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Article ; Online: Pulmonary thromboembolism in conjunction with intracavitary thrombus caused by severe acute respiratory syndrome coronavirus-2 infection in a patient living with human immunodeficiency virus.

Silva, Ana Carolina Veronese / Machado-Junior, Paulo André Bispo / Anizelli, Leticia Bressan / Stocco, Rebecca Benicio / Moura, Lidia Ana Zytynski / Motta Junior, Jarbas da Silva / Blume, Gustavo Gavazzoni

Revista da Sociedade Brasileira de Medicina Tropical

2021 Volume 54, Page(s) e01572021

Abstract: Approximately one-third of patients with coronavirus disease 2019 (COVID-19) present with coagulation disorders and hematological changes. However, the clinical manifestations of COVID-19 and prognoses of people living with human immunodeficiency virus ( ... ...

Abstract	Approximately one-third of patients with coronavirus disease 2019 (COVID-19) present with coagulation disorders and hematological changes. However, the clinical manifestations of COVID-19 and prognoses of people living with human immunodeficiency virus (HIV) remain controversial. This study reports the case of a 27-year-old HIV-infected man who regularly used antiretroviral medications, had no other comorbidities and was admitted for acute respiratory distress syndrome caused by COVID-19. Complementary examinations during hospitalization revealed a diagnosis of pulmonary thromboembolism in association with an intracavitary thrombus.
MeSH term(s)	Adult ; COVID-19 ; HIV ; HIV Infections/complications ; Humans ; Male ; Pulmonary Embolism/etiology ; SARS-CoV-2 ; Thrombosis
Language	English
Publishing date	2021-06-02
Publishing country	Brazil
Document type	Case Reports
ZDB-ID	1038126-0
ISSN	1678-9849 ; 0037-8682
ISSN (online)	1678-9849
ISSN	0037-8682
DOI	10.1590/0037-8682-0157-2021
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Article ; Online: Pulmonary thromboembolism in conjunction with intracavitary thrombus caused by severe acute respiratory syndrome coronavirus-2 infection in a patient living with human immunodeficiency virus

Ana Carolina Veronese Silva / Paulo André Bispo Machado-Junior / Leticia Bressan Anizelli / Rebecca Benicio Stocco / Lidia Ana Zytynski Moura / Jarbas da Silva Motta Junior / Gustavo Gavazzoni Blume

Revista da Sociedade Brasileira de Medicina Tropical, Vol

2021 Volume 54

Abstract: Abstract Approximately one-third of patients with coronavirus disease 2019 (COVID-19) present with coagulation disorders and hematological changes. However, the clinical manifestations of COVID-19 and prognoses of people living with human ... ...

Abstract	Abstract Approximately one-third of patients with coronavirus disease 2019 (COVID-19) present with coagulation disorders and hematological changes. However, the clinical manifestations of COVID-19 and prognoses of people living with human immunodeficiency virus (HIV) remain controversial. This study reports the case of a 27-year-old HIV-infected man who regularly used antiretroviral medications, had no other comorbidities and was admitted for acute respiratory distress syndrome caused by COVID-19. Complementary examinations during hospitalization revealed a diagnosis of pulmonary thromboembolism in association with an intracavitary thrombus.
Keywords	COVID-19 ; Blood coagulation disorders ; HIV Infections ; Arctic medicine. Tropical medicine ; RC955-962
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Sociedade Brasileira de Medicina Tropical (SBMT)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Covid-19 cytokine storm in pulmonary tissue: Anatomopathological and immunohistochemical findings.

Ribeiro Dos Santos Miggiolaro, Anna Flavia / da Silva Motta Junior, Jarbas / Busatta Vaz de Paula, Caroline / Nagashima, Seigo / Alessandra Scaranello Malaquias, Mineia / Baena Carstens, Lucas / N Moreno-Amaral, Andrea / Pellegrino Baena, Cristina / de Noronha, Lucia

Respiratory medicine case reports

2020 Volume 31, Page(s) 101292

Abstract: The COVID-19 pandemic is a worldwide threat, and information on physiopathological aspects of the disease is limited. Despite efforts in searching treatment options, a better understanding of the SARS-CoV-2 pathways can contribute to managing severe ... ...

