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Article: Vascular endothelial growth factor isoforms differentially protect neurons against neurotoxic events associated with Alzheimer's disease.

Alalwany, Roaa H / Hawtrey, Tom / Morgan, Kevin / Morris, Jonathan C / Donaldson, Lucy F / Bates, David O

2023 Volume 16, Page(s) 1181626

Abstract: Alzheimer's disease (AD) is the most common cause of dementia, the chronic and progressive deterioration of memory and cognitive abilities. AD can be pathologically characterised by neuritic plaques and neurofibrillary tangles, formed by the aberrant ... ...

Abstract	Alzheimer's disease (AD) is the most common cause of dementia, the chronic and progressive deterioration of memory and cognitive abilities. AD can be pathologically characterised by neuritic plaques and neurofibrillary tangles, formed by the aberrant aggregation of β-amyloid and tau proteins, respectively. We tested the hypothesis that VEGF isoforms VEGF-A
Language	English
Publishing date	2023-06-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452967-9
ISSN	1662-5099
ISSN	1662-5099
DOI	10.3389/fnmol.2023.1181626
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Article: Chondrosarcoma of the Femur: Is Local Recurrence Influenced by the Presence of an Extraosseous Component?

Laitinen, Minna K / Parry, Michael C / Morris, Guy V / Grimer, Robert J / Sumathi, Vaiyapuri / Stevenson, Jonathan D / Jeys, Lee M

Cancers

2024 Volume 16, Issue 2

Abstract: Background: Chondrosarcoma (CS) is the second most common surgically treated primary malignancy of the bone. The current study explored the effect of the margin and extraosseous tumor component in CS in the femur on local recurrence (LR), LR-free ... ...

Abstract	Background: Chondrosarcoma (CS) is the second most common surgically treated primary malignancy of the bone. The current study explored the effect of the margin and extraosseous tumor component in CS in the femur on local recurrence (LR), LR-free survival (LRFS), and disease-specific survival (DSS). Methods: Among 202 patients, 115 were in the proximal extremity of the femur, 4 in the corpus of the femur, and 83 in the distal extremity of femur; 105 patients had an extraosseous tumor component. Results: In the Kaplan-Meier analysis, factors significant for decreased LRFS were the extraosseous tumor component ( Conclusions: In CS of the femur, the presence of an extraosseous tumor component has a predictive role in LRFS, and extraosseous tumor component arising from the superior aspect was significant for decreased LRFS. Wide margins were more commonly achieved when the tumor had only an intraosseous component, and the rate of LR was significantly higher in cases with an extraosseous tumor component. When the extraosseous component arose from the superior aspect of the femur, LR occurred more frequently despite achieving adequate margins.
Language	English
Publishing date	2024-01-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16020363
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Article ; Online: Comparison of gastric inflammation and metaplasia induced by

Druffner, Sara R / Venkateshwaraprabu, Shrinidhi / Khadka, Stuti / Duncan, Benjamin C / Morris, Maeve T / Sen-Kilic, Emel / Damron, Fredrick H / Liechti, George W / Busada, Jonathan T

Microbiology spectrum

2024 , Page(s) e0001524

Abstract: Gastric cancer is the fifth most diagnosed cancer in the world. Infection by the bacteria : Importance: Mouse infection models ... ...

Abstract	Gastric cancer is the fifth most diagnosed cancer in the world. Infection by the bacteria Importance: Mouse infection models with
Language	English
Publishing date	2024-04-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.00015-24
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Article ; Online: Safety and histopathologic yield of percutaneous CT-guided biopsies of the skull base, orbit, and calvarium.

Betting, Theodore / Benson, John C / Madhavan, Ajay / Shlapak, Darya / Morris, Padraig / Morris, Jonathan / Diehn, Felix / Verdoorn, Jared / Liebo, Greta / Carr, Carrie

Neuroradiology

2024 Volume 66, Issue 3, Page(s) 417–425

Abstract: Purpose: Although CT-guided biopsies of the calvarium, skull base, and orbit are commonly performed, the best approaches, efficacy, and safety of such procedures remain scantly described in the literature. This retrospective review of percutaneous ... ...

