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Article ; Online: Review of Fractional Nonablative Lasers for the Treatment of Dermatologic Conditions in Darker Skin Phototypes.

Aggarwal, Ishita / Rossi, Marcus / Puyana, Carolina / Tsoukas, Maria

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

2024 Volume 50, Issue 5, Page(s) 459–466

Abstract: Background: Fractional nonablative lasers (NAFLs) have demonstrated efficacy and safety for treating dermatologic conditions in patients with darker skin phototypes. Nonablative lasers are preferred in darker skin tones due to lower risk of ... ...

Abstract	Background: Fractional nonablative lasers (NAFLs) have demonstrated efficacy and safety for treating dermatologic conditions in patients with darker skin phototypes. Nonablative lasers are preferred in darker skin tones due to lower risk of postinflammatory hyperpigmentation. Objective: This review aims to identify the ideal laser options and parameters for treating common dermatologic conditions in patients with skin types IV-VI. Materials and methods: A comprehensive literature search was conducted on PubMed in May 2023. Of 1,065 articles were identified, and 40 articles met the inclusion criteria. The studies were classified based on design, dermatologic condition, and skin phototype of patients, and assigned levels of evidence according to the Modified Criteria of the Oxford Center of Evidence Based Medicine. Results: Strong level 1 evidence supports the treatment of melasma and atrophic scars using NAFL. Moderate level 2 evidence was found for using NAFL in acne vulgaris, striae, and skin rejuvenation; 45% of the studies examined skin types III-IV, 20% III-V, 7.5% II-IV, 5% II-V, 5% IV alone, and 2.5% I-IV. Conclusion: Further research is needed to determine the optimal treatment modalities and parameters for skin types V and VI. Appropriate device selection and conservative treatment settings are crucial for optimizing outcomes and minimizing adverse events.
MeSH term(s)	Humans ; Acne Vulgaris/complications ; Acne Vulgaris/therapy ; Melanosis/therapy ; Skin Pigmentation/radiation effects ; Rejuvenation ; Skin Diseases/therapy ; Laser Therapy/instrumentation ; Laser Therapy/adverse effects ; Laser Therapy/methods ; Cicatrix/etiology ; Cicatrix/therapy ; Striae Distensae/therapy ; Skin Aging/radiation effects
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1227586-4
ISSN	1524-4725 ; 1076-0512
ISSN (online)	1524-4725
ISSN	1076-0512
DOI	10.1097/DSS.0000000000004111
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Article ; Online: Pathological and Therapeutical Implications of Pyroptosis in Psoriasis and Hidradenitis Suppurativa: A Narrative Review.

Krajewski, Piotr K / Tsoukas, Maria / Szepietowski, Jacek C

Current issues in molecular biology

2024 Volume 46, Issue 1, Page(s) 663–676

Abstract: This manuscript explores the role of pyroptosis, an inflammatory programmed cell death, in the pathogenesis of two chronic dermatoses, psoriasis and hidradenitis suppurativa (HS). The diseases, though clinically diverse, share common pathogenetic ... ...

Abstract	This manuscript explores the role of pyroptosis, an inflammatory programmed cell death, in the pathogenesis of two chronic dermatoses, psoriasis and hidradenitis suppurativa (HS). The diseases, though clinically diverse, share common pathogenetic pathways involving the unbalanced interaction between the adaptive and innate immune systems. This review focuses on the molecular changes in psoriatic and HS skin, emphasizing the activation of dendritic cells, secretion of interleukins (IL-17, IL-22, and TNF-α), and the involvement of inflammasomes, particularly NLRP3. This manuscript discusses the role of caspases, especially caspase-1, in driving pyroptosis and highlights the family of gasdermins (GSDMs) as key players in the formation of pores leading to cell rupture and the release of proinflammatory signals. This study delves into the potential therapeutic implications of targeting pyroptosis in psoriasis and HS, examining existing medications like biologics and Janus kinase inhibitors. It also reviews the current limitations and challenges in developing therapies that selectively target pyroptosis. Additionally, the manuscript explores the role of pyroptosis in various inflammatory disorders associated with psoriasis and HS, such as inflammatory bowel disease, diabetes mellitus, and cardiovascular disorders. The review concludes by emphasizing the need for further research to fully elucidate the pathomechanisms of these dermatoses and develop effective, targeted therapies.
Language	English
Publishing date	2024-01-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2000024-8
ISSN	1467-3045 ; 1467-3037
ISSN (online)	1467-3045
ISSN	1467-3037
DOI	10.3390/cimb46010043
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Article ; Online: Field Cancerization Therapies for the Management of Actinic Keratosis: An Updated Review.

