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Article ; Online: Azithromycin: can its benefit be ruled out in mild COVID-19?

Rodríguez-Molinero, Alejandro

2021 Volume 9, Issue 10, Page(s) 1079–1081

MeSH term(s)	Azithromycin ; COVID-19/drug therapy ; Humans ; SARS-CoV-2
Chemical Substances	Azithromycin (83905-01-5)
Language	English
Publishing date	2021-07-09
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	2686754-0
ISSN	2213-2619 ; 2213-2600
ISSN (online)	2213-2619
ISSN	2213-2600
DOI	10.1016/S2213-2600(21)00289-7
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Article ; Online: Mejorando la predicción de caídas con la autopercepción del riesgo de caer: «¿cuál es la probabilidad de que usted se caiga en los próximos meses?».

Gálvez-Barrón, César / Formiga, Francesc / Rodríguez-Molinero, Alejandro

Revista espanola de geriatria y gerontologia

2021 Volume 56, Issue 4, Page(s) 193–194

Title translation	Improving falls prediction by the self-perception of the risk of falling: "Do you think you may fall in the next few months?"
MeSH term(s)	Accidental Falls/prevention & control ; Aged ; Diagnostic Self Evaluation ; Geriatric Assessment ; Humans ; Risk Assessment ; Time Factors
Language	Spanish
Publishing date	2021-06-08
Publishing country	Spain
Document type	Journal Article
ZDB-ID	605609-x
ISSN	1578-1747 ; 0211-139X
ISSN (online)	1578-1747
ISSN	0211-139X
DOI	10.1016/j.regg.2021.04.010
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Zs.B 2677: Show issues

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Article ; Online: Alterations in testicular positioning after normal descent: acquired cryptorchidism.

Grande-Moreillo, Carme / Fuentes-Carretero, Sara / Margarit-Mallol, Jaume / Pérez-López, Carlos / Rodríguez-Molinero, Alejandro

Andrology

2023

Abstract: Background: Acquired cryptorchidism or acquired undescended testis (UDT) is defined as the displacement of a testicle outside the scrotal sac after normal descent has been verified. There are still no clear guidelines on its management.: Objectives: ... ...

Abstract	Background: Acquired cryptorchidism or acquired undescended testis (UDT) is defined as the displacement of a testicle outside the scrotal sac after normal descent has been verified. There are still no clear guidelines on its management. Objectives: To analyze patients who underwent surgery for UDT in our setting to determine the prevalence of acquired cryptorchidism and to analyze the demographic and clinical characteristics of the population of children diagnosed with both acquired and congenital cryptorchidism, the age of presentation of both entities and the percentage of bilateral involvement. Materials and methods: This was a retrospective descriptive study using data from the clinical history of patients who underwent surgery for cryptorchidism between 2011 and 2022. The type of cryptorchidism, acquired or congenital, was recorded. Demographic and clinical data were collected. Results: A total of 367 patients and 442 testicular units were included in the study (75 patients had bilateral involvement). In 54.75% (95% CI: 50.09%-59.40%) of the cases analyzed, cryptorchidism was acquired, and the mean age at the time of surgery was 7.39 years (SD 2.95). Twenty percent (95% CI: 16.29%-24.58%) of the patients presented with bilateral cryptorchidism and 64% (95% CI: 52.88%-75.11%) out of them were acquired on both sides. The diagnosis was metachronous in 42.6% (95% CI: 31.21%-54.12%) of bilateral cryptorchidism cases. Discussion and conclusion: Acquired cryptorchidism accounts for more than half of cryptorchidism cases requiring surgery in our setting, with a clearly different age of presentation than that for congenital cryptorchidism. Therefore, it is necessary to monitor the presence of the testes in the scrotal sac until adolescence. It is also important to monitor patients with a history of cryptorchidism, not only for the management of the operated testicle but also for the early identification of patients who will develop metachronous contralateral cryptorchidism.
Language	English
Publishing date	2023-11-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2696108-8
ISSN	2047-2927 ; 2047-2919
ISSN (online)	2047-2927
ISSN	2047-2919
DOI	10.1111/andr.13557
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Zs.A 6983: Show issues

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Article ; Online: Incidence of urinary incontinence after hip fracture surgery and associated risk factors: a prospective study.

