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  1. Article ; Online: Micromonosporaceae

    Alas, Imraan / Braun, Doug R / Ericksen, Spencer S / Salamzade, Rauf / Kalan, Lindsay / Rajski, Scott R / Bugni, Tim S

    Microbial genomics

    2024  Volume 10, Issue 1

    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835258-0
    ISSN 2057-5858 ; 2057-5858
    ISSN (online) 2057-5858
    ISSN 2057-5858
    DOI 10.1099/mgen.0.001167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Draft Genome Sequence of

    Chanana, Shaurya / Braun, Doug R / Rajski, Scott R / Bugni, Tim S

    Microbiology resource announcements

    2020  Volume 9, Issue 34

    Abstract: ... ...

    Abstract Pseudenhygromyxa
    Language English
    Publishing date 2020-08-20
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.00657-20
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  3. Article: hcapca

    Chanana, Shaurya / Thomas, Chris S / Zhang, Fan / Rajski, Scott R / Bugni, Tim S

    Metabolites

    2020  Volume 10, Issue 7

    Abstract: Microbial natural product discovery programs face two main challenges today: rapidly prioritizing strains for discovering new molecules and avoiding the rediscovery of already known molecules. Typically, these problems have been tackled using biological ... ...

    Abstract Microbial natural product discovery programs face two main challenges today: rapidly prioritizing strains for discovering new molecules and avoiding the rediscovery of already known molecules. Typically, these problems have been tackled using biological assays to identify promising strains and techniques that model variance in a dataset such as PCA to highlight novel chemistry. While these tools have shown successful outcomes in the past, datasets are becoming much larger and require a new approach. Since PCA models are dependent on the members of the group being modeled, large datasets with many members make it difficult to accurately model the variance in the data. Our tool,
    Language English
    Publishing date 2020-07-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo10070297
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  4. Article ; Online: Rapid Unambiguous Structure Elucidation of Streptnatamide A, a New Cyclic Peptide Isolated from A Marine-derived Streptomyces sp.

    Yan, Jia-Xuan / Wu, Qihao / Maity, Mitasree / Braun, Doug R / Alas, Imraan / Wang, Xiao / Yin, Xing / Zhu, Yanlong / Bell, Bailey A / Rajski, Scott R / Ge, Ying / Richardson, Douglas D / Zhong, Wendy / Bugni, Tim S

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2023  Volume 29, Issue 56, Page(s) e202301813

    Abstract: Cyclic peptides have been excellent source of drug leads. With the advances in discovery platforms, the pharmaceutical industry has a growing interest in cyclic peptides and has pushed several into clinical trials. However, structural complexity of ... ...

    Abstract Cyclic peptides have been excellent source of drug leads. With the advances in discovery platforms, the pharmaceutical industry has a growing interest in cyclic peptides and has pushed several into clinical trials. However, structural complexity of cyclic peptides brings extreme challenges for structure elucidation efforts. Isotopic fine structure analysis, Nuclear magnetic resonance (NMR), and detailed tandem mass spectrometry rapidly provided peptide sequence for streptnatamide A, a cyclic peptide isolated from a marine-derived Streptomyces sp. Marfey's analysis determined the stereochemistry of all amino acids, enabling the unambiguous structure determination of this compound. A non-ribosomal peptide synthetase biosynthetic gene cluster (stp) was tentatively identified and annotated for streptnatamide A based on the in silico analysis of whole genome sequencing data. These analytical tools will be powerful tools to overcome the challenges for cyclic peptide structure elucidation and accelerate the development of bioactive cyclic peptides.
    MeSH term(s) Peptides, Cyclic/chemistry ; Streptomyces/metabolism ; Amino Acid Sequence ; Amino Acids/chemistry ; Tandem Mass Spectrometry/methods
    Chemical Substances Peptides, Cyclic ; Amino Acids
    Language English
    Publishing date 2023-09-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202301813
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  5. Article ; Online: High Throughput Small Molecule Screen for Reactivation of

    Hunt, Jack F V / Li, Meng / Risgaard, Ryan / Ananiev, Gene E / Wildman, Scott / Zhang, Fan / Bugni, Tim S / Zhao, Xinyu / Bhattacharyya, Anita

    Cells

    2021  Volume 11, Issue 1

    Abstract: Fragile X syndrome (FXS) is the most common inherited cause of autism and intellectual disability. The majority of FXS cases are caused by transcriptional repression of ... ...

