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  1. Article ; Online: Remote screening accuracy of first-time hearing aid users.

    Siggaard, Lene Dahl / Jacobsen, Henrik / Hougaard, Dan Dupont / Høgsbro, Morten

    Danish medical journal

    2024  Volume 71, Issue 4

    Abstract: Introduction: Capacity constraints in Danish hearing healthcare may lead to diagnostic delays and repetitive pre-treatment audiological exams for hearing-impaired patients. This study investigated the effectiveness of remote ear-nose-throat (ENT) ... ...

    Abstract Introduction: Capacity constraints in Danish hearing healthcare may lead to diagnostic delays and repetitive pre-treatment audiological exams for hearing-impaired patients. This study investigated the effectiveness of remote ear-nose-throat (ENT) specialist assessments (RESA) for complicated hearing loss, comparing the accuracy of private ENT specialists and medical audiologists.
    Methods: RESA screening accuracy was determined for four ENT specialists, individually and as subspecialised groups. These assessments were benchmarked against "gold standard" in-person ENT assessments for 445 potential adult first-time hearing aid users.
    Results: Medical audiologists initially recorded lower RESA screening specificity and positive predictive values than private ENT specialists. However, after making two adjustments to the dataset, these differences were neutralised. Screening sensitivity was consistent across individual and grouped subspecialities.
    Conclusions: RESA screening is a promising tool for timely diagnosis and treatment. The findings reveal that both private ENT specialists and medical audiologists may conduct RESA with high consistency and uniformity.
    Funding: This research was funded by the Danish Health Data Authority and the North Denmark Region, but does not reflect their views. The study received no commercial support.
    Trial registration: Not relevant.
    MeSH term(s) Adult ; Humans ; Hearing Aids ; Hearing ; Hearing Loss
    Language English
    Publishing date 2024-03-15
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 2648771-8
    ISSN 2245-1919 ; 2245-1919
    ISSN (online) 2245-1919
    ISSN 2245-1919
    DOI 10.61409/A08230501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Chronic cough associated with COPD exacerbation, pneumonia and death in the general population.

    Landt, Eskild M / Çolak, Yunus / Nordestgaard, Børge G / Lange, Peter / Dahl, Morten

    ERJ open research

    2024  Volume 10, Issue 1

    Abstract: Background: Chronic cough affects up to 10% of the general population and was previously perceived as a comorbidity of underlying conditions, but is nowadays classified as a disease in its own entity that could confer increased risk of morbidity and ... ...

    Abstract Background: Chronic cough affects up to 10% of the general population and was previously perceived as a comorbidity of underlying conditions, but is nowadays classified as a disease in its own entity that could confer increased risk of morbidity and mortality. We tested the hypothesis that chronic cough is associated with increased risk of COPD exacerbation, pneumonia and all-cause mortality in the general population.
    Methods: We identified 2801 individuals with chronic cough, defined as cough lasting >8 weeks, among 44 756 randomly selected individuals from the Copenhagen General Population Study, and recorded COPD exacerbations, pneumonia and all-cause mortality during follow-up.
    Results: During up to 5.9 years of follow-up (median 3.4 years), 173 individuals experienced COPD exacerbation, 767 experienced pneumonia and 894 individuals died. Individuals with chronic cough
    Conclusion: Chronic cough is associated with higher risks of COPD exacerbation, pneumonia and death, independent of airflow limitation and smoking.
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00697-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Causal risk factors for asthma in Mendelian randomization studies: A systematic review and meta-analysis.

    Mikkelsen, Heidi / Landt, Eskild Morten / Benn, Marianne / Nordestgaard, Børge Grønne / Dahl, Morten

    Clinical and translational allergy

    2022  Volume 12, Issue 11, Page(s) e12207

    Abstract: Background: Several risk factors for asthma have been proposed; however, the causality of these associations is sometimes unclear. Mendelian randomization is a powerful epidemiological approach that can help elucidate the causality of risk factors. The ... ...