Abstract	Purpose: Although CT-guided biopsies of the calvarium, skull base, and orbit are commonly performed, the best approaches, efficacy, and safety of such procedures remain scantly described in the literature. This retrospective review of percutaneous biopsies illustrates several approaches to challenging biopsy targets and provides a review of procedural planning considerations and histopathologic yield. Methods: A retrospective review of CT-guided biopsies of the skull base, calvarium, and orbit between 1/1/2010 and 10/30/2020 was conducted. Patient demographics and procedural factors were recorded, including lesion size and location, biopsy approach, and needle gauge. Outcomes were also noted, including CT dose length product, complications, and histopathologic yield. Results: Sixty-one CT-guided biopsies were included in the final analysis: 34 skull base, 23 calvarial, and 4 orbital lesions. The initial diagnostic yield was 32/34 (94%) for skull base lesions, with one false-negative and one non-diagnostic sample. Twenty-one of twenty-three (91%) biopsies in the calvarium were initially diagnostic, with one false-negative and one non-diagnostic sample. In the orbit, 4/4 biopsies were diagnostic. The total complication rate for the cohort was 4/61 (6.6%). Three complications were reported in skull base procedures (2 immediate and 1 delayed). A single complication was reported in a calvarial biopsy, and no complications were reported in orbital biopsies. Conclusion: Percutaneous CT-guided core needle biopsies can be performed safely and with a high diagnostic yield for lesions in the skull base, calvarium, and orbit.
MeSH term(s)	Humans ; Orbit/diagnostic imaging ; Head ; Skull Base/diagnostic imaging ; Image-Guided Biopsy/methods ; Tomography, X-Ray Computed/methods ; Retrospective Studies
Language	English
Publishing date	2024-01-10
Publishing country	Germany
Document type	Review ; Journal Article
ZDB-ID	123305-1
ISSN	1432-1920 ; 0028-3940
ISSN (online)	1432-1920
ISSN	0028-3940
DOI	10.1007/s00234-023-03266-y
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Zs.A 658: Show issues

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Article ; Online: Is Outcome of Total Hip Arthroplasty for Hip Fracture Inferior to That of Arthritis in a Contemporary Arthroplasty Practice?

Verhaegen, Jeroen C F / Bourget-Murray, Jonathan / Morris, Jared / Horton, Isabel / Papp, Steve / Grammatopoulos, George

The Journal of arthroplasty

2023 Volume 38, Issue 7 Suppl 2, Page(s) S276–S283

Abstract: Background: Outcome of total hip arthroplasty (THA) for femoral neck fractures (FNF) has been associated with higher complication rates. However, THA for FNF is not always performed by arthroplasty surgeons. This study aimed to compare THA outcomes for ... ...

Abstract	Background: Outcome of total hip arthroplasty (THA) for femoral neck fractures (FNF) has been associated with higher complication rates. However, THA for FNF is not always performed by arthroplasty surgeons. This study aimed to compare THA outcomes for FNF to osteoarthritis (OA). In doing so, we described contemporary THA failure modes for FNF performed by arthroplasty surgeons. Methods: This was a retrospective, multisurgeon study from an academic center. Of FNFs treated between 2010 and 2020, 177 received THA by an arthroplasty surgeon [mean age 67 years (range, 42 to 97), sex: 64.4% women]. These were matched (1:2) for age and sex with 354 THAs performed for hip OA, by the same surgeons. No dual-mobilities were used. Outcomes included radiologic measurements (inclination/anteversion and leg length), mortality, complications, reoperation rates and patient-reported outcomes including Oxford Hip Score. Results: Postoperative mean leg-length difference was 0 mm (range, -10 to -10 mm), with a mean cup inclination and anteversion of 41 and 26°, respectively. There was no difference in radiological measurements between FNF and OA patients (P = .3). At a 5-year follow-up, mortality rate was significantly higher in the FNF-THA group compared to the OA-THA group (15.3 versus 1.1%; P < .001). There was no difference in complications (7.3 versus 4.2%; P = .098) or reoperation rates (5.1 versus 2.9%; P = .142) between the groups. Dislocation rate was 1.7%. Oxford Hip Score at the final follow-up was similar [43.7 points (range, 10 to 48) versus 43.6 points (range, 10 to 48); P = .030]. Conclusion: THA for the treatment of FNF is a reliable option and is associated with satisfactory outcomes. Instability was not a common reason of failure, despite not using dual-mobility articulations in this at-risk population. This is likely due to THAs being performed by the arthroplasty staff. When patients live beyond 2 years, similar clinical and radiographic outcomes with low rates of revision can be expected compared to elective THA for OA. Level of evidence: III, case-control study.
MeSH term(s)	Humans ; Female ; Aged ; Male ; Arthroplasty, Replacement, Hip ; Retrospective Studies ; Case-Control Studies ; Treatment Outcome ; Femoral Neck Fractures/surgery ; Osteoarthritis, Hip/surgery ; Reoperation ; Hip Prosthesis
Language	English
Publishing date	2023-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	632770-9
ISSN	1532-8406 ; 0883-5403
ISSN (online)	1532-8406
ISSN	0883-5403
DOI	10.1016/j.arth.2023.02.069
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Zs.A 2134: Show issues

