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  1. Article ; Online: Leaders in Cardiovascular Research: Peter Libby.

    Guzik, Tomasz J / Libby, Peter

    Cardiovascular research

    2019  Volume 115, Issue 6, Page(s) e61–e62

    MeSH term(s) Biomedical Research/history ; Cardiovascular Diseases/history ; Cardiovascular Diseases/therapy ; Diffusion of Innovation ; Forecasting ; History, 20th Century ; History, 21st Century
    Language English
    Publishing date 2019-06-17
    Publishing country England
    Document type Biography ; Historical Article ; Interview ; Portrait ; Video-Audio Media
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvz069
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  2. Article ; Online: Peter Libby, MD: a conversation with the editor.

    Libby, Peter

    The American journal of cardiology

    2012  Volume 110, Issue 5, Page(s) 741–760

    MeSH term(s) Cardiology/history ; Editorial Policies ; History, 20th Century ; Humans ; Male ; Publishing/history ; United States
    Language English
    Publishing date 2012-09-01
    Publishing country United States
    Document type Historical Article ; Interview
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2012.04.058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Inflammation and the pathogenesis of atherosclerosis.

    Libby, Peter

    Vascular pharmacology

    2023  Volume 154, Page(s) 107255

    Abstract: The notion that inflammation contributes to atherosclerosis has now gained considerable currency. Inflammation participates in atherosclerosis inception, progression, and thrombotic complications. Induced expression of endothelial leukocyte adhesion ... ...

    Abstract The notion that inflammation contributes to atherosclerosis has now gained considerable currency. Inflammation participates in atherosclerosis inception, progression, and thrombotic complications. Induced expression of endothelial leukocyte adhesion molecules and chemoattractant cytokines recruit blood cells to the arterial intima. Lesions can contain virtually every type of leukocyte. Monocytes mature into macrophages and imbibe lipids becoming foam cells, a hallmark of the atherosclerotic lesion. T lymphocytes can instruct the more numerous macrophages to express genes involved in the progression of the atheroma and its eventual destabilization. Inflammation is becoming clinically actionable to refine risk prediction, allocate treatments, and as a therapeutic target.
    MeSH term(s) Humans ; Atherosclerosis/genetics ; Atherosclerosis/metabolism ; Macrophages/metabolism ; Plaque, Atherosclerotic/pathology ; Monocytes/pathology ; Inflammation/metabolism
    Language English
    Publishing date 2023-12-28
    Publishing country United States
    Document type Editorial
    ZDB-ID 2082846-9
    ISSN 1879-3649 ; 1537-1891 ; 1879-3649
    ISSN (online) 1879-3649 ; 1537-1891
    ISSN 1879-3649
    DOI 10.1016/j.vph.2023.107255
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  4. Article ; Online: Coronary artery disease and myocardial ischemic syndromes 2023 Proceedings of an International Expert Meeting Pisa, Italy 16-17 June 2023.

    De Caterina, Raffaele / Libby, Peter

    Vascular pharmacology

    2024  Volume 155, Page(s) 107370

    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Editorial
    ZDB-ID 2082846-9
    ISSN 1879-3649 ; 1537-1891 ; 1879-3649
    ISSN (online) 1879-3649 ; 1537-1891
    ISSN 1879-3649
    DOI 10.1016/j.vph.2024.107370
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  5. Article ; Online: The changing Nature of atherosclerosis: what we thought we knew, what we think we know, and what we have to learn.

    Libby, Peter

    European heart journal

    2021  Volume 42, Issue 47, Page(s) 4781–4782

    MeSH term(s) Atherosclerosis ; Humans
    Language English
    Publishing date 2021-12-14
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehab438
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  6. Article ; Online: The biology of atherosclerosis comes full circle: lessons for conquering cardiovascular disease.

    Libby, Peter

    Nature reviews. Cardiology

    2021  Volume 18, Issue 10, Page(s) 683–684

    MeSH term(s) Atherosclerosis ; Biology ; Cardiovascular Diseases/prevention & control ; Humans
    Language English
    Publishing date 2021-08-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/s41569-021-00609-1
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  7. Article ; Online: Colchicine's Role in Cardiovascular Disease Management.

    Buckley, Leo F / Libby, Peter

    Arteriosclerosis, thrombosis, and vascular biology

    2024  Volume 44, Issue 5, Page(s) 1031–1041

    Abstract: Colchicine-an anti-inflammatory alkaloid-has assumed an important role in the management of cardiovascular inflammation ≈3500 years after its first medicinal use in ancient Egypt. Primarily used in high doses for the treatment of acute gout flares during ...

    Abstract Colchicine-an anti-inflammatory alkaloid-has assumed an important role in the management of cardiovascular inflammation ≈3500 years after its first medicinal use in ancient Egypt. Primarily used in high doses for the treatment of acute gout flares during the 20th century, research in the early 21st century demonstrated that low-dose colchicine effectively treats acute gout attacks, lowers the risk of recurrent pericarditis, and can add to secondary prevention of major adverse cardiovascular events. As the first Food and Drug Administration-approved targeted anti-inflammatory cardiovascular therapy, colchicine currently has a unique role in the management of atherosclerotic cardiovascular disease. The safe use of colchicine requires careful monitoring for drug-drug interactions, changes in kidney and liver function, and counseling regarding gastrointestinal upset. Future research should elucidate the mechanisms of anti-inflammatory effects of colchicine relevant to atherosclerosis, the potential role of colchicine in primary prevention, in other cardiometabolic conditions, colchicine's safety in cardiovascular patients, and opportunities for individualizing colchicine therapy using clinical and molecular diagnostics.
    MeSH term(s) Humans ; Anti-Inflammatory Agents/therapeutic use ; Anti-Inflammatory Agents/adverse effects ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/prevention & control ; Colchicine/therapeutic use ; Colchicine/adverse effects ; Drug Interactions ; Gout Suppressants/therapeutic use ; Gout Suppressants/adverse effects ; Treatment Outcome
    Chemical Substances Anti-Inflammatory Agents ; Colchicine (SML2Y3J35T) ; Gout Suppressants
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.124.319851
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  8. Book: Essential atlas of cardiovascular disease

