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  1. Article ; Online: MARBURGER, P., REINHARDT, M., SCHRÖDER, M.

    V. Brandl

    Technikfolgenabschätzung – Theorie und Praxis, Vol 8, Iss 3-

    Die Bewältigung von Langzeitrisiken im Umwelt- und Technikrecht

    1999  Volume 4

    Keywords Technology ; T ; Social Sciences ; H
    Language German
    Publishing date 1999-09-01T00:00:00Z
    Publisher Karlsruhe Institute of Technology, Institute for Technology Assessment and Systems Analysis (ITAS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Re article "Evaluation of limulus amebocyte lysate and recombinant endotoxin alternative assays for an assessment of endotoxin detection specificity", published in European Journal of Pharmaceutical Sciences 159 (2021) 105716.

    Brandl, Martin

    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

    2021  Volume 163, Page(s) 105877

    MeSH term(s) Animals ; Biological Assay ; Endotoxins ; Horseshoe Crabs ; Pharmaceutical Preparations
    Chemical Substances Endotoxins ; Pharmaceutical Preparations
    Language English
    Publishing date 2021-05-09
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 1154366-8
    ISSN 1879-0720 ; 0928-0987
    ISSN (online) 1879-0720
    ISSN 0928-0987
    DOI 10.1016/j.ejps.2021.105877
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  3. Article ; Online: Using molecularly dissolved drug concentrations in PBBMs improves the prediction of oral absorption from supersaturating formulations.

    Holzem, Florentin Lukas / Petrig Schaffland, Jeannine / Brandl, Martin / Bauer-Brandl, Annette / Stillhart, Cordula

    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

    2024  Volume 194, Page(s) 106703

    Abstract: Predicting the absorption of drugs from enabling formulations is still challenging due to the limited capabilities of standard physiologically based biopharmaceutics models (PBBMs) to capture complex absorption processes. Amongst others, it is often ... ...

    Abstract Predicting the absorption of drugs from enabling formulations is still challenging due to the limited capabilities of standard physiologically based biopharmaceutics models (PBBMs) to capture complex absorption processes. Amongst others, it is often assumed that both, molecularly and apparently dissolved drug in the gastrointestinal lumen are prone to absorption. A recently introduced method for measuring concentrations of molecularly dissolved drug in a dynamic in vitro dissolution setup using microdialysis has opened new opportunities to test this hypothesis and refine mechanistic PBBM approaches. In the present study, we compared results of PBBMs that used either molecularly or apparently dissolved concentrations in the simulated gastrointestinal lumen as input parameters. The in vitro dissolution data from three supersaturating formulations of Posaconazole (PCZ) were used as model input. The modeling outcome was verified using PCZ concentration vs. time profiles measured in human intestinal aspirates and in the blood plasma. When using apparently dissolved drug concentrations (i.e., the sum of colloid-associated and molecularly dissolved drug) the simulated systemic plasma exposures were overpredicted, most pronouncedly with the ASD-based tablet. However, if the concentrations of molecularly dissolved drug were used as input values, the PBBM resulted in accurate prediction of systemic exposures for all three PCZ formulations. The present study impressively demonstrated the value of considering molecularly dissolved drug concentrations as input value for PBBMs of supersaturating drug formulations.
    MeSH term(s) Humans ; Biopharmaceutics/methods ; Solubility ; Administration, Oral ; Colloids ; Intestinal Absorption/physiology ; Models, Biological
    Chemical Substances Colloids
    Language English
    Publishing date 2024-01-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1154366-8
    ISSN 1879-0720 ; 0928-0987
    ISSN (online) 1879-0720
    ISSN 0928-0987
    DOI 10.1016/j.ejps.2024.106703
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  4. Article ; Online: Blood-Brain Barrier Breakdown in Neuroinflammation: Current In Vitro Models.

    Brandl, Sarah / Reindl, Markus

    International journal of molecular sciences

    2023  Volume 24, Issue 16

    Abstract: The blood-brain barrier, which is formed by tightly interconnected microvascular endothelial cells, separates the brain from the peripheral circulation. Together with other central nervous system-resident cell types, including pericytes and astrocytes, ... ...

