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  1. Article ; Online: Improved photocatalytic activity of TiO

    Han, Xiaochi / Dong, Wenbo / Li, Longyu / Zhou, Xuemei

    Chemical communications (Cambridge, England)

    2023  Volume 59, Issue 79, Page(s) 11863–11866

    Abstract: In this work, one-dimensional ... ...

    Abstract In this work, one-dimensional TiO
    Language English
    Publishing date 2023-10-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc03305h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Impacts of the Zero-Markup Drug Policy on Hospitalization Expenses of Patients with Stroke in Western China: An Interrupted Time Series Analysis.

    Wu, Yanghaotian / Han, Xuemei / Qiu, Jingfu

    Risk management and healthcare policy

    2024  Volume 17, Page(s) 777–788

    Abstract: Background: In 2016, an innovative medical pricing reform called zero-markup drug policy (ZMDP) was implemented in selected pilot cities in China, which focuses on curbing the unreasonable growth of medical expenses. This study aimed to evaluate the ... ...

    Abstract Background: In 2016, an innovative medical pricing reform called zero-markup drug policy (ZMDP) was implemented in selected pilot cities in China, which focuses on curbing the unreasonable growth of medical expenses. This study aimed to evaluate the impacts of ZMDP on medical expenditure of stroke in western China.
    Methods: The quantitative data of inpatients diagnosed with stroke was extracted from the medical insurance system in 7 tertiary public hospitals. An interrupted time series (ITS) was used to analyze the instantaneous level and long-term trend changes of hospitalization expenses per visit from January 2015 to November 2018.
    Results: A total of 22,407 stroke inpatients were extracted. The total hospitalization expense per visit had the highest proportion of 20,000 CNY and above (33.66%). After the ZMDP, the median total hospitalization expense and western medicine expense per visit decreased by 631.74 CNY and 966.35 CNY, respectively (
    Conclusion: The economic burden of stroke inpatients decreased significantly with the implementation of the ZMDP, especially for the drug expenses. The medical service expenses increased significantly, reflecting the improvement in the value of medical staff's technical labor. However, the unexpected increase in the examination expenses was likely to be associated with the unreasonable medical compensation mechanism.
    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2495128-6
    ISSN 1179-1594
    ISSN 1179-1594
    DOI 10.2147/RMHP.S456977
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Comparative analysis of Herceptin N-Linked glycosylation by HILIC-FLD and LC-MS/MS methods.

    Rauniyar, Navin / Khetani, Joy / Han, Xuemei

    Journal of pharmaceutical and biomedical analysis

    2024  Volume 244, Page(s) 116123

    Abstract: Monoclonal antibodies like Herceptin play a pivotal role in modern therapeutics, with their glycosylation patterns significantly influencing their bioactivity. To characterize the N-glycan profile and their relative abundance in Herceptin, we employed ... ...

    Abstract Monoclonal antibodies like Herceptin play a pivotal role in modern therapeutics, with their glycosylation patterns significantly influencing their bioactivity. To characterize the N-glycan profile and their relative abundance in Herceptin, we employed two analytical methods: hydrophilic interaction chromatography with fluorescence detection (HILIC-FLD) for released glycans and liquid chromatography tandem mass spectrometry (LC-MS/MS) for glycopeptides. Our analysis included 21 European Union (EU)-Herceptin lots and 14 United States (US)-Herceptin lots. HILIC-FLD detected 25 glycan species, including positional isomers, revealing comparable chromatographic profiles for both EU and US lots. On the other hand, LC-MS/MS identified 26 glycoforms within the glycopeptide EEQYNSTYR. Both methods showed that a subset of glycans dominated the total abundance. Notably, EU-Herceptin lots with an expiration date of October 2022 exhibited increased levels of afucosylated and high mannose N-glycans. Our statistical comparisons showed that the difference in quantitative results between HILIC-FLD and LC-MS/MS is significant, indicating that the absolute quantitative values depend on the choice of the analytical method. However, despite these differences, both methods demonstrated a strong correlation in relative glycan proportions. This study contributes to the comprehensive analysis of Herceptin's glycosylation, offering insights into the influence of analytical methods on glycan quantification and providing valuable information for the biopharmaceutical industry.
    MeSH term(s) Trastuzumab/analysis ; Trastuzumab/chemistry ; Glycosylation ; Tandem Mass Spectrometry/methods ; Hydrophobic and Hydrophilic Interactions ; Chromatography, Liquid/methods ; Polysaccharides/analysis ; Polysaccharides/chemistry ; Humans ; Glycopeptides/analysis ; Glycopeptides/chemistry ; Antineoplastic Agents, Immunological/analysis ; Antineoplastic Agents, Immunological/chemistry ; Liquid Chromatography-Mass Spectrometry
    Chemical Substances Trastuzumab (P188ANX8CK) ; Polysaccharides ; Glycopeptides ; Antineoplastic Agents, Immunological
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article ; Comparative Study
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/j.jpba.2024.116123
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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Research progress on the mechanism of diabetic nephropathy: A bibliometric analysis on the 10-year studies.

