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Article: Validation of the Anticolitis Efficacy of the Jian-Wei-Yu-Yang Formula.

Yan, Jing / Tang, Yan / Yu, Wei / Jiang, Lu / Liu, Chen / Li, Qi / Zhang, Zhiqiang / Shao, Changlei / Zheng, Yang / Liu, Xihao / Liu, Xincheng

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 9110704

Abstract: ... to its repetitive remission and relapse. The Jian-Wei-Yu-Yang (JW) formula has a historical application ...

Abstract	Background: Inflammatory bowel disease (IBD) is a major cause of morbidity and mortality due to its repetitive remission and relapse. The Jian-Wei-Yu-Yang (JW) formula has a historical application in the clinic to combat gastrointestinal disorders. The investigation aimed to explore the molecular and cellular mechanisms of JW. Methods: 2% dextran sodium sulfate (DSS) was diluted in drinking water and given to mice for 5 days to establish murine models of experimental colitis, and different doses of JW solution were administered for 14 days. Network pharmacology analysis and weighted gene co-expression network analysis (WGCNA) were utilized to predict the therapeutic role of JW against experimental colitis and colitis-associated colorectal cancer (CAC). 16S rRNA sequencing and untargeted metabolomics were conducted using murine feces. Western blotting, immunocytochemistry, and wound healing experiments were performed to confirm the molecular mechanisms. Results: (1) Liquid chromatography with mass spectrometry was utilized to confirm the validity of the JW formula. The high dose of JW treatment markedly attenuated DSS-induced experimental colitis progression, and the targets were enriched in inflammation, infection, and tumorigenesis. (2) The JW targets were related to the survival probability in patients with colorectal cancer, underlying a potential therapeutic value in CRC intervention. (3) Moreover, the JW therapy successfully rescued the decreased richness and diversity of microbiota, suppressed the potentially pathogenic phenotype of the gut microorganisms, and increased cytochrome P450 activity in murine colitis models. (4) Our Conclusion: The JW capsule attenuated the progression of murine colitis by a prompt resolution of inflammation and bloody stool and by re-establishing a microbiome profile that favors re-epithelization and prevents carcinogenesis.
Language	English
Publishing date	2022-08-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/9110704
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Article ; Online: San-wei-tan-xiang capsule attenuates atherosclerosis by increasing lysosomal activity in adipose tissue macrophages.

Ye, Heng / Wang, Gang / Wang, Xuchao / Wang, Lin / Ni, Wei / Chen, Linjian / Zhu, Yifan / Zhao, Longshan / Xiong, Zhili / Wang, Yan / Dai, Cuilian / Liu, Binbin

Journal of ethnopharmacology

2023 Volume 312, Page(s) 116444

Abstract: ... of lipids and regulation of macrophage cholesterol efflux (MCE). San-wei-tan-xiang (SWTX) capsule ...

Abstract	Ethnopharmacological relevance: Dyslipidemia is the leading risk factor of atherosclerosis (AS). Adipose tissue macrophages (ATMs) can regulate postprandial cholesterol levels via uptake and hydrolyzation of lipids and regulation of macrophage cholesterol efflux (MCE). San-wei-tan-xiang (SWTX) capsule, a Traditional Chinese medicine, exerts clinical benefits in patients with atherosclerotic cardiovascular diseases. Aim of the study: This work is aimed to evaluate the chemical ingredients and mechanisms of SWTX in anti-AS. Materials and methods: The chemical ingredients of SWTX identified by liquid chromatography coupled with tandem mass spectrometry were used for network pharmacological analysis. The atheroprotective function of SWTX was evaluated in ApoE Results: The chemical ingredients identified in SWTX were predicated to be important for lipid metabolism and AS. Animals studies suggested that SWTX effectively attenuated the atherosclerotic plaque growth, elevated postprandial HDL cholesterol levels, elevated the proportion of Tim4 and CD36-expressed ATMs, and upregulated the uptake of lipid and lysosomal activity in ATMs. SWTX-induced elevation of postprandial HDL cholesterol levels was dependent on increased lysosomal activity, since chloroquine, an inhibitor of lysosomal function, blocked the effect of SWTX. Lastly, some predicated bioactive compounds in SWTX can elevate lysosomal activity in vitro. Conclusion: SWTX could attenuate atherosclerotic plaque formation by elevating lysosomal activity and enhancing MCE in ATMs.
MeSH term(s)	Mice ; Animals ; Plaque, Atherosclerotic/metabolism ; Cholesterol, HDL ; Atherosclerosis/drug therapy ; Atherosclerosis/prevention & control ; Atherosclerosis/etiology ; Macrophages ; Cholesterol/metabolism ; Lysosomes/metabolism ; Apolipoproteins E
Chemical Substances	Cholesterol, HDL ; Cholesterol (97C5T2UQ7J) ; Apolipoproteins E
Language	English
Publishing date	2023-04-13
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116444
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Article ; Online: Optimized Extraction, Identification and Anti-Biofilm Action of Wu Wei Zi (

