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Article ; Online: Jiao-tai-wan and its effective component-berberine improve diabetes and depressive disorder through the cAMP/PKA/CREB signaling pathway.

Tang, Yueheng / Gao, Yang / Nie, Kexin / Wang, Hongzhan / Chen, Shen / Su, Hao / Huang, Wenya / Dong, Hui

2024 Volume 324, Page(s) 117829

Abstract: Ethnopharmacological relevance: Jiao-tai-wan (JTW), a classic herbal formula ...

Abstract	Ethnopharmacological relevance: Jiao-tai-wan (JTW), a classic herbal formula of traditional Chinese medicine recorded in Han Shi Yi Tong, has been used to alleviate sleep disorders since ancient times. In modern pharmacological research, JTW has been adopted for treating diabetes mellitus and even exerts antidepressant effects. However, the potential mechanisms deserve further elucidation. Aim of the study: The prevalence of diabetes mellitus combined with depressive disorder (DD) is continuing to increase, yet it is currently under-recognized and its treatment remains inadequate. The present study aims to explore the underlying therapeutics and mechanisms of JTW on DD. Materials and methods: Chronic restraint stress was used on db/db mice to construct a mouse model of DD. The therapeutic effects of JTW were assessed by glucolipid metabolic indexes, behavioral tests, and depression-related neurotransmitter levels. The inflammatory status and cell apoptosis of different mice were investigated and the changes in the cAMP/PKA/CREB pathway were detected. Combining the results of fingerprinting with molecular docking, the active components of JTW were screened. A cellular model was constructed by intervention of glucose combined with corticosterone (CORT). The levels of apoptosis and depression-related neurotransmitters in HT-22 cells were examined, and the changes in the cAMP/PKA/CREB pathway were tested. Finally, the activator and inhibitor of the PKA protein were used for reverse validation experiments. Results: JTW could improve the impaired glucose tolerance, lipid metabolism disorders, and depression-like symptoms in DD mice. Meanwhile, JTW could alleviate the inflammatory status, suppress the microglia activation, and improve hippocampal neuron apoptosis in DD mice. The dual effects of JTW might be associated with the activation of the cAMP/PKA/CREB pathway. Berberine (Ber) was identified for the in vitro experiment, it could reverse the apoptosis of HT-22 cells and up-regulate the depression-related neurotransmitter levels, and the effects of Ber were related to the activation of the cAMP/PKA/CREB pathway as well. Conclusion: JTW could exert both hypoglycemic and antidepressant effects through activating the cAMP/PKA/CREB signaling pathway, its active component, Ber, could improve the damage to HT-22 cells induced by glucose combined with CORT via the activation of the cAMP/PKA/CREB pathway. Ber may be one of the effective components of the dual effects of JTW.
MeSH term(s)	Mice ; Animals ; Berberine/pharmacology ; Berberine/therapeutic use ; Molecular Docking Simulation ; Signal Transduction ; Diabetes Mellitus/drug therapy ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Glucose/metabolism ; Depressive Disorder/drug therapy ; Neurotransmitter Agents ; Drugs, Chinese Herbal
Chemical Substances	jiao tai wan ; Berberine (0I8Y3P32UF) ; Antidepressive Agents ; Glucose (IY9XDZ35W2) ; Neurotransmitter Agents ; Drugs, Chinese Herbal
Language	English
Publishing date	2024-02-01
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.117829
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Article: [An exploration on the factors of Jiao Xun's compilation and edit of

Liu, Y X / Wang, R H

Zhonghua yi shi za zhi (Beijing, China : 1980)

2019 Volume 48, Issue 6, Page(s) 334–341

Abstract: Wu shi ben ... ...

Abstract	Wu shi ben cao
MeSH term(s)	China ; History, Ancient ; Materia Medica
Chemical Substances	Materia Medica
Language	Chinese
Publishing date	2019-01-21
Publishing country	China
Document type	Historical Article ; Journal Article
ZDB-ID	1052411-3
ISSN	0255-7053
ISSN	0255-7053
DOI	10.3760/cma.j.issn.0255-7053.2018.06.003
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Zs.A 4688: Show issues

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Article ; Online: Traditional herbal formula Jiao-tai-wan improves chronic restrain stress-induced depression-like behaviors in mice.

Tang, Yueheng / Wang, Hongzhan / Nie, Kexin / Gao, Yang / Su, Hao / Wang, Zhi / Lu, Fuer / Huang, Wenya / Dong, Hui

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2022 Volume 153, Page(s) 113284

Abstract: Objectives: Jiao-tai-wan (JTW) has been often used to treat insomnia and diabetes mellitus. Recent ...

