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  1. Article ; Online: Exploring the therapeutic potential of defective interfering particles in reducing the replication of SARS-CoV-2

    Locke, Macauley / Grebennikov, Dmitry / Sazonov, Igor / López-Garcá, Martín / Loguinova, Marina / Meyerhans, Andreas / Bocharov, Gennady / Molina-París, Carmen

    bioRxiv

    Abstract: SARS-CoV-2 still presents a global threat to human health due to the continued emergence of new strains and waning immunity amongst vaccinated populations. Therefore, it is still relevant to investigate potential therapeutics, such as therapeutic ... ...

    Abstract SARS-CoV-2 still presents a global threat to human health due to the continued emergence of new strains and waning immunity amongst vaccinated populations. Therefore, it is still relevant to investigate potential therapeutics, such as therapeutic interfering particles (TIPs). Mathematical and computational modelling are valuable tools to study viral infection dynamics for predictive analysis. Here, we expand on the previous work by Grebennikov et al. (2021) on SARS-CoV-2 intra-cellular replication dynamics to include defective interfering particles (DIPs) as potential therapeutic agents. We formulate a deterministic model that describes the replication of wild-type (WT) SARS-CoV-2 virus in the presence of DIPs. Sensitivity analysis of parameters to several model outputs is employed to inform us on those parameters to be carefully calibrated from experimental data. We then study the effects of co-infection on WT replication and how DIP dose perturbs the release of WT viral particles. Furthermore, we provide a stochastic formulation of the model that is compared to the deterministic one. These models could be further developed into population-level models or used to guide the development and dose of TIPs.
    Keywords covid19
    Language English
    Publishing date 2024-03-11
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2024.03.11.584367
    Database COVID19

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  2. Article ; Online: Annotated Checklist of Marine Amphipods (Crustacea: Amphipoda) of India.

    Thacker, Dimple / Patel, Krupal / Myers, Alan / Guerra-Garca, Jos M / Zeidler, Wolfgang / Trivedi, Jigneshkumar

    Zootaxa

    2023  Volume 5340, Issue 1, Page(s) 1–90

    Abstract: An annotated checklist of the marine amphipods recorded from Indian waters is compiled ...

    Abstract An annotated checklist of the marine amphipods recorded from Indian waters is compiled from the available peer-reviewed literature. A total of 266 species belonging to 133 genera and 56 families are listed. The maximum numbers of species were recorded from the South Indian Ecoregion (177 species, 98 genera, 47 families), followed by the Western India Ecoregion (101 species, 72 genera, 36 families), the Eastern Indian Ecoregion (99 species, 65 genera, 35 families), the Northern Bay of Bengal Ecoregion (92 species, 53 genera, 29 families), the Maldives Ecoregion (32 species, 24 genera, 16 families), and the Andaman and Nicobar Islands Ecoregion (31 species, 22 genera, 18 families). Notes on the questionable identifications and records of some amphipods are also provided.
    MeSH term(s) Humans ; Animals ; Amphipoda ; India
    Language English
    Publishing date 2023-09-05
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1175-5334
    ISSN (online) 1175-5334
    DOI 10.11646/zootaxa.5340.1.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Annotated and updated checklist of marine crabs (Decapoda: Brachyura) of Mozambique supported by morphological and molecular data from shelf and slope species of the MOZAMBIQUE surveys.

    Muoz, Isabel / Garca-Isarch, Eva / Cuesta, Jose A

    Zootaxa

    2021  Volume 5056, Issue 1, Page(s) 1–67

    Abstract: An updated checklist of Mozambican marine brachyuran crabs is generated based on an exhaustive ...

    Abstract An updated checklist of Mozambican marine brachyuran crabs is generated based on an exhaustive revision of the existing literature, together with the additional records provided by the specimens collected throughout the three MOZAMBIQUE surveys carried out in Mozambican waters during three consecutive years (20072009) by the Instituto Espaol de Oceanografa, (Spanish Institute of Oceanography, IEO). A total of 269 species, grouped in 15 superfamilies, 26 families and 172 genera are reported in the checklist, and a detailed inventory is produced with the list and remarks about the brachyuran species collected. Thirty-nine crab species belonging to 19 families were identified based on morphological characteristics and/or genetic tools. DNA barcode sequences (16S rRNA and/or COI) were obtained for 37 species, including 16S and COI sequences that are new for 26 and 14 species, respectively. Colour photographs of fresh specimens illustrate the comments about most species, being the first time that the original colour pattern is described for some of them. New records in Mozambican waters are reported for the species Paromolopsis boasi, Mursia aspera, Carcinoplax ischurodous, Tanaoa pustulosus, Euclosiana exquisita, Oxypleurodon difficilis, Naxioides robillardi, Samadinia galathea, Cyrtomaia gaillardi, Paramaja gibba, Pleistacantha ori, Parathranites granosus, Parathranites orientalis, Ovalipes iridescens and Charybdis smithii, and second records for Moloha alcocki, Samadinia pulchra and Charybdis africana. In addition, Raninoides crosnieri, S. galathea and P. ori were collected for the first time after their descriptions. The female of Samadinia galathea is described for the first time, and a potential new species of Mursia is reported. Some records expand the known bathymetric range of certain species and/or their general distribution. New molecular and morphological data suggest the necessity of the revision of P. boasi, R. crosnieri, C. africana and the genera Platymaia and Carcinoplax. The variability and taxonomic validity of some morphological characters in brachyuran systematic is discussed.
    MeSH term(s) Animals ; Brachyura/genetics ; Female ; Lice Infestations ; Mozambique ; RNA, Ribosomal, 16S
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2021-10-19
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1175-5334
    ISSN (online) 1175-5334
    DOI 10.11646/zootaxa.5056.1.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Estado de la coinfección tuberculosis/virus de la inmunodeficiencia humana en el municipio de Armenia(Colombia)

