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Article ; Online: Toll-like receptor-agonist-based therapies for respiratory viral diseases: thinking outside the cell.

Girkin, Jason L N / Maltby, Steven / Bartlett, Nathan W

European respiratory review : an official journal of the European Respiratory Society

2022 Volume 31, Issue 164

Abstract: Respiratory virus infections initiate in the upper respiratory tract (URT). Innate immunity is critical for initial control of infection at this site, particularly in the absence of mucosal virus-neutralising antibodies. If the innate immune response is ... ...

Abstract	Respiratory virus infections initiate in the upper respiratory tract (URT). Innate immunity is critical for initial control of infection at this site, particularly in the absence of mucosal virus-neutralising antibodies. If the innate immune response is inadequate, infection can spread to the lower respiratory tract (LRT) causing community-acquired pneumonia (as exemplified by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)/coronavirus disease 2019). Vaccines for respiratory viruses (influenza and SARS-CoV-2) leverage systemic adaptive immunity to protect from severe lung disease. However, the URT remains vulnerable to infection, enabling viral transmission and posing an ongoing risk of severe disease in populations that lack effective adaptive immunity.Innate immunity is triggered by host cell recognition of viral pathogen-associated molecular patterns
MeSH term(s)	Antiviral Agents ; COVID-19 ; Humans ; Immunity, Innate ; Lung ; SARS-CoV-2 ; Toll-Like Receptors
Chemical Substances	Antiviral Agents ; Toll-Like Receptors
Language	English
Publishing date	2022-05-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1077620-5
ISSN	1600-0617 ; 0905-9180
ISSN (online)	1600-0617
ISSN	0905-9180
DOI	10.1183/16000617.0274-2021
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Article ; Online: Resilience, science, technology, engineering, and mathematics (STEM), and anger: A linguistic inquiry into the psychological processes associated with resilience in secondary school STEM learning.

Hall, Sophie S / McGill, Ross Morrison / Puttick, Steven / Maltby, John

The British journal of educational psychology

2022 Volume 92, Issue 3, Page(s) 1215–1238

Abstract: Aim: To examine resilience in Science, Technology, Engineering, and Mathematics (STEM) learning within an ecological model, identifying the psychological processes associated with resilient, and non-resilient learning to develop a framework for ... ...

Abstract	Aim: To examine resilience in Science, Technology, Engineering, and Mathematics (STEM) learning within an ecological model, identifying the psychological processes associated with resilient, and non-resilient learning to develop a framework for promoting STEM resilience. Sample and method: From a sample of secondary-school students (n = 4,936), 1,577 students who found their STEM lesson difficult were identified. Students were assessed on three resilience capabilities and asked to write a commentary on how they responded to the lesson. Results: Factor analysis revealed that resilience in STEM learning could be positioned within the ecological systems model, with students' resilience being comprised of three capabilities; the ability to quickly and easily recover (Recovery), remain focussed on goals (Ecological), and naturally adjust (Adaptive capacity). Using a linguistic analysis programme, we identified the prevalence of words within the student commentaries which related to seven psychological processes. Greater ability to recover was negatively related to negative emotional processes. To increase the specificity of this relationship, we identified high and low resilient students and compared their commentaries. Low resilient students used significantly more anger words. Qualitative analysis revealed interpersonal sources of anger (anger at teacher due to lack of support) and intrapersonal sources of anger (including rumination, expression and control, and seeking distraction). Conclusions: Anger is a key process that distinguishes students who struggle to recover from a difficult STEM lesson. An ecological systems model may prove useful for understanding STEM resilience and developing intervention pathways. Implications for teacher education include the importance of students' perceptions of teacher support.
MeSH term(s)	Anger ; Humans ; Linguistics ; Mathematics ; Resilience, Psychological ; Schools ; Technology
Language	English
Publishing date	2022-03-19
Publishing country	England
Document type	Journal Article
ZDB-ID	1501130-6
ISSN	2044-8279 ; 0007-0998
ISSN (online)	2044-8279
ISSN	0007-0998
DOI	10.1111/bjep.12496
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Article ; Online: Correction: Evaluation of a Virtual Reality Platform to Train Stress Management Skills for a Defense Workforce: Multisite, Mixed Methods Feasibility Study.

Kluge, Murielle G / Maltby, Steven / Kuhne, Caroline / Walker, Nicole / Bennett, Neanne / Aidman, Eugene / Nalivaiko, Eugene / Walker, Frederick Rohan

Journal of medical Internet research

2023 Volume 25, Page(s) e54504

Abstract: This corrects the article DOI: 10.2196/46368.]. ...