    Libby, Peter

    2009  

    Author's details Peter Libby
    Keywords Cardiovascular Diseases
    Language English
    Size X, 382 S. : zahlr. Ill., graph. Darst.
    Edition 1. ed.
    Publisher Springer u.a.
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    Accompanying material 1 CD-ROM (12 cm)
    HBZ-ID HT016126471
    ISBN 1-57340-309-1 ; 978-1-57340-309-2
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2009 C 88 order for loan Magazin
    2009 MO 714 <<[Begleitmaterial]>> order for loan Magazin

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  9. Article ; Online: Targeting Inflammatory Pathways in Cardiovascular Disease: The Inflammasome, Interleukin-1, Interleukin-6 and Beyond.

    Libby, Peter

    Cells

    2021  Volume 10, Issue 4

    Abstract: Recent clinical trials have now firmly established that inflammation participates causally in human atherosclerosis. These observations point the way toward novel treatments that add to established therapies to help stem the growing global epidemic of ... ...

    Abstract Recent clinical trials have now firmly established that inflammation participates causally in human atherosclerosis. These observations point the way toward novel treatments that add to established therapies to help stem the growing global epidemic of cardiovascular disease. Fortunately, we now have a number of actionable targets whose clinical exploration will help achieve the goal of optimizing beneficial effects while avoiding undue interference with host defenses or other unwanted actions. This review aims to furnish the foundation for this quest by critical evaluation of the current state of anti-inflammatory interventions within close reach of clinical application, with a primary focus on innate immunity. In particular, this paper highlights the pathway from the inflammasome, through interleukin (IL)-1 to IL-6 supported by a promising body of pre-clinical, clinical, and human genetic data. This paper also considers the use of biomarkers to guide allocation of anti-inflammatory therapies as a step toward realizing the promise of precision medicine. The validation of decades of experimental work and association studies in humans by recent clinical investigations provides a strong impetus for further efforts to target inflammation in atherosclerosis to address the considerable risk that remains despite current therapies.
    MeSH term(s) Animals ; Cardiovascular Diseases/pathology ; Humans ; Inflammasomes/metabolism ; Inflammation/pathology ; Interleukin-1/metabolism ; Interleukin-6/metabolism ; Precision Medicine
    Chemical Substances Inflammasomes ; Interleukin-1 ; Interleukin-6
    Language English
    Publishing date 2021-04-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10040951
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  10. Article ; Online: Inflammation in Atherosclerosis-No Longer a Theory.

    Libby, Peter

    Clinical chemistry

    2021  Volume 67, Issue 1, Page(s) 131–142

    Abstract: Background: Inflammation links to atherosclerosis and its complications in various experimental investigations. Animal studies have implicated numerous inflammatory mediators in the initiation and complication of atherosclerosis. Numerous studies in ... ...

    Abstract Background: Inflammation links to atherosclerosis and its complications in various experimental investigations. Animal studies have implicated numerous inflammatory mediators in the initiation and complication of atherosclerosis. Numerous studies in humans have shown associations of biomarkers of inflammation with cardiovascular events provoked by atheromata. Inflammatory status, determined by the biomarker C-reactive protein, can guide the allocation of statin therapy to individuals without elevated low-density lipoprotein (LDL) concentrations to prevent first ever adverse cardiovascular events.
    Content: Until recently, no direct evidence has shown that an intervention that selectively limits inflammation can improve outcomes in patients with atherosclerosis. A recent study, based on decades of preclinical investigation, treated patients who had sustained a myocardial infarction and whose LDL was well-controlled on statin treatment with an antibody that neutralizes interleukin-1 beta. This trial, conducted in over 10 000 individuals, showed a reduction in major adverse cardiac events, establishing for the first time the clinical efficacy of an anti-inflammatory intervention in atherosclerosis. Two large subsequent studies have shown that colchicine treatment can also prevent recurrent events in patients recovering from an acute coronary syndrome or in the stable phase of coronary artery disease. These clinical trials have transformed inflammation in atherosclerosis from theory to practice.
    Summary: Much work remains to optimize further anti-inflammatory interventions, minimize unwanted actions, and refine patient selection. This long road from discovery in the laboratory to successful clinical trials represents a victory for medical science, and opens a new avenue to reducing the risk that remains despite current treatments for atherosclerosis.
    MeSH term(s) Adaptive Immunity/immunology ; Animals ; Anti-Inflammatory Agents/therapeutic use ; Atherosclerosis/immunology ; Atherosclerosis/prevention & control ; Biomarkers/analysis ; Biomarkers/metabolism ; C-Reactive Protein/analysis ; C-Reactive Protein/metabolism ; Cytokines/metabolism ; Humans ; Immunity, Innate/immunology ; Inflammation/drug therapy ; Inflammation/metabolism ; Leukocytes/immunology ; Macrophages/immunology
    Chemical Substances Anti-Inflammatory Agents ; Biomarkers ; Cytokines ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2021-01-23
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1093/clinchem/hvaa275
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