    Nelson Enrique Arenas / Natalia Ramírez / Gilberto González / Silvana Rubertoneb / Adriana M Garca / Jorge Enrique Gómez-Marín / Liliana Quintero

    Infectio, Vol 16, Iss 3, Pp 140-

    experiencia de 10 años Status of tuberculosis/HIV coinfection in the municipality of Armenia (Colombia): Ten years experience

    2012  Volume 147

    Abstract: La tuberculosis (TB) representa una de las principales complicaciones clínicas en personas inmunocomprometidas por virus de la inmunodeficiencia humana (VIH). Así, cuando las acciones diagnósticas y terapéuticas no son tempranas, el resultado puede ... ...

    Abstract La tuberculosis (TB) representa una de las principales complicaciones clínicas en personas inmunocomprometidas por virus de la inmunodeficiencia humana (VIH). Así, cuando las acciones diagnósticas y terapéuticas no son tempranas, el resultado puede llegar a ser letal. Metodología: Se llevó a cabo un estudio descriptivo y retrospectivo de los casos de coinfección TB/VIH en el período comprendido entre los años 2000 y 2010 en el municipio de Armenia. Se revisaron las fichas de notificación de ambos eventos (Sistema Nacional de Vigilancia en Salud Pública), actas de visitas domiciliarias, tarjetas individuales de tratamiento y certificados de defunción. Resultados: Se incluyeron 113 pacientes con diagnóstico confirmado de coinfección TB/VIH, lo que representa una prevalencia global de 6,8% en 10 años en Armenia. La edad promedio de los pacientes fue 34,3 años (11 a 68 años), y los más comprometidos fueron los del grupo de 14 a 34 años de sexo masculino (91% en formas extrapulmonares y 75% en pulmonares). La TB extrapulmonar o la miliar predominaron con un 50,4% (n = 57), sobre la TB pulmonar. Las formas extrapulmonares más comunes fueron: ganglionar 50% (n = 32), meníngea 19,3% (n = 11), miliar 8,8% (n = 5), pleural 7% (n = 4), peritoneal 7% (n = 4) y vertebral (mal de Pott) 1,8% (n = 1). En 8 casos hubo presentación mixta (pulmonar y extrapulmonar). La letalidad fue del 100% en pacientes infectados por VIH y asociados con cepas resistentes. Conclusiones: Los resultados de este estudio resaltan la importancia de implementar acciones colaborativas entre los programas de TB/VIH para mejorar el diagnóstico y reducir la mortalidad la diseminación de cepas resistentes. Tuberculosis represents one of the top clinical complications in immunocompromised HIVinfected people. When diagnostic and therapeutic interventions are delayed, outcomes could be fatal due to imminent progress of this deadly combination. Methodology: We carried out a descriptive retrospective study from registered TB/HIV cases from 2000 to 2010 in the municipality of Armenia. Notification forms from both diseases TB and HIV (SIVIGILA), record of home visits, individual treatment cards and death certificates were used as data sources. Results: 113 patients were included with TB/HIV confirmed tests, which represents a global prevalence of 6.8% during 10 years in Armenia. The mean age among patients was 34.3 years (ranging from 11 to 68 years), and the group between 14 and 34 years and male (91% extrapulmonary and 75% pulmonary forms) was the most commonly involved. According to the disease presentation, extrapulmonary TB form (50.4%, n = 57) was more frequent than the pulmonary form. The frequency of extrapulmonary forms was: ganglionar, 50% (n = 32); meningeal, 19.3% (n = 11); miliar, 8.8% (n = 5); pleural, 7% (n = 4); peritoneal, 7% (n = 4), and Pott’s disease, 1.8% (n = 1). In eight cases both forms presented simultaneously (pulmonary and extrapulmonary). Lethality was 100% among VIH positive patients infected with resistant strains. Conclusions: Our results highlight the importance of implementing collaborative actions between TB and HIV programs to improve diagnosis and to reduce mortality and resistant strain dissemination.
    Keywords Tuberculosis ; VIH ; Diagnóstico ; Tuberculosis pulmonar ; HIV ; Diagnosis ; Pulmonary tuberculosis ; Infectious and parasitic diseases ; RC109-216 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language Spanish
    Publishing date 2012-09-01T00:00:00Z
    Publisher Asociación Colombiana de Infectología.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Environmental gradients and macroalgae in Mediterranean marshes: the case of Pego-Oliva marsh (East Iberian Peninsula)

