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Article ; Online: Integrated multi-omics reveals anaplerotic rewiring in methylmalonyl-CoA mutase deficiency.

Forny, Patrick / Bonilla, Ximena / Lamparter, David / Shao, Wenguang / Plessl, Tanja / Frei, Caroline / Bingisser, Anna / Goetze, Sandra / van Drogen, Audrey / Harshman, Keith / Pedrioli, Patrick G A / Howald, Cedric / Poms, Martin / Traversi, Florian / Bürer, Céline / Cherkaoui, Sarah / Morscher, Raphael J / Simmons, Luke / Forny, Merima /

Xenarios, Ioannis / Aebersold, Ruedi / Zamboni, Nicola / Rätsch, Gunnar / Dermitzakis, Emmanouil T / Wollscheid, Bernd / Baumgartner, Matthias R / Froese, D Sean

Nature metabolism

2023 Volume 5, Issue 1, Page(s) 80–95

Abstract: Methylmalonic aciduria (MMA) is an inborn error of metabolism with multiple monogenic causes and a poorly understood pathogenesis, leading to the absence of effective causal treatments. Here we employ multi-layered omics profiling combined with ... ...

Abstract	Methylmalonic aciduria (MMA) is an inborn error of metabolism with multiple monogenic causes and a poorly understood pathogenesis, leading to the absence of effective causal treatments. Here we employ multi-layered omics profiling combined with biochemical and clinical features of individuals with MMA to reveal a molecular diagnosis for 177 out of 210 (84%) cases, the majority (148) of whom display pathogenic variants in methylmalonyl-CoA mutase (MMUT). Stratification of these data layers by disease severity shows dysregulation of the tricarboxylic acid cycle and its replenishment (anaplerosis) by glutamine. The relevance of these disturbances is evidenced by multi-organ metabolomics of a hemizygous Mmut mouse model as well as through identification of physical interactions between MMUT and glutamine anaplerotic enzymes. Using stable-isotope tracing, we find that treatment with dimethyl-oxoglutarate restores deficient tricarboxylic acid cycling. Our work highlights glutamine anaplerosis as a potential therapeutic intervention point in MMA.
MeSH term(s)	Mice ; Animals ; Methylmalonyl-CoA Mutase/genetics ; Methylmalonyl-CoA Mutase/metabolism ; Glutamine ; Multiomics ; Metabolism, Inborn Errors/genetics
Chemical Substances	Methylmalonyl-CoA Mutase (EC 5.4.99.2) ; Glutamine (0RH81L854J)
Language	English
Publishing date	2023-01-26
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2522-5812
ISSN (online)	2522-5812
DOI	10.1038/s42255-022-00720-8
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Article ; Online: Effect of familial diabetes status and age at diagnosis on type 2 diabetes risk: a nation-wide register-based study from Denmark.

Silverman-Retana, Omar / Hulman, Adam / Nielsen, Jannie / Ekstrøm, Claus T / Carstensen, Bendix / Simmons, Rebecca K / Bjerg, Lasse / Johnston, Luke W / Witte, Daniel R

Diabetologia

2020 Volume 63, Issue 5, Page(s) 934–943

Abstract: Aims/hypothesis: We assessed whether the risk of developing type 2 diabetes and the age of onset varied with the age at diabetes diagnosis of affected family members.: Methods: We performed a national register-based open cohort study of individuals ... ...

