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  1. Book: Bio-nanomedicine for cancer therapy

    Fontana, Flavia / Santos, Hélder A.

    (Advances in experimental medicine and biology ; 1295)

    2021  

    Author's details Flavia Fontana, Hélder Santos editors
    Series title Advances in experimental medicine and biology ; 1295
    Collection
    Language English
    Size viii, 360 Seiten, Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT020834890
    ISBN 978-3-030-58173-2 ; 9783030581749 ; 3-030-58173-X ; 3030581748
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3192 -1295- not available for loan Zeitschriften-Lesesaal

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  2. Article: Recovery, Characterization, Functionality and Applications of Bioactive Compounds from Food-Plant Products and Their By-Products.

    Fontana, Ariel

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 23

    Abstract: Sustainability in the food industry has been frequently linked to strategies that avoid, or at least minimize, the amount of by-products in food production [ ... ]. ...

    Abstract Sustainability in the food industry has been frequently linked to strategies that avoid, or at least minimize, the amount of by-products in food production [...].
    Language English
    Publishing date 2023-11-24
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12233964
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  3. Article ; Online: Unravelling the nexus: Towards a unified model of development, ageing, and cancer.

    Fontana, Alessandro

    Bio Systems

    2023  Volume 231, Page(s) 104966

    Abstract: This work presents a comprehensive model that aims to unify our understanding of embryogenesis, ageing, and cancer. While there have been previous attempts to construct models separately for two of these phenomena (such as embryogenesis and cancer, ... ...

    Abstract This work presents a comprehensive model that aims to unify our understanding of embryogenesis, ageing, and cancer. While there have been previous attempts to construct models separately for two of these phenomena (such as embryogenesis and cancer, ageing and cancer), models encompassing all three are relatively scarce, if not entirely absent. The model's most notable feature is the presence of driver cells throughout the body, which may correspond to Spemann's organisers. These driver cells play a vital role in propelling development as they dynamically emerge from non-driver cells and inhabit specialised niches. Remarkably, this continuous process persists throughout an organism's entire lifespan, signifying that development unfolds from conception to the end of life. Driver cells orchestrate change events through the induction of distinctive epigenetic patterns of gene activation. Events occurring at young age drive development, are subject to high evolutionary pressure and hence carefully optimised. Events occurring after reproduction age are subject to decreasing evolutionary pressure: for this reason, such events are "pseudorandom" -deterministic but erratic. Some of these events lead to age-related benign conditions, such as gray hair. Some lead to serious age-related diseases, such as diabetes and Alzheimer's disease. Furthermore, some of these events might perturb epigenetically key pathways involved in driver activation and formation, leading to cancer. In our model, this driver cell-based mechanism represents the backbone of multicellular biology: understanding and correcting its functioning may give the chance to solve a wide range of conditions at once.
    MeSH term(s) Humans ; Aging/genetics ; Epigenomics ; Embryonic Development/genetics ; Fertilization ; Neoplasms/genetics
    Language English
    Publishing date 2023-07-06
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 186234-0
    ISSN 1872-8324 ; 0303-2647
    ISSN (online) 1872-8324
    ISSN 0303-2647
    DOI 10.1016/j.biosystems.2023.104966
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 768: Show issues Location:
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  4. Book ; Online ; E-Book: Cough: Pathophysiology, Diagnosis and Treatment

    Zanasi, Alessandro / Fontana, Giovanni A. / Mutolo, Donatella

    2020  

    Abstract: This book provides an updated and comprehensive overview of cough, while opening new perspectives for their treatment and management. It enables readers to not only discover new physiologic features and mechanisms but also to gain an in-depth ... ...