Aggarwal, Ishita / Puyana, Carolina / Chandan, Neha / Jetter, Nathan / Tsoukas, Maria

American journal of clinical dermatology

2024

Abstract: Field cancerization theory highlights that the skin surrounding actinic keratoses (AK) is also at increased risk for possible malignant transformation; thus, field-directed treatments may both reduce the risk of AK recurrence and potentially reduce the ... ...

Abstract	Field cancerization theory highlights that the skin surrounding actinic keratoses (AK) is also at increased risk for possible malignant transformation; thus, field-directed treatments may both reduce the risk of AK recurrence and potentially reduce the risk of development of cutaneous squamous cell carcinoma (cSCC). Photodynamic therapy (PDT) with either aminolevulinic acid (ALA) or methylaminolevulinate (MAL), as well as topical treatments such as 5-fluorouracil (5-FU), diclofenac gel, piroxicam, imiquimod, and ingenol mebutate, have all shown higher efficacy than vehicle treatments. PDT is widely recognized for its high efficacy; however, concerns for associated pain have driven new studies to begin using alternative illumination and pretreatment techniques, including lasers. Among topical treatments, a combination of 5-FU and salicylic acid (5-FU-SA) has shown to be the most effective but also causes the most adverse reactions. Tirbanibulin, a new topical agent approved for use in 2020, boasts a favorable safety profile in comparison with imiquimod, 5-FU, and diclofenac. Meanwhile, ingenol mebutate is no longer recommended for the treatment of AKs due to concerns for increased risk of cSCC development. Moving forward, an increasing number of studies push for standardization of outcome measures to better predict risk of future cSCC and use of more effective measures of cost to better guide patients. Here, we present an updated and comprehensive narrative review both confirming the efficacy of previously mentioned therapies as well as highlighting new approaches to PDT and discussing the use of lasers and novel topical treatments for treatment of AK.
Language	English
Publishing date	2024-02-13
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	1502476-3
ISSN	1179-1888 ; 1175-0561
ISSN (online)	1179-1888
ISSN	1175-0561
DOI	10.1007/s40257-023-00839-8
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Article ; Online: Kawasaki disease and MIS-C share a host immune response.

Tsoukas, Paul / Yeung, Rae S M

Nature reviews. Rheumatology

2022 Volume 18, Issue 10, Page(s) 555–556

MeSH term(s)	COVID-19/complications ; Humans ; Immunity ; Mucocutaneous Lymph Node Syndrome ; Systemic Inflammatory Response Syndrome
Language	English
Publishing date	2022-08-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	2491532-4
ISSN	1759-4804 ; 1759-4790
ISSN (online)	1759-4804
ISSN	1759-4790
DOI	10.1038/s41584-022-00820-5
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Zs.A 6338: Show issues

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Article ; Online: Nevus trichilemmocysticus: a case report and review of the rare type of epidermal nevi.

Chang, Christy / Kuritza, Victoria / Liu, Wenhua / Tsoukas, Maria

International journal of dermatology

2023 Volume 63, Issue 1, Page(s) e2–e4

MeSH term(s)	Humans ; Nevus/diagnosis ; Nevus, Pigmented ; Skin Neoplasms/diagnosis ; Skin Neoplasms/surgery
Language	English
Publishing date	2023-09-14
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	412254-9
ISSN	1365-4632 ; 0011-9059 ; 1461-1244
ISSN (online)	1365-4632
ISSN	0011-9059 ; 1461-1244
DOI	10.1111/ijd.16828
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Article ; Online: Hidradenitis suppurativa perspectives during the COVID-19 pandemic.

