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  1. Article ; Online: The Benefits of Collaboration.

    Blunt, John W / Munro, Murray H G

    Marine drugs

    2023  Volume 21, Issue 2

    Abstract: We have been very humbled by the decision of ... ...

    Abstract We have been very humbled by the decision of the
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md21020065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Structure determination: molecules under the microscope.

    Blunt, John W

    Nature chemistry

    2010  Volume 2, Issue 10, Page(s) 799–800

    MeSH term(s) Crystallography, X-Ray ; Magnetic Resonance Spectroscopy ; Microscopy, Scanning Probe/methods ; Molecular Structure
    Language English
    Publishing date 2010-09-23
    Publishing country England
    Document type Comment ; News
    ZDB-ID 2464596-5
    ISSN 1755-4349 ; 1755-4330
    ISSN (online) 1755-4349
    ISSN 1755-4330
    DOI 10.1038/nchem.849
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Acute Kidney Injury and mortality prognosis in Acute Coronary Syndrome patients: A meta-analysis.

    Pickering, John W / Blunt, Isabella R H / Than, Martin P

    Nephrology (Carlton, Vic.)

    2016  Volume 23, Issue 3, Page(s) 237–246

    Abstract: Aim: The aim of this study is to provide a robust estimate of mortality risk in acute coronary syndrome (ACS)-associated acute kidney injury (AKI) to inform clinical practice and policy.: Methods: A meta-analysis of cohort studies evaluating outcomes ...

    Abstract Aim: The aim of this study is to provide a robust estimate of mortality risk in acute coronary syndrome (ACS)-associated acute kidney injury (AKI) to inform clinical practice and policy.
    Methods: A meta-analysis of cohort studies evaluating outcomes of ACS and which reported AKI and AKI-associated mortality. Studies were excluded if they incorporated patients not admitted through the emergency department (i.e. for elective procedures), were limited to cardiogenic shock or cardiac arrest, or relied on registry data for outcomes without further adjudication. The predictor was ACS-associated AKI and outcomes early (30 day or in-hospital) mortality and late-mortality (post-hospital discharge).
    Results: Thirty-six studies with 37 unique cohorts comprising 100 476 patients were included. The pooled rate of ACS-associated AKI was 15.8%. In 32 cohorts reporting early mortality, the crude early mortality rate was 15.0% amongst those with AKI compared with 2.0% amongst those without AKI. The pooled estimate of the relative risk of AKI-associated early mortality was 4.1 (95% confidence interval: 3.3 to 5.0) with high heterogeneity between studies (I
    Conclusions: Acute coronary syndrome-associated AKI is associated with more than a three-fold increase in early mortality and more than two-fold in long-term mortality.
    MeSH term(s) Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/mortality ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/mortality ; Hospital Mortality ; Humans ; Odds Ratio ; Prevalence ; Prognosis ; Risk Assessment ; Risk Factors ; Time Factors
    Language English
    Publishing date 2016-12-16
    Publishing country Australia
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 1303661-0
    ISSN 1440-1797 ; 1320-5358
    ISSN (online) 1440-1797
    ISSN 1320-5358
    DOI 10.1111/nep.12984
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4822: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Fifty years of capacity building in the search for new marine natural products.

    Leal, Miguel C / Anaya-Rojas, Jaime M / Munro, Murray H G / Blunt, John W / Melian, Carlos J / Calado, Ricardo / Lürig, Moritz D

    Proceedings of the National Academy of Sciences of the United States of America

    2020  Volume 117, Issue 39, Page(s) 24165–24172

    Abstract: The Convention on Biological Diversity, and the Nagoya Protocol in particular, provide a framework for the fair and equitable sharing of benefits arising from the utilization of biological resources and traditional knowledge, and ultimately aim to ... ...

    Abstract The Convention on Biological Diversity, and the Nagoya Protocol in particular, provide a framework for the fair and equitable sharing of benefits arising from the utilization of biological resources and traditional knowledge, and ultimately aim to promote capacity-building in the developing world. However, measuring capacity-building is a challenging task due to its intangible nature. By compiling and analyzing a database of scientific peer-reviewed publications over a period of 50 y (1965 to 2015), we investigated capacity-building in global marine natural product discovery. We used publication and authorship metrics to assess how the capacity to become scientifically proficient, prolific, and independent has changed in bioprospecting countries. Our results show that marine bioprospecting is a dynamically growing field of research with continuously increasing numbers of participating countries, publications, and scientists. Yet despite longstanding efforts to promote equitability and scientific independence, not all countries have similarly increased their capacity to explore marine biodiversity within their national jurisdiction areas. Although developing countries show an increasing trend in the number of publications, a few developed countries still account for almost one-half of all publications in the field. Multiple lines of evidence suggest that economic capacity affects how well countries with species-rich marine ecosystems can scientifically explore those resources. Overall, the capacity-building data analyzed here provides a timely contribution to the ongoing international debate about access to and benefit-sharing of biological resources for countries exploring biodiversity within and outside their national jurisdiction areas.
    MeSH term(s) Aquatic Organisms ; Biodiversity ; Biological Products ; Bioprospecting/history ; History, 20th Century ; History, 21st Century ; International Cooperation
    Chemical Substances Biological Products
    Language English
    Publishing date 2020-09-14
    Publishing country United States
    Document type Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2007610117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Marine natural products.