Abstract	[This corrects the article DOI: 10.2196/46368.].
Language	English
Publishing date	2023-11-20
Publishing country	Canada
Document type	Published Erratum
ZDB-ID	2028830-X
ISSN	1438-8871 ; 1438-8871
ISSN (online)	1438-8871
ISSN	1438-8871
DOI	10.2196/54504
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Article: Comparing approaches for selection, development, and deployment of extended reality (XR) teaching applications: A case study at The University of Newcastle Australia.

Kluge, Murielle G / Maltby, Steven / Kuhne, Caroline / Evans, Darrell J R / Walker, Frederick Rohan

Education and information technologies

2022 Volume 28, Issue 4, Page(s) 4531–4562

Abstract: The use of extended reality (XR) technology in education offers many advantages for transferring knowledge and practical skills training at the higher education level. As a result, many Universities over the past 5 + years have undertaken pilot programs ... ...

Abstract	The use of extended reality (XR) technology in education offers many advantages for transferring knowledge and practical skills training at the higher education level. As a result, many Universities over the past 5 + years have undertaken pilot programs to both develop XR content and assess how to best implement it within existing teaching and learning systems. Unfortunately, very few of these efforts have included structured evaluation or documentation. As such, limited published evidence exists to inform processes and approaches that may assist or hinder broad scale implementation. This leads many Universities to unnecessarily commit significant time and resources to testing identical or similar approaches, resulting in repeated identification of the same or similar challenges. In response to this situation, The University of Newcastle, Australia decided to systematically document the approach for selection, development and implementation of four new virtual-reality (VR) teaching applications. The current paper contains a detailed intrinsic case study, outlining the process and critical elements that shaped the selection of suitable teaching content, software development, hardware solutions and implementation. Details are provided on how decisions were made, what components were considered helpful, challenges identified, and important lessons outlined. These findings will be useful to organisations and individuals as they look to develop pathways and processes to integrate XR technology, particularly within their existing training and educational frameworks. Supplementary information: The online version contains supplementary material available at 10.1007/s10639-022-11364-2.
Language	English
Publishing date	2022-10-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2001930-0
ISSN	1573-7608 ; 1360-2357
ISSN (online)	1573-7608
ISSN	1360-2357
DOI	10.1007/s10639-022-11364-2
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Article ; Online: Evaluation of a Virtual Reality Platform to Train Stress Management Skills for a Defense Workforce: Multisite, Mixed Methods Feasibility Study.

Kluge, Murielle G / Maltby, Steven / Kuhne, Caroline / Walker, Nicole / Bennett, Neanne / Aidman, Eugene / Nalivaiko, Eugene / Walker, Frederick Rohan

Journal of medical Internet research

2023 Volume 25, Page(s) e46368

Abstract: Background: Psychological stress-related injuries within first-responder organizations have created a need for the implementation of effective stress management training. Most stress management training solutions have limitations associated with scaled ... ...

Abstract	Background: Psychological stress-related injuries within first-responder organizations have created a need for the implementation of effective stress management training. Most stress management training solutions have limitations associated with scaled adoption within the workforce. For instance, those that are effective in civilian populations often do not align with the human performance culture embedded within first-responder organizations. Programs involving expert-led instructions that are high in quality are often expensive. Objective: This study sought to evaluate a tailored stress management training platform within the existing training schedule of the Australian Defense Force (ADF). The platform, known as Performance Edge (PE), is a novel virtual reality (VR) and biofeedback-enabled stress management skills training platform. Focusing on practical training of well-established skills and strategies, the platform was designed to take advantage of VR technology to generate an immersive and private training environment. This study aimed to assess the feasibility of delivering the VR platform within the existing group-based training context and intended training population. In this setting, the study further aimed to collect data on critical predictors of user acceptance and technology adoption in education, including perceived usability, usefulness, and engagement, while also assessing training impacts. Methods: This study used a mixed methods, multisite approach to collect observational, self-reported, and biometric data from both training staff and trainers within a real-world "on-base" training context in the ADF. Validated scales include the Presence Questionnaire and User Engagement Scale for perceived usefulness, usability, and engagement, as well as the State Mindfulness Scale and Relaxation Inventory, to gain insights into immediate training impacts for specific training modules. Additional surveys were specifically developed to assess implementation feedback, intention to use skills, and perceived training impact and value. Results: PE training was delivered to 189 ADF trainees over 372 training sessions. The platform was easy to use at an individual level and was feasible to deliver in a classroom setting. Trainee feedback consistently showed high levels of engagement and a sense of presence with the training content and environment. PE is overall perceived as an effective and useful training tool. Self-report and objective indices confirmed knowledge improvement, increased skill confidence, and increased competency after training. Specific training elements resulted in increased state mindfulness, increased physical relaxation, and reduced breathing rate. The ability to practice cognitive strategies in a diverse, private, and immersive training environment while in a group setting was highlighted as particularly valuable. Conclusions: This study found the VR-based platform (PE) to be a feasible stress management training solution for group-based training delivery in a defense population. Furthermore, the intended end users, both trainers and trainees, perceive the platform to be usable, useful, engaging, and effective for training, suggesting end-user acceptance and potential for technology adoption.
MeSH term(s)	Humans ; Australia ; Biofeedback, Psychology ; Biometry ; Educational Status ; Feasibility Studies
Language	English
Publishing date	2023-11-06
Publishing country	Canada
Document type	Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2028830-X
ISSN	1438-8871 ; 1438-8871
ISSN (online)	1438-8871
ISSN	1438-8871
DOI	10.2196/46368
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Article ; Online: Severe asthma: We can fix it? We can try!

