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  1. Article ; Online: Marine pharmacology in 2018: Marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action.

    Mayer, Alejandro M S / Pierce, Marsha L / Howe, Katelyn / Rodríguez, Abimael D / Taglialatela-Scafati, Orazio / Nakamura, Fumiaki / Fusetani, Nobuhiro

    Pharmacological research

    2022  Volume 183, Page(s) 106391

    Abstract: The 2018 marine pharmacology literature review represents a continuation of the previous 11 reviews of a series initiated in 1998. Preclinical marine pharmacology research during 2018 was performed by investigators in 44 countries and contributed novel ... ...

    Abstract The 2018 marine pharmacology literature review represents a continuation of the previous 11 reviews of a series initiated in 1998. Preclinical marine pharmacology research during 2018 was performed by investigators in 44 countries and contributed novel pharmacology for 195 marine compounds. The peer-reviewed marine natural products pharmacology literature reported antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral activities for 53 compounds, 73 compounds which presented antidiabetic and anti-inflammatory activities as well as affecting the immune and nervous system, while in contrast 69 compounds were reported to show miscellaneous mechanisms of action which may contribute upon further investigation to several pharmacological classes. Thus, in 2018, the preclinical marine natural product pharmacology pipeline continued to report novel pharmacology as well as new lead compounds for the clinical marine pharmaceutical pipeline, which currently contributes to therapeutic strategies for several disease categories.
    MeSH term(s) Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Antifungal Agents ; Antiprotozoal Agents/pharmacology ; Antiprotozoal Agents/therapeutic use ; Antitubercular Agents/pharmacology ; Antitubercular Agents/therapeutic use ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Biological Products/pharmacology ; Biological Products/therapeutic use ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Marine Biology ; Nervous System
    Chemical Substances Anti-Inflammatory Agents ; Antifungal Agents ; Antiprotozoal Agents ; Antitubercular Agents ; Antiviral Agents ; Biological Products ; Hypoglycemic Agents
    Language English
    Publishing date 2022-08-06
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2022.106391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 721: Show issues Location:
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  2. Article ; Online: Classical and Alternative Activation of Rat Microglia Treated with Ultrapure

    Memedovski, Zylfi / Czerwonka, Evan / Han, Jin / Mayer, Joshua / Luce, Margaret / Klemm, Lucas C / Hall, Mary L / Mayer, Alejandro M S

    Toxins

    2020  Volume 12, Issue 5

    Abstract: The possible relationship between periodontal disease resulting from the infection of gingival tissue by the Gram-negative ... ...

    Abstract The possible relationship between periodontal disease resulting from the infection of gingival tissue by the Gram-negative bacterium
    MeSH term(s) Animals ; Cells, Cultured ; Cytokines/metabolism ; Inflammation Mediators/metabolism ; Lipopolysaccharides/isolation & purification ; Lipopolysaccharides/pharmacology ; Matrix Metalloproteinase 9/metabolism ; Microglia/drug effects ; Microglia/metabolism ; Oxidative Stress/drug effects ; Phenotype ; Porphyromonas gingivalis/metabolism ; Rats ; Superoxides/metabolism ; Thromboxane B2/metabolism
    Chemical Substances Cytokines ; Inflammation Mediators ; Lipopolysaccharides ; Superoxides (11062-77-4) ; Thromboxane B2 (54397-85-2) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Mmp9 protein, rat (EC 3.4.24.35)
    Language English
    Publishing date 2020-05-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins12050333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Marine Drugs Best Paper Award 2015

    Alejandro M. S. Mayer

    Marine Drugs, Vol 13, Iss 2, Pp 1068-

    2015  Volume 1070

    Abstract: Marine Drugs began a “Best Paper Award” in 2013 [1,2] to recognize outstanding papers published in our journal in the area of research, development, and production of drugs from the sea, including marine natural product chemistry. We are pleased to ... ...

    Abstract Marine Drugs began a “Best Paper Award” in 2013 [1,2] to recognize outstanding papers published in our journal in the area of research, development, and production of drugs from the sea, including marine natural product chemistry. We are pleased to announce the third annual “Marine Drugs Best Paper Award” for 2015. Nominations were selected by the Editor-in-Chief and Associate Editors of Marine Drugs from all papers published in 2011; reviews and articles being evaluated separately. The following five papers have won a “Best Paper Award”:[.]
    Keywords n/a ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2015-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Marine Pharmacology in 2016–2017: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

    Mayer, Alejandro M. S. / Guerrero, Aimee J. / Rodríguez, Abimael D. / Taglialatela-Scafati, Orazio / Nakamura, Fumiaki / Fusetani, Nobuhiro

    Marine drugs. 2021 Jan. 21, v. 19, no. 2

    2021  

    Abstract: The review of the 2016–2017 marine pharmacology literature was prepared in a manner similar as the 10 prior reviews of this series. Preclinical marine pharmacology research during 2016–2017 assessed 313 marine compounds with novel pharmacology reported ... ...