    Blunt, John W / Copp, Brent R / Keyzers, Robert A / Munro, Murray H G / Prinsep, Michèle R

    Natural product reports

    2017  Volume 34, Issue 3, Page(s) 235–294

    Abstract: Covering: 2015. Previous review: Nat. Prod. Rep., 2016, 33, 382-431This review covers the literature published in 2015 for marine natural products (MNPs), with 1220 citations (792 for the period January to December 2015) referring to compounds isolated ... ...

    Abstract Covering: 2015. Previous review: Nat. Prod. Rep., 2016, 33, 382-431This review covers the literature published in 2015 for marine natural products (MNPs), with 1220 citations (792 for the period January to December 2015) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1340 in 429 papers for 2015), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.
    MeSH term(s) Animals ; Biological Products/chemistry ; Biological Products/isolation & purification ; Bryozoa/chemistry ; Cnidaria/chemistry ; Echinodermata/chemistry ; Eukaryota/chemistry ; Marine Biology ; Molecular Structure ; Mollusca/chemistry ; Phytoplankton/chemistry ; Rhodophyta/chemistry ; Urochordata/chemistry
    Chemical Substances Biological Products
    Language English
    Publishing date 2017-03-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2002546-4
    ISSN 1460-4752 ; 0265-0568
    ISSN (online) 1460-4752
    ISSN 0265-0568
    DOI 10.1039/c6np00124f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Data, ¹H-NMR databases, data manipulation, …

    Blunt, John W / Munro, Murray H. G

    Phytochemistry reviews. 2013 Sept., v. 12, no. 3

    2013  

    Abstract: Research on all aspects of marine natural products has become increasingly dependent on access to databases of information on bibliography, taxonomy, compound structures, spectroscopic and physical properties data, and biological activities. Convenient ... ...

    Abstract Research on all aspects of marine natural products has become increasingly dependent on access to databases of information on bibliography, taxonomy, compound structures, spectroscopic and physical properties data, and biological activities. Convenient access to and effective use of these databases, especially a ¹H NMR database, can lead to a more efficient use of time and effort in (marine) natural product investigations. A survey of the available databases is presented and how appropriate application can markedly reduce the effort required in the process of dereplication.
    Keywords databases ; nuclear magnetic resonance spectroscopy ; physical properties ; surveys ; taxonomy
    Language English
    Dates of publication 2013-09
    Size p. 435-447.
    Publishing place Springer-Verlag
    Document type Article
    ZDB-ID 2065661-0
    ISSN 1572-980X ; 1568-7767
    ISSN (online) 1572-980X
    ISSN 1568-7767
    DOI 10.1007/s11101-012-9245-5
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Marine natural products.

    Blunt, John W / Carroll, Anthony R / Copp, Brent R / Davis, Rohan A / Keyzers, Robert A / Prinsep, Michèle R

    Natural product reports

    2018  Volume 35, Issue 1, Page(s) 8–53

    Abstract: Covering: 2016. Previous review: Nat. Prod. Rep., 2017, 34, 235-294This review covers the literature published in 2016 for marine natural products (MNPs), with 757 citations (643 for the period January to December 2016) referring to compounds isolated ... ...

    Abstract Covering: 2016. Previous review: Nat. Prod. Rep., 2017, 34, 235-294This review covers the literature published in 2016 for marine natural products (MNPs), with 757 citations (643 for the period January to December 2016) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1277 in 432 papers for 2016), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that led to the revision of structures or stereochemistries, have been included.
    MeSH term(s) Animals ; Aquatic Organisms/chemistry ; Aquatic Organisms/metabolism ; Biological Products/chemistry ; Biological Products/pharmacology ; Bryozoa/chemistry ; Chlorophyta/chemistry ; Cnidaria/chemistry ; Echinodermata/chemistry ; Molecular Structure ; Mollusca/chemistry ; Phaeophyceae/chemistry ; Phytoplankton/chemistry ; Porifera/chemistry ; Rhodophyta/chemistry ; Seawater/microbiology ; Urochordata/chemistry ; Wetlands
    Chemical Substances Biological Products
    Language English
    Publishing date 2018-01-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2002546-4
    ISSN 1460-4752 ; 0265-0568
    ISSN (online) 1460-4752
    ISSN 0265-0568
    DOI 10.1039/c7np00052a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Marine natural products.