Abstract	The COVID-19 pandemic is a worldwide threat, and information on physiopathological aspects of the disease is limited. Despite efforts in searching treatment options, a better understanding of the SARS-CoV-2 pathways can contribute to managing severe cases. In this study, we aim to describe pathological and immunopathogenic findings of two different cases, both in the high-risk group. Post-mortem lung biopsies were analyzed by traditional and immunohistochemical methods. Tissue expression of innate and adaptive immune response biomarkers was tested. We observed a higher innate response in case 1 with an abundance of mast cells, scarce CD8
Keywords	covid19
Language	English
Publishing date	2020-11-12
Publishing country	England
Document type	Case Reports
ZDB-ID	2666110-X
ISSN	2213-0071
ISSN	2213-0071
DOI	10.1016/j.rmcr.2020.101292
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mast Cells in Alveolar Septa of COVID-19 Patients: A Pathogenic Pathway That May Link Interstitial Edema to Immunothrombosis.

Motta Junior, Jarbas da Silva / Miggiolaro, Anna Flavia Ribeiro Dos Santos / Nagashima, Seigo / de Paula, Caroline Busatta Vaz / Baena, Cristina Pellegrino / Scharfstein, Julio / de Noronha, Lucia

Frontiers in immunology

2020 Volume 11, Page(s) 574862

Abstract: It is currently believed that innate immunity is unable to prevent the spread of SARS-CoV-2 from the upper airways to the alveoli of high-risk groups of patients. SARS-CoV-2 replication in ACE-2-expressing pneumocytes can drive the diffuse alveolar ... ...

Abstract	It is currently believed that innate immunity is unable to prevent the spread of SARS-CoV-2 from the upper airways to the alveoli of high-risk groups of patients. SARS-CoV-2 replication in ACE-2-expressing pneumocytes can drive the diffuse alveolar injury through the cytokine storm and immunothrombosis by upregulating the transcription of chemokine/cytokines, unlike several other respiratory viruses. Here we report histopathology data obtained in post-mortem lung biopsies of COVID-19, showing the increased density of perivascular and septal mast cells (MCs) and IL-4-expressing cells (
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Betacoronavirus/immunology ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Female ; Humans ; Influenza A Virus, H1N1 Subtype/immunology ; Influenza, Human/immunology ; Influenza, Human/pathology ; Influenza, Human/virology ; Interleukin-4/immunology ; Male ; Mast Cells/immunology ; Mast Cells/pathology ; Middle Aged ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; Proto-Oncogene Proteins c-kit/immunology ; Pulmonary Alveoli/immunology ; Pulmonary Alveoli/pathology ; Pulmonary Alveoli/virology ; Pulmonary Edema/immunology ; Pulmonary Edema/pathology ; Pulmonary Edema/virology ; SARS-CoV-2 ; Thrombosis/immunology ; Thrombosis/pathology ; Thrombosis/virology
Chemical Substances	IL4 protein, human ; Interleukin-4 (207137-56-2) ; KIT protein, human (EC 2.7.10.1) ; Proto-Oncogene Proteins c-kit (EC 2.7.10.1)
Keywords	covid19
Language	English
Publishing date	2020-09-18
Publishing country	Switzerland
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.574862
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: IL-4/IL-13 remodeling pathway of COVID-19 lung injury.

Vaz de Paula, Caroline Busatta / de Azevedo, Marina Luise Viola / Nagashima, Seigo / Martins, Ana Paula Camargo / Malaquias, Mineia Alessandra Scaranello / Miggiolaro, Anna Flavia Ribeiro Dos Santos / da Silva Motta Júnior, Jarbas / Avelino, Gibran / do Carmo, Leticia Arianne Panini / Carstens, Lucas Baena / de Noronha, Lucia

Scientific reports

2020 Volume 10, Issue 1, Page(s) 18689

Abstract: The COVID-19 fatality rate is high when compared to the H1N1pdm09 (pandemic Influenza A virus H1N1 subtype) rate, and although both cause an aggravated inflammatory response, the differences in the mechanisms of both pandemic pneumonias need ... ...