Abstract	Aims/hypothesis: We assessed whether the risk of developing type 2 diabetes and the age of onset varied with the age at diabetes diagnosis of affected family members. Methods: We performed a national register-based open cohort study of individuals living in Denmark between 1995 and 2012. The population under study consisted of all individuals aged 30 years or older without diagnosed diabetes at the start date of the cohort (1 January 1995) and who had information about their parents' identity. Individuals who turned 30 years of age during the observation period and had available parental identity information were also added to the cohort from that date (open cohort design). These criteria restricted the study population mostly to people born between 1960 and 1982. Multivariable Poisson regression models adjusted for current age and highest educational attainment were used to estimate incidence rate ratios (IRRs) of type 2 diabetes. Results: We followed 2,000,552 individuals for a median of 14 years (24,034,059 person-years) and observed 76,633 new cases of type 2 diabetes. Compared with individuals of the same age and sex who did not have a parent or full sibling with diabetes, the highest risk of developing type 2 diabetes was observed in individuals with family members diagnosed at an early age. The IRR was progressively lower with a higher age at diabetes diagnosis in family members: 3.9 vs 1.4 for those with a parental age at diagnosis of 50 or 80 years, respectively; and 3.3 vs 2.0 for those with a full sibling's age at diagnosis of 30 or 60 years, respectively. Conclusions/interpretation: People with a family member diagnosed with diabetes at an earlier age are more likely to develop diabetes and also to develop it at an earlier age than those with a family member diagnosed in later life. This finding highlights the importance of expanding our understanding of the interplay between genetic diabetes determinants and the social, behavioural and environmental diabetes determinants that track in families across generations. Accurate registration of age at diagnosis should form an integral part of recording a diabetes family history, as it provides easily obtainable and highly relevant detail that may improve identification of individuals at increased risk of younger onset of type 2 diabetes. In particular, these individuals may benefit from closer risk factor assessment and follow-up, as well as prevention strategies that may involve the family.
MeSH term(s)	Adult ; Age Factors ; Aged ; Cohort Studies ; Denmark/epidemiology ; Diabetes Mellitus, Type 2/epidemiology ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Registries ; Risk Factors
Language	English
Publishing date	2020-02-19
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1694-9
ISSN	1432-0428 ; 0012-186X
ISSN (online)	1432-0428
ISSN	0012-186X
DOI	10.1007/s00125-020-05113-8
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Article ; Online: Prepectoral Dual-Port Tissue Expander Placement: Can This Eliminate Suction Drain Use?

Franck, Philipp / Chadab, Tara / Poveromo, Luke / Ellison, Angela / Simmons, Rache / Otterburn, David Mark

Annals of plastic surgery

2020 Volume 85, Issue S1 Suppl 1, Page(s) S60–S62

Abstract: Objectives: The most common method of performing breast reconstruction after a mastectomy is using tissue expanders. Significant drainage that can lead to seromas and possible infection is a common sequela after mastectomies, and therefore, closed ... ...