Abstract	Objectives: Jiao-tai-wan (JTW) has been often used to treat insomnia and diabetes mellitus. Recent studies found its antidepressant activity, but the related mechanism is not clear. This study is to evaluate the therapeutic effects of JTW on chronic restraint stress (CRS)-induced depression mice and explore the potential mechanisms. Methods: CRS was used to set up a depression model. Mice in different groups were treated with 0.9 % saline, JTW and fluoxetine. After the last day of CRS, the behavioral tests were conducted. The levels of neurotransmitters, inflammatory cytokines and HPA axis index were detected and the protein expressions of NLRP3 inflammasome complex were determined. H&E, NISSL, TUNEL and immunofluorescence staining were used to observe histopathological changes and the activation of microglia and astrocytes. The potential mechanisms were explored via network pharmacology and verified by Western blot. Results: The assessment of liver and kidney function showed that JTW was non-toxic. Behavioral tests proved that JTW can effectively ameliorate depression-like symptoms in CRS mice, which may be related to the inhibition of NLRP3 inflammasome activation. JTW can also improve the inflammatory state and HPA axis hyperactivity in mice, and has a protective effect on CRS-induced hippocampal neurons damage. The network pharmacology analysis and the results of Western blot suggested that the antidepressant effects of JTW may be related to the MAPK signaling pathway. Conclusion: Our findings indicated that JTW may exert antidepressant effects in CRS-induced mice by inhibiting NLRP3 inflammasome activation and improving inflammatory state, and MAPK signaling pathway may also be involved.
MeSH term(s)	Animals ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Depression/drug therapy ; Drugs, Chinese Herbal ; Hypothalamo-Hypophyseal System ; Inflammasomes ; Mice ; NLR Family, Pyrin Domain-Containing 3 Protein ; Pituitary-Adrenal System
Chemical Substances	Antidepressive Agents ; Drugs, Chinese Herbal ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; jiao tai wan
Language	English
Publishing date	2022-06-17
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2022.113284
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Ud II Zs.198: Show issues

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Article ; Online: Chemical profile and miscarriage prevention evaluation of Jiao-Ai Decoction, a classical traditional Chinese formula.

Zhang, Min / Geng, Ting / Jing, Shao-Heng / Li, Lin / Wang, Kan / Zhang, Qiao / Zhang, Yi / Zhou, Shi-Kang / Gao, Ping / Ding, An-Wei / Zhang, Li

Journal of pharmaceutical and biomedical analysis

2022 Volume 217, Page(s) 114832

Abstract: Jiao-Ai Decoction (JAD), a classical traditional Chinese formula composed of seven Chinese herbs ...

Abstract	Jiao-Ai Decoction (JAD), a classical traditional Chinese formula composed of seven Chinese herbs, has been widely used in clinical practice for the treatment of abortion for a long time. However, the material basis and pharmacological mechanism remain unclear. An integrative method combining ultra-performance liquid chromatography coupled with mass spectrometry (UPLC-MS/MS) analysis and therapeutic effect evaluation based on the hypothalamus-pituitary-ovarian axis (HPOA) was employed to elaborate these problems. Firstly, the chemical profile of JAD was identified by UPLC-Q-TOF-MS. Secondly, the main target ingredients from JAD were determined by UPLC-T-Q-MS. Finally, the miscarriage prevention of JAD on threatened abortion pregnant rats induced by mifepristone was investigated. Threatened abortion model in rats were replicated, uterine bleeding quantity (UBQ) and histopathological sections were measured, the contents of luteinizing hormone (LH), follicular stimulating hormone (FSH), estradiol (E
MeSH term(s)	Abortion, Spontaneous/drug therapy ; Abortion, Threatened/drug therapy ; Abortion, Threatened/prevention & control ; Animals ; China ; Chromatography, High Pressure Liquid/methods ; Chromatography, Liquid ; Drugs, Chinese Herbal/analysis ; Female ; Humans ; Pregnancy ; Rats ; Tandem Mass Spectrometry/methods
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2022-05-13
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2022.114832
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Article ; Online: Network pharmacology identification and in vivo validation of key pharmacological pathways of Qin Jiao for gout and arthritis

Xiaoxiong Yang / Yu Wang / Xueli Ding / Shanshan Ju / Xiaoye An / Bing Zhang / Zhijian Lin

Pharmaceutical Biology, Vol 61, Iss 1, Pp 1525-

2023 Volume 1535

Abstract: ... on patients, which might diminish quality of life. Qin Jiao, a perennial herb found in northwestern China and ... of Qin Jiao on gout and joint inflammation and elucidates its potential mechanism for gouty arthritis ... to assess the applications of Qin Jiao in arthritis treatment. Study 2 was performed to discover ...