    Author's details edited by Alessandro Zanasi, Giovanni A. Fontana, Donatella Mutolo
    Abstract This book provides an updated and comprehensive overview of cough, while opening new perspectives for their treatment and management. It enables readers to not only discover new physiologic features and mechanisms but also to gain an in-depth understanding of the diagnostic workup of cough, still one of the most frequent and challenging symptoms in daily medical practice. The book also provides insights into cough’s features and pathogenesis, as well as into pharmacologic and non-pharmacologic treatments. The most frequent causes of chronic cough (asthma, postnasal drip, gastroesophageal reflux and chronic hypersensitivity syndrome) and different types of pediatric cough are also explored. Coughing is a common symptom, occurring in many clinical settings, and as such the book appeals a broad readership, including pulmonologists specialized in cough, general practitioners, internists, pediatricians and otorhinolaryngologists. .
    Keywords Respiratory organs—Diseases ; General practice (Medicine) ; Pediatrics ; Otorhinolaryngology ; Pharmacotherapy ; Gastroenterology  ; Pneumology/Respiratory System ; General Practice / Family Medicine ; Gastroenterology ; Tos ; Fisiologia patològica ; Diagnòstic ; Terapèutica
    Subject code 616.2
    Language English
    Size 1 online resource (X, 181 p. 13 illus. in color.)
    Edition 1st ed. 2020.
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-48571-4 ; 3-030-48570-6 ; 978-3-030-48571-9 ; 978-3-030-48570-2
    DOI 10.1007/978-3-030-48571-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Diagnosis and management of immune mediated liver injury from checkpoint inhibitors.

    Likhitsup, Alisa / Fontana, Robert J

    Current opinion in gastroenterology

    2024  Volume 40, Issue 3, Page(s) 164–171

    Abstract: Purpose of review: The aim is to summarize the latest data on the incidence, clinical manifestations, and management of immune- mediated liver injury from checkpoint inhibitors (ILICI).: Recent findings: ILICI develops in 10-15% of oncology patients ... ...

    Abstract Purpose of review: The aim is to summarize the latest data on the incidence, clinical manifestations, and management of immune- mediated liver injury from checkpoint inhibitors (ILICI).
    Recent findings: ILICI develops in 10-15% of oncology patients receiving immunotherapy with most having asymptomatic serum aminotransferase and/or alkaline phosphatase elevations. Most grade 1-2 ILICI patients improve with drug discontinuation and/or short-term oral corticosteroids. In contrast, the 2-3% with grade 3/4 hepatotoxicity frequently require oral or intravenous corticosteroids and some are hospitalized to initiate further immunosuppression with mycophenolate mofetil or azathioprine. Liver biopsy is generally reserved for patients with atypical features or those with severe hepatotoxicity who fail to respond to treatment. Up to 3% of ILICI patients with a cholestatic profile have MRI evidence of intra or extrahepatic cholangitis that responds poorly to immunosuppression. Most ILICI patients improve during follow-up and liver-related death is very uncommon (<1%). Up to 30% of rechallenged ILICI patients develop recurrent hepatotoxicity with a shorter latency.
    Summary: ILICI is increasingly encountered by gastroenterologists evaluating oncology patients with abnormal liver biochemistries. A stepwise approach to exclude viral hepatitis, alcohol, hepatic metastases, and pancreaticobiliary disease is recommended. The majority of ILICI patients fully recover with ICI discontinuation and short-term corticosteroids or a second line immunosuppressant.
    MeSH term(s) Humans ; Liver Neoplasms ; Immunosuppressive Agents/adverse effects ; Adrenal Cortex Hormones/therapeutic use ; Chemical and Drug Induced Liver Injury/diagnosis ; Chemical and Drug Induced Liver Injury/etiology
    Chemical Substances Immunosuppressive Agents ; Adrenal Cortex Hormones
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 632571-3
    ISSN 1531-7056 ; 0267-1379
    ISSN (online) 1531-7056
    ISSN 0267-1379
    DOI 10.1097/MOG.0000000000001015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2072: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  6. Article ; Online: The changing landscape of heart failure treatment in transthyretin amyloid cardiomyopathy: Is the time ripe for clinical use of sodium-glucose cotransporter 2 inhibitors?

    Porcari, Aldostefano / Fontana, Marianna

    European journal of heart failure

    2024  

    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Editorial
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.3245
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5299: Show issues Location:
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  7. Article: Preparative Fractionation of Phenolic Compounds and Isolation of an Enriched Flavonol Fraction from Winemaking Industry By-Products by High-Performance Counter-Current Chromatography.