    Ren, Rui / Yang, Tingxiao / Yang, Xuemei / Han, Xiaolei

    Asian journal of surgery

    2023  Volume 46, Issue 10, Page(s) 4631–4632

    MeSH term(s) Humans ; Diabetic Nephropathies/therapy ; Signal Transduction ; Bibliometrics ; Diabetes Mellitus
    Language English
    Publishing date 2023-06-01
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.05.052
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    In stock of ZB MED Cologne/Königswinter

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  5. Article: hoxa1a

    Wang, Hongjie / He, Jingwei / Han, Xuemei / Wu, Xiuzhi / Ye, Xuebin / Lv, Wenchao / Zu, Yao

    Biology

    2023  Volume 12, Issue 7

    Abstract: Mutations ... ...

    Abstract Mutations in
    Language English
    Publishing date 2023-06-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12070899
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  6. Article ; Online: Long-term efficacy of mandibular advancement devices in the treatment of adult obstructive sleep apnea

    Min Yu / Yanyan Ma / Fang Han / Xuemei Gao

    PLoS ONE, Vol 18, Iss

    A systematic review and meta-analysis

    2023  Volume 11

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Dimethyl sulfoxide as a gas phase charge-reducing agent for the determination of PEGylated proteins' intact mass.

    Skjærvø, Øystein / Togle, Alyssa / Sutton, Haley / Han, Xuemei / Rauniyar, Navin

    Analytical methods : advancing methods and applications

    2024  

    Abstract: Determination of PEGylated proteins' intact mass by mass spectrometry is challenging due to the molecules' large size, excessive charges, and instrument limitations. Previous efforts have been reported. However, signal variability, ion coalescence, and a ...

    Abstract Determination of PEGylated proteins' intact mass by mass spectrometry is challenging due to the molecules' large size, excessive charges, and instrument limitations. Previous efforts have been reported. However, signal variability, ion coalescence, and a generally low degree of robustness have been observed. In this work, we have explored the capabilities of post-column infusion of dimethyl sulfoxide (DMSO) following reversed-phase liquid chromatography-mass spectrometry (RP-LCMS) to determine PEG-filgrastim' intact mass, and to characterize its PEG moiety. The method was optimized around reproducibility (six preparations, and three injection replicates) with an in-house prepared PEG-filgrastim standard. The method showed a mass accuracy of ≤1.2 Da. The average molecular weight (MW
    Language English
    Publishing date 2024-04-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515210-5
    ISSN 1759-9679 ; 1759-9660
    ISSN (online) 1759-9679
    ISSN 1759-9660
    DOI 10.1039/d4ay00660g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Network of Soil Fungi and the Microfauna Community under Diverse Anthropic Disturbances under

    Lin, Xiaoyue / Han, Xuemei / Yang, Jiading / Liu, Fengyu / Li, Yuying / Chen, Zhaojin

    Plants (Basel, Switzerland)

    2024  Volume 13, Issue 3

    Abstract: The reservoir coastal zone is the transitional zone between the terrestrial ecosystem and the aquatic ecosystem. Soil is an essential part of the terrestrial ecosystem and vital for life on Earth. To understand the composition and diversity of the soil ... ...

    Abstract The reservoir coastal zone is the transitional zone between the terrestrial ecosystem and the aquatic ecosystem. Soil is an essential part of the terrestrial ecosystem and vital for life on Earth. To understand the composition and diversity of the soil eukaryotic microbial community under the background of artificial planting of
    Language English
    Publishing date 2024-01-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13030393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A Three-Dimensional Open-Framework Tin(II) Sulfate with Near-Unity Photoluminescence Quantum Yield.

    Wen, Xuemei / Wang, Jing / Zhang, Zhizhuan / Han, Xiangyu / Zeng, Hongmei / Zou, Guohong / Xu, Dingguo / Lin, Zhien

    Inorganic chemistry

    2024  

    Abstract: A new open-framework tin(II) sulfate, formulated as ... ...

    Abstract A new open-framework tin(II) sulfate, formulated as C
    Language English
    Publishing date 2024-05-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.4c00943
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  10. Article ; Online: Central retinal artery occlusion caused by radiation-induced carotid stenosis.

    Lu, Qingli / Han, Xiangning / Liu, Pei / Lin, Xuemei / Wu, Songdi

    Acta neurologica Belgica

    2023  Volume 124, Issue 1, Page(s) 371–373

    MeSH term(s) Humans ; Carotid Stenosis/etiology ; Carotid Stenosis/complications ; Retinal Artery Occlusion/diagnostic imaging ; Retinal Artery Occlusion/etiology ; Carotid Artery Diseases/complications ; Carotid Artery, Internal
    Language English
    Publishing date 2023-07-30
    Publishing country Italy
    Document type Letter
    ZDB-ID 127315-2
    ISSN 2240-2993 ; 0300-9009
    ISSN (online) 2240-2993
    ISSN 0300-9009
    DOI 10.1007/s13760-023-02346-3
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    In stock of ZB MED Cologne/Königswinter

    Ui I Zs.57: Show issues Location:
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