481-3834-0
    Database Former special subject collection: coastal and deep sea fishing

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  3. Book: Modern alkaloids

    Fattorusso, Ernesto

    structure, isolation, synthesis and biology

    2008  

    Author's details ed. by Ernesto Fattorusso and Orazio Taglialatela-Scafati
    Keywords Alkaloids ; Alkaloids/Structure ; Alkaloide
    Language English
    Size XXIV, 665 S, Ill., graph. Darst, 240 mm x 170 mm
    Publisher WILEY-VCH
    Publishing place Weinheim
    Document type Book
    Note Literaturangaben
    ISBN 3527315217 ; 9783527315215
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  4. Book: Modern alkaloids

    Fattorusso, Ernesto

    structure, isolation, synthesis and biology

    2008  

    Author's details ed. by Ernesto Fattorusso and Orazio Taglialatela-Scafati
    Keywords Alkaloids ; Alkaloids/Structure ; Alkaloide
    Language English
    Size XXIV, 665 S, Ill., graph. Darst, 240 mm x 170 mm
    Publisher WILEY-VCH
    Publishing place Weinheim
    Document type Book
    Note Literaturangaben
    ISBN 3527315217 ; 9783527315215
    Database Federal Institute for Risk Assessment

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Book: Modern alkaloids

    Fattorusso, Ernesto

    structure, isolation, synthesis and biology

    2008  

    Author's details ed. by Ernesto Fattorusso and Orazio Taglialatela-Scafati
    Keywords Alkaloids ; Alkaloids/Structure ; Alkaloide
    Language English
    Size XXIV, 665 S, Ill., graph. Darst, 240 mm x 170 mm
    Document type Book
    Note Literaturangaben
    ISBN 3527315217 ; 9783527315215
    Database Leibniz Institute of Plant Biochemistry

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  6. Article: Thorexanthin, a New Carotenoid Pigment from the Caribbean Sponge Thorecta horridus

    Fattorusso, Ernesto / Virginia Lanzotti / Silvana Magno / Luciano Mayol

    Zeitschrift für Naturforschung. 2014 June 2, v. 47, no. 10

    2014  

    Abstract: The red-pigmented caribbean sponge Thorecta horridus contains thorexanthin (3-methoxy-β-X-caroten-4-one) as a new carotenoid pigment. Its structure was determined by spectroscopic methods, including 2 D NMR experiments. ...

    Abstract The red-pigmented caribbean sponge Thorecta horridus contains thorexanthin (3-methoxy-β-X-caroten-4-one) as a new carotenoid pigment. Its structure was determined by spectroscopic methods, including 2 D NMR experiments.
    Keywords carotenoids ; nuclear magnetic resonance spectroscopy ; Caribbean
    Language English
    Dates of publication 2014-0602
    Size p. 1477-1479.
    Publishing place Verlag der Zeitschrift für Naturforschung
    Document type Article
    ZDB-ID 124635-5
    ISSN 0340-5087 ; 0044-3174 ; 0932-0776 ; 0341-0447 ; 0341-0420
    ISSN 0340-5087 ; 0044-3174 ; 0932-0776 ; 0341-0447 ; 0341-0420
    DOI 10.1515/znb-1992-1020
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4' 47/11 b: Show issues
    Z 9.8: Show issues

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  7. Article ; Online: The interaction of heme with plakortin and a synthetic endoperoxide analogue: new insights into the heme-activated antimalarial mechanism.

    Persico, Marco / Fattorusso, Roberto / Taglialatela-Scafati, Orazio / Chianese, Giuseppina / de Paola, Ivan / Zaccaro, Laura / Rondinelli, Francesca / Lombardo, Marco / Quintavalla, Arianna / Trombini, Claudio / Fattorusso, Ernesto / Fattorusso, Caterina / Farina, Biancamaria

    Scientific reports

    2017  Volume 7, Page(s) 45485

    Abstract: In the present work we performed a combined experimental and computational study on the interaction of the natural antimalarial endoperoxide plakortin and its synthetic analogue 4a with heme. Obtained results indicate that the studied compounds produce ... ...

    Abstract In the present work we performed a combined experimental and computational study on the interaction of the natural antimalarial endoperoxide plakortin and its synthetic analogue 4a with heme. Obtained results indicate that the studied compounds produce reactive carbon radical species after being reductively activated by heme. In particular, similarly to artemisinin, the formation of radicals prone to inter-molecular reactions should represent the key event responsible for Plasmodium death. To our knowledge this is the first experimental investigation on the reductive activation of simple antimalarial endoperoxides (1,2-dioxanes) by heme and results were compared to the ones previously obtained from the reaction with FeCl
    MeSH term(s) Antimalarials/chemistry ; Antimalarials/metabolism ; Binding Sites ; Dioxanes/chemistry ; Dioxanes/metabolism ; Dioxanes/pharmacology ; Ferrous Compounds/chemistry ; Ferrous Compounds/metabolism ; Heme/chemistry ; Heme/metabolism ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Molecular Conformation ; Molecular Docking Simulation
    Chemical Substances Antimalarials ; Dioxanes ; Ferrous Compounds ; Heme (42VZT0U6YR) ; ferrous chloride (S3Y25PHP1W)
    Language English
    Publishing date 2017-04-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep45485
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Marine antimalarials.