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Article ; Online: Asymptomatic right internal carotid artery pseudoaneurysm and Eagle's syndrome.

Rocco, Raffaele / Bower, Thomas C / Macedo, Thanila A / Kasperbauer, Jan / Morris, Jonathan / Mendes, Bernardo C

Journal of vascular surgery

2022 Volume 75, Issue 2, Page(s) 695–696

MeSH term(s)	Aneurysm, False/diagnosis ; Aneurysm, False/etiology ; Aneurysm, False/surgery ; Asymptomatic Diseases ; Blood Vessel Prosthesis Implantation/methods ; Carotid Artery, Internal ; Computed Tomography Angiography/methods ; Femoral Artery/transplantation ; Follow-Up Studies ; Humans ; Imaging, Three-Dimensional ; Male ; Ossification, Heterotopic/complications ; Temporal Bone/abnormalities ; Young Adult
Language	English
Publishing date	2022-01-24
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	605700-7
ISSN	1097-6809 ; 0741-5214
ISSN (online)	1097-6809
ISSN	0741-5214
DOI	10.1016/j.jvs.2021.02.016
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Zs.A 1933: Show issues

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Article: Corrigendum: A reversible cell penetrating peptide-cargo linkage allows dissection of cell penetrating peptide-and cargo- dependent effects on internalization and identifies new functionalities of putative endolytic peptides.

Morris, Daniel P / Snipes, Lucy C / Hill, Stephanie A / Woods, Michael M / Mbugua, Maria M / Wade, Lydia R / McMurry, Jonathan L

Frontiers in pharmacology

2023 Volume 14, Page(s) 1152506

Abstract: This corrects the article DOI: 10.3389/fphar.2022.1070464.]. ...

Abstract	[This corrects the article DOI: 10.3389/fphar.2022.1070464.].
Language	English
Publishing date	2023-04-18
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1152506
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Article ; Online: Geriatric chronic recurrent multifocal osteomyelitis (CRMO) mimicking multifocal multiple myeloma: a first in an octogenarian.

Sgaglione, Jonathan / Muran, Andrew / Rhode, Matthew / Goodman, Howard J / Edelman, Morris C / Shah, Suhail Ahmed / Greenberg, Andrew S / Kenan, Shachar

Skeletal radiology

2024

Abstract: Chronic recurrent multifocal osteomyelitis (CRMO), an autoinflammatory bone disorder characterized by non-bacterial osteomyelitis causing recurrent multifocal bone lesions, is a well-known, yet uncommon pediatric condition that rarely affects adults; to ... ...

Abstract	Chronic recurrent multifocal osteomyelitis (CRMO), an autoinflammatory bone disorder characterized by non-bacterial osteomyelitis causing recurrent multifocal bone lesions, is a well-known, yet uncommon pediatric condition that rarely affects adults; to date, it has never been diagnosed over the age of 75. The following report will discuss the first octogenarian diagnosed with CRMO and therefore represents an exceptionally rare presentation of a rare disease. An 83-year-old woman presented with progressive right shoulder, forearm, and hip pain, with associated weight loss and global weakness, requiring a wheelchair for mobility. Imaging revealed a pathologic right ulna fracture in addition to lytic lesions of the right proximal humerus and proximal femur. The clinical picture was thus that of a patient with probable multiple myeloma versus metastatic disease. After an extensive workup, however, the lesions were not malignant; histologic findings were instead suggestive of chronic osteomyelitis with negative cultures. Given the multifocal nature of this condition, combined with a lack of clinical symptoms of infection, a diagnosis of CRMO was rendered. The patient underwent intramedullary nailing of the right femur and splinting of the ulna, with a subsequent remarkable recovery to painless ambulation, complete union of the right ulna fracture, and resolution of the lytic lesions without receiving any targeted medical treatment. This case highlights the importance of maintaining CRMO on the differential for multifocal skeletal lesions, regardless of age. Performing a thorough workup with necessary imaging, biopsy, and culture are critical to establishing this diagnosis, which can only made as a diagnosis of exclusion.
Language	English
Publishing date	2024-03-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	527592-1
ISSN	1432-2161 ; 0364-2348
ISSN (online)	1432-2161
ISSN	0364-2348
DOI	10.1007/s00256-024-04653-z
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Zs.A 1304: Show issues