    Fontana, Ariel / Schieber, Andreas

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 12

    Abstract: High-performance counter-current chromatography (HPCCC) was used as a tool for the isolation and fractionation of phenolic compounds (PCs) in extracts from wine lees (WL) and grape pomace (GP). The biphasic solvent systems applied for HPCCC separation ... ...

    Abstract High-performance counter-current chromatography (HPCCC) was used as a tool for the isolation and fractionation of phenolic compounds (PCs) in extracts from wine lees (WL) and grape pomace (GP). The biphasic solvent systems applied for HPCCC separation were
    Language English
    Publishing date 2023-06-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12122242
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  8. Article: Phenolic, Nutritional and Sensory Characteristics of Bakery Foods Formulated with Grape Pomace.

    Antoniolli, Andrea / Becerra, Lucía / Piccoli, Patricia / Fontana, Ariel

    Plants (Basel, Switzerland)

    2024  Volume 13, Issue 5

    Abstract: The potentiality of cv. Malbec grape pomace (GP) as a functional ingredient in the formulation of bakery foods (muffins, biscuits and cereal bars) was studied. The effect of GP addition on the phenolic compounds (PCs) composition, nutritional and sensory ...

    Abstract The potentiality of cv. Malbec grape pomace (GP) as a functional ingredient in the formulation of bakery foods (muffins, biscuits and cereal bars) was studied. The effect of GP addition on the phenolic compounds (PCs) composition, nutritional and sensory properties were evaluated. The addition of GP increased the content of dietary fiber, proteins, ash, total phenolic content (TPC), antiradical capacity (AC), anthocyanins and non-anthocyanin PCs while decreasing the carbohydrates content. The main PCs given by the GP to supplemented foods were quercetin-3-
    Language English
    Publishing date 2024-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13050590
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  9. Article ; Online: Linking fluctuation and dissipation in spatially extended out-of-equilibrium systems.

    Fontana, Alex / Bellon, Ludovic

    Physical review. E

    2023  Volume 107, Issue 3-1, Page(s) 34118

    Abstract: For systems in equilibrium at a temperature T, thermal noise and energy damping are related to T through the fluctuation-dissipation theorem (FDT). We study here an extension of the FDT to an out-of-equilibrium steady state: a microcantilever subject to ... ...

    Abstract For systems in equilibrium at a temperature T, thermal noise and energy damping are related to T through the fluctuation-dissipation theorem (FDT). We study here an extension of the FDT to an out-of-equilibrium steady state: a microcantilever subject to a constant heat flux. The resulting thermal profile in this spatially extended system interplays with the local energy dissipation field to prescribe the amplitude of mechanical fluctuations. Using three samples with different damping profiles (localized or distributed), we probe this approach and experimentally demonstrate the link between fluctuations and dissipation. The thermal noise can therefore be predicted a priori from the measurement of the dissipation as a function of the maximum temperature of the micro-oscillator.
    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.107.034118
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  10. Article ; Online: Detection of UV-Induced Deletions in Mitochondrial DNA.

    Fontana, Gabriele A / Gahlon, Hailey L

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2615, Page(s) 281–292

    Abstract: Mitochondrial DNA (mtDNA) mutations are found in several human pathologies and are associated with aging. Deletion mutations in mtDNA result in the loss of essential genes for mitochondrial function. Over 250 deletion mutations have been reported and the ...

    Abstract Mitochondrial DNA (mtDNA) mutations are found in several human pathologies and are associated with aging. Deletion mutations in mtDNA result in the loss of essential genes for mitochondrial function. Over 250 deletion mutations have been reported and the common deletion is the most frequent mtDNA deletion linked to disease. This deletion removes 4977 base pairs of mtDNA. It has previously been shown that exposure to UVA radiation can promote the formation of the common deletion. Furthermore, aberrations in mtDNA replication and repair are associated with formation of the common deletion. However, molecular mechanisms describing the formation of this deletion are poorly characterized. This chapter describes a method to irradiate human skin fibroblasts with physiological doses of UVA and the subsequent detection of the common deletion by quantitative PCR analysis.
    MeSH term(s) Humans ; DNA, Mitochondrial/genetics ; Sequence Deletion ; Mitochondria/genetics ; Aging/genetics ; Mutation
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2023-02-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2922-2_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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