Abstract	The COVID-19 fatality rate is high when compared to the H1N1pdm09 (pandemic Influenza A virus H1N1 subtype) rate, and although both cause an aggravated inflammatory response, the differences in the mechanisms of both pandemic pneumonias need clarification. Thus, our goal was to analyze tissue expression of interleukins 4, 13, (IL-4, IL-13), transforming growth factor-beta (TGF-β), and the number of M2 macrophages (Sphingosine-1) in patients who died by COVID-19, comparing with cases of severe pneumopathy caused by H1N1pdm09, and a control group without lung injury. Six lung biopsy samples of patients who died of SARS-CoV-2 (COVID-19 group) were used and compared with ten lung samples of adults who died from a severe infection of H1N1pdm09 (H1N1 group) and eleven samples of patients who died from different causes without lung injury (CONTROL group). The expression of IL-4, IL-13, TGF-β, and M2 macrophages score (Sphingosine-1) were identified through immunohistochemistry (IHC). Significantly higher IL-4 tissue expression and Sphingosine-1 in M2 macrophages were observed in the COVID-19 group compared to both the H1N1 and the CONTROL groups. A different mechanism of diffuse alveolar damage (DAD) in SARS-CoV-2 compared to H1N1pdm09 infections were observed. IL-4 expression and lung remodeling are phenomena observed in both SARS-CoV-2 and H1N1pdm09. However, SARS-CoV-2 seems to promote lung damage through different mechanisms, such as the scarce participation Th1/Th17 response and the higher participation of the Th2. Understanding and managing the aggravated and ineffective immune response elicited by SARS-CoV-2 merits further clarification to improve treatments propose.
MeSH term(s)	Aged ; Aged, 80 and over ; Biomarkers/metabolism ; COVID-19 ; Coronavirus Infections/metabolism ; Coronavirus Infections/pathology ; Female ; Humans ; Interleukin-13/genetics ; Interleukin-13/metabolism ; Interleukin-4/genetics ; Interleukin-4/metabolism ; Lung/metabolism ; Lung/pathology ; Macrophages/metabolism ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/pathology ; Sphingosine/metabolism ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism
Chemical Substances	Biomarkers ; Interleukin-13 ; Transforming Growth Factor beta ; Interleukin-4 (207137-56-2) ; Sphingosine (NGZ37HRE42)
Keywords	covid19
Language	English
Publishing date	2020-10-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-75659-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mast Cells in Alveolar Septa of COVID-19 Patients

Motta Junior, Jarbas da Silva / Miggiolaro, Anna Flavia Ribeiro dos Santos / Nagashima, Seigo / de Paula, Caroline Busatta Vaz / Baena, Cristina Pellegrino / Scharfstein, Julio / de Noronha, Lucia

Frontiers in Immunology

A Pathogenic Pathway That May Link Interstitial Edema to Immunothrombosis

2020 Volume 11

Keywords	covid19
Publisher	Frontiers Media SA
Publishing country	ch
Document type	Article ; Online
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.574862
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

anatomopathological and immunohistochemical findings

2020 , Page(s) 101292

Keywords	Pulmonary and Respiratory Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	2666110-X
ISSN	2213-0071
ISSN	2213-0071
DOI	10.1016/j.rmcr.2020.101292
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Audio / Video ; Online: Image_1_Mast Cells in Alveolar Septa of COVID-19 Patients

Jarbas da Silva Motta Junior / Anna Flavia Ribeiro dos Santos Miggiolaro / Seigo Nagashima / Caroline Busatta Vaz de Paula / Cristina Pellegrino Baena / Julio Scharfstein / Lucia de Noronha

A Pathogenic Pathway That May Link Interstitial Edema to Immunothrombosis.JPEG

2020

Abstract	It is currently believed that innate immunity is unable to prevent the spread of SARS-CoV-2 from the upper airways to the alveoli of high-risk groups of patients. SARS-CoV-2 replication in ACE-2-expressing pneumocytes can drive the diffuse alveolar injury through the cytokine storm and immunothrombosis by upregulating the transcription of chemokine/cytokines, unlike several other respiratory viruses. Here we report histopathology data obtained in post-mortem lung biopsies of COVID-19, showing the increased density of perivascular and septal mast cells (MCs) and IL-4-expressing cells (n = 6), in contrast to the numbers found in pandemic H1N1-induced pneumonia (n = 10) or Control specimens (n = 10). Noteworthy, COVID-19 lung biopsies showed a higher density of CD117 + cells, suggesting that c-kit positive MCs progenitors were recruited earlier to the alveolar septa. These findings suggest that MC proliferation/differentiation in the alveolar septa might be harnessed by the shift toward IL-4 expression in the inflamed alveolar septa. Future studies may clarify whether the fibrin-dependent generation of the hyaline membrane, processes that require the diffusion of procoagulative plasma factors into the alveolar lumen and the endothelial dysfunction, are preceded by MC-driven formation of interstitial edema in the alveolar septa.
Keywords	Immunology ; Applied Immunology (incl. Antibody Engineering ; Xenotransplantation and T-cell Therapies) ; Autoimmunity ; Cellular Immunology ; Humoural Immunology and Immunochemistry ; Immunogenetics (incl. Genetic Immunology) ; Innate Immunity ; Transplantation Immunology ; Tumour Immunology ; Immunology not elsewhere classified ; Genetic Immunology ; Animal Immunology ; Veterinary Immunology ; SARS-CoV-2 ; COVID 19 ; mast cells (MC) ; cell-mediated immunity ; immune responses ; interleukin-4 (IL-4) ; covid19
Subject code	610
Publishing date	2020-09-18T04:03:45Z
Publishing country	uk
Document type	Audio / Video ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mast Cells in Alveolar Septa of COVID-19 Patients

