LIVIVO - Search results -

Search results

Result 1 - 10 of total 33

Search options

Article: Identification of protein profile in metacyclic and amastigote-like stages of Leishmania tropica: a proteomic approach.

Ashrafmansouri, Marzieh / Amiri-Dashatan, Nasrin / Ahmadi, Nayebali

2022 Volume 12, Issue 1, Page(s) 142

Abstract: Leishmaniasis is a tropical disease that leads to various clinical phenotypes. This study aimed to investigate protein expression changes in metacyclic and amastigote-like stages of L. tropica isolated from Iranian cutaneous leishmaniasis patients. ... ...

Abstract	Leishmaniasis is a tropical disease that leads to various clinical phenotypes. This study aimed to investigate protein expression changes in metacyclic and amastigote-like stages of L. tropica isolated from Iranian cutaneous leishmaniasis patients. Isolated samples were cultured and species type identified using PCR-RFLP technique. The promastigotes were grown in RPMI1640 media and differentiated to metacyclic and amastigote-like forms, followed by the extracted proteins of both successive stages carried out for proteomics and bioinformatics analysis. Using SWATH-MS quantitative proteomics technique, a total 176 and 155 distinct proteins were identified in metacyclic and axenic amastigote stages, respectively. Of these, 65 proteins were altered significantly (p-value < 0.05 and fold change ≥ 2) between studied stages. Several gene ontology (GO) categories were enriched for biological process during conversion of metacyclic promastigotes into amastigote-like, which "metabolic process" (GO: 0044281, P-Value: 6.52e-5), and "translation" (GO: 0006412, p-value: 5.01e-14) were disclosed as the top category in up and down-regulated proteins, respectively. Also, the KEGG pathway analysis indicated "metabolic pathways" and "ribosome" term as the most important pathways in up and down-regulated proteins, respectively. According to protein interaction network analysis, enolase (ENOL) has been detected as main hub proteins during differentiation, followed by Putative NADH-dependent fumarate reductase (LmjF.35.1180) and 40S ribosomal protein S2 (LmjF.32.0450). Overall, protein changes possibly play important roles in L. tropica biology. Anabolic pathways were down-regulated, whereas catabolic pathways were up-regulated during L. tropica differentiation. These protein expression changes could provide parasite survival in host macrophages, and could use as novel potential drug and vaccine targets for leishmaniasis.
Language	English
Publishing date	2022-11-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2621432-5
ISSN	2191-0855
ISSN	2191-0855
DOI	10.1186/s13568-022-01481-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Mass Spectrometry-Based Proteomics Research to Fight COVID-19: An Expert Review on Hopes and Challenges.

Amiri-Dashatan, Nasrin / Koushki, Mehdi / Rezaei-Tavirani, Mostafa

Omics : a journal of integrative biology

2022 Volume 26, Issue 1, Page(s) 19–34

Abstract: The COVID-19 pandemic caused by the severe acute respiratory syndrome (SARS)-CoV-2 infection is a systemic disease and a major planetary health burden. While SARS-CoV-2 impacts host biology extensively, our knowledge of these alterations from a systems ... ...

Abstract	The COVID-19 pandemic caused by the severe acute respiratory syndrome (SARS)-CoV-2 infection is a systemic disease and a major planetary health burden. While SARS-CoV-2 impacts host biology extensively, our knowledge of these alterations from a systems perspective remains incomplete. Moreover, there is currently only a limited description of this systemic disease. For precision diagnosis and treatment of SARS-CoV-2, multiomics technologies and systems science research offer significant prospects. This expert review offers a critical analysis of the prospects and challenges of the emerging mass spectrometry-based proteomics approaches to the study of COVID-19 as seen through a systems medicine lens. We also discuss the ways in which proteomics is poised to offer hope for diagnostics and therapeutics innovation on SARS-CoV-2 infection as the disease transitions from a pandemic to an endemic disease, and thus further challenging the health systems and services worldwide in the coming decade. Proteomics is an important high-throughput technology platform to achieve a functional overview of the ways in which COVID-19 changes host biology, and hence, can help identify possible points of entry for innovation in medicines and vaccines, among others.
MeSH term(s)	COVID-19 ; Humans ; Mass Spectrometry ; Pandemics ; Proteomics ; SARS-CoV-2
Language	English
Publishing date	2022-01-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2030312-9
ISSN	1557-8100 ; 1536-2310
ISSN (online)	1557-8100
ISSN	1536-2310
DOI	10.1089/omi.2021.0182
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Screening the critical protein subnetwork to delineate potential mechanisms and protective agents associated with arsenic-induced cutaneous squamous cell carcinoma: A toxicogenomic study.