    Abstract Background: Several risk factors for asthma have been proposed; however, the causality of these associations is sometimes unclear. Mendelian randomization is a powerful epidemiological approach that can help elucidate the causality of risk factors. The aim of the present study was to identify causal risk factors for asthma through Mendelian Randomization studies.
    Methods: A systematic search of PubMed and EMBASE was conducted, to identify studies investigating risk factors for asthma or respiratory allergies through Mendelian Randomization. When two or more studies investigated the same risk factor a meta-analysis was conducted. Of 239 studies initially identified, 41 were included.
    Results: A causal association between adiposity and adult asthma risk was found in 10 out of 12 studies with a summary risk ratio of 1.05 per kg/m
    Conclusion: This systematic review and meta-analysis found evidence for causal effects of adiposity, puberty timing, linoleic acid, alcohol, immune related proteins, and depression on risk of asthma.
    Language English
    Publishing date 2022-11-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2630865-4
    ISSN 2045-7022
    ISSN 2045-7022
    DOI 10.1002/clt2.12207
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: α

    Winther, Sine V / Landt, Eskild M / Nordestgaard, Børge G / Seersholm, Niels / Dahl, Morten

    ERJ open research

    2023  Volume 9, Issue 5

    Abstract: Background: Individuals with α: Methods: In a nationwide nested study of 2209 patients with α: Results: Individuals with : Conclusion: Individuals with ... ...

    Abstract Background: Individuals with α
    Methods: In a nationwide nested study of 2209 patients with α
    Results: Individuals with
    Conclusion: Individuals with α
    Language English
    Publishing date 2023-09-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00319-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Projected future European power sector water usage across power scenarios and corresponding trends in water availability.

    Mapes, Andrea Sainz / Larsen, Morten Andreas Dahl

    Journal of environmental management

    2023  Volume 343, Page(s) 118208

    Abstract: The current transition toward added renewables into the power mix is essential to mitigate climate change effects, but the energy transition has environmental impacts outside the scope of greenhouse gas emissions that also need attention. One such impact ...

    Abstract The current transition toward added renewables into the power mix is essential to mitigate climate change effects, but the energy transition has environmental impacts outside the scope of greenhouse gas emissions that also need attention. One such impact is the water-energy dependency nexus, where water dependencies are also seen for non-fossil technologies such as concentrated solar power (CSP), bioenergy and hydropower and mitigation technologies such as carbon capture and storage (CCS). In this light, the selection of power production technologies can potentially affect long-term water resource renewability and dry summer conditions, causing, e.g., power plant shutdowns. In this study, we employ an established and validated scheme of water consumption and withdrawal rates across energy conversion technologies at the European scale to project corresponding water usage rates towards 2050 for EU30 countries. We further use the entire range of global- and regional climate model ensembles for low-, medium- and high-emission scenarios to project trends and robustness estimates of freshwater resources and availability at the distributed level for corresponding countries and years towards 2100. The results show a high sensitivity of water usage rates to the implementation of energy technologies such as CSP and CCS, as well as the decommissioning rates of fossil technologies and some scenarios generally show unaltered or even vastly increasing water consumption and withdrawal rates. Further, the assumptions on using CCS technologies, an evolving field, show a high impact. The assessment of hydro-climatic projections showed some degree of overlaps between decreasing water availabilities and increasing power sector water usage, especially for one power production scenario with a high share of CCS implementation. Further, a vast climate model spread in water availability was seen for both yearly means and summer minima, emphasising the need to include extremes in water management, and the water availability was highly dependent on the emission scenario in some regions.
    MeSH term(s) Water ; Greenhouse Gases ; Environment ; Climate Change
    Chemical Substances Water (059QF0KO0R) ; Greenhouse Gases
    Language English
    Publishing date 2023-06-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2023.118208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Digital vs. physical ear-nose-and-throat specialist assessment screening for complicated hearing loss and serious ear disorders in hearing-impaired adults prior to hearing aid treatment

    Lene Dahl Siggaard / Henrik Jacobsen / Dan Dupont Hougaard / Morten Høgsbro

    Frontiers in Digital Health, Vol

    a randomized controlled trial

    2023  Volume 5

    Abstract: IntroductionThis study introduces a digital assessment tool for asynchronous and remote ear-nose-and-throat (ENT) specialist assessment screening for complicated hearing loss and serious ear disorders in hearing-impaired adults prior to hearing aid (HA) ... ...