Dovalovsky, Katrina / Puyana, Carolina / Tsoukas, Maria M

Clinics in dermatology

2023 Volume 41, Issue 5, Page(s) 622–627

Abstract: The COVID-19 pandemic created a new set of challenges regarding the care of patients with hidradenitis suppurativa (HS). Access to safe, timely medical care and the use of immunosuppressive therapy were central topics of concern for patients and ... ...

Abstract	The COVID-19 pandemic created a new set of challenges regarding the care of patients with hidradenitis suppurativa (HS). Access to safe, timely medical care and the use of immunosuppressive therapy were central topics of concern for patients and providers. In addition, the incidence and severity of SARS-CoV-2 infection in patients with HS were critical to examine during the evolving pandemic and to provide recommendations for patients for makinginformed decisions about their disease and its management. Another consideration of the COVID-19 pandemic was the role of the internet to connect individuals with HS with each other and experts in the field. This is a unique contribution that collectively examines the perspectives of HS medical care and support during the COVID-19 pandemic.
MeSH term(s)	Humans ; Hidradenitis Suppurativa/complications ; Hidradenitis Suppurativa/drug therapy ; COVID-19/epidemiology ; Pandemics ; SARS-CoV-2 ; Incidence ; Severity of Illness Index
Language	English
Publishing date	2023-08-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	1064149-x
ISSN	1879-1131 ; 0738-081X
ISSN (online)	1879-1131
ISSN	0738-081X
DOI	10.1016/j.clindermatol.2023.08.018
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Article ; Online: Pediatric Hospitalizations for Atopic Dermatitis in the United States; Characteristics Associated with the Atopic Triad.

Zimmerman, Lacey / Tsoukas, Zoe / Nikas, Odysseas Vassilios / Puyana, Carolina / Tsoukas, Maria M

Skinmed

2022 Volume 20, Issue 5, Page(s) 344–349

Abstract: Atopic dermatitis (AD) is one of the most common skin disorders in pediatric patients. Many patients with AD also have asthma and/or allergic rhinitis; when combined, these constitute the atopic triad. ...

Abstract	Atopic dermatitis (AD) is one of the most common skin disorders in pediatric patients. Many patients with AD also have asthma and/or allergic rhinitis; when combined, these constitute the atopic triad.
MeSH term(s)	Aged ; Infant ; Female ; Child ; United States/epidemiology ; Humans ; Male ; Dermatitis, Atopic/epidemiology ; Dermatitis, Atopic/complications ; Retrospective Studies ; Medicare ; Asthma/epidemiology ; Asthma/complications ; Hospitalization ; Rhinitis, Allergic/epidemiology ; Rhinitis, Allergic/complications
Language	English
Publishing date	2022-10-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171125-2
ISSN	1751-7125 ; 1540-9740
ISSN (online)	1751-7125
ISSN	1540-9740
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Article ; Online: Pediatric Hospitalizations for Atopic Dermatitis in the United States; Characteristics Associated with the Atopic Triad.

Zimmerman, Lacey / Tsoukas, Zoe / Nikas, Odysseas Vassilios / Puyana, Carolina / Tsoukas, Maria M

Skinmed

2022 Volume 20, Issue 4, Page(s) 344–349

Abstract	Atopic dermatitis (AD) is one of the most common skin disorders in pediatric patients. Many patients with AD also have asthma and/or allergic rhinitis; when combined, these constitute the atopic triad.
MeSH term(s)	Aged ; Infant ; Female ; Child ; United States/epidemiology ; Humans ; Male ; Dermatitis, Atopic/epidemiology ; Dermatitis, Atopic/complications ; Retrospective Studies ; Medicare ; Asthma/epidemiology ; Asthma/complications ; Hospitalization ; Rhinitis, Allergic/epidemiology ; Rhinitis, Allergic/complications
Language	English
Publishing date	2022-10-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171125-2
ISSN	1751-7125 ; 1540-9740
ISSN (online)	1751-7125
ISSN	1540-9740
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Article ; Online: Applications of bakuchiol in dermatology: Systematic review of the literature.