Koushki, Mehdi / Amiri-Dashatan, Nasrin / Rezaei-Tavirani, Mostafa / Robati, Reza M / Fateminasab, Fatemeh / Rahimi, Shadi / Razzaghi, Zahra / Farahani, Masoumeh

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2024 Volume 185, Page(s) 114451

Abstract: Recent studies show that complex mechanisms are involved in arsenic-induced malignant transformation of cells. This study aimed to decipher molecular mechanisms associated with arsenic-induced cutaneous squamous cell carcinoma (cSCC) and suggest ... ...

Abstract	Recent studies show that complex mechanisms are involved in arsenic-induced malignant transformation of cells. This study aimed to decipher molecular mechanisms associated with arsenic-induced cutaneous squamous cell carcinoma (cSCC) and suggest potential protective factors. RNA-seq-based differentially expressed genes between arsenic-exposed human keratinocytes (HaCaT) and controls were used to construct a protein-protein interaction (PPI) network and discover critical subnetwork-based mechanisms. Protective compounds against arsenic toxicity were determined and their target interactions in the core sub-network were identified by the comparative toxicogenomic database (CTD). The binding affinity between the effective factor and target was calculated by molecular docking. A total of 15 key proteins were screened out as critical arsenic-responsive subnetwork (FN1, IL-1A, CCN2, PECAM1, FGF5, EDN1, FGF1, PXDN, DNAJB9, XBP1, ERN1, PDIA4, DNAJB11, FOS, PDIA6) and 7 effective protective agents were identified (folic acid, quercetin, zinc, acetylcysteine, methionine, catechin, selenium). The GeneMANIA predicted detailed interactions of the subnetwork and revealed terms related to unfolded protein response as the main processes. FN1, IL1A and CCN2, as top significant genes, had good docking affinity with folic acid and quercetin, as selected key compounds. Integration of gene expression and protein-protein interaction related to arsenic exposure in cSCC explored the potential mechanisms and protective agents.
MeSH term(s)	Humans ; Arsenic/toxicity ; Carcinoma, Squamous Cell/chemically induced ; Carcinoma, Squamous Cell/genetics ; Quercetin ; Molecular Docking Simulation ; Toxicogenetics ; Skin Neoplasms/chemically induced ; Skin Neoplasms/genetics ; Skin Neoplasms/metabolism ; Protective Agents ; Folic Acid/adverse effects ; Membrane Proteins ; Molecular Chaperones ; HSP40 Heat-Shock Proteins
Chemical Substances	Arsenic (N712M78A8G) ; Quercetin (9IKM0I5T1E) ; Protective Agents ; Folic Acid (935E97BOY8) ; DNAJB9 protein, human ; Membrane Proteins ; Molecular Chaperones ; HSP40 Heat-Shock Proteins
Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2024.114451
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 529: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid

Koushki, Mehdi / Farrokhi Yekta, Reyhaneh / Amiri-Dashatan, Nasrin

Journal of Functional Foods. 2023 May, v. 104 p.105502-

2023

Abstract: Cancer is identified as second leading causes of death and imposes a significant psychological and economic burden on societies. Due to its high prevalence, and a main cause of death worldwide, there is a continuing need to discover new potential ... ...

