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Article ; Online: Baricitinib for the treatment of alopecia areata in adults: Real-world analysis of 36 patients.

Moreno-Vílchez, Carlos / Bonfill-Ortí, Montserrat / Bauer-Alonso, Andrea / Notario, Jaime / Figueras-Nart, Ignasi

Journal of the American Academy of Dermatology

2024 Volume 90, Issue 5, Page(s) 1059–1061

MeSH term(s)	Adult ; Humans ; Alopecia Areata/drug therapy ; Alopecia ; Azetidines/therapeutic use ; Purines/therapeutic use ; Pyrazoles ; Sulfonamides
Chemical Substances	baricitinib (ISP4442I3Y) ; Azetidines ; Purines ; Pyrazoles ; Sulfonamides
Language	English
Publishing date	2024-01-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2023.09.089
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Article: Evaluation of antioxidant capacity, structure, and surface morphology of ginger (

Jorge-Montalvo, Paola / Vílchez-Perales, Carlos / Visitación-Figueroa, Lizardo

Heliyon

2023 Volume 9, Issue 6, Page(s) e16516

Abstract: The antioxidant capacity of ginger depends on the type of variety, growing conditions, postharvest, drying method, extraction, and measurement, among others. The objective of the research was to compare the efficiency of ultrasound (US), magnetic ... ...

Abstract	The antioxidant capacity of ginger depends on the type of variety, growing conditions, postharvest, drying method, extraction, and measurement, among others. The objective of the research was to compare the efficiency of ultrasound (US), magnetic agitation (AM), maceration (M), and reflux (R) extraction methods. In the GFD (fresh air-dried ginger) extract, the contents of total phenolic content (TFC), 6-gingerol (6-G), and 6-shogaol (6-S) were evaluated; as well as the antioxidant capacity by FRAP (ferric reducing antioxidant power) and IC
Language	English
Publishing date	2023-05-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e16516
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Valorisation of

Jorge-Montalvo, Paola / Vílchez-Perales, Carlos / Visitación-Figueroa, Lizardo

Heliyon

2023 Volume 9, Issue 8, Page(s) e19137

Abstract: During the postharvest phase of ginger, 2.6%-5% by weight of ginger rhizome residues are generated, which are disposed in landfills and constitute a continuous source of organic contamination causing serious environmental problems. The objective of this ... ...

Abstract	During the postharvest phase of ginger, 2.6%-5% by weight of ginger rhizome residues are generated, which are disposed in landfills and constitute a continuous source of organic contamination causing serious environmental problems. The objective of this study was to valorise ginger postharvest residues (shoot, finger, slice, trunk, root, and rootles) from district Pichanaki (Peru) as dry powdered byproducts with an antioxidant capacity similar to that of rhizome. The nutrition composition, phenolic compounds, such as total phenolic content, total flavonoid content, 6-gingerol content, and 6-shogaol content, antioxidant capacity expressed by ferric reducing antioxidant power and IC
Language	English
Publishing date	2023-08-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e19137
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Article ; Online: Health Literacy Concepts, Themes, and Research Trends Globally and in Latin America and the Caribbean: A Bibliometric Review.

Paucar-Caceres, Alberto / Vílchez-Román, Carlos / Quispe-Prieto, Silvia

International journal of environmental research and public health

2023 Volume 20, Issue 22

Abstract: 1) Background: Health literacy (HL) debates have increased significantly in the last two decades. HL concepts/themes and models have achieved substantial development in the US and Europe. Although there have been some efforts to develop HL in Latin ... ...