Puyana, Carolina / Chandan, Neha / Tsoukas, Maria

Journal of cosmetic dermatology

2022

Abstract: Background: Bakuchiol (BAK), a meroterpene phenol abundant in the plant Psoralea corylifolia, is an emerging cosmeceutical agent with promising anti-aging, anti-inflammatory, and antibacterial properties. The trend for "clean" skincare products and ... ...

Abstract	Background: Bakuchiol (BAK), a meroterpene phenol abundant in the plant Psoralea corylifolia, is an emerging cosmeceutical agent with promising anti-aging, anti-inflammatory, and antibacterial properties. The trend for "clean" skincare products and search for anti-aging retinoid alternatives have poised BAK as a "must-have" ingredient in skincare. Aims: Our aim was to review the data for the applications of BAK in dermatology. Methods: This is a systematic review of PubMed. Results: Thirty articles matched our search terms ["Bakuchiol" and "Dermatology"] or ["Bakuchiol" and "Skin"] of which one did not meet inclusion criteria, 16 were pre-clinical studies, seven clinical studies, three commentaries, two narrative reviews, and one report on adverse events. BAK has been mostly studied for its effects on photoaging, acne, and post-inflammatory hyperpigmentation (PIH), showing beneficial results comparable to those achieved by topical retinoids. While having no structural resemblance to retinoids, BAK can function as a retinol analog, through retinol-like regulation of gene expression. In in vivo studies, BAK was used alone or in combination with other products resulting in a significant reduction in photodamage, hyperpigmentation, wrinkle scores, and acne severity. Additionally, in vitro studies hinted at its anti-cancer properties by inhibiting epidermal growth factor induced neoplastic cell transformation. Also, demonstrated potential applications in psoriasis by normalizing keratinocyte activity and in pigmentary disorders through inhibition of melanogenesis. There was one adverse event case reported of contact dermatitis in the literature. Conclusions: Bakuchiol is a retinol alternative with anti-aging, antibacterial, and anti-inflammatory properties. Additional studies are warranted to better understand its applications in dermatology.
Language	English
Publishing date	2022-09-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.15420
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Article ; Online: Rapid measurement of epidermal thickness in OCT images of skin.

Lin, Chieh-Hsi / Lukas, Brandon E / Rajabi-Estarabadi, Ali / May, Julia Rome / Pang, Yanzhen / Puyana, Carolina / Tsoukas, Maria / Avanaki, Kamran

Scientific reports

2024 Volume 14, Issue 1, Page(s) 2230

Abstract: Epidermal thickness (ET) changes are associated with several skin diseases. To measure ET, segmentation of optical coherence tomography (OCT) images is essential; manual segmentation is very time-consuming and requires training and some understanding of ... ...

Abstract	Epidermal thickness (ET) changes are associated with several skin diseases. To measure ET, segmentation of optical coherence tomography (OCT) images is essential; manual segmentation is very time-consuming and requires training and some understanding of how to interpret OCT images. Fast results are important in order to analyze ET over different regions of skin in rapid succession to complete a clinical examination and enable the physician to discuss results with the patient in real time. The well-known CNN-graph search (CNN-GS) methodology delivers highly accurate results, but at a high computational cost. Our objective was to build a computational core, based on CNN-GS, able to accurately segment OCT skin images in real time. We accomplished this by fine-tuning the hyperparameters, testing a range of speed-up algorithms including pruning and quantization, designing a novel pixel-skipping process, and implementing the final product with efficient use of core and threads on a multicore central processing unit (CPU). We name this product CNN-GS-skin. The method identifies two defined boundaries on OCT skin images in order to measure ET. We applied CNN-GS-skin to OCT skin images, taken from various body sites of 63 healthy individuals. Compared with CNN-GS, our described method reduced computation time by 130 [Formula: see text] with minimal reduction in ET determination accuracy (from 96.38 to 94.67%).
MeSH term(s)	Humans ; Tomography, Optical Coherence/methods ; Skin/diagnostic imaging ; Epidermis/diagnostic imaging ; Algorithms ; Software
Language	English
Publishing date	2024-01-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-47051-6
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