    Fattorusso, Ernesto / Taglialatela-Scafati, Orazio

    Marine drugs

    2009  Volume 7, Issue 2, Page(s) 130–152

    Abstract: Malaria is an infectious disease causing at least 1 million deaths per year, and, unfortunately, the chemical entities available to treat malaria are still too limited. In this review we highlight the contribution of marine chemistry in the field of ... ...

    Abstract Malaria is an infectious disease causing at least 1 million deaths per year, and, unfortunately, the chemical entities available to treat malaria are still too limited. In this review we highlight the contribution of marine chemistry in the field of antimalarial research by reporting the most important results obtained until the beginning of 2009, with particular emphasis on recent discoveries. About 60 secondary metabolites produced by marine organisms have been grouped into three structural types and discussed in terms of their reported antimalarial activities. The major groups of metabolites include isonitrile derivatives, alkaloids and endoperoxide derivatives. The following discussion evidences that antimalarial marine molecules can efficiently integrate the panel of lead compounds isolated from terrestrial sources with new chemical backbones and, sometimes, with unique functional groups.
    MeSH term(s) Alkaloids/chemistry ; Alkaloids/pharmacology ; Animals ; Antimalarials/chemistry ; Antimalarials/pharmacology ; Cyanobacteria/chemistry ; Diterpenes/chemistry ; Diterpenes/pharmacology ; Marine Biology ; Nitriles/chemistry ; Nitriles/pharmacology ; Peroxides/chemistry ; Peroxides/pharmacology ; Plasmodium/drug effects ; Porifera/chemistry
    Chemical Substances Alkaloids ; Antimalarials ; Diterpenes ; Nitriles ; Peroxides
    Language English
    Publishing date 2009-04-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md7020130
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  9. Article: Marine endoperoxides as antimalarial lead compounds

    Fattorusso, Ernesto / Taglialatela-Scafati, Orazio

    Phytochemistry reviews proceedings of the Phytochemical Society of Europe. 2010 Dec., v. 9, no. 4

    2010  

    Abstract: Malaria, a pathology caused by protozoa belonging to the genus Plasmodium, is one of the major threats to global health, with about 300-500 million new clinical cases occurring every year and 1-3 million annual deaths. The recrudescence in the number of ... ...

    Abstract Malaria, a pathology caused by protozoa belonging to the genus Plasmodium, is one of the major threats to global health, with about 300-500 million new clinical cases occurring every year and 1-3 million annual deaths. The recrudescence in the number of fatal cases registered in recent years can be attributed to the diffusion of multi-drug resistant strains of Plasmodium, which make less effective the limited armamentarium of available drugs. Living organisms are a recognized source of potentially bioactive molecules and, among them, marine natural products are emerging as one of the most interesting sources to be exploited for the discovery of new antimalarial compounds. In this article we will report results obtained for a single class of marine metabolites, namely endoperoxide-containing derivatives. Many of these molecules possess a simple six-membered 1,2-dioxygenated ring bearing two or three alkyl/aryl groups of different complexity. They can be divided according to the group linked at one of the two endoperoxide-oxygen bearing carbons: peroxyketal derivatives (methoxy group) or non-peroxyketal derivatives (methyl/ethyl groups). Molecules belonging to these classes show in vitro antimalarial activity in the nanomolar range on chloroquine-resistant strains. A number of investigations gave insights into the mechanism of action of these molecules, suggesting structural changes to optimize their antimalarial activity.
    Keywords malaria ; artemisinin ; peroxides
    Language English
    Dates of publication 2010-12
    Size p. 515-524.
    Publisher Springer Netherlands
    Publishing place Dordrecht
    Document type Article
    ZDB-ID 2065661-0
    ISSN 1572-980X ; 1568-7767
    ISSN (online) 1572-980X
    ISSN 1568-7767
    DOI 10.1007/s11101-010-9197-6
    Database NAL-Catalogue (AGRICOLA)

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  10. Book: Modern alkaloids

    Fattorusso, Ernesto / Taglialatela-Scafati, Orazio

    structure, isolation, synthesis and biology

    2008  

    Author's details edited by Ernesto Fattorusso and Orazio Taglialatela-Scafati
    Keywords Alkaloids. ; Alkaloids/Structure.
    Language English
    Size xxiv, 665 p. :, ill. ;, 25 cm.
    Publisher Wiley-VCH
    Publishing place Weinheim ; Chichester
    Document type Book
    ISBN 9783527315215 ; 3527315217
    Database NAL-Catalogue (AGRICOLA)

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    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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