Abstract	(1) Background: Health literacy (HL) debates have increased significantly in the last two decades. HL concepts/themes and models have achieved substantial development in the US and Europe. Although there have been some efforts to develop HL in Latin America and the Caribbean (LAC), these seem to be few and scattered. This paper reviews and discusses developments of HL concepts and themes globally and in LAC over the last two decades. (2) Purpose: This study aimed to identify the prevalent health literacy concepts/themes deployed globally and in LAC as reported in academic journals from 2005 to 2022. We looked into which fields of knowledge have been informing HL research over the last decades. (3) Methods: We conducted a structured search on the Web of Science (WoS), Scopus, PubMed, and SciELO databases to extract the textual data for bibliometric analysis. We analyzed the textual data with VOSviewer and Biblioshiny to better understand health literacy themes and strands currently being researched in the LAC region. We conducted the searches in two periods: the first in May 2023 and the second in October 2023. (4) Results: The bibliometric study highlighted five WoS categories informing most HL global studies: (i) public environmental occupational health; (ii) environmental sciences; (iii) health policy services; (iv) health care science services; and (v) communication. The two predominant categories in LAC are public environmental occupation health and health policy services. Journals hosting HL publications come from these WoS categories. Themes in HL publications can be organized into four thematic clusters: (i)
MeSH term(s)	Latin America ; Health Literacy ; Caribbean Region ; Bibliometrics ; Public Health
Language	English
Publishing date	2023-11-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20227084
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Article: Methylmercury Effect and Distribution in Two Extremophile Microalgae Strains

Simansky, Samuel / Holub, Jiří / Márová, Ivana / Cuaresma, María / Garbayo, Ines / Torronteras, Rafael / Vílchez, Carlos / Gojkovic, Zivan

Microorganisms

2024 Volume 12, Issue 3

Abstract: The main entrance point of highly toxic organic Hg forms, including methylmercury (MeHg), into the aquatic food web is phytoplankton, which is greatly represented by various natural microalgal species. Processes associated with MeHg fate in microalgae ... ...

Abstract	The main entrance point of highly toxic organic Hg forms, including methylmercury (MeHg), into the aquatic food web is phytoplankton, which is greatly represented by various natural microalgal species. Processes associated with MeHg fate in microalgae cells such as uptake, effects on cells and toxicity, Hg biotransformation, and intracellular stability are detrimental to the process of further biomagnification and, as a consequence, have great importance for human health. The study of MeHg uptake and distribution in cultures of marine halophile
Language	English
Publishing date	2024-02-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms12030434
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Article ; Online: Honeycomb buccal mucosa lesions induced by checkpoint inhibitors.

Moreno-Vílchez, Carlos / Servitje, Octavio / Marcoval, Joaquim

Medicina clinica

2021 Volume 158, Issue 9, Page(s) 446–447

MeSH term(s)	Humans ; Mouth Mucosa/pathology ; Mouth Neoplasms/chemically induced ; Mouth Neoplasms/drug therapy ; Mouth Neoplasms/pathology
Language	Spanish
Publishing date	2021-10-15
Publishing country	Spain
Document type	Letter
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2021.07.022
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Article: Interaction of Naturally Occurring Phytoplankton with the Biogeochemical Cycling of Mercury in Aquatic Environments and Its Effects on Global Hg Pollution and Public Health.

Gojkovic, Zivan / Simansky, Samuel / Sanabria, Alain / Márová, Ivana / Garbayo, Inés / Vílchez, Carlos

Microorganisms

2023 Volume 11, Issue 8

Abstract: The biogeochemical cycling of mercury in aquatic environments is a complex process driven by various factors, such as ambient temperature, seasonal variations, methylating bacteria activity, dissolved oxygen levels, and Hg interaction with dissolved ... ...

Abstract	The biogeochemical cycling of mercury in aquatic environments is a complex process driven by various factors, such as ambient temperature, seasonal variations, methylating bacteria activity, dissolved oxygen levels, and Hg interaction with dissolved organic matter (DOM). As a consequence, part of the Hg contamination from anthropogenic activity that was buried in sediments is reinserted into water columns mainly in highly toxic organic Hg forms (methylmercury, dimethylmercury, etc.). This is especially prominent in the coastal shallow waters of industrial regions worldwide. The main entrance point of these highly toxic Hg forms in the aquatic food web is the naturally occurring phytoplankton. Hg availability, intake, effect on population size, cell toxicity, eventual biotransformation, and intracellular stability in phytoplankton are of the greatest importance for human health, having in mind that such Hg incorporated inside the phytoplankton cells due to biomagnification effects eventually ends up in aquatic wildlife, fish, seafood, and in the human diet. This review summarizes recent findings on the topic of organic Hg form interaction with natural phytoplankton and offers new insight into the matter with possible directions of future research for the prevention of Hg biomagnification in the scope of climate change and global pollution increase scenarios.
Language	English
Publishing date	2023-08-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11082034
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Article ; Online: Dermatomyositis in a donor and receptor of allogenic hematopoietic stem cell transplantation: Auto- or alloimmune disease?

Moreno-Vílchez, Carlos / Jucglà, Anna / Fornons-Servent, Rosa / Marcoval, Joaquim / Figueras-Nart, Ignasi

International journal of rheumatic diseases

2023 Volume 27, Issue 1, Page(s) e14806

Abstract: We present the case of a 63-year-old woman who developed dermatomyositis after hematopoietic stem cell transplantation. Anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibodies were positive and pulmonary involvement was severe and ... ...

Abstract	We present the case of a 63-year-old woman who developed dermatomyositis after hematopoietic stem cell transplantation. Anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibodies were positive and pulmonary involvement was severe and progressive. In addition, we also report that the patient's sister and donor also developed dermatomyositis. She had positive anti-PL7 antibodies and negative anti-MDA5 antibodies. The occurrence of autoimmune diseases after allogeneic hematopoietic stem cell transplantation is infrequent and difficult to interpret due to the reconstitution of the immune system and the multifactorial origin of most of these diseases. To our knowledge, this is the first described case of a hematopoietic progenitor transplant donor and recipient developing dermatomyositis. These findings make us wonder whether the dermatomyositis in this case is due to a shared genetic predisposition or to the donor's disease developing in the recipient.
MeSH term(s)	Female ; Humans ; Middle Aged ; Dermatomyositis/diagnosis ; Hematopoietic Stem Cell Transplantation/adverse effects ; Tissue Donors ; Autoantibodies
Chemical Substances	Autoantibodies
Language	English
Publishing date	2023-06-26
Publishing country	England
Document type	Case Reports
ZDB-ID	2426924-4
ISSN	1756-185X ; 1756-1841
ISSN (online)	1756-185X
ISSN	1756-1841
DOI	10.1111/1756-185X.14806
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Zs.A 6098: Show issues

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Article ; Online: Dermatofibrosarcoma protuberans. A study of 148 patients.

Marcoval, Joaquim / Moreno-Vílchez, Carlos / Torrecilla-Vall-Llossera, Clara / Muntaner-Virgili, Clara / Pérez Sidelnikova, Diana / Sanjuán, Xavier / Penin, Rosa Maria

Dermatology (Basel, Switzerland)

2024

Abstract: Introduction: Dermatofibrosarcoma protuberans (DFSP) is the most common sarcoma of the skin. Although distant metastases are infrequent, DFSP is highly aggressive locally with frequent local recurrences. It has been reported that the presence within the ...