Zhang, Zongyi / Zhao, Yanan / Cai, Jing / Wang, Tong / Song, Yujie / Lu, Jingyi / Du, Hairuo / Wang, Wenfang / Zhao, Yan / Guo, Lei

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 5

Abstract: The pathogenicity of ... ...

Abstract	The pathogenicity of foodborne
MeSH term(s)	Vibrio parahaemolyticus/genetics ; Schisandra ; Biofilms
Chemical Substances	schizandrol B (58546-54-6) ; schizandrer A (82042-38-4) ; schizandrin C (C8754W6B3G)
Language	English
Publishing date	2023-02-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28052268
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Article: The Cao-Xiang-Wei-Kang formula attenuates the progression of experimental colitis by restoring the homeostasis of the microbiome and suppressing inflammation.

Yu, Wei / Li, Qi / Shao, Changlei / Zhang, Yijia / Kang, Cai / Zheng, Yang / Liu, Xihao / Liu, Xincheng / Yan, Jing

Frontiers in pharmacology

2022 Volume 13, Page(s) 946065

Abstract: ... Xiang-Wei-Kang (CW) formula has been utilized to treat gastrointestinal disorders in the clinic ...

Abstract	Inflammatory bowel disease (IBD) is pathologically characterized by an immune response accommodative insufficiency and dysbiosis accompanied by persistent epithelial barrier dysfunction. The Cao-Xiang-Wei-Kang (CW) formula has been utilized to treat gastrointestinal disorders in the clinic. The present study was designed to delineate the pharmacological mechanisms of this formula from different aspects of the etiology of ulcerative colitis (UC), a major subtype of IBD. Dextran sodium sulfate (DSS) was given to mice for a week at a concentration of 2%, and the CW solution was administered for 3 weeks. 16S rRNA gene sequencing and untargeted metabolomics were conducted to examine the changes in the microbiome profile, and biochemical experiments were performed to confirm the therapeutic functions predicted by system pharmacology analysis. The CW treatment hampered DSS-induced experimental colitis progression, and the targets were enriched in inflammation, infection, and tumorigenesis, which was corroborated by suppressed caspase 3 (Casp3) and interleukin-1b (IL-1b) and increased cleaved caspase 3 expression and casp-3 activity in the colon samples from colitis mice subjected to the CW therapy. Moreover, the CW therapy rescued the decreased richness and diversity, suppressed the potentially pathogenic phenotype of the gut microorganisms, and reversed the altered linoleic acid metabolism and cytochrome P450 activity in murine colitis models. In our
Language	English
Publishing date	2022-09-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.946065
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Article ; Online: San-wei-tan-xiang capsule attenuates atherosclerosis by increasing lysosomal activity in adipose tissue macrophages

Ye, Heng / Wang, Gang / Wang, Xuchao / Wang, Lin / Ni, Wei / Chen, Linjian / Zhu, Yifan / Zhao, Longshan / Xiong, Zhili / Wang, Yan / Dai, Cuilian / Liu, Binbin

Journal of Ethnopharmacology. 2023 Aug., v. 312 p.116444-

2023

Abstract: ... of macrophage cholesterol efflux (MCE). San-wei-tan-xiang (SWTX) capsule, a Traditional Chinese medicine, exerts ...