    Abstract The review of the 2016–2017 marine pharmacology literature was prepared in a manner similar as the 10 prior reviews of this series. Preclinical marine pharmacology research during 2016–2017 assessed 313 marine compounds with novel pharmacology reported by a growing number of investigators from 54 countries. The peer-reviewed literature reported antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral activities for 123 marine natural products, 111 marine compounds with antidiabetic and anti-inflammatory activities as well as affecting the immune and nervous system, while in contrast 79 marine compounds displayed miscellaneous mechanisms of action which upon further investigation may contribute to several pharmacological classes. Therefore, in 2016–2017, the preclinical marine natural product pharmacology pipeline generated both novel pharmacology as well as potentially new lead compounds for the growing clinical marine pharmaceutical pipeline, and thus sustained with its contributions the global research for novel and effective therapeutic strategies for multiple disease categories.
    Keywords anti-inflammatory activity ; anti-inflammatory agents ; antibiotics ; antiviral properties ; glycemic effect ; immune system ; mechanism of action ; nervous system ; pipelines ; therapeutics
    Language English
    Dates of publication 2021-0121
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2175190-0
    ISSN 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md19020049
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Lipopolysaccharide from the Cyanobacterium

    Swartzendruber, Julie A / Del Toro, Rosalinda Monroy / Incrocci, Ryan / Seangmany, Nessa / Gurr, Joshua R / Mayer, Alejandro M S / Williams, Philip G / Swanson-Mungerson, Michelle

    Toxins

    2022  Volume 14, Issue 4

    Abstract: Glucocorticoid-resistant asthma, which predominates with neutrophils instead of eosinophils, is an increasing health concern. One potential source for the induction of neutrophil-predominant asthma is aerosolized lipopolysaccharide (LPS). Cyanobacteria ... ...

    Abstract Glucocorticoid-resistant asthma, which predominates with neutrophils instead of eosinophils, is an increasing health concern. One potential source for the induction of neutrophil-predominant asthma is aerosolized lipopolysaccharide (LPS). Cyanobacteria have recently caused significant tidal blooms, and aerosolized cyanobacterial LPS has been detected near the cyanobacterial overgrowth. We hypothesized that cyanobacterial LPS contributes to lung inflammation by increasing factors that promote lung inflammation and neutrophil recruitment. To test this hypothesis, c57Bl/6 mice were exposed intranasally to LPS from the cyanobacterium member,
    MeSH term(s) Animals ; Asthma/pathology ; Chemokines/metabolism ; Cyanobacteria/metabolism ; Cytokines/metabolism ; Glucocorticoids/metabolism ; Inflammation/metabolism ; Intercellular Adhesion Molecule-1/metabolism ; Lipopolysaccharides/metabolism ; Lipopolysaccharides/toxicity ; Lung/pathology ; Mice ; Neutrophil Infiltration ; Neutrophils/metabolism ; Pneumonia/chemically induced ; Pneumonia/metabolism ; Pneumonia/pathology
    Chemical Substances Chemokines ; Cytokines ; Glucocorticoids ; Lipopolysaccharides ; Intercellular Adhesion Molecule-1 (126547-89-5)
    Language English
    Publishing date 2022-04-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins14040267
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Marine Drugs Best Paper Award 2014

    Alejandro M. S. Mayer

    Marine Drugs, Vol 12, Iss 2, Pp 1157-

    2014  Volume 1159

    Abstract: Marine Drugs initiated a “Best Paper Award” in 2013 [1] to recognize outstanding papers published in our journal in the area of research, development and production of drugs from the sea, including marine natural product chemistry. We are pleased to ... ...

    Abstract Marine Drugs initiated a “Best Paper Award” in 2013 [1] to recognize outstanding papers published in our journal in the area of research, development and production of drugs from the sea, including marine natural product chemistry. We are pleased to announce the second “Marine Drugs Best Paper Award” for 2014. Nominations were selected by the Editor-in-Chief, Associate Editors and Editorial Board Members of Marine Drugs from all papers published in 2010; reviews and articles being evaluated separately.
    Keywords n/a ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2014-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Marine Pharmacology in 2016-2017: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action.

    Mayer, Alejandro M S / Guerrero, Aimee J / Rodríguez, Abimael D / Taglialatela-Scafati, Orazio / Nakamura, Fumiaki / Fusetani, Nobuhiro

    Marine drugs

    2021  Volume 19, Issue 2

    Abstract: The review of the 2016-2017 marine pharmacology literature was prepared in a manner similar as the 10 prior reviews of this series. Preclinical marine pharmacology research during 2016-2017 assessed 313 marine compounds with novel pharmacology reported ... ...