Jarbas da Silva Motta Junior / Anna Flavia Ribeiro dos Santos Miggiolaro / Seigo Nagashima / Caroline Busatta Vaz de Paula / Cristina Pellegrino Baena / Julio Scharfstein / Lucia de Noronha

Frontiers in Immunology, Vol

A Pathogenic Pathway That May Link Interstitial Edema to Immunothrombosis

2020 Volume 11

Abstract	It is currently believed that innate immunity is unable to prevent the spread of SARS-CoV-2 from the upper airways to the alveoli of high-risk groups of patients. SARS-CoV-2 replication in ACE-2-expressing pneumocytes can drive the diffuse alveolar injury through the cytokine storm and immunothrombosis by upregulating the transcription of chemokine/cytokines, unlike several other respiratory viruses. Here we report histopathology data obtained in post-mortem lung biopsies of COVID-19, showing the increased density of perivascular and septal mast cells (MCs) and IL-4-expressing cells (n = 6), in contrast to the numbers found in pandemic H1N1-induced pneumonia (n = 10) or Control specimens (n = 10). Noteworthy, COVID-19 lung biopsies showed a higher density of CD117+ cells, suggesting that c-kit positive MCs progenitors were recruited earlier to the alveolar septa. These findings suggest that MC proliferation/differentiation in the alveolar septa might be harnessed by the shift toward IL-4 expression in the inflamed alveolar septa. Future studies may clarify whether the fibrin-dependent generation of the hyaline membrane, processes that require the diffusion of procoagulative plasma factors into the alveolar lumen and the endothelial dysfunction, are preceded by MC-driven formation of interstitial edema in the alveolar septa.
Keywords	SARS-CoV-2 ; COVID 19 ; mast cells (MC) ; cell-mediated immunity ; immune responses ; interleukin-4 (IL-4) ; Immunologic diseases. Allergy ; RC581-607 ; covid19
Subject code	610
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Lung Neutrophilic Recruitment and IL-8/IL-17A Tissue Expression in COVID-19.

Azevedo, Marina Luise Viola / Zanchettin, Aline Cristina / Vaz de Paula, Caroline Busatta / Motta Júnior, Jarbas da Silva / Malaquias, Mineia Alessandra Scaranello / Raboni, Sonia Mara / Neto, Plínio Cezar / Zeni, Rafaela Chiuco / Prokopenko, Amanda / Borges, Nícolas Henrique / Godoy, Thiago Mateus / Benevides, Ana Paula Kubaski / de Souza, Daiane Gavlik / Baena, Cristina Pellegrino / Machado-Souza, Cleber / de Noronha, Lucia

Frontiers in immunology

2021 Volume 12, Page(s) 656350

Abstract: The new SARS-CoV-2 virus differs from the pandemic Influenza A virus H1N1 subtype (H1N1pmd09) how it induces a pro-inflammatory response in infected patients. This study aims to evaluate the involvement of SNPs and tissue expression of IL-17A and the ... ...

Abstract	The new SARS-CoV-2 virus differs from the pandemic Influenza A virus H1N1 subtype (H1N1pmd09) how it induces a pro-inflammatory response in infected patients. This study aims to evaluate the involvement of SNPs and tissue expression of IL-17A and the neutrophils recruitment in
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; COVID-19/genetics ; COVID-19/immunology ; COVID-19/pathology ; Female ; Gene Expression Regulation/immunology ; Humans ; Influenza A Virus, H1N1 Subtype/genetics ; Influenza A Virus, H1N1 Subtype/immunology ; Influenza, Human/genetics ; Influenza, Human/immunology ; Interleukin-17/genetics ; Interleukin-17/immunology ; Interleukin-8/genetics ; Interleukin-8/immunology ; Lung/immunology ; Lung/pathology ; Lung/virology ; Male ; Middle Aged ; Neutrophils/immunology ; Neutrophils/pathology ; Neutrophils/virology ; Polymorphism, Single Nucleotide ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology
Chemical Substances	CXCL8 protein, human ; IL17A protein, human ; Interleukin-17 ; Interleukin-8
Language	English
Publishing date	2021-03-30
Publishing country	Switzerland
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.656350
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