    Blunt, John W / Copp, Brent R / Keyzers, Robert A / Munro, Murray H G / Prinsep, Michèle R

    Natural product reports

    2016  Volume 33, Issue 3, Page(s) 382–431

    Abstract: This review covers the literature published in 2014 for marine natural products (MNPs), with 1116 citations (753 for the period January to December 2014) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red ... ...

    Abstract This review covers the literature published in 2014 for marine natural products (MNPs), with 1116 citations (753 for the period January to December 2014) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1378 in 456 papers for 2014), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.
    MeSH term(s) Animals ; Biological Products/chemical synthesis ; Biological Products/chemistry ; Biological Products/isolation & purification ; Bryozoa/chemistry ; Cnidaria/chemistry ; Echinodermata/chemistry ; Marine Biology ; Molecular Structure ; Mollusca/chemistry ; Phytoplankton/chemistry ; Porifera/chemistry ; Rhodophyta/chemistry ; Urochordata/chemistry
    Chemical Substances Biological Products
    Language English
    Publishing date 2016-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2002546-4
    ISSN 1460-4752 ; 0265-0568
    ISSN (online) 1460-4752
    ISSN 0265-0568
    DOI 10.1039/c5np00156k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Marine natural products

    Blunt, John W / Copp, Brent R / Keyzers, Robert A / Munro, Murray H. G / Prinsep, Michèle R

    Natural product reports. 2017 Mar. 17, v. 34, no. 3

    2017  

    Abstract: Covering: 2015. Previous review: Nat. Prod. Rep., 2016, 33, 382–431 This review covers the literature published in 2015 for marine natural products (MNPs), with 1220 citations (792 for the period January to December 2015) referring to compounds isolated ... ...

    Abstract Covering: 2015. Previous review: Nat. Prod. Rep., 2016, 33, 382–431 This review covers the literature published in 2015 for marine natural products (MNPs), with 1220 citations (792 for the period January to December 2015) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1340 in 429 papers for 2015), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.
    Keywords Bryozoa ; Cnidaria ; Echinodermata ; Rhodophyta ; Urochordata ; bioactive properties ; biosynthesis ; littoral zone ; microorganisms ; molluscs ; phytoplankton ; stereochemistry
    Language English
    Dates of publication 2017-0317
    Size p. 235-294.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 2002546-4
    ISSN 1460-4752 ; 0265-0568
    ISSN (online) 1460-4752
    ISSN 0265-0568
    DOI 10.1039/c6np00124f
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Natural products discovery needs improved taxonomic and geographic information.

    Leal, Miguel C / Hilário, Ana / Munro, Murray H G / Blunt, John W / Calado, Ricardo

    Natural product reports

    2016  Volume 33, Issue 6, Page(s) 747–750

    Abstract: Covering: up to 2016Marine and terrestrial organisms yield a remarkable chemical diversity and are important sources for discovery of new chemical products. In order to maximize the bioprospecting efficiency of natural products (NP), taxonomy, geography ... ...

    Abstract Covering: up to 2016Marine and terrestrial organisms yield a remarkable chemical diversity and are important sources for discovery of new chemical products. In order to maximize the bioprospecting efficiency of natural products (NP), taxonomy, geography and biodiversity are starting to be used to draw conclusions on which taxonomic groups and/or regions may be of interest for future research. However, accurate taxonomic information and sampling location of source organisms have often been overlooked. Although these issues were already reported a few decades ago and improvements have been made, such outstanding problems are still recurrent in recent peer-reviewed literature. Here, we focus on the importance of taxonomic and geographic identification of source material and illustrate how taxonomic and geographic data of source organisms continues to be poorly handled. It is our opinion that this issue needs to be discussed within the NP community with the ultimate goal of improving publication standards and guaranteeing the scientific principle of research reproducibility. Moreover, by doing so, it will be possible to take advantage of information available in the literature to develop cross-disciplinary meta-analyses that may help to advance the state of the art of NP research and future bioprospecting endeavours.
    MeSH term(s) Biodiversity ; Biological Products/chemistry ; Biological Products/classification ; Molecular Structure ; Reproducibility of Results
    Chemical Substances Biological Products
    Language English
    Publishing date 2016-06-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2002546-4
    ISSN 1460-4752 ; 0265-0568
    ISSN (online) 1460-4752
    ISSN 0265-0568
    DOI 10.1039/c5np00130g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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