    Abstract The review of the 2016-2017 marine pharmacology literature was prepared in a manner similar as the 10 prior reviews of this series. Preclinical marine pharmacology research during 2016-2017 assessed 313 marine compounds with novel pharmacology reported by a growing number of investigators from 54 countries. The peer-reviewed literature reported antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral activities for 123 marine natural products, 111 marine compounds with antidiabetic and anti-inflammatory activities as well as affecting the immune and nervous system, while in contrast 79 marine compounds displayed miscellaneous mechanisms of action which upon further investigation may contribute to several pharmacological classes. Therefore, in 2016-2017, the preclinical marine natural product pharmacology pipeline generated both novel pharmacology as well as potentially new lead compounds for the growing clinical marine pharmaceutical pipeline, and thus sustained with its contributions the global research for novel and effective therapeutic strategies for multiple disease categories.
    MeSH term(s) Animals ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/isolation & purification ; Anti-Bacterial Agents/pharmacology ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/isolation & purification ; Anti-Inflammatory Agents/pharmacology ; Antifungal Agents/chemistry ; Antifungal Agents/isolation & purification ; Antifungal Agents/pharmacology ; Antiprotozoal Agents/chemistry ; Antiprotozoal Agents/isolation & purification ; Antiprotozoal Agents/pharmacology ; Antitubercular Agents/chemistry ; Antitubercular Agents/isolation & purification ; Antitubercular Agents/pharmacology ; Antiviral Agents/chemistry ; Antiviral Agents/isolation & purification ; Antiviral Agents/pharmacology ; Aquatic Organisms/chemistry ; Aquatic Organisms/isolation & purification ; Biological Products/chemistry ; Biological Products/isolation & purification ; Biological Products/pharmacology ; Humans ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/isolation & purification ; Hypoglycemic Agents/pharmacology ; Immune System/drug effects ; Immune System/physiology ; Nervous System/drug effects ; Pharmacological and Toxicological Phenomena
    Chemical Substances Anti-Bacterial Agents ; Anti-Inflammatory Agents ; Antifungal Agents ; Antiprotozoal Agents ; Antitubercular Agents ; Antiviral Agents ; Biological Products ; Hypoglycemic Agents
    Language English
    Publishing date 2021-01-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md19020049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Special issue on marine toxins.

    Mayer, Alejandro M S

    Marine drugs

    2009  Volume 7, Issue 1, Page(s) 19–23

    MeSH term(s) Animals ; Humans ; Marine Toxins/adverse effects ; Marine Toxins/therapeutic use ; Research ; Toxins, Biological/analysis ; Toxins, Biological/chemistry
    Chemical Substances Marine Toxins ; Toxins, Biological
    Language English
    Publishing date 2009-01-29
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md7010019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Marine Pharmacology in 2016–2017

    Alejandro M. S. Mayer / Aimee J. Guerrero / Abimael D. Rodríguez / Orazio Taglialatela-Scafati / Fumiaki Nakamura / Nobuhiro Fusetani

    Marine Drugs, Vol 19, Iss 2, p

    Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

    2021  Volume 49

    Abstract: The review of the 2016–2017 marine pharmacology literature was prepared in a manner similar as the 10 prior reviews of this series. Preclinical marine pharmacology research during 2016–2017 assessed 313 marine compounds with novel pharmacology reported ... ...

    Abstract The review of the 2016–2017 marine pharmacology literature was prepared in a manner similar as the 10 prior reviews of this series. Preclinical marine pharmacology research during 2016–2017 assessed 313 marine compounds with novel pharmacology reported by a growing number of investigators from 54 countries. The peer-reviewed literature reported antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral activities for 123 marine natural products, 111 marine compounds with antidiabetic and anti-inflammatory activities as well as affecting the immune and nervous system, while in contrast 79 marine compounds displayed miscellaneous mechanisms of action which upon further investigation may contribute to several pharmacological classes. Therefore, in 2016–2017, the preclinical marine natural product pharmacology pipeline generated both novel pharmacology as well as potentially new lead compounds for the growing clinical marine pharmaceutical pipeline, and thus sustained with its contributions the global research for novel and effective therapeutic strategies for multiple disease categories.
    Keywords drug ; marine ; sea ; chemical ; natural product ; pharmacology ; Biology (General) ; QH301-705.5
    Subject code 333
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Corrigendum to "Future directions for the discovery of natural product-derived immunomodulating drugs: An IUPHAR positional review" [Pharmacol. Res. 177 (2022) 106076].

    Wainwright, Cherry L / Teixeira, Mauro M / Adelson, David L / Buenz, Eric J / David, Bruno / Glaser, Keith B / Harata-Lee, Yuka / Howes, Melanie-Jayne R / Izzo, Angelo A / Maffia, Pasquale / Mayer, Alejandro M S / Mazars, Claire / Newman, David J / Lughadha, Eimear Nic / Pimenta, Adriano M C / Parra, John A A / Qu, Zhipeng / Shen, Hanyuan / Spedding, Michael /
    Wolfender, Jean-Luc

    Pharmacological research

    2022  Volume 180, Page(s) 106207

    Language English
    Publishing date 2022-04-12
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2022.106207
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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