    Abstract The blood-brain barrier, which is formed by tightly interconnected microvascular endothelial cells, separates the brain from the peripheral circulation. Together with other central nervous system-resident cell types, including pericytes and astrocytes, the blood-brain barrier forms the neurovascular unit. Upon neuroinflammation, this barrier becomes leaky, allowing molecules and cells to enter the brain and to potentially harm the tissue of the central nervous system. Despite the significance of animal models in research, they may not always adequately reflect human pathophysiology. Therefore, human models are needed. This review will provide an overview of the blood-brain barrier in terms of both health and disease. It will describe all key elements of the in vitro models and will explore how different compositions can be utilized to effectively model a variety of neuroinflammatory conditions. Furthermore, it will explore the existing types of models that are used in basic research to study the respective pathologies thus far.
    MeSH term(s) Animals ; Humans ; Blood-Brain Barrier ; Endothelial Cells ; Neuroinflammatory Diseases ; Brain ; Central Nervous System
    Language English
    Publishing date 2023-08-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241612699
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  5. Article ; Online: An Electrochemical Aptasensor for the Detection of Freshwater Cyanobacteria.

    Pham, Mai-Lan / Maghsoomi, Somayeh / Brandl, Martin

    Biosensors

    2024  Volume 14, Issue 1

    Abstract: ... ...

    Abstract Aphanizomenon
    MeSH term(s) Cyanobacteria ; Cyanobacteria Toxins ; Electrodes ; Fresh Water ; Limit of Detection ; Oligonucleotides
    Chemical Substances Cyanobacteria Toxins ; Oligonucleotides
    Language English
    Publishing date 2024-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios14010028
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  6. Article ; Online: Therapeutic approaches of diametaphyseal radius fractures in children.

    Stark, D / Denzinger, M / Ebert, L / Brandl, R / Knorr, C

    Archives of orthopaedic and trauma surgery

    2024  Volume 144, Issue 3, Page(s) 1179–1188

    Abstract: Background: There are clear standards for when to operate on both distal epiphyseal and diaphyseal forearm fractures in children. However, paediatric surgeons are often faced with fractures in the transition zone between metaphysis and diaphysis. This ... ...

    Abstract Background: There are clear standards for when to operate on both distal epiphyseal and diaphyseal forearm fractures in children. However, paediatric surgeons are often faced with fractures in the transition zone between metaphysis and diaphysis. This aim of the study is to compare different treatment approaches for diametaphyseal forearm fractures, to classify different types of these fractures, and to define further assessment parameters and treatment recommendations.
    Methods: This retrospective study included all patients with diametaphyseal radial fractures who were seen at a paediatric surgery clinic between 01.01.2010 and 31.12.2013. Patients were treated either non-surgically (C) or surgically using bicortical Kirschner wire (BC-KW), intramedullary K-wire (IM-KW), elastic stable intramedullary nailing (ESIN), or combined bicortical and intramedullary K-wire (BCIM-KW).
    Results: During the study period, 547 patients presented with forearm fractures of which 88 patients (16%) had a fracture in the diametaphyseal region. The majority of diametaphyseal fractures were greenstick fractures (54.4%) followed by transverse fractures (44.3%). Distal fractures were predominantly treated with bicortical K-wiring (BC-KW, 40.5%) or non-surgically (C, 26.2%). Proximal fractures were treated by ESIN osteosynthesis (50%), followed by IM-KW (30%). Intermediate fractures were just as likely to be treated with one out of the 5 above-mentioned techniques. The ulna was involved in 64 of 88 cases. Depending on the type of fracture, it was treated either by ESIN osteosynthesis or non-surgically. No superior operative technique was identified.
    Conclusions: The description of diametaphyseal fractures as a separate entity is important, because the therapy of these fractures is heterogeneous and challenging. A classification into proximal, intermediate, and distal may be useful in clinical decision-making. Despite the retrospective nature of this study, our data suggest that the use of a K-wire or combined technique BCIM-KW-technique, whenever technically feasible, achieves better radiological results without secondary dislocation. Further prospective studies are needed to provide better guidance to trauma surgeons.
    MeSH term(s) Child ; Humans ; Retrospective Studies ; Radius Fractures/diagnostic imaging ; Radius Fractures/surgery ; Radius ; Forearm Injuries/complications ; Forearm Injuries/surgery ; Fracture Fixation, Internal ; Fracture Fixation, Intramedullary/adverse effects ; Treatment Outcome ; Bone Nails
    Language English
    Publishing date 2024-01-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80407-1
    ISSN 1434-3916 ; 0003-9330 ; 0344-8444
    ISSN (online) 1434-3916
    ISSN 0003-9330 ; 0344-8444
    DOI 10.1007/s00402-023-05118-z
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  7. Article ; Online: Hydrogenated phospholipid, a promising excipient in amorphous solid dispersions of fenofibrate for oral delivery: Preparation and in-vitro biopharmaceutical characterization.