Abstract	Dyslipidemia is the leading risk factor of atherosclerosis (AS). Adipose tissue macrophages (ATMs) can regulate postprandial cholesterol levels via uptake and hydrolyzation of lipids and regulation of macrophage cholesterol efflux (MCE). San-wei-tan-xiang (SWTX) capsule, a Traditional Chinese medicine, exerts clinical benefits in patients with atherosclerotic cardiovascular diseases. This work is aimed to evaluate the chemical ingredients and mechanisms of SWTX in anti-AS. The chemical ingredients of SWTX identified by liquid chromatography coupled with tandem mass spectrometry were used for network pharmacological analysis. The atheroprotective function of SWTX was evaluated in ApoE⁻/⁻ mice fed a cholesterol-enriched diet. The chemical ingredients identified in SWTX were predicated to be important for lipid metabolism and AS. Animals studies suggested that SWTX effectively attenuated the atherosclerotic plaque growth, elevated postprandial HDL cholesterol levels, elevated the proportion of Tim4 and CD36-expressed ATMs, and upregulated the uptake of lipid and lysosomal activity in ATMs. SWTX-induced elevation of postprandial HDL cholesterol levels was dependent on increased lysosomal activity, since chloroquine, an inhibitor of lysosomal function, blocked the effect of SWTX. Lastly, some predicated bioactive compounds in SWTX can elevate lysosomal activity in vitro. SWTX could attenuate atherosclerotic plaque formation by elevating lysosomal activity and enhancing MCE in ATMs.
Keywords	Oriental traditional medicine ; adipose tissue ; atherosclerosis ; chloroquine ; diet ; high density lipoprotein cholesterol ; hyperlipidemia ; lipid metabolism ; liquid chromatography ; macrophages ; risk factors ; tandem mass spectrometry ; Adipose tissue macrophage ; Lysosomal activity ; Postprandial cholesterol level ; San-wei-tan-xiang capsule
Language	English
Dates of publication	2023-08
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116444
Database	NAL-Catalogue (AGRICOLA)

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Article: [Clinical Study of San Wei Sheng Huo Decoction in the Treatment of Refractory Chemotherapy-Induced Thrombocytopenia].

Li, Ru / Xiong, Shao-Quan / He, Li-Fang / Wu, Guo-Yu / Yuan, Yan-Wen

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

2023 Volume 54, Issue 1, Page(s) 161–164

Abstract: ... thrombocytopenia (RCIT) with San Wei Sheng Huo Decoction (SWSHD) as the main formula.: Methods ...

Abstract	Objective: To investigate the efficacy and safety of treating refractory chemotherapy-induced thrombocytopenia (RCIT) with San Wei Sheng Huo Decoction (SWSHD) as the main formula. Methods: A retrospective study was conducted and the data of RCIT patients treated with SWSHD as the main formula were collected. Changes in peripheral blood platelet (PLT) levels at different time points of treatment were examined and the significant effective rate (SER) and effective rate (ER) were analyzed. We measured the increase in peripheral blood PLT count before and after treatment, analyzed the differences in PLT count increase for different degrees of RCIT treatment, and evaluated the safety of the treatment. Results: A total of 35 cases of RCIT were included in the study. With SWSHD as the main treatment formula, the 2-week ER and SER were 74.29% and 14.29%, respectively, the 2-month ER and SER were 84.38% and 60.50, respectively, and the 1-year ER and SER were 92.31% and 80.77%, respectively. PLT count increased at all time points after treatment compared with that before treatment ( Conclusion: SWSHD takes effect rapidly and its effect is long-lasting and stable. Furthermore, SWSHD has a more significant effect on severe RCIT.
MeSH term(s)	Humans ; Retrospective Studies ; Thrombocytopenia/chemically induced ; Thrombocytopenia/drug therapy ; Platelet Count ; Blood Platelets ; Antineoplastic Agents/adverse effects
Chemical Substances	Antineoplastic Agents
Language	Chinese
Publishing date	2023-01-16
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2106840-9
ISSN	1672-173X
ISSN	1672-173X
DOI	10.12182/20230160506
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Article: Jia-Wei-Si-Miao-Yong-An decoction modulates intestinal flora and metabolites in acute coronary syndrome model.