Abstract	Objectives: The most common method of performing breast reconstruction after a mastectomy is using tissue expanders. Significant drainage that can lead to seromas and possible infection is a common sequela after mastectomies, and therefore, closed suction drains are routinely placed during the initial surgery (Vardanian et al. Plast Reconstr Surg. 2011;128:403-410). Drains, however, are associated with increased pain and discomfort for the patient and have been attributed to an increased infection rate by some authors (Degnim et al. Ann Surg. 2013;258:240-247; Saratzis et al. Clin Breast Cancer. 2009;9:243-246). We report on our experience using a dual-chamber tissue expander placed in the prepectoral space without acellular dermal matrix or other supportive material, which allows for drainage of periprosthetic fluid and avoids drain placement. Patients and methods: A retrospective, single-institution review of patients' records was performed for all patients who underwent prepectoral tissue expander placement between January 2018 and June 2019. Patients who had drains placed or who underwent autologous reconstruction in combination with expander placement were excluded. Thirty-nine patients were selected, with a total of 66 expander placements. Demographics including body mass index, comorbidities, history of smoking or steroid use, perioperative chemotherapy and radiation therapy, and intraoperative details and indications for surgery were retrospectively collected. Outcomes were separated into minor and major complications. Major complications were defined as complications that required surgical intervention. Results: There were 51 prepectoral reconstructions with a dual-chamber tissue expander and no further surgical drain and 15 reconstructions using a standard expander with an additional closed suction drain. Overall complications for the no-drain cohort were 13.7% compared with 20% in the drain cohort (P = 0.68). Surgical site infection rate is 7.84% in the no-drain cohort compared with 13.3% in the drain cohort (P = 0.61). Mean numeric postoperative pain score at 6 hours was 3.2 in the no-drain cohort compared with 4.3 in the drain cohort (P = 0.03) and 4.17 compared with 5.6 at 12 hours, respectively (P = 0.04). Mean time to exchange of implant in the no-drain cohort was 152 days versus 126 days in the drain cohort (P = 0.38). Median follow-up times were 157 days for the no-drain cohort and 347 days for the drain cohort. Conclusions: Immediate breast reconstruction using a dual-chamber tissue expander offers a drain-free alternative to the immediate implant-based breast reconstruction. Our infection rate with 7.8% is lower than our own reported rates with subpectoral tissue expander reconstruction using either acellular dermal matrix or poly-4-hydroxybutyrate (17% and 11%). The overall complication rate is similar to historic data associated with breast reconstruction after mastectomy and suggests that dual-chamber expander placement offers a safe alternative possibly decreasing the patient's postoperative pain and discomfort that often is associated with closed suction drains (Saratzis et al. Clin Breast Cancer. 2009;9:243-246).
MeSH term(s)	Breast Implants ; Breast Neoplasms/surgery ; Humans ; Mammaplasty ; Mastectomy ; Retrospective Studies ; Suction ; Tissue Expansion ; Tissue Expansion Devices
Language	English
Publishing date	2020-07-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	423835-7
ISSN	1536-3708 ; 0148-7043
ISSN (online)	1536-3708
ISSN	0148-7043
DOI	10.1097/SAP.0000000000002344
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Article ; Online: Safety and Immunogenicity of a Tetravalent Dengue DNA Vaccine Administered with a Cationic Lipid-Based Adjuvant in a Phase 1 Clinical Trial.

Danko, Janine R / Kochel, Tadeusz / Teneza-Mora, Nimfa / Luke, Thomas C / Raviprakash, Kanakatte / Sun, Peifang / Simmons, Monika / Moon, James E / De La Barrera, Rafael / Martinez, Luis Javier / Thomas, Stephen J / Kenney, Richard T / Smith, Larry / Porter, Kevin R

The American journal of tropical medicine and hygiene

2018 Volume 98, Issue 3, Page(s) 849–856

Abstract: We conducted an open label, dose escalation Phase 1 clinical trial of a tetravalent dengue DNA vaccine (TVDV) formulated in ... ...

Abstract	We conducted an open label, dose escalation Phase 1 clinical trial of a tetravalent dengue DNA vaccine (TVDV) formulated in Vaxfectin
MeSH term(s)	Adjuvants, Immunologic/administration & dosage ; Adjuvants, Immunologic/chemistry ; Adult ; Antibodies, Neutralizing/biosynthesis ; Antibodies, Viral/biosynthesis ; Dengue/immunology ; Dengue/prevention & control ; Dengue/virology ; Dengue Vaccines/administration & dosage ; Dengue Vaccines/adverse effects ; Dengue Virus/immunology ; Fatigue/etiology ; Fatigue/physiopathology ; Female ; Headache/etiology ; Headache/physiopathology ; Humans ; Immunity, Cellular/drug effects ; Immunization Schedule ; Immunogenicity, Vaccine ; Injections, Intramuscular ; Interferon-gamma/biosynthesis ; Interferon-gamma/immunology ; Male ; Myalgia/etiology ; Myalgia/physiopathology ; Patient Safety ; Phosphatidylethanolamines/administration & dosage ; Phosphatidylethanolamines/chemistry ; Vaccination ; Vaccines, DNA/administration & dosage ; Vaccines, DNA/adverse effects
Chemical Substances	Adjuvants, Immunologic ; Antibodies, Neutralizing ; Antibodies, Viral ; Dengue Vaccines ; Phosphatidylethanolamines ; Vaccines, DNA ; vaxfectin ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2018-01-18
Publishing country	United States
Document type	Clinical Trial, Phase I ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.17-0416
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Article ; Online: Steps to diversify priority-setting research in conservation: reflections on de Gracia 2021.