Abstract	Cancer is identified as second leading causes of death and imposes a significant psychological and economic burden on societies. Due to its high prevalence, and a main cause of death worldwide, there is a continuing need to discover new potential anticancer compounds. Plant-derived compounds have recently attracted more attention among researchers for their potent anti-cancer properties. A numerous research, including in-vitro, in-vivo, preclinical, clinical, and epidemiological studies, has indicated that the flavonoid of silymarin have comprehensive preventive and therapeutic effects on array of inflammation-driven diseases, including cancer. Silymarin have clear anti-cancer activities through distinctive mechanisms including modulation of apoptosis in-vitro and survival in-vivo. The chemoprotection of silymarin and its constituent suggest they could be promising therapeutic agents in various cancer types. This review focus on the silymarin in vivo and in vitro effects in a variety of cancers, and explores signaling pathways that modulated by this compound.
Keywords	apoptosis ; death ; silymarin ; therapeutics ; Natural product ; Polyphenol ; Flavonoid ; Cancer ; Chemoprevention ; SMEDDS ; SLNs ; PVA ; SIL ; SILNPs ; SLM ; TMC ; WHO ; MAPK ; ERK ; BCl-2 ; Bcl-xL ; IL-6 ; STAT3 ; NF-κβ ; IL-1β ; PG-E2 ; IFN-γ ; NO ; TGF-β2 ; MMP-2 ; MMP-9 ; VEGFR1 ; GC ; CRC ; PTX ; HIF-1α ; C-MYC ; LC-MS/MS ; MMPs ; TGF-β ; TCF-4 ; ODC ; mRNA ; BPO ; BG ; SOD ; GPX ; AOM ; CAP ; UV ; BrCa ; ER-α ; ERBB2 ; DXL ; BCRP ; SMSWE ; REF ; AMAPK
Language	English
Dates of publication	2023-05
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2511964-3
ISSN	1756-4646
ISSN	1756-4646
DOI	10.1016/j.jff.2023.105502
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 7830: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Serum cortisol concentration and COVID-19 severity: a systematic review and meta-analysis.

Amiri-Dashatan, Nasrin / Koushki, Mehdi / Parsamanesh, Negin / Chiti, Hossein

Journal of investigative medicine : the official publication of the American Federation for Clinical Research

2022 Volume 70, Issue 3, Page(s) 766–772

Abstract: The novel COVID-19 outbreak is a major health threat to human beings with multiorgan injuries. However, its endocrine system manifestations are much less studied. In this study, we aimed to reassess the available findings on the association between ... ...

Abstract	The novel COVID-19 outbreak is a major health threat to human beings with multiorgan injuries. However, its endocrine system manifestations are much less studied. In this study, we aimed to reassess the available findings on the association between cortisol level and severity of COVID-19 infection. We conducted a systematic search on Medline/PubMed, Scopus, Web of Science, and Cochrane Library databases. To pool data, a random-effects model was performed depending on the heterogeneity among studies. Sensitivity analysis was also carried out by removing each study systematically. In addition, subgroup and meta-regression analyses were performed depending on the presence of the variables of sex and age. Subsequently, 11 studies (5 observational studies and 6 case reports) were included in the meta-analysis. Pooled analysis on the observational studies showed significantly higher levels of cortisol in patients with severe COVID-19 in comparison with those with mild-to-moderate COVID-19 (standardized mean difference: 1.48 µg/dL; 95% CI (0.51 to 2.46); p=0.003). Assessment of the results of case reports revealed that the patients with severe COVID-19 demonstrated higher cortisol levels than the patients with mild-to-moderate COVID-19. No publication bias was observed using the Begg's (p=0.08) and Egger's tests (p=0.09). Meta-regression illustrated a significant correlation between cortisol levels with sex. The serum cortisol level seems to be higher in patients with severe COVID-19 infection. This finding could be helpful to detect patients with poor prognosis at early stages of the disease, although age and sex may modify this level.
MeSH term(s)	Age Factors ; COVID-19/blood ; COVID-19/diagnosis ; Humans ; Hydrocortisone/blood ; SARS-CoV-2 ; Sex Factors
Chemical Substances	Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2022-01-20
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	1217870-6
ISSN	1708-8267 ; 0009-9279 ; 1081-5589
ISSN (online)	1708-8267
ISSN	0009-9279 ; 1081-5589
DOI	10.1136/jim-2021-001989
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 307: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Comparison of gene expression of pyruvate kinase and tryparedoxin peroxidase in metacyclic promastigote forms of Leishmania (L.) tropica and L. major by real-time PCR

Amiri-Dashatan, Nasrin / Koushki, Mehdi / Ahmadi, Nayebali

Annals of parasitology

2020 Volume 66, Issue 1, Page(s) 13–18

MeSH term(s)	Gene Expression Regulation, Enzymologic ; Humans ; Iran ; Leishmania tropica/enzymology ; Leishmania tropica/genetics ; Leishmaniasis, Cutaneous/parasitology ; Life Cycle Stages/genetics ; Peroxidases/genetics ; Protozoan Proteins/genetics ; Pyruvate Kinase/genetics ; Real-Time Polymerase Chain Reaction
Chemical Substances	Protozoan Proteins ; Peroxidases (EC 1.11.1.-) ; tryparedoxin peroxidase (EC 1.11.1.-) ; Pyruvate Kinase (EC 2.7.1.40)
Language	English
Publishing date	2020-03-20
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2672322-0
ISSN	2299-0631 ; 0043-5163
ISSN	2299-0631 ; 0043-5163
DOI	10.17420/ap6601.233
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 102: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Stage-Specific Differential Gene Expression of Glutathione Peroxidase in