    Abstract IntroductionThis study introduces a digital assessment tool for asynchronous and remote ear-nose-and-throat (ENT) specialist assessment screening for complicated hearing loss and serious ear disorders in hearing-impaired adults prior to hearing aid (HA) treatment. The +60 population will nearly double from 12% to 22% between 2015 and 2050 increasing the incidence of age-induced hearing impairment and the need for hearing rehabilitation. If un-diagnosed, age-related hearing loss negatively affects quality of life by accelerating social distancing and early retirement as well as increasing risk of anxiety, depression, and dementia. Therefore, innovative measures are essential to provide timely diagnostics and treatment.MethodsA total of 751 hearing-impaired adults without previous HA usage or experience were randomly assigned to digital or physical ENT specialist assessment screening prior to HA treatment initiation in 20 public and private hearing rehabilitation and ENT specialist clinics in the North Denmark Region. A total of 501 test group participants were assigned to digital assessment screening and 250 control group participants to physical assessment screening prior to HA treatment.ResultsIn all, 658 (88%) participants completed the trial and were eligible for analysis. Digital screening sensitivity (0.85, 95% confidence interval (CI) 0.71–0.94) was significantly higher than physical screening sensitivity (0.2, 95% CI: 0.03–0.56). Screening specificity was high for both assessment methods.DiscussionIn a setting where hearing-impaired adults were assessed for HA treatment, digital ENT specialist assessment screening did not compromise patient safety or increase the risk of misdiagnosis in patients with complicated hearing loss and/or serious ear disorders when compared to physical ENT specialist assessment screening.Clinical Trial registrationhttps://clinicaltrials.gov/ct2/show/NCT05154539, identifier: NCT05154539.
    Keywords digital assessment ; hearing loss (MesH term) ; screening ; hearing-impaired adults ; hearing aid ; Medicine ; R ; Public aspects of medicine ; RA1-1270 ; Electronic computers. Computer science ; QA75.5-76.95
    Subject code 390 ; 150
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Implant treatment after traumatic tooth loss: A systematic review.

    Nørgaard Petersen, Frej / Jensen, Simon Storgård / Dahl, Morten

    Dental traumatology : official publication of International Association for Dental Traumatology

    2022  Volume 38, Issue 2, Page(s) 105–116

    Abstract: Background/aims: Treatment after traumatic tooth loss is challenging and is currently guided by expert opinion and the individual patient situation. The aim of this study was to provide an overview on the outcome of dental implant treatment in the ... ...