Jucker, Tommaso / Amano, Tatsuya / Bell, Alexandra / Garnett, Emma E / Geffert, Jan Laurens / Guth, Miriam K / Hacket-Pain, Andrew / Luke, Sarah H / Mumby, Hannah S / Nunes, Matheus / Rademacher, Tim / Rose, David C / Schleicher, Judith / Simmons, Benno I / Zabala, Aiora / Mukherjee, Nibedita

Conservation biology : the journal of the Society for Conservation Biology

2021 Volume 35, Issue 4, Page(s) 1324–1326

Language	English
Publishing date	2021-06-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	58735-7
ISSN	1523-1739 ; 0888-8892
ISSN (online)	1523-1739
ISSN	0888-8892
DOI	10.1111/cobi.13790
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Article ; Online: Genomic investigations of unexplained acute hepatitis in children.

Morfopoulou, Sofia / Buddle, Sarah / Torres Montaguth, Oscar Enrique / Atkinson, Laura / Guerra-Assunção, José Afonso / Moradi Marjaneh, Mahdi / Zennezini Chiozzi, Riccardo / Storey, Nathaniel / Campos, Luis / Hutchinson, J Ciaran / Counsell, John R / Pollara, Gabriele / Roy, Sunando / Venturini, Cristina / Antinao Diaz, Juan F / Siam, Ala'a / Tappouni, Luke J / Asgarian, Zeinab / Ng, Joanne /

Hanlon, Killian S / Lennon, Alexander / McArdle, Andrew / Czap, Agata / Rosenheim, Joshua / Andrade, Catarina / Anderson, Glenn / Lee, Jack C D / Williams, Rachel / Williams, Charlotte A / Tutill, Helena / Bayzid, Nadua / Martin Bernal, Luz Marina / Macpherson, Hannah / Montgomery, Kylie-Ann / Moore, Catherine / Templeton, Kate / Neill, Claire / Holden, Matt / Gunson, Rory / Shepherd, Samantha J / Shah, Priyen / Cooray, Samantha / Voice, Marie / Steele, Michael / Fink, Colin / Whittaker, Thomas E / Santilli, Giorgia / Gissen, Paul / Kaufer, Benedikt B / Reich, Jana / Andreani, Julien / Simmonds, Peter / Alrabiah, Dimah K / Castellano, Sergi / Chikowore, Primrose / Odam, Miranda / Rampling, Tommy / Houlihan, Catherine / Hoschler, Katja / Talts, Tiina / Celma, Cristina / Gonzalez, Suam / Gallagher, Eileen / Simmons, Ruth / Watson, Conall / Mandal, Sema / Zambon, Maria / Chand, Meera / Hatcher, James / De, Surjo / Baillie, Kenneth / Semple, Malcolm Gracie / Martin, Joanne / Ushiro-Lumb, Ines / Noursadeghi, Mahdad / Deheragoda, Maesha / Hadzic, Nedim / Grammatikopoulos, Tassos / Brown, Rachel / Kelgeri, Chayarani / Thalassinos, Konstantinos / Waddington, Simon N / Jacques, Thomas S / Thomson, Emma / Levin, Michael / Brown, Julianne R / Breuer, Judith

Nature

2023 Volume 617, Issue 7961, Page(s) 564–573

Abstract: Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the ... ...

Abstract	Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK
MeSH term(s)	Child ; Humans ; Acute Disease/epidemiology ; Adenovirus Infections, Human/epidemiology ; Adenovirus Infections, Human/immunology ; Adenovirus Infections, Human/virology ; B-Lymphocytes/immunology ; Gene Expression Profiling ; Genomics ; Hepatitis/epidemiology ; Hepatitis/immunology ; Hepatitis/virology ; Immunohistochemistry ; Liver/immunology ; Liver/virology ; Proteomics ; T-Lymphocytes/immunology
Language	English
Publishing date	2023-03-30
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-023-06003-w
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Warm winters and cool springs negatively influence recruitment of Atlantic salmon (Salmo salar L.) in a southern England chalk stream.