Amiri-Dashatan, Nasrin / Koushki, Mehdi / Rezaei-Tavirani, Mostafa / Ahmadi, Nayebalia

Reports of biochemistry & molecular biology

2021 Volume 9, Issue 3, Page(s) 324–330

Abstract: Background: Leishmania (L) major: Methods: The samples were cultured in Novy-Nicolle-Mc Neal medium to obtain the promastigotes and identified using PCR-RFLP technique. They were then grown in RPMI1640 media for mass cultivation. The expression level ...

Abstract	Background: Leishmania (L) major Methods: The samples were cultured in Novy-Nicolle-Mc Neal medium to obtain the promastigotes and identified using PCR-RFLP technique. They were then grown in RPMI1640 media for mass cultivation. The expression level of TDPX gene was compared by Real-time PCR. Results: By comparison of expression level, up-regulation of TDPX gene was observed (5.37 and 2.29 folds) in Conclusion: Our data provide a foundation for identifying infectivity and high survival related factors in the
Language	English
Publishing date	2021-03-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2743890-9
ISSN	2322-3480
ISSN	2322-3480
DOI	10.29252/rbmb.9.3.324
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Identification of differential protein expression and putative drug target in metacyclic stage of Leishmania major and Leishmania tropica: A quantitative proteomics and computational view.

Amiri-Dashatan, Nasrin / Ahmadi, Nayebali / Rezaei-Tavirani, Mostafa / Koushki, Mehdi

Comparative immunology, microbiology and infectious diseases

2021 Volume 75, Page(s) 101617

Abstract: Cutaneous leishmaniasis (CL) is an infectious disease that commonly caused by Leishmania (L.) major and L.tropica. Recently there has been a growing interest in proteomics analysis on Leishmania for drug target discovery. Therefore, we aimed to ... ...

Abstract	Cutaneous leishmaniasis (CL) is an infectious disease that commonly caused by Leishmania (L.) major and L.tropica. Recently there has been a growing interest in proteomics analysis on Leishmania for drug target discovery. Therefore, we aimed to distinguish proteins which might be characteristic for each of the species from those shared by both to the detection of drug targets, which may become helpful for designing new drugs for CL. To identify differences in protein profiles of L. major and L. tropica, we conducted a Sequential window acquisition of all theoretical fragment ion spectra mass spectrometry (SWATH-MS) analysis. Totally 67 differentially expressed proteins (DEPs) (fold change> 2 and p < 0.05) were identified between species. Of these, 42 and 25 proteins were up-regulated in L. major and L. tropica, respectively. Several enriched GO terms were identified via biological process of up-regulated proteins. Furthermore, the small molecule metabolic process and translation were detected as significant biological processes for up-regulated proteins in L. major, while translation was identified for L. tropica. Also, KEGG analysis has revealed glycolysis/gluconeogenesis and translation as the top pathways in the proteins up-regulated in L. major and L. tropica, respectively. Finally glycosomal malate dehydrogenase was identified as putative drug target using network and homology analyses. The DEPs between the species are essential in host-pathogen interactions and parasite survival in the macrophage. Furthermore, L. major and L. tropica possibly uses different pathogenicity mechanisms that leads to anthroponotic or zoonotic CL. Our results may help in the drug discovery and chemotherapeutic interventions.
MeSH term(s)	Animals ; Leishmania major/genetics ; Leishmania tropica/genetics ; Leishmaniasis, Cutaneous/veterinary ; Pharmaceutical Preparations ; Proteomics
Chemical Substances	Pharmaceutical Preparations
Language	English
Publishing date	2021-01-27
Publishing country	England
Document type	Journal Article
ZDB-ID	436522-7
ISSN	1878-1667 ; 0147-9571
ISSN (online)	1878-1667
ISSN	0147-9571
DOI	10.1016/j.cimid.2021.101617
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1443: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Identification of Agents with Potential Leishmania Malate Dehydrogenase Inhibitor Activity

Nasrin Amiri-Dashatan / Mehdi Koushki / Marzieh Ashrafmansouri / Nayebali Ahmadi

Journal of Mazandaran University of Medical Sciences, Vol 31, Iss 204, Pp 49-

A Proteomic and Molecular Docking Approach

2022 Volume 61

Abstract: Background and purpose: Leishmaniasis is one of the most important infectious diseases caused by different species of the Leishmania, which is a public health problem worldwide. So far, no effective vaccine is introduced for this disease and drug therapy ...