    Abstract Fragile X syndrome (FXS) is the most common inherited cause of autism and intellectual disability. The majority of FXS cases are caused by transcriptional repression of the
    MeSH term(s) Drug Evaluation, Preclinical ; Fragile X Mental Retardation Protein/metabolism ; Fragile X Syndrome/pathology ; Genetic Loci ; High-Throughput Screening Assays ; Humans ; Neural Stem Cells/drug effects ; Neural Stem Cells/metabolism ; Neurons/drug effects ; Neurons/metabolism ; Reproducibility of Results ; Small Molecule Libraries/pharmacology
    Chemical Substances Small Molecule Libraries ; Fragile X Mental Retardation Protein (139135-51-6)
    Language English
    Publishing date 2021-12-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11010069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Symbiosis-inspired approaches to antibiotic discovery.

    Adnani, Navid / Rajski, Scott R / Bugni, Tim S

    Natural product reports

    2017  Volume 34, Issue 7, Page(s) 784–814

    Abstract: Covering: 2010 up to 2017Life on Earth is characterized by a remarkable abundance of symbiotic and highly refined relationships among life forms. Defined as any kind of close, long-term association between two organisms, symbioses can be mutualistic, ... ...

    Abstract Covering: 2010 up to 2017Life on Earth is characterized by a remarkable abundance of symbiotic and highly refined relationships among life forms. Defined as any kind of close, long-term association between two organisms, symbioses can be mutualistic, commensalistic or parasitic. Historically speaking, selective pressures have shaped symbioses in which one organism (typically a bacterium or fungus) generates bioactive small molecules that impact the host (and possibly other symbionts); the symbiosis is driven fundamentally by the genetic machineries available to the small molecule producer. The human microbiome is now integral to the most recent chapter in animal-microbe symbiosis studies and plant-microbe symbioses have significantly advanced our understanding of natural products biosynthesis; this also is the case for studies of fungal-microbe symbioses. However, much less is known about microbe-microbe systems involving interspecies interactions. Microbe-derived small molecules (i.e. antibiotics and quorum sensing molecules, etc.) have been shown to regulate transcription in microbes within the same environmental niche, suggesting interspecies interactions whereas, intraspecies interactions, such as those that exploit autoinducing small molecules, also modulate gene expression based on environmental cues. We, and others, contend that symbioses provide almost unlimited opportunities for the discovery of new bioactive compounds whose activities and applications have been evolutionarily optimized. Particularly intriguing is the possibility that environmental effectors can guide laboratory expression of secondary metabolites from "orphan", or silent, biosynthetic gene clusters (BGCs). Notably, many of the studies summarized here result from advances in "omics" technologies and highlight how symbioses have given rise to new anti-bacterial and antifungal natural products now being discovered.
    MeSH term(s) Animals ; Anti-Bacterial Agents ; Bacteria/metabolism ; Biological Evolution ; Fungi/physiology ; Humans ; Molecular Structure ; Multigene Family ; Plants/metabolism ; Symbiosis/physiology
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2017--06
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2002546-4
    ISSN 1460-4752 ; 0265-0568
    ISSN (online) 1460-4752
    ISSN 0265-0568
    DOI 10.1039/c7np00009j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Phenyl-Lactic Acid Is an Active Ingredient in Bactericidal Supernatants of Lactobacillus crispatus.

    Abdul-Rahim, Omar / Wu, Qihao / Price, Travis K / Pistone, Giuseppe / Diebel, Katherine / Bugni, Tim S / Wolfe, Alan J

    Journal of bacteriology

    2021  Volume 203, Issue 19, Page(s) e0036021

    Abstract: Lactobacillus crispatus is a well-established probiotic with antimicrobial activity against pathogens across several niches of the human body generally attributed to the production of bacteriostatic molecules, including hydrogen peroxide and lactic acid. ...

    Abstract Lactobacillus crispatus is a well-established probiotic with antimicrobial activity against pathogens across several niches of the human body generally attributed to the production of bacteriostatic molecules, including hydrogen peroxide and lactic acid. Here, we show that the cell-free supernatants of clinical isolates of L. crispatus harbor robust bactericidal activity. We further identify phenyl-lactic acid as a bactericidal compound with properties and a susceptibility range nearly identical to that of the cell-free supernatant. As such, we hypothesize that phenyl-lactic acid is a key active ingredient in L. crispatus supernatant.
    MeSH term(s) Anti-Infective Agents/chemistry ; Anti-Infective Agents/metabolism ; Anti-Infective Agents/pharmacology ; Bacteria/drug effects ; Candida/drug effects ; Lactates/chemistry ; Lactates/metabolism ; Lactates/pharmacology ; Lactobacillus crispatus/metabolism
    Chemical Substances Anti-Infective Agents ; Lactates ; 3-phenyllactic acid (156-05-8)
    Language English
    Publishing date 2021-09-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/JB.00360-21
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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.50: Show issues Location:
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  8. Article ; Online: Bacillimidazoles A-F, Imidazolium-Containing Compounds Isolated from a Marine

    Yan, Jia-Xuan / Wu, Qihao / Helfrich, Eric J N / Chevrette, Marc G / Braun, Doug R / Heyman, Heino / Ananiev, Gene E / Rajski, Scott R / Currie, Cameron R / Clardy, Jon / Bugni, Tim S

    Marine drugs

    2022  Volume 20, Issue 1

    Abstract: Chemical investigations of a marine sponge- ... ...

    Abstract Chemical investigations of a marine sponge-associated
    MeSH term(s) Animals ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Aquatic Organisms ; Bacillus ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Microbial Sensitivity Tests ; Porifera
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-01-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md20010043
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  9. Article ; Online: Bulbiferates A and B: Antibacterial Acetamidohydroxybenzoates from a Marine Proteobacterium,

    Jayanetti, Dinith R / Braun, Doug R / Barns, Kenneth J / Rajski, Scott R / Bugni, Tim S

    Journal of natural products

    2019  Volume 82, Issue 7, Page(s) 1930–1934

    Abstract: Here we report the discovery of two new 3-acetamido-4-hydroxybenzoate esters, bulbiferates A ( ...

    Abstract Here we report the discovery of two new 3-acetamido-4-hydroxybenzoate esters, bulbiferates A (
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/isolation & purification ; Anti-Bacterial Agents/pharmacology ; Escherichia coli/drug effects ; Gammaproteobacteria/chemistry ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Microbial Sensitivity Tests ; Molecular Structure ; Seawater/microbiology ; Spectrum Analysis/methods ; Structure-Activity Relationship
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2019-06-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.9b00312
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1144: Show issues Location:
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  10. Article ; Online: Phallusialides A-E, Pyrrole-Derived Alkaloids Discovered from a Marine-Derived

    Zhang, Fan / Braun, Doug R / Chanana, Shaurya / Rajski, Scott R / Bugni, Tim S

    Journal of natural products

    2019  Volume 82, Issue 12, Page(s) 3432–3439

    Abstract: Integrating MS-based metabolomics approaches, LC-MS-PCA and molecular networking enabled the targeted isolation of five new pyrrole-derived alkaloids, phallusialides A-E ( ...

    Abstract Integrating MS-based metabolomics approaches, LC-MS-PCA and molecular networking enabled the targeted isolation of five new pyrrole-derived alkaloids, phallusialides A-E (
    MeSH term(s) Alkaloids/chemistry ; Alkaloids/isolation & purification ; Alkaloids/pharmacology ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Escherichia coli/drug effects ; Metabolomics ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Microbial Sensitivity Tests ; Micromonospora/metabolism ; Molecular Structure ; Pyrroles/chemistry ; Spectrum Analysis/methods
    Chemical Substances Alkaloids ; Anti-Bacterial Agents ; Pyrroles
    Language English
    Publishing date 2019-12-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.9b00808
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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