    Abstract Background/aims: Treatment after traumatic tooth loss is challenging and is currently guided by expert opinion and the individual patient situation. The aim of this study was to provide an overview on the outcome of dental implant treatment in the anterior maxilla after traumatic tooth loss, based on a systematic review of the existing evidence.
    Materials and methods: A systematic search of the literature was performed on PubMed, Cochran Library and Web of Science following the PRISMA guidelines based on a structured research question (PICO). All clinical studies of five patients or more with follow-up of at least 1 year after implant loading were included. Patients were at least 18 years of age. Cohen's Kappa-coefficient was calculated. The Newcastle-Ottawa Scale was applied to assess the quality of the included studies. Descriptive statistical methods were applied.
    Results: Nine hundred and ninety-nine articles were identified through the systematic search. Finally, six articles were eligible for inclusion. The studies comprised prospective and retrospective cohort studies and case series. From these, 96 patients with 120 implants were included. The age ranged from 18 to 59 years. The survival rates of implants and superstructures were 97% and 95%, respectively, after a mean follow-up of 3.5 years. Mean marginal bone resorption was 0.56 mm (range 0.21-1.30 mm). Complication rates were 7% and 11% on implant and superstructure level, respectively. Patient-reported outcome measures and objective evaluations showed a high level of satisfaction with the aesthetic outcome. Bone augmentation was performed in 60 implant sites. Three patients underwent pre-surgical orthodontic treatment. The maxillary central incisor was the most frequently replaced tooth (70%).
    Conclusions: This systematic review revealed a low level of evidence on the outcome of dental implant treatment after traumatic tooth loss. Systematic reporting of treatment outcomes of tooth replacements after dental trauma is highly encouraged to further guide dentists for the benefit of these challenging patients.
    MeSH term(s) Adolescent ; Adult ; Dental Implantation, Endosseous/methods ; Dental Implants ; Dental Implants, Single-Tooth ; Follow-Up Studies ; Humans ; Maxilla/surgery ; Middle Aged ; Prospective Studies ; Retrospective Studies ; Tooth Loss/etiology ; Treatment Outcome ; Young Adult
    Chemical Substances Dental Implants
    Language English
    Publishing date 2022-01-08
    Publishing country Denmark
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2030722-6
    ISSN 1600-9657 ; 1600-4469
    ISSN (online) 1600-9657
    ISSN 1600-4469
    DOI 10.1111/edt.12730
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Projected future European power sector water usage across power scenarios and corresponding trends in water availability

    Mapes, Andrea Sainz / Larsen, Morten Andreas Dahl

    Journal of Environmental Management. 2023 Oct., v. 343 p.118208-

    2023  

    Abstract: The current transition toward added renewables into the power mix is essential to mitigate climate change effects, but the energy transition has environmental impacts outside the scope of greenhouse gas emissions that also need attention. One such impact ...

    Abstract The current transition toward added renewables into the power mix is essential to mitigate climate change effects, but the energy transition has environmental impacts outside the scope of greenhouse gas emissions that also need attention. One such impact is the water-energy dependency nexus, where water dependencies are also seen for non-fossil technologies such as concentrated solar power (CSP), bioenergy and hydropower and mitigation technologies such as carbon capture and storage (CCS). In this light, the selection of power production technologies can potentially affect long-term water resource renewability and dry summer conditions, causing, e.g., power plant shutdowns. In this study, we employ an established and validated scheme of water consumption and withdrawal rates across energy conversion technologies at the European scale to project corresponding water usage rates towards 2050 for EU30 countries. We further use the entire range of global- and regional climate model ensembles for low-, medium- and high-emission scenarios to project trends and robustness estimates of freshwater resources and availability at the distributed level for corresponding countries and years towards 2100. The results show a high sensitivity of water usage rates to the implementation of energy technologies such as CSP and CCS, as well as the decommissioning rates of fossil technologies and some scenarios generally show unaltered or even vastly increasing water consumption and withdrawal rates. Further, the assumptions on using CCS technologies, an evolving field, show a high impact. The assessment of hydro-climatic projections showed some degree of overlaps between decreasing water availabilities and increasing power sector water usage, especially for one power production scenario with a high share of CCS implementation. Further, a vast climate model spread in water availability was seen for both yearly means and summer minima, emphasising the need to include extremes in water management, and the water availability was highly dependent on the emission scenario in some regions.
    Keywords bioenergy ; carbon sequestration ; climate change ; climate models ; energy conversion ; environmental management ; freshwater ; greenhouse gases ; power generation ; power plants ; solar energy ; summer ; water power ; water utilization ; Water-energy nexus ; Future water usage ; Energy scenarios ; Water consumption and withdrawal ; Projected trends in water availability ; CORDEX regional Climate models
    Language English
    Dates of publication 2023-10
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2023.118208
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Venous thromboembolism associated with severe dyspnoea and asthma in 102 792 adults.