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Article ; Online: The ideological divide in confidence in science and participation in medical research.

Gabel, Matthew / Gooblar, Jonathan / Roe, Catherine M / Morris, John C

Scientific reports

2021 Volume 11, Issue 1, Page(s) 3120

Abstract: In the United States, the wide ideological divergence in public confidence in science poses a potentially significant problem for the scientific enterprise. We examine the behavioral consequences of this ideological divide for Americans' contributions to ...

Abstract	In the United States, the wide ideological divergence in public confidence in science poses a potentially significant problem for the scientific enterprise. We examine the behavioral consequences of this ideological divide for Americans' contributions to medical research. Based on a mass survey of American adults, we find that engagement in a wide range of medical research activities is a function of a latent propensity to participate. The propensity is systematically higher among liberals than among conservatives. A substantial part of this ideological divide is due to conservative Americans' lower confidence in science. These findings raise important issues for the recruitment of subjects for medical studies and the generalizability of results from such studies.
MeSH term(s)	Adult ; Biomedical Research/ethics ; Educational Status ; Female ; Humans ; Male ; Mass Media/ethics ; Middle Aged ; Morale ; Patient Participation/psychology ; Politics ; Surveys and Questionnaires ; Trust/psychology ; United States
Language	English
Publishing date	2021-02-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-82516-6
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Article ; Online: Increased cognitive effort costs in healthy aging and preclinical Alzheimer's disease.

Aschenbrenner, Andrew J / Crawford, Jennifer L / Peelle, Jonathan E / Fagan, Anne M / Benzinger, Tammie L S / Morris, John C / Hassenstab, Jason / Braver, Todd S

Psychology and aging

2023 Volume 38, Issue 5, Page(s) 428–442

Abstract	Life-long engagement in cognitively demanding activities may mitigate against declines in cognitive ability observed in healthy or pathological aging. However, the "mental costs" associated with completing cognitive tasks also increase with age and may be partly attributed to increases in preclinical levels of Alzheimer's disease (AD) pathology, specifically amyloid. We test whether cognitive effort costs increase in a domain-general manner among older adults, and further, whether such age-related increases in cognitive effort costs are associated with working memory (WM) capacity or amyloid burden, a signature pathology of AD. In two experiments, we administered a behavioral measure of cognitive effort costs (cognitive effort discounting) to a sample of older adults recruited from online sources (Experiment 1) or from ongoing longitudinal studies of aging and dementia (Experiment 2). Experiment 1 compared age-related differences in cognitive effort costs across two domains, WM and speech comprehension. Experiment 2 compared cognitive effort costs between a group of participants who were rated positive for amyloid relative to those with no evidence of amyloid. Results showed age-related increases in cognitive effort costs were evident in both domains. Cost estimates were highly correlated between the WM and speech comprehension tasks but did not correlate with WM capacity. In addition, older adults who were amyloid positive had higher cognitive effort costs than those who were amyloid negative. Cognitive effort costs may index a domain-general trait that consistently increases in aging. Differences in cognitive effort costs associated with amyloid burden suggest a potential neurobiological mechanism for age-related differences. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
MeSH term(s)	Humans ; Aged ; Alzheimer Disease/psychology ; Aging ; Healthy Aging ; Memory, Short-Term ; Cognition
Language	English
Publishing date	2023-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	635596-1
ISSN	1939-1498 ; 0882-7974
ISSN (online)	1939-1498
ISSN	0882-7974
DOI	10.1037/pag0000742
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Zs.A 3194: Show issues

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