Marsh, Jessica E / Lauridsen, Rasmus B / Riley, William D / Simmons, Olivia M / Artero, Céline / Scott, Luke J / Beaumont, William R C / Beaumont, William A / Davy-Bowker, John / Lecointre, Thomas / Roberts, Dylan E / Gregory, Stephen D

Journal of fish biology

2021 Volume 99, Issue 3, Page(s) 1125–1129

Abstract: Previous work suggests that juvenile salmon recruitment in rain-fed rivers is negatively influenced by warm and wet winters and cool springs. We tested whether this is generally applicable to a southern England chalk stream characterized by comparatively ...

Abstract	Previous work suggests that juvenile salmon recruitment in rain-fed rivers is negatively influenced by warm and wet winters and cool springs. We tested whether this is generally applicable to a southern England chalk stream characterized by comparatively stable discharges and temperatures. We found that warm spawning and cool emergence temperatures negatively influenced juvenile recruitment between 2015 and 2020. Together these findings suggest an ability to predict juvenile productivity from water temperature records around spawning and fry emergence, thereby allowing time for management interventions in years of unfavourable temperatures.
MeSH term(s)	Animals ; Calcium Carbonate ; Rivers ; Salmo salar ; Seasons ; Temperature
Chemical Substances	Calcium Carbonate (H0G9379FGK)
Language	English
Publishing date	2021-05-10
Publishing country	England
Document type	Journal Article
ZDB-ID	410564-3
ISSN	1095-8649 ; 0022-1112
ISSN (online)	1095-8649
ISSN	0022-1112
DOI	10.1111/jfb.14760
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Article: Le rôle du stress in situ dans la détermination de la conductivité hydraulique d’un aquifère rocheux fracturé (Australie) El papel de la tensión in situ en la determinación de la conectividad hidráulica en un acuífero de rocas fracturadas (Australia) O papel da tensão in situ na caraterização da conetividade hidráulica num aquífero fraturado

Mortimer, Luke / Aydin, Adnan / Simmons, Craig T / Heinson, Graham / Love, Andrew J

Hydrogeology journal. 2011 Nov., v. 19, no. 7

2011

Abstract: Fracture network connectivity is a spatially variable property that is difficult to quantify from standard hydrogeological datasets. This critical property is related to the distributions of fracture density, orientation, dimensions, intersections, ... ...

Title translation	The role of in situ stress in determining hydraulic connectivity in a fractured rock aquifer (Australia)
Abstract	Fracture network connectivity is a spatially variable property that is difficult to quantify from standard hydrogeological datasets. This critical property is related to the distributions of fracture density, orientation, dimensions, intersections, apertures and roughness. These features that determine the inherent connectivity of a fracture network can be modified by secondary processes including weathering, uplift and unloading and other mechanisms that lead to fracture deformation in response to in situ stress. This study focussed on a fractured rock aquifer in the Clare Valley, South Australia, and found that fracture network connectivity could be discriminated from several geological, geophysical and hydrogeological field datasets at various scales including single well and local- to regional-scale data. Representative hydromechanical models of the field site were not only consistent with field observations but also highlighted the strong influence of in situ stress in determining the distribution of fracture hydraulic apertures and the formation of hydraulic chokes that impede fluid flow. The results of this multi-disciplinary investigation support the notion that the hydraulic conductivity of a fracture network is limited to the least hydraulically conductive interconnected fractures, which imposes a physical limit on the bulk hydraulic conductivity of a fractured rock aquifer.
Keywords	aquifers ; data collection ; deformation ; hydraulic conductivity ; models ; rocks ; roughness ; stress response ; valleys ; weathering ; wells ; South Australia
Language	English
Dates of publication	2011-11
Size	p. 1293-1312.
Publishing place	Springer-Verlag
Document type	Article
ZDB-ID	1227482-3
ISSN	0941-2816 ; 1431-2174
ISSN	0941-2816 ; 1431-2174
DOI	10.1007/s10040-011-0760-z
Database	NAL-Catalogue (AGRICOLA)