Abstract	AbstractContext: Gout is a chronic disease that imposes a huge financial and health burden on patients, which might diminish quality of life. Qin Jiao, a perennial herb found in northwestern China and Japan, is commonly used for treating various ailments.Objective: This study investigates the effects of Qin Jiao on gout and joint inflammation and elucidates its potential mechanism for gouty arthritis.Materials and methods: Study 1, a literature review was conducted using PubMed, Web of Science, and CNKI to assess the applications of Qin Jiao in arthritis treatment. Study 2 was performed to discover the component targets and gouty disease targets via TCMSP, OMIM, GeneCards and DRUGBANK, and network pharmacology analysis. Study 3, male Sprague-Dawley (SD) rats were divided into normal, model, colchicine, Qin Jiao low-dose (QJL), and Qin Jiao high-dose group (QJH), oral gavage for 40 d. Serum, synovial fluid, and synovial membrane tissue were collected to measure the expression levels of IL-1β, IL-6, and STAT3.Results: The research also identified potential targets and pharmacological pathways of Qin Jiao for gout treatment. In vivo study demonstrated Qin Jiao can reduce IL-1β levels in serum and ankle flushing fluid. ELISA analysis confirmed that Qin Jiao significantly reduces the protein expression of IL-6 and STAT3.Discussion and conclusion: Qin Jiao exerts anti-inflammatory effects on gouty arthritis by modulating the IL-6/STAT3 pathway. This study provides a biological basis for the use of Qin Jiao in treating arthritis-related diseases and offers experimental evidence for potential future drug development.
Keywords	Joint inflammation ; Chinese herbs ; Kampo medicine ; IL-6/STAT3 pathway ; joint arthritis ; Therapeutics. Pharmacology ; RM1-950
Subject code	610
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Vertebral Artery Origin Stent Placement Using the Dual Lumen Qureshi-Jiao Guidecatheter.

Qureshi, Adnan I / Wang, Yabing / Afzal, Mohammad Rauf / Jiao, Liqun

Journal of vascular and interventional neurology

2018 Volume 9, Issue 6, Page(s) 38–42

Abstract: Objective: We report the first experience with a new dual lumen guide catheter with lumen A with curved tip designed for delivery of stent and angioplasty catheters and lumen B with side exit for coaxial placement of stiff 0.014 inch wire.: Methods: ... ...

Abstract	Objective: We report the first experience with a new dual lumen guide catheter with lumen A with curved tip designed for delivery of stent and angioplasty catheters and lumen B with side exit for coaxial placement of stiff 0.014 inch wire. Methods: We prospectively determined technical success, intended procedure (stent delivery at target lesion and a final residual stenosis <30%) completed without a need for a different catheter, and technical ease, intended procedure completed without ≥3 unsuccessful attempts in patients with symptomatic vertebral artery origin stenosis. Vertebral artery origin was classified as type A if originated from ascending segment and type B if originated from an arch or horizontal segment of subclavian artery. Results: The mean age of the four treated patients was 66.2 years (range 64-68 years). The mean percentage of vertebral artery origin stenosis was 82.7% (range 60-92%). The origin of vertebral artery from subclavian artery was classified as type A and type B origins in two patients each. The dual lumen catheter was advanced over an exchange length of 0.035 inch glide wire in one patient and directly through transfemoral insertion in three patients. Technical success and technical ease was achieved in all four procedures. Post procedure residual stenosis was 6% (range 5-7%). The primary operator rated the performance of guide catheter as superior compared with another catheter used in such procedures. Conclusion: The present study demonstrates the feasibility of performing stent placement for vertebral artery origin stenosis by using a dual lumen catheter with superior performance.
Language	English
Publishing date	2018-02-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2627963-0
ISSN	1944-141X ; 1941-5893
ISSN (online)	1944-141X
ISSN	1941-5893
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Medicine-Engineering Interdisciplinary Research Based on Bibliometric Analysis: A Case Study on Medicine-Engineering Institutional Cooperation of Shanghai Jiao Tong University.

Wang, Qingwen / Cui, Tingting / Deng, Peiwen

Journal of Shanghai Jiaotong University (science)

2022 , Page(s) 1–16

Abstract: ... Targeted at the scientific literature and patent literature published by Shanghai Jiao Tong University ...