Zhao, Ning / Wang, Ying / Ma, Yan / Liang, Xiaoxue / Zhang, Xi / Gao, Yuan / Dong, Yingying / Bai, Dong / Hu, Jingqing

Frontiers in cardiovascular medicine

2023 Volume 9, Page(s) 1038273

Abstract: Aims: We assessed the efficacy of the traditional Chinese medicine formulation Jia-Wei-Si-Miao ...

Abstract	Aims: We assessed the efficacy of the traditional Chinese medicine formulation Jia-Wei-Si-Miao-Yong-An decoction (HJ11) in the treatment of acute coronary syndrome and evaluated its impact on the intestinal microbiota and their metabolites. Methods: An acute coronary syndrome model was established in rats, which were randomly assigned to the model, HJ11 treatment, and atorvastatin treatment groups. Rats were then administered saline solution (model and sham operation control groups) or drugs by oral gavage for 28 d. Echocardiography was performed and serum creatine kinase-MB and cardiac troponin I levels were monitored to examine the cardiac function. Inflammation was evaluated using hematoxylin and eosin staining of heart tissue, and serum interleukin-2, interleukin-6, tumor necrosis factor alpha, and high-sensitivity C-reactive protein measurements. Gut microbiota composition was analyzed Results: HJ11 improved cardiac function and attenuated inflammation in rats with acute coronary syndrome. Relative to the untreated model group, the HJ11-treated group presented normalized Firmicutes/Bacteroidetes ratio and reduced abundances of the bacterial genera Conclusion: This work demonstrated that HJ11 effectively treats acute coronary syndrome. HJ11 seems to increase the abundance of beneficial bacterial taxa (
Language	English
Publishing date	2023-01-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.1038273
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Article ; Online: Asicimbex Yan, Deng & Wei, a new genus with eight new species and four new combinations (Hymenoptera, Cimbicidae)

Yan, Yu-Chen / Yan, Wen-Long / Deng, Tie-Jun / Wei, Mei-Cai

Journal of Hymenoptera Research. 2022 June 30, v. 91 p.265-308

2022

Abstract: ... Asicimbex Yan, Deng & Wei gen. nov., A. concavicaputus Yan & Wei sp. nov., A. dengi Yan & Wei sp. nov ... A. koreanus Yan & Wei sp. nov., A. lii Yan & Wei sp. nov., A. latistriatus Yan, Deng & Wei sp. nov ... A. maculotegularis Yan & Wei sp. nov., A. nanjingensis Yan & Wei sp. nov. and A. shengi Yan & Wei sp. nov. Four new ...

Abstract	AbstractA new genus and eight new species of Cimbicinae from the East Asia are described: Asicimbex Yan, Deng & Wei gen. nov., A. concavicaputus Yan & Wei sp. nov., A. dengi Yan & Wei sp. nov., A. koreanus Yan & Wei sp. nov., A. lii Yan & Wei sp. nov., A. latistriatus Yan, Deng & Wei sp. nov., A. maculotegularis Yan & Wei sp. nov., A. nanjingensis Yan & Wei sp. nov. and A. shengi Yan & Wei sp. nov. Four new combinations are proposed: A. eous (Semenov, 1935) comb. nov., A. elminus (Li & Wu, 2003) comb. nov., A. ulmusvorus (Yang, 1996) comb. nov. and A. malaisei (Gussakovskij, 1947) comb. nov., all from Agenocimbex. The 12 known species of Asicimbex are separated into two species groups. Asicimbex stands between Agenocimbex Rohwer 1910 and Cimbex Olivier 1791. The differences between Asicimbex and Cimbex, Asicimbex and Palaeocimbex are discussed in detail. Descriptions, remarks, illustrations, a key to the known species of Asicimbex and a key to genera of Cimbicinae are provided. A. malaisei is confirmed as a valid species and recorded from China for the first time, with the female described for the first time. The distribution of the genus is also briefly discussed.
Keywords	Cimbex ; females ; new genus ; new species ; research ; China ; Cimbicinae ; distribution pattern ; Eastern Asia ; Sawflies ; Tenthredinoidea
Language	English
Dates of publication	2022-0630
Size	p. 265-308.
Publishing place	Pensoft Publishers
Document type	Article ; Online
ZDB-ID	2477175-2
ISSN	1314-2607 ; 1070-9428
ISSN (online)	1314-2607
ISSN	1070-9428
DOI	10.3897/jhr.91.83710
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Article ; Online: Asicimbex Yan, Deng & Wei, a new genus with eight new species and four new combinations (Hymenoptera, Cimbicidae)