    Czajkowski, Mikołaj / Jacobsen, Ann-Christin / Bauer-Brandl, Annette / Brandl, Martin / Skupin-Mrugalska, Paulina

    International journal of pharmaceutics

    2023  Volume 644, Page(s) 123294

    Abstract: ... as the model drug. FEN, incorporated within ASDs by melting or freeze-drying (up to 20% m/m), stayed amorphous ...

    Abstract Amorphous solid dispersions (ASD) represent a viable formulation strategy to improve dissolution and bioavailability of poorly soluble drugs. Our study aimed to evaluate the feasibility and potential role of hydrogenated phospholipid (HPL) as a matrix material and solubilizing additive for binary (alone) or ternary (in combination with polymers) solid dispersions, using fenofibrate (FEN) as the model drug. FEN, incorporated within ASDs by melting or freeze-drying (up to 20% m/m), stayed amorphous during short-term stability studies. The solubility enhancing potential of HPL depended on the dissolution medium. In terms of enhancing in vitro permeation, solid dispersions with HPL were found equally or slightly more potent as compared to the polymer-based ASD. For studied ASD, in vitro permeation was found substantially enhanced as compared to a suspension of crystalline FEN and at least equal compared to marketed formulations under comparable conditions (literature data). Additionally, while the permeation of neat FEN and FEN in binary solid dispersions was affected by the dissolution medium (i.e., the "prandial state"), for ternary solid dispersions the permeation was independent of the "prandial state" (FaSSIF = FeSSIF). This suggests that ternary solid dispersions containing both polymer and HPL may represent a viable formulation strategy to mitigate fenofibrate's food effect.
    MeSH term(s) Fenofibrate/chemistry ; Excipients ; Biological Products ; Phospholipids ; Polymers/chemistry ; Pharmaceutical Preparations ; Solubility
    Chemical Substances Fenofibrate (U202363UOS) ; Excipients ; Biological Products ; Phospholipids ; Polymers ; Pharmaceutical Preparations
    Language English
    Publishing date 2023-08-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2023.123294
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  8. Book ; Thesis: Der Einfluss von Dapiprazolhydrochlorid (Remydrial, Augentropfen) auf die Rückbildung medikamentös induzierter Mydriasis durch Tropicamid und seine Auswirkungen auf Fahr- und Flugtauglichkeit

    Brandl, Michaela

    2003  

    Author's details vorgelegt von Michaela Brandl
    Language German
    Size II, 57 Bl. : Ill., graph. Darst., 21 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis München, Univ., Diss., 2003
    HBZ-ID HT013808068
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2003 D 1712 order for loan Magazin

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  9. Article: Keratitis solaris – Prävention, Diagnostik und Therapie der UV-bedingten Augenerkrankung

    Brandl, Michaela

    Flugmedizin · Tropenmedizin · Reisemedizin - FTR

    2020  Volume 27, Issue 01, Page(s) 10–13

    Abstract: UV-Strahlung ist ein großes Risiko für Augenschäden. Die Erkrankung Keratitis solaris, auch bekannt als „Schneeblindheit“ oder Keratitis photoelectrica, wird in diesem Beitrag vorgestellt. Sie lässt sich behandeln, kann jedoch starke Schmerzen ... ...

    Abstract UV-Strahlung ist ein großes Risiko für Augenschäden. Die Erkrankung Keratitis solaris, auch bekannt als „Schneeblindheit“ oder Keratitis photoelectrica, wird in diesem Beitrag vorgestellt. Sie lässt sich behandeln, kann jedoch starke Schmerzen verursachen und Erkrankte durch eingeschränkte Sicht in gefährliche Situationen bringen. Fester Bestandteil jeder Tour sollte deshalb eine geeignete Sonnenbrille sein, die auch weitere UV-bedingte Augenerkrankungen verhindern kann.
    Keywords UV radiation ; eye damage ; keratitis solaris ; sunglasses
    Language German
    Publishing date 2020-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2277004-5
    ISSN 1864-175X ; 1864-4538
    ISSN (online) 1864-175X
    ISSN 1864-4538
    DOI 10.1055/a-1079-8362
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  10. Article ; Online: Insight into the mechanism behind oral bioavailability-enhancement by nanosuspensions through combined dissolution/permeation studies.

    Lynnerup, Jakob Tobias / Eriksen, Jonas Borregaard / Bauer-Brandl, Annette / Holsæter, Ann Mari / Brandl, Martin

    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

    2023  Volume 184, Page(s) 106417

    Abstract: As numerous new drug candidates are poorly water soluble, enabling formulations are needed to increase their bioavailability for oral administration. Nanoparticles are a conceptually simple, yet resource consuming strategy for increasing drug dissolution ...

    Abstract As numerous new drug candidates are poorly water soluble, enabling formulations are needed to increase their bioavailability for oral administration. Nanoparticles are a conceptually simple, yet resource consuming strategy for increasing drug dissolution rate, as predicting in vivo oral absorption using in vitro dissolution remains difficult. The objective of this study was to obtain insight into nanoparticle characteristics and performance utilizing an in vitro combined dissolution/permeation setup. Two examples of poorly soluble drugs were examined (cinnarizine and fenofibrate). Nanosuspensions were produced by top-down wet bead milling using dual asymmetric centrifugation, obtaining particle diameters of approx. 300 nm. DSC and XRPD studies indicated that nanocrystals of both drugs were present with retained crystallinity, however with some disturbances. Equilibrium solubility studies showed no significant increase in drug solubility over the nanoparticles, as compared to the raw APIs. Combined dissolution/permeation experiments revealed significantly increased dissolution rates for both compounds compared to the raw APIs. However, there were substantial differences between the dissolution curves of the nanoparticles as fenofibrate exhibited supersaturation followed by precipitation, whereas cinnarizine did not exhibit any supersaturation, but instead a shift towards faster dissolution rate. Permeation rates were found significantly increased for both nanosuspensions when compared to the raw APIs, indicating a direct implication that formulation strategies are needed, be it stabilization of supersaturation by precipitation inhibition and/or dissolution rate enhancement. This study indicates that in vitro dissolution/permeation studies can be employed to better understand the oral absorption enhancement of nanocrystal formulations.
    MeSH term(s) Administration, Oral ; Biological Availability ; Cinnarizine/administration & dosage ; Cinnarizine/chemistry ; Fenofibrate/administration & dosage ; Fenofibrate/chemistry ; Nanoparticles/administration & dosage ; Nanoparticles/chemistry ; Particle Size ; Pharmaceutical Preparations ; Solubility
    Chemical Substances Cinnarizine (3DI2E1X18L) ; Fenofibrate (U202363UOS) ; Pharmaceutical Preparations
    Language English
    Publishing date 2023-03-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1154366-8
    ISSN 1879-0720 ; 0928-0987
    ISSN (online) 1879-0720
    ISSN 0928-0987
    DOI 10.1016/j.ejps.2023.106417
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