McDonald, Vanessa M / Maltby, Steven / Gibson, Peter G

Respirology (Carlton, Vic.)

2018 Volume 23, Issue 3, Page(s) 260–261

MeSH term(s)	Adolescent ; Adult ; Asthma/diagnosis ; Asthma/metabolism ; Asthma/therapy ; Biomarkers/metabolism ; Child ; Disease Management ; Female ; Humans ; Inflammation/diagnosis ; Inflammation/metabolism ; Male ; Nitric Oxide/metabolism ; Severity of Illness Index ; Young Adult
Chemical Substances	Biomarkers ; Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2018-01-05
Publishing country	Australia
Document type	Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	1435849-9
ISSN	1440-1843 ; 1323-7799
ISSN (online)	1440-1843
ISSN	1323-7799
DOI	10.1111/resp.13249
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Article ; Online: Evaluation of a Virtual Reality Platform to Train Stress Management Skills for a Defense Workforce

Murielle G Kluge / Steven Maltby / Caroline Kuhne / Nicole Walker / Neanne Bennett / Eugene Aidman / Eugene Nalivaiko / Frederick Rohan Walker

Journal of Medical Internet Research, Vol 25, p e

Multisite, Mixed Methods Feasibility Study

2023 Volume 46368

Abstract: BackgroundPsychological stress-related injuries within first-responder organizations have created a need for the implementation of effective stress management training. Most stress management training solutions have limitations associated with scaled ... ...

Abstract	BackgroundPsychological stress-related injuries within first-responder organizations have created a need for the implementation of effective stress management training. Most stress management training solutions have limitations associated with scaled adoption within the workforce. For instance, those that are effective in civilian populations often do not align with the human performance culture embedded within first-responder organizations. Programs involving expert-led instructions that are high in quality are often expensive. ObjectiveThis study sought to evaluate a tailored stress management training platform within the existing training schedule of the Australian Defense Force (ADF). The platform, known as Performance Edge (PE), is a novel virtual reality (VR) and biofeedback-enabled stress management skills training platform. Focusing on practical training of well-established skills and strategies, the platform was designed to take advantage of VR technology to generate an immersive and private training environment. This study aimed to assess the feasibility of delivering the VR platform within the existing group-based training context and intended training population. In this setting, the study further aimed to collect data on critical predictors of user acceptance and technology adoption in education, including perceived usability, usefulness, and engagement, while also assessing training impacts. MethodsThis study used a mixed methods, multisite approach to collect observational, self-reported, and biometric data from both training staff and trainers within a real-world “on-base” training context in the ADF. Validated scales include the Presence Questionnaire and User Engagement Scale for perceived usefulness, usability, and engagement, as well as the State Mindfulness Scale and Relaxation Inventory, to gain insights into immediate training impacts for specific training modules. Additional surveys were specifically developed to assess implementation feedback, intention to use skills, and perceived ...
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7 ; Public aspects of medicine ; RA1-1270
Subject code	796
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	JMIR Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Upper Respiratory Tract OC43 Infection Model for Investigating Airway Immune-Modifying Therapies.