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Article ; Audio / Video: Desmethoxymajusculamide C, a Cyanobacterial Depsipeptide with Potent Cytotoxicity in Both Cyclic and Ring-Opened Forms

Simmons, T. Luke / Nogle, Lisa M / Media, Joseph / Valeriote, Frederick A / Mooberry, Susan L / Gerwick, William H

Journal of natural products. 2009 June 26, v. 72, no. 6

2009

Keywords	Lyngbya majuscula ; extracts ; metabolites ; cytotoxicity ; fractionation ; nuclear magnetic resonance spectroscopy ; mass spectrometry ; chemical degradation ; chemical structure ; peptides ; inhibitory concentration 50 ; medicinal properties ; colorectal neoplasms ; human cell lines ; temporal variation ; cell death ; depsipeptides ; Fiji
Language	English
Dates of publication	2009-0626
Size	p. 1011-1016.
Document type	Article ; Audio / Video
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/np9001674
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Article ; Online: Ten-year assessment of the 100 priority questions for global biodiversity conservation.

Jucker, Tommaso / Wintle, Bonnie / Shackelford, Gorm / Bocquillon, Pierre / Geffert, Jan Laurens / Kasoar, Tim / Kovacs, Eszter / Mumby, Hannah S / Orland, Chloé / Schleicher, Judith / Tew, Eleanor R / Zabala, Aiora / Amano, Tatsuya / Bell, Alexandra / Bongalov, Boris / Chambers, Josephine M / Corrigan, Colleen / Durán, América P / Duvic-Paoli, Leslie-Anne /

Emilson, Caroline / Emilson, Erik J S / da Silva, Jéssica Fonseca / Garnett, Emma E / Green, Elizabeth J / Guth, Miriam K / Hacket-Pain, Andrew / Hinsley, Amy / Igea, Javier / Kunz, Martina / Luke, Sarah H / Lynam, William / Martin, Philip A / Nunes, Matheus H / Ockendon, Nancy / Pavitt, Aly / Payne, Charlotte L R / Plutshack, Victoria / Rademacher, Tim T / Robertson, Rebecca J / Rose, David C / Serban, Anca / Simmons, Benno I / Tayleur, Catherine / Wordley, Claire F R / Mukherjee, Nibedita

Conservation biology : the journal of the Society for Conservation Biology

2018 Volume 32, Issue 6, Page(s) 1457–1463

Abstract: In 2008, a group of conservation scientists compiled a list of 100 priority questions for the conservation of the world's biodiversity. However, now almost a decade later, no one has yet published a study gauging how much progress has been made in ... ...

Abstract	In 2008, a group of conservation scientists compiled a list of 100 priority questions for the conservation of the world's biodiversity. However, now almost a decade later, no one has yet published a study gauging how much progress has been made in addressing these 100 high-priority questions in the peer-reviewed literature. We took a first step toward reexamining the 100 questions to identify key knowledge gaps that remain. Through a combination of a questionnaire and a literature review, we evaluated each question on the basis of 2 criteria: relevance and effort. We defined highly relevant questions as those that - if answered - would have the greatest impact on global biodiversity conservation and quantified effort based on the number of review publications addressing a particular question, which we used as a proxy for research effort. Using this approach, we identified a set of questions that, despite being perceived as highly relevant, have been the focus of relatively few review publications over the past 10 years. These questions covered a broad range of topics but predominantly tackled 3 major themes: conservation and management of freshwater ecosystems, role of societal structures in shaping interactions between people and the environment, and impacts of conservation interventions. We believe these questions represent important knowledge gaps that have received insufficient attention and may need to be prioritized in future research.
MeSH term(s)	Biodiversity ; Conservation of Natural Resources ; Ecosystem ; Fresh Water
Language	English
Publishing date	2018-09-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	58735-7
ISSN	1523-1739 ; 0888-8892
ISSN (online)	1523-1739
ISSN	0888-8892
DOI	10.1111/cobi.13159
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