    Garca, Mara Eugenia / Marina AboalauthorLaboratory of Algology, Department of Plant Biology, University of Murcia, Campus Espinardo, E-30100, Murcia, Spain
    Language English
    Document type Article
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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  6. Article: Ocean warming ameliorates the negative effects of ocean acidification on Paracentrotus lividus larval development and settlement

    Garca, Eliseba / Sabrina ClementeauthorBiodiversidad, Ecologa Marina y Conservacin, Dpto. Biologa Animal (Ciencias Marinas), Facultad de Biologa, Universidad de La Laguna, c/ Astrofsico Francisco Snchez s/n 38206 La Laguna, Tenerife, Islas Canarias, Spain / Jos Carlos HernndezauthorBiodiversidad, Ecologa Marina y Conservacin, Dpto. Biologa Animal (Ciencias Marinas), Facultad de Biologa, Universidad de La Laguna, c/ Astrofsico Francisco Snchez s/n 38206 La Laguna, Tenerife, Islas Canarias, Spain
    Language English
    Document type Article
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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  7. Article: Acetonebutanolethanol (ABE) production by Clostridium beijerinckii from wheat straw hydrolysates: Efficient use of penta and hexa carbohydrates

    Bellido, Carolina / Marina Loureiro PintoauthorDepartment of Chemical Engineering and Environmental Technology, University of Valladolid, Dr. Mergelina s/n, 47011 Valladolid, Spain / Mnica CocaauthorDepartment of Chemical Engineering and Environmental Technology, University of Valladolid, Dr. Mergelina s/n, 47011 Valladolid, Spain / Gerardo Gonzlez-BenitoauthorDepartment of Chemical Engineering and Environmental Technology, University of Valladolid, Dr. Mergelina s/n, 47011 Valladolid, Spain / Mara Teresa Garca-Cuberoauthor
    Language English
    Document type Article
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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  8. Article: Is the establishment of MPAs enough to preserve endangered intertidal species? The case of Patella ferruginea in Mal di Ventre Island (W Sardinia, Italy)

    Coppa, Stefania / G. Andrea De LuciaauthorConsiglio Nazionale delle Ricerche, Istituto per l'Ambiente Marino Costiero (CNRIAMC), Oristano, Italy / Giorgio MassaroauthorArea Marina Protetta Penisola del SinisIsola di Mal di Ventre, Cabras, Italy / Andrea CameddaauthorConsiglio Nazionale delle Ricerche, Istituto per l'Ambiente Marino Costiero (CNRIAMC), Oristano, Italy / Stefano Marraauthor / Paolo MagniauthorConsiglio Nazionale delle Ricerche, Istituto per l'Ambiente Marino Costiero (CNRIAMC), Oristano, Italy / Angelo PerilliauthorConsiglio Nazionale delle Ricerche, Istituto per l'Ambiente Marino Costiero (CNRIAMC), Oristano, Italy / Massimiliano Di BitettoauthorConsiglio Nazionale delle Ricerche (CNR), Rome, Italy / Jos Carlos GarcaGmezauthorLaboratorio de Biologa Marina, Departamento de Zoologa, Universidad de Sevilla, Seville, Spain / Free EspinosaauthorLaboratorio de Biologa Marina, Departamento de Zoologa, Universidad de Sevilla, Seville, Spain
    Language English
    Document type Article
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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  9. Article: Redox processes in pore water of anoxic sediments with shallow gas

    Ramrez-Prez, A.M. / E. de BlasauthorDepartment of Plant Biology and Soil Science, University of Vigo, 32004 Ourense, Spain / S. Garca-GilauthorDepartment of Marine Geosciences, University of Vigo, 36310 Vigo, Spain
    Language English
    Document type Article
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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  10. Article: Marine protection is needed for Magellanic penguins in Argentina based on long-term data

    Dee Boersma, P. / Ginger A. RebstockauthorDepartment of Biology, University of Washington, Box 351800, Seattle, WA 98195-1800, USAGlobal Penguin Society, Marcos Zar 2716, 9120 Puerto Madryn, Chubut, ArgentinaWildlife Conservation Society, 2300 Southern Blvd., Bronx, NY 10460, USA / Pablo Garca-BorborogluauthorDepartment of Biology, University of Washington, Box 351800, Seattle, WA 98195-1800, USAGlobal Penguin Society, Marcos Zar 2716, 9120 Puerto Madryn, Chubut, ArgentinaCentro Nacional Patagnico (CONICET), Boulevard Brown 2825, 9120 Puerto Madryn, Chubut, Argentina
    Language English
    Document type Article
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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