Girkin, Jason L N / Bryant, Nathan E / Loo, Su-Ling / Hsu, Alan / Kanwal, Amama / Williams, Teresa C / Maltby, Steven / Turville, Stuart G / Wark, Peter A B / Bartlett, Nathan W

American journal of respiratory cell and molecular biology

2023 Volume 69, Issue 6, Page(s) 614–622

Abstract: Respiratory virus infections initiate and transmit from the upper respiratory tract (URT). Coronaviruses, including OC43, are a major cause of respiratory infection and disease. Failure to mount an effective antiviral immune response in the nasal mucosa ... ...

Abstract	Respiratory virus infections initiate and transmit from the upper respiratory tract (URT). Coronaviruses, including OC43, are a major cause of respiratory infection and disease. Failure to mount an effective antiviral immune response in the nasal mucosa increases the risk of severe disease and person-to-person transmission, highlighting the need for URT infection models to support the development of nasal treatments that improve coronavirus antiviral immunity. We aimed to determine if OC43 productively infected the mouse URT and would therefore be a suitable model to assess the efficacy and mechanism of action of nasal-targeting immune-modifying treatments. We administered OC43 via intranasal inoculation to wild-type Balb/c mice and assessed virus airway tropism (by comparing total respiratory tract vs. URT-only virus exposure) and characterized infection-induced immunity by quantifying specific antiviral cytokines and performing gene array assessment of immune genes. We then assessed the effect of immune-modulating therapies, including an immune-stimulating TLR2/6 agonist (INNA-X) and the immune-suppressing corticosteroid fluticasone propionate (FP). OC43 replicated in nasal respiratory epithelial cells, with peak viral RNA observed 2 days after infection. Prophylactic treatment with INNA-X accelerated expression of virus-induced IFN-λ and IFN-stimulated genes. In contrast, intranasal FP treatment increased nasal viral load by 2.4 fold and inhibited virus-induced IFN and IFN-stimulated gene expression. Prior INNA-X treatment reduced the immune-suppressive effect of FP. We demonstrate that the mouse nasal epithelium is permissive to OC43 infection and strengthen the evidence that TLR2 activation is a β-coronavirus innate immune determinant and therapeutic target.
MeSH term(s)	Humans ; Animals ; Mice ; Toll-Like Receptor 2 ; Respiratory Tract Infections/drug therapy ; Cytokines/metabolism ; Nasal Mucosa/metabolism ; Interferon Lambda
Chemical Substances	Toll-Like Receptor 2 ; Cytokines ; Interferon Lambda
Language	English
Publishing date	2023-08-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1025960-0
ISSN	1535-4989 ; 1044-1549
ISSN (online)	1535-4989
ISSN	1044-1549
DOI	10.1165/rcmb.2023-0202MA
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Article ; Online: Severe asthma: Can we fix it? Prologue to seeking innovative solutions for severe asthma.

McDonald, Vanessa M / Maltby, Steven / Gibson, Peter G

Respirology (Carlton, Vic.)

2016 Volume 22, Issue 1, Page(s) 19–20

Keywords	covid19
Language	English
Publishing date	2016-11-30
Publishing country	Australia
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Address
ZDB-ID	1435849-9
ISSN	1440-1843 ; 1323-7799
ISSN (online)	1440-1843
ISSN	1323-7799
DOI	10.1111/resp.12956
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Article ; Online: Current State and General Perceptions of the Use of Extended Reality (XR) Technology at the University of Newcastle

Murielle G. Kluge / Steven Maltby / Angela Keynes / Eugene Nalivaiko / Darrell J. R. Evans / Frederick R. Walker

SAGE Open, Vol

Interviews and Surveys From Staff and Students

2022 Volume 12

Abstract: Extended reality (XR) technology is an emerging teaching tool within the higher education sector. Many institutions are currently running pilot projects, primarily assessing individual XR teaching tools typically being led by innovative/technology-driven ...

Abstract	Extended reality (XR) technology is an emerging teaching tool within the higher education sector. Many institutions are currently running pilot projects, primarily assessing individual XR teaching tools typically being led by innovative/technology-driven teaching staff, which may introduce a self-selection bias and may not represent the general attitudes of the broader staff and student population. We applied a mixed-methods approach to gain insight into end-user acceptability, value areas, barriers, and opportunities for the adoption of XR in teaching at an Australian University. A university-wide online survey and targeted interview sessions with XR technology users show a general readiness for broad adoption of XR technologies in university education. Whilst existing XR teaching applications were described as “successful,” relatively few applications were sustainably integrated into the curriculum. Our data highlights the existing barriers for the successful transition from individual use-cases of XR tools to broader adoption across university institutions.
Keywords	History of scholarship and learning. The humanities ; AZ20-999 ; Social Sciences ; H
Subject code	020
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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