    Nilausen, Kristin Felicia / Landt, Eskild Morten / Al-Shuweli, Suzan / Nordestgaard, Børge G / Bødtger, Uffe / Dahl, Morten

    ERJ open research

    2023  Volume 9, Issue 6

    Abstract: Background: The most recent guideline on acute pulmonary embolism (PE) indicates possible long-term sequelae such as dyspnoea and chronic thromboembolic pulmonary hypertension after a PE event. However, effects on lung function or asthma risk have not ... ...

    Abstract Background: The most recent guideline on acute pulmonary embolism (PE) indicates possible long-term sequelae such as dyspnoea and chronic thromboembolic pulmonary hypertension after a PE event. However, effects on lung function or asthma risk have not been evaluated in the general population.
    Methods: We tested whether individuals with a venous thromboembolism (VTE) encompassing PE and deep vein thrombosis (DVT) have reduced lung function, or greater risks of dyspnoea and asthma using data from 102 792 adults from the Copenhagen General Population Study. Diagnoses of PE, DVT and asthma were collected from the national Danish Patient Registry. Factor V Leiden and prothrombin G20210A gene variants were determined using TaqMan assays.
    Results: Prevalences of PE, DVT and VTE were 2.2%, 3.6% and 5.2%, respectively. Individuals with VTE had forced expiratory volume in 1 s of 92% predicted compared with 96% pred in individuals without VTE (p<0.001). Individuals with VTE
    Conclusion: Individuals with VTE have worse lung function and higher risks of severe dyspnoea and asthma, and may account for 3.5% and 3.0% of people with severe dyspnoea and asthma, respectively, in the general population.
    Language English
    Publishing date 2023-11-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00631-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Venous thromboembolism associated with severe dyspnoea and asthma in 102 792 adults

    Kristin Felicia Nilausen / Eskild Morten Landt / Suzan Al-Shuweli / Børge G. Nordestgaard / Uffe Bødtger / Morten Dahl

    ERJ Open Research, Vol 9, Iss

    2023  Volume 6

    Abstract: Background The most recent guideline on acute pulmonary embolism (PE) indicates possible long-term sequelae such as dyspnoea and chronic thromboembolic pulmonary hypertension after a PE event. However, effects on lung function or asthma risk have not ... ...

    Abstract Background The most recent guideline on acute pulmonary embolism (PE) indicates possible long-term sequelae such as dyspnoea and chronic thromboembolic pulmonary hypertension after a PE event. However, effects on lung function or asthma risk have not been evaluated in the general population. Methods We tested whether individuals with a venous thromboembolism (VTE) encompassing PE and deep vein thrombosis (DVT) have reduced lung function, or greater risks of dyspnoea and asthma using data from 102 792 adults from the Copenhagen General Population Study. Diagnoses of PE, DVT and asthma were collected from the national Danish Patient Registry. Factor V Leiden and prothrombin G20210A gene variants were determined using TaqMan assays. Results Prevalences of PE, DVT and VTE were 2.2%, 3.6% and 5.2%, respectively. Individuals with VTE had forced expiratory volume in 1 s of 92% predicted compared with 96% pred in individuals without VTE (p<0.001). Individuals with VTE versus those without had adjusted OR (95% CI) for light, moderate and severe dyspnoea of 1.4 (1.2–1.6), 1.6 (1.4–1.8) and 1.7 (1.5–1.9), respectively. Individuals with VTE versus those without had an adjusted OR for asthma of 1.6 (95% CI 1.4–1.8). Factor V Leiden and prothrombin G20210A genotype also associated with increased risk of asthma (p for trend=0.002). Population-attributable fractions of severe dyspnoea and asthma due to VTE were 3.5% and 3.0%, respectively, in the population. Conclusion Individuals with VTE have worse lung function and higher risks of severe dyspnoea and asthma, and may account for 3.5% and 3.0% of people with severe dyspnoea and asthma, respectively, in the general population.
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher European Respiratory Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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