Abstract	This article aims to provide reference for medicine-engineering interdisciplinary research. Targeted at the scientific literature and patent literature published by Shanghai Jiao Tong University, this article attempts to set up co-occurrence matrix of medicine-engineering institutional information which was extracted from address fields of the papers, so as to construct the medicine-engineering intersection datasets. The dataset of scientific literature was analyzed using bibliometrics and visualization methods from multiple dimensions, and the most active factors, such as trends of output, journal and subject distribution, were identified from the indicators of category normalized citation impact (CNCI), times cited, keywords, citation topics and the degree of medicine-engineering interdisplinary. Research on hotspots and trends was discussed in detail. Analyses of the dataset of patent literature showed research themes and measured the degree for technology convergence of medicine-engineering.
Language	English
Publishing date	2022-05-16
Publishing country	China
Document type	Journal Article
ZDB-ID	2630146-5
ISSN	1995-8188 ; 1007-1172
ISSN (online)	1995-8188
ISSN	1007-1172
DOI	10.1007/s12204-022-2418-5
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Article ; Online: The effect and mechanism of Jiao-tai-wan in the treatment of diabetes mellitus with depression based on network pharmacology and experimental analysis.

Tang, Yueheng / Su, Hao / Wang, Hongzhan / Lu, Fuer / Nie, Kexin / Wang, Zhi / Huang, Wenya / Dong, Hui

Molecular medicine (Cambridge, Mass.)

2021 Volume 27, Issue 1, Page(s) 154

Abstract: ... around the world, bringing a serious burden to patients and their families. Jiao-tai-wan (JTW), a well-known ...

Abstract	Background: The incidence of diabetes mellitus (DM) and depression is increasing year by year around the world, bringing a serious burden to patients and their families. Jiao-tai-wan (JTW), a well-known traditional Chinese medicine (TCM), has been approved to have hypoglycemic and antidepressant effects, respectively, but whether JTW has such dual effects and its potential mechanisms is still unknown. This study is to evaluate the dual therapeutic effects of JTW on chronic restraint stress (CRS)-induced DM combined with depression mice, and to explore the underlying mechanisms through network pharmacology. Methods: CRS was used on db/db mice for 21 days to induce depression-like behaviors, so as to obtain the DM combined with depression mouse model. Mice were treated with 0.9% saline (0.1 ml/10 g), JTW (3.2 mg/kg) and Fluoxetine (2.0 mg/kg), respectively. The effect of JTW was accessed by measuring fasting blood glucose (FBG) levels, conducting behavioral tests and observing histopathological change. The ELISA assay was used to evaluate the levels of inflammatory cytokines and the UHPLC-MS/MS method was used to determine the depression-related neurotransmitters levels in serum. The mechanism exploration of JTW against DM and depression were performed via a network pharmacological method. Results: The results of blood glucose measurement showed that JTW has a therapeutic effect on db/db mice. Behavioral tests and the levels of depression-related neurotransmitters proved that JTW can effectively ameliorate depression-like symptoms in mice induced by CRS. In addition, JTW can also improve the inflammatory state and reduce the number of apoptotic cells in the hippocampus. According to network pharmacology, 28 active compounds and 484 corresponding targets of JTW, 1407 DM targets and 1842 depression targets were collected by screening the databases, and a total of 117 targets were obtained after taking the intersection. JTW plays a role in reducing blood glucose level and antidepressant mainly through active compounds such as quercetin, styrene, cinnamic acid, ethyl cinnamate, (R)-Canadine, palmatine and berberine, etc., the key targets of its therapeutic effect include INS, AKT1, IL-6, VEGF-A, TNF and so on, mainly involved in HIF-1 signal pathway, pathways in cancer, Hepatitis B, TNF signal pathway, PI3K-Akt signal pathway and MAPK signaling pathway, etc. CONCLUSION: Our experimental study showed that JTW has hypoglycemic and antidepressant effects. The possible mechanism was explored by network pharmacology, reflecting the characteristics of multi-component, multi-target and multi-pathway, which provides a theoretical basis for the experimental research and clinical application of JTW in the future.
MeSH term(s)	Animals ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Apoptosis/drug effects ; Behavior, Animal/drug effects ; Blood Glucose/drug effects ; C-Reactive Protein/analysis ; Cytokines/blood ; Depression/drug therapy ; Depression/genetics ; Depression/metabolism ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/metabolism ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Hippocampus/drug effects ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Male ; Mice ; Network Pharmacology ; Neurotransmitter Agents/blood ; Protein Interaction Maps
Chemical Substances	Antidepressive Agents ; Blood Glucose ; Cytokines ; Drugs, Chinese Herbal ; Hypoglycemic Agents ; Neurotransmitter Agents ; jiao tai wan ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2021-12-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1283676-x
ISSN	1528-3658 ; 1076-1551
ISSN (online)	1528-3658
ISSN	1076-1551
DOI	10.1186/s10020-021-00414-z
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Zs.A 4456: Show issues

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Article ; Online: Anti-depressive effects of Jiao-Tai-Wan on CORT-induced depression in mice by inhibiting inflammation and microglia activation.