Abstract	Introduction: Dermatofibrosarcoma protuberans (DFSP) is the most common sarcoma of the skin. Although distant metastases are infrequent, DFSP is highly aggressive locally with frequent local recurrences. It has been reported that the presence within the tumour of areas histopathologically mimicking fibrosarcoma may increase the risk of recurrence. Objective: To review the clinical features of our patients with DFSP and the factors associated with recurrence of the tumour, focusing on the presence of fibrosarcomatous areas. Methods: Retrospective study of patients with DFSP diagnosed in 1990-2021 in a tertiary university hospital. The medical records were reviewed to obtain the following data: age, sex, tumour location, diameter, and evolution time, presence of fibrosarcomatous areas, development of recurrence, and follow-up. Factors possibly associated with disease-free survival were analyzed with Kaplan-Meier method and multivariate Cox regression. Results: 148 patients (74 women/74 men, mean age 46.28 years, SD 14.431) were included in the study. Tumours involved head and neck in 15 cases, thorax in 31, abdomen in 16, upper back in 43, lower back in 10, upper extremities in 10, and lower extremities in 23. Fibrosarcoma-like areas were observed in 16 tumours (10.81%) . In 17 patients (11.49%) recurrences were observed (13 local recurrences, 3 lung metastasis, and 1 local recurrence with lung metastasis). Fibrosarcomatous DFSP recurred more frequently than classic DFSP (50% vs. 6.82%, respectively), and its disease free survival was significantly lower (p<0.001). In multivariate Cox regression the presence of fibrosarcomatous areas was the only factor influencing disease free survival. Conclusions: It is important to identify the fibrosarcomatous variant since it recurs more frequently and has lower recurrence-free survival. Distant metastases, mainly in the lung, are also more frequent in fibrosarcomatous DFSP.
Language	English
Publishing date	2024-01-16
Publishing country	Switzerland
Document type	News
ZDB-ID	1099692-8
ISSN	1421-9832 ; 1018-8665
ISSN (online)	1421-9832
ISSN	1018-8665
DOI	10.1159/000536172
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Article ; Online: Effects of fat sources on liver characteristics and intestinal morphometry in an early-life animal model.

Gutiérrez Zorrilla, Ivonne M / Bernuy-Osorio, Nataly D / Zea Mendoza, Otto / Yabar Villanueva, Emilio Fredy / Vílchez-Perales, Carlos

Revista peruana de medicina experimental y salud publica

2024 Volume 40, Issue 4, Page(s) 459–465

Abstract: Motivation for the study. There is little evidence on whether the consumption of fat sources containing different proportions of fatty acids has an effect on the characteristics of the liver and small intestine at an early age. Main findings. We found ... ...

Title translation	Efectos de fuentes de grasa sobre características del hígado y la morfometría intestinal en un modelo animal a temprana edad.
Abstract	Motivation for the study. There is little evidence on whether the consumption of fat sources containing different proportions of fatty acids has an effect on the characteristics of the liver and small intestine at an early age. Main findings. We found that the intake of fat sources containing unsaturated fatty acids contributes to maintaining the characteristics of both organs; whereas, consumption of sources containing saturated fatty acids favors inflammation in the liver and small intestine. Implications. The consumption of quinoa oil constitutes an alternative to protect these noble organs in an animal model at an early age. We aimed to determine the effect of the consumption of three sources of fatty acids on the relative weight, macroscopic and microscopic characteristics of the liver, and intestinal morphometry in an early-life animal model. Seventy-six randomly distributed chicks received one of the diets (T1: 97.0% basal diet (BD) + 3.0% inert material, T2: 97.0% BD + 3.0% partially hydrogenated vegetable shortening, T3: 97.0% BD + 3.0% quinoa oil, and T4: 97.0% BD + 3.0% fish oil) until the seventh day of life; samples were then extracted in order to be analyzed. We found that the animals that consumed quinoa oil (T3) or fish oil (T4) had favorable results associated to lower liver weight and better absorption of nutrients at intestinal level due to higher values in the hair length and crypt depth ratio, in comparison to partially hydrogenated vegetable shortening (T2). In conclusion, quinoa oil constitutes a healthy option for consumption and an alternative source to fish oil.
MeSH term(s)	Animals ; Fatty Acids ; Liver ; Fish Oils/pharmacology ; Plant Oils/pharmacology ; Diet ; Dietary Fats/pharmacology
Chemical Substances	Fatty Acids ; Fish Oils ; Plant Oils ; Dietary Fats
Language	English
Publishing date	2024-04-08
Publishing country	Peru
Document type	Journal Article
ZDB-ID	2120092-0
ISSN	1726-4642 ; 1726-4642
ISSN (online)	1726-4642
ISSN	1726-4642
DOI	10.17843/rpmesp.2023.404.12804
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