Yu-Chen Yan / Wen-Long Yan / Tie-Jun Deng / Mei-Cai Wei

Journal of Hymenoptera Research, Vol 91, Iss , Pp 265-

2022 Volume 308

Abstract: ... Deng & Wei gen. nov., A. concavicaputus Yan & Wei sp. nov., A. dengi Yan & Wei sp. nov., A. koreanus ... Yan & Wei sp. nov., A. lii Yan & Wei sp. nov., A. latistriatus Yan, Deng & Wei sp. nov ... A. maculotegularis Yan & Wei sp. nov., A. nanjingensis Yan & Wei sp. nov. and A. shengi Yan & Wei sp. nov. Four new ...

Abstract	A new genus and eight new species of Cimbicinae from the East Asia are described: Asicimbex Yan, Deng & Wei gen. nov., A. concavicaputus Yan & Wei sp. nov., A. dengi Yan & Wei sp. nov., A. koreanus Yan & Wei sp. nov., A. lii Yan & Wei sp. nov., A. latistriatus Yan, Deng & Wei sp. nov., A. maculotegularis Yan & Wei sp. nov., A. nanjingensis Yan & Wei sp. nov. and A. shengi Yan & Wei sp. nov. Four new combinations are proposed: A. eous (Semenov, 1935) comb. nov., A. elminus (Li & Wu, 2003) comb. nov., A. ulmusvorus (Yang, 1996) comb. nov. and A. malaisei (Gussakovskij, 1947) comb. nov., all from Agenocimbex. The 12 known species of Asicimbex are separated into two species groups. Asicimbex stands between Agenocimbex Rohwer 1910 and Cimbex Olivier 1791. The differences between Asicimbex and Cimbex, Asicimbex and Palaeocimbex are discussed in detail. Descriptions, remarks, illustrations, a key to the known species of Asicimbex and a key to genera of Cimbicinae are provided. A. malaisei is confirmed as a valid species and recorded from China for the first time, with the female described for the first time. The distribution of the genus is also briefly discussed.
Keywords	Zoology ; QL1-991
Subject code	590
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Pensoft Publishers
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Zuotai (β-HgS)-containing 70 Wei Zhen-Zhu-Wan differs from mercury chloride and methylmercury on hepatic cytochrome P450 in mice.

Nie, Yu / Xu, Shang-Fu / Lu, Yan-Liu / Zhao, Xiu-Rong / Li, Cen / Wei, Li-Xin / Liu, Jie

F1000Research

2021 Volume 10, Page(s) 203

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Animals ; Chlorides ; Cytochrome P-450 Enzyme System ; Liver ; Mercuric Chloride ; Mercury ; Mercury Compounds ; Methylmercury Compounds ; Mice
Chemical Substances	Chlorides ; Mercury Compounds ; Methylmercury Compounds ; zuotai ; Mercuric Chloride (53GH7MZT1R) ; Cytochrome P-450 Enzyme System (9035-51-2) ; Mercury (FXS1BY2PGL)
Language	English
Publishing date	2021-03-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2699932-8
ISSN	2046-1402 ; 2046-1402
ISSN (online)	2046-1402
ISSN	2046-1402
DOI	10.12688/f1000research.40667.2
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