Bai, Guiqin / Qiao, Yiqi / Lo, Po-Chieh / Song, Lei / Yang, Yuna / Duan, Lining / Wei, Sufen / Li, Min / Huang, Shuiqing / Zhang, Beiping / Wang, Qi / Yang, Cong

Journal of ethnopharmacology

2021 Volume 283, Page(s) 114717

Abstract: Ethnopharmacological relevance: Jiao-Tai-Wan (JTW) is a very famous traditional Chinese medicine ...

Abstract	Ethnopharmacological relevance: Jiao-Tai-Wan (JTW) is a very famous traditional Chinese medicine formula for the treatment of psychiatric disorders, especially in anxiety, insomnia and depression. However, its molecular mechanism of treatment remains indistinct. Aim of the study: We aimed to reveal the action mechanism of JTW on anti-depression via inhibiting microglia activation and pro-inflammatory response both in vivo and in vitro. Material and methods: The corticosterone (CORT)-induced depression mouse model was used to evaluate the therapeutic efficacy of JTW. Behavioral tests (open field, elevated plus maze, tail suspension and forced swim test) were conducted to evaluate the effect of JTW on depressive-like behaviors. The levels of inflammatory factors and the concentration of neurotransmitters were detected by RT-qPCR or ELISA assays. Then three hippocampal tissue samples per group (Control, CORT, and JTW group) were sent for RNA sequencing (RNA-seq). Transcriptomics data analysis was used to screen the key potential therapeutic targets and signaling pathways of JTW. Based on 8 bioactive species of JTW by our previous study using High-performance liquid chromatography (HPLC) analysis, molecular docking analyses were used to predict the interaction of JTW-derived compounds and depression targets. Finally, the results of transcriptome and molecular docking analyses were combined to verify the targets, key pathways, and efficacy of JTW treatment in vivo and vitro. Results: JTW ameliorated CORT-induced depressive-like behaviors, neuronal damage and enhanced the levels of monoamine neurotransmitters in the serum of mice. JTW also inhibited CORT-induced inflammatory activation of microglia and decreased the serum levels of interleukin- 6(IL-6) and interleukin- 1β (IL-1β) in vivo. Transcriptomic data analysis showed there were 10 key driver analysis (KDA) genes with the strongest correlation which JTW regulated in depression mice. Molecular docking analysis displayed bioactive compound Magnoflorine had the strongest binding force to the key gene colony-stimulating factor 1 receptor (CSF1R), which is the signaling microglia dependent upon for their survival. Meanwhile, CSF1R staining showed it was consistent with inflammatory activation of microglia. Our vitro experiment also showed JTW and CSF1R inhibitor significantly reduced lipopolysaccharide (LPS)/interferon-gamma (IFNɣ)-induced inflammatory activation response in macrophage cells. Conclusions: Our study suggests that JTW might ameliorate CORT-induced neuronal damage in depression mice by inhibiting CSF1R mediated microglia activation and pro-inflammatory response.
MeSH term(s)	Animals ; Animals, Outbred Strains ; Antidepressive Agents/pharmacology ; Behavior, Animal/drug effects ; Corticosterone/toxicity ; Depression/drug therapy ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Hippocampus/drug effects ; Inflammation/drug therapy ; Male ; Mice ; Microglia/drug effects ; Microglia/metabolism ; Molecular Docking Simulation ; RAW 264.7 Cells
Chemical Substances	Antidepressive Agents ; Drugs, Chinese Herbal ; jiao tai wan ; Corticosterone (W980KJ009P)
Language	English
Publishing date	2021-10-07
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2021.114717
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Article ; Online: Jiao Shao: A forerunner of physiological psychology and comparative psychology in China.

Wang, Lijun / Qian, Yanyan / Su, Yanjie

Protein & cell

2018 Volume 10, Issue 9, Page(s) 623–627

MeSH term(s)	China ; History, 20th Century ; History, 21st Century ; Psychology, Comparative/history ; Psychophysiology/history
Language	English
Publishing date	2018-11-14
Publishing country	Germany
Document type	Biography ; Historical Article ; Journal Article ; Portrait
ZDB-ID	2543451-2
ISSN	1674-8018 ; 1674-800X
ISSN (online)	1674-8018
ISSN	1674-800X
DOI	10.1007/s13238-018-0592-x
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