Abstract	Background and purpose: Leishmaniasis is one of the most important infectious diseases caused by different species of the Leishmania, which is a public health problem worldwide. So far, no effective vaccine is introduced for this disease and drug therapy is associated with many side effects. Therefore, this study was designed to identify novel FDA-approved compounds with anti-leishmanial activity. Materials and methods: In this experimental study, proteomics, protein network analysis, and molecular docking were used. Protein profile was identified by LC-MS/MS and protein network analysis was performed using Cytoscape. Processing of the compound structure and molecular docking was performed by HyperChem and AutoDock Vina, respectively. Finally, docking results were interpreted by LigPlot+. Results: Based on proteomics and protein network analysis, glycosomal malate dehydrogenase was suggested as a potential drug target. Among the compounds, the best docking results were associated with Conivaptan and Avodart with a binding energy level of -10.5 and -10.2, respectively. Also, molecular docking studies showed that the most important bonds involved in drug-receptor binding were hydrogen and hydrophobic bonds. Conclusion: The current study demonstrated the importance of integrated proteomics, protein network and docking to identify novel compounds with anti-Leishmania properties. According to this study, Conivaptan and Avodart, also approved by the Food and Drug Administration, are effective inhibitors of glycosomal malate dehydrogenase in Leishmania major and Leishmania tropica which meanwhile require further in-vitro and in-vivo experiments.
Keywords	leishmania ; cutaneous leishmaniasis ; glycosomal malate dehydrogenase ; drug target ; molecular docking ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	540
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Mazandaran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: A quantitative proteomic and bioinformatics analysis of proteins in metacyclogenesis of Leishmania tropica.

Amiri-Dashatan, Nasrin / Rezaei-Tavirani, Mostafa / Ahmadi, Nayebali

Acta tropica

2019 Volume 202, Page(s) 105227

Abstract: Recently there has a growing interest in MS-based analysis on Leishmania for biology study, host-parasite interaction and drug target discovery. The aims of this study were to analyzed protein profiles in the procyclic and metacyclic stages of L. tropica, ...

Abstract	Recently there has a growing interest in MS-based analysis on Leishmania for biology study, host-parasite interaction and drug target discovery. The aims of this study were to analyzed protein profiles in the procyclic and metacyclic stages of L. tropica, and investigate their potential role in metacyclogenesis molecular mechanisms. Sequential window acquisition of all theoretical fragment ion spectra mass spectrometry (SWATH-MS) analysis was used to analyze protein profiles in each of procyclic and metacyclic stages. Proteins with a fold change>2 or <0.5 and p < 0.05 were considered to be significantly differentially expressed proteins (DEPs). The DEPs were subjected to gene ontology (GO), KEGG pathway and network analysis using PANTHER and STRING database, respectively. Quantitative real-time PCR of six selected genes validated the proteomic data. We quantified a total of 352 proteins in procyclic and metacyclic cells and 56 differentially expressed proteins (27 up/ 29down-regulated in metacyclic compared to procyclic). On the basis of biological processes in GO, the DEPs were primarily involved in ``metabolic process'' (GO: 0008152) and ``cellular process'' (GO: 0009987). In addition, several enriched GO terms were identified via molecular function, which among them ``catalytic activity'' (GO: 0003824) and ``binding'' (GO: 0005488) were disclosed as top category. The KEGG pathway analysis indicated ``metabolic pathways'' (p-value: 3.80E-08) including 17 genes term as the top pathway in DEPs. These findings bring a new insight in our understanding of the molecular characterization of metacyclogenesis and infective form in L. tropica. Comparative analysis of the proteome of both developmental stages of the L. tropica would help to the identification of proteins candidates for the development of new potential drug targets and vaccines.
MeSH term(s)	Computational Biology ; Leishmania tropica/metabolism ; Mass Spectrometry ; Proteome/analysis ; Proteomics/methods ; Protozoan Proteins/chemistry ; Protozoan Proteins/metabolism
Chemical Substances	Proteome ; Protozoan Proteins
Language	English
Publishing date	2019-10-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	210415-5
ISSN	1873-6254 ; 0001-706X
ISSN (online)	1873-6254
ISSN	0001-706X
DOI	10.1016/j.actatropica.2019.105227
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.136: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito