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  1. Article: Jiang Tang Xiao Ke Granule, a Classic Chinese Herbal Formula, Improves the Effect of Metformin on Lipid and Glucose Metabolism in Diabetic Mice.

    Zhang, Yi / An, Hong / Pan, Si-Yuan / Zhao, Dan-Dan / Zuo, Jia-Cheng / Li, Xiao-Ke / Gao, Ya / Mu, Qian-Qian / Yu, Na / Ma, Yue / Mo, Fang-Fang / Gao, Si-Hua

    Evidence-based complementary and alternative medicine : eCAM

    2016  Volume 2016, Page(s) 1592731

    Abstract: ... combined with Jiang Tang Xiao Ke (JTXK) granule derived from the "Di Huang Tang" were evaluated in mice ...

    Abstract In the present study, the hypoglycemic, hypolipidemic, and antioxidative effects of metformin (MET) combined with Jiang Tang Xiao Ke (JTXK) granule derived from the "Di Huang Tang" were evaluated in mice with type 2 diabetes mellitus (DM) induced by high-fat diet/streptozotocin. DM mice were orally treated with MET (0.19 g/kg) either alone or combined with different doses (1.75, 3.5, or 7 g/kg) of JTXK for 4 weeks. Results showed that the serum and hepatic glucose, lipids, and oxidative stress levels were elevated in DM mice, when compared with the normal mice. MET treatment decreased FBG and serum glucagon levels of DM mice. Combination treatment with MET and JTXK 3.5 g/kg increased the hypoglycemia and insulin sensitivity at 4 weeks when compared with the DM mice treated with MET alone. However, neither MET nor MET/JTXK treatment could completely reverse the hyperglycemia in DM mice. JTXK enhanced the serum triglyceride (TG) and hepatic lipid-lowering effect of MET in a dose-dependent manner in DM mice. JTXK 1.75 and 3.5 g/kg improved the hepatoprotective effect of MET in DM mice. Synergistic effect of combination treatment with MET and JTXK on antioxidant stress was also found in DM mice compared with MET alone.
    Language English
    Publishing date 2016-06-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2016/1592731
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
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  2. Article ; Online: Network Pharmacology Analysis of Traditional Chinese Medicine Formula Xiao Ke Yin Shui Treating Type 2 Diabetes Mellitus

    Jiewen Zhou / Qiuyan Wang / Zhinan Xiang / Qilin Tong / Jun Pan / Luosheng Wan / Jiachun Chen

    Evidence-Based Complementary and Alternative Medicine, Vol

    2019  Volume 2019

    Abstract: Xiao Ke Yin Shui (XKYS) formula is a traditional Chinese medicine formula treating type 2 ...

    Abstract Xiao Ke Yin Shui (XKYS) formula is a traditional Chinese medicine formula treating type 2 diabetes mellitus (T2DM). XKYS formula consists of four herbs, i.e., Coptidis rhizoma, Liriopes radix, bitter melon, and Cassiae semen. Herein, the chemical profiles of four herb extracts were investigated, and further analysis of the underlying mechanism of XKYS formula treating T2DM was performed using network pharmacology. The main components were selected for our network-based research. Targets of XKYS formula were mainly collected from two databases, SwissTargetPrediction and Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), and the text-mining method was also implemented. T2DM relating genes and therapeutic targets were collected from five databases. Subsequently, STRING and Cytoscape were employed for the analysis of protein-protein interaction (PPI) networks. Functional annotation and pathway analysis were conducted to investigate the functions and relating pathways of target genes. The content of 12 compounds in the herb extracts was determined. With the analysis of PPI networks, a total of 76 genes were found to be important nodes and could be defined as the main target genes regulated by XKYS formula in the treatment of T2DM and its complications. Components in XKYS formula mainly regulate proteins including protein kinase B (Akt), phosphatidylinositol 3-kinase (PI3K), insulin receptor substrate (IRS), and tumor necrosis factor (TNF). XKYS formula exerts therapeutic effects in a synergetic manner and exhibits antidiabetic effect mainly via reducing insulin resistance. These findings could be guidelines in the further investigation of this formula.
    Keywords Other systems of medicine ; RZ201-999
    Subject code 572
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  3. Article ; Online: Jiang Tang Xiao Ke Granule, a Classic Chinese Herbal Formula, Improves the Effect of Metformin on Lipid and Glucose Metabolism in Diabetic Mice

    Yi Zhang / Hong An / Si-Yuan Pan / Dan-Dan Zhao / Jia-Cheng Zuo / Xiao-Ke Li / Ya Gao / Qian-Qian Mu / Na Yu / Yue Ma / Fang-Fang Mo / Si-Hua Gao

    Evidence-Based Complementary and Alternative Medicine, Vol

    2016  Volume 2016

    Abstract: ... combined with Jiang Tang Xiao Ke (JTXK) granule derived from the “Di Huang Tang” were evaluated in mice ...

    Abstract In the present study, the hypoglycemic, hypolipidemic, and antioxidative effects of metformin (MET) combined with Jiang Tang Xiao Ke (JTXK) granule derived from the “Di Huang Tang” were evaluated in mice with type 2 diabetes mellitus (DM) induced by high-fat diet/streptozotocin. DM mice were orally treated with MET (0.19 g/kg) either alone or combined with different doses (1.75, 3.5, or 7 g/kg) of JTXK for 4 weeks. Results showed that the serum and hepatic glucose, lipids, and oxidative stress levels were elevated in DM mice, when compared with the normal mice. MET treatment decreased FBG and serum glucagon levels of DM mice. Combination treatment with MET and JTXK 3.5 g/kg increased the hypoglycemia and insulin sensitivity at 4 weeks when compared with the DM mice treated with MET alone. However, neither MET nor MET/JTXK treatment could completely reverse the hyperglycemia in DM mice. JTXK enhanced the serum triglyceride (TG) and hepatic lipid-lowering effect of MET in a dose-dependent manner in DM mice. JTXK 1.75 and 3.5 g/kg improved the hepatoprotective effect of MET in DM mice. Synergistic effect of combination treatment with MET and JTXK on antioxidant stress was also found in DM mice compared with MET alone.
    Keywords Other systems of medicine ; RZ201-999
    Subject code 630
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  4. Article: Jiang Tang Xiao Ke Granule Play an Anti-diabetic Role in Diabetic Mice Pancreatic Tissue by Regulating the mRNAs and MicroRNAs Associated with PI3K-Akt Signaling Pathway.

    Mo, Fang-Fang / An, Tian / Zhang, Zi-Jian / Liu, Yu-Fei / Liu, Hai-Xia / Pan, Yan-Yun / Miao, Jia-Nan / Zhao, Dan-Dan / Yang, Xiu-Yan / Zhang, Dong-Wei / Jiang, Guang-Jian / Gao, Si-Hua

    Frontiers in pharmacology

    2017  Volume 8, Page(s) 795

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2017-11-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2017.00795
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Xin bian ma ke si zhu yi wen yi xue

    Pan, Tianqiang

    Marxist literary theory : A new course

    (Fu dan bo xue wen xue xi lie ; 复旦博学文学系列)

    2005  

    Author's details Pan tian qiang zhu bian
    Series title Fu dan bo xue wen xue xi lie
    复旦博学文学系列
    Language Chinese
    Size 4, 8, 358 S, Ill
    Edition Di 1 ban
    Publisher Fu dan da xue chu ban she
    Publishing place Shang hai
    Document type Book
    ISBN 7309043405 ; 9787309043402
    Database Former special subject collection: coastal and deep sea fishing

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    Inter-library loan at ZB MED

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  6. Book: Xiu ke

    Pan, Shicheng

    (Bing li sheng li xue cong shu)

    1982  

    Author's details Pan Shicheng, Luo Zhengyao zhu bian ; Ma Enqing ... [et al.] bian xie
    Series title Bing li sheng li xue cong shu
    MeSH term(s) Shock
    Language Chinese
    Size 2, 554 p. :, ill.
    Edition Di 1 ban.
    Publisher Ren min wei sheng chu ban she : Xin hua shu dian Beijing fa xing suo fa xing
    Publishing place Beijing Shi
    Document type Book
    Database Catalogue of the US National Library of Medicine (NLM)

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  7. Book: Shang hai fo jiao bei ke wen xian ji

    Chai, Zhiguang / Pan, Mingquan

    2004  

    Author's details Chai zhi guang, pan ming quan zhu bian
    Keywords Buddhist inscriptions ; Historical markers ; Shanghai (China)
    Language Chinese
    Size 2, 3, 2, 16, 316 p. [8] p. of plates, col. ill, 21 cm
    Edition Di 1 ban
    Publisher Shang hai gu ji chu ban she
    Publishing place Shang hai
    Document type Book
    ISBN 7532536327 ; 9787532536320
    Database Former special subject collection: coastal and deep sea fishing

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    Order via subito

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    Inter-library loan at ZB MED

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  8. Book: Ke ji Han yu jiao cheng

    Pan, Zushou / 潘, 祖绶 / Zheng, Yu / Huang, Weiping / Chu, Fuzhang

    : zhong ji yue du ke ben

    1991  

    Title variant Scientific Chinese : Middle Level Extensive Reading ; Volume II
    Language Chinese ; English
    Size 137 S., Ill.
    Edition Di 1 ban
    Publisher Tianjin da xue chu ban she
    Publishing place Tianjin
    Document type Book
    ISBN 756180234X ; 9787561802342
    Database Former special subject collection: coastal and deep sea fishing

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    Inter-library loan at ZB MED

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  9. Book: Xin xue guan wai ke jin zhan

    Pan, Zhi

    1983  

    Author's details zhu bian Pan Zhi ; bian xie ren yuan Fang Rongbao ... [et al.]
    MeSH term(s) Cardiovascular Surgical Procedures
    Language Chinese
    Size 5, 224 p. :, ill.
    Publisher Ren min wei sheng chu ban she : Xin hua shu dian Beijing fa xing suo fa xing
    Publishing place Beijing Shi
    Document type Book
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Article: [Developments in Research on the Relationship Between

    Zhang, Ke-Ke / Sun, Yan / Pan, Yi-Huai

    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

    2023  Volume 54, Issue 1, Page(s) 20–26

    Abstract: Porphyromonas ... ...

    Abstract Porphyromonas gingivalis
    MeSH term(s) Humans ; Porphyromonas gingivalis/genetics ; Arthritis, Rheumatoid
    Language Chinese
    Publishing date 2023-01-16
    Publishing country China
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 2106840-9
    ISSN 1672-173X
    ISSN 1672-173X
    DOI 10.12182/20230160509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2708: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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