Arroyo-Huidobro, Marta / de la Fuente, Josefa López / Pagespetit, Mar Riera / Perez, Oscar Macho / Morera, Jaume Roig / López, Anna Maria Abelleira / Casanova, David Aivar / Garcia-Lerma, Esther / Pérez-López, Carlos / Rodríguez-Molinero, Alejandro

BMC geriatrics

2024 Volume 24, Issue 1, Page(s) 3

Abstract: Background: The contribution of the postoperative process to developing or worsening urinary incontinence (UI) after hip fracture surgery (HFS) remains unclear. We aimed to evaluate UI incidence and worsening among older patients undergoing HFS, and ... ...

Abstract	Background: The contribution of the postoperative process to developing or worsening urinary incontinence (UI) after hip fracture surgery (HFS) remains unclear. We aimed to evaluate UI incidence and worsening among older patients undergoing HFS, and explore associated risk factors. Methods: This prospective cohort study included patients ≥ 75 years admitted between October 2019 and October 2021 to the Traumatology Service of three hospitals in the Consorci Sanitari de Alt-Penedès i Garraf (Barcelona, Spain) with hip fracture requiring surgical treatment. UI was assessed using the first two questions of the International Consultation on Incontinence Questionnaire - Short Form (ICIQ-SF) at baseline and at days 30 (± 3 days) and 90 (± 3 days) after HFS. Surgery-related data and post-surgical complications were recorded. Results: A total of 248 patients with a mean (SD) age of 85.8 (6.78) years were included; 77.8% were female and 154 (62.1%) had UI at baseline. After HFS, 3.24% experienced urinary tract infections (UTIs), 3.64%, acute urinary retention (AUR), 8.57%, constipation, and 53.9%, prolonged catheterization (> 24 h). Fifty-eight patients without baseline UI developed UI at 30 days, resulting in a UI incidence of 61.7% (95% CI 51.1-71.54) between days 0 and 30. Of the 248 patients, 146 (59.1%) experienced worsening of UI. AUR and UTIs were identified as risk factors for UI development and worsening after HFS, respectively. Conclusion: The incidence of UI in older patients after HFS is significant. Patient management protocols should consider AUR and UTIs to reduce or eliminate the incidence of UI in older patients undergoing HFS.
MeSH term(s)	Humans ; Female ; Aged ; Aged, 80 and over ; Male ; Prospective Studies ; Incidence ; Urinary Incontinence/diagnosis ; Urinary Incontinence/epidemiology ; Urinary Incontinence/etiology ; Hip Fractures/epidemiology ; Hip Fractures/surgery ; Risk Factors ; Surveys and Questionnaires ; Quality of Life
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-023-04597-4
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Article ; Online: Parotid irrigation: A promising option for juvenile recurrent parotitis.

Grande-Moreillo, Carme / Margarit-Mallol, Jaume / Fuentes-Carretero, Sara / Torolla, Alina / Martí-Camps, Montse / Rodríguez-Molinero, Alejandro

American journal of otolaryngology

2022 Volume 43, Issue 3, Page(s) 103398

Abstract: Objective: To study whether irrigating the parotid gland with saline solution through the parotid duct reduces the number of inflammatory episodes in patients with juvenile recurrent parotitis (JRP) over a 1-year period.: Methods: This was a ... ...

Abstract	Objective: To study whether irrigating the parotid gland with saline solution through the parotid duct reduces the number of inflammatory episodes in patients with juvenile recurrent parotitis (JRP) over a 1-year period. Methods: This was a retrospective cohort study using the electronic clinical history data of patients with JRP that were treated with parotid irrigation under general anaesthesia at the Paediatric Surgery units of Consorci Sanitari Alt Penedès-Garraf and Hospital Universitari Mútua de Terrassa. The number of inflammation episodes in the year before and the year after treatment was analysed. Results: A total of 15 patients with JRP were evaluated, of whom 10 met the criteria for irrigation. Data from 9 patients were available. The procedure was performed without incident in all of the patients. There was no difficulty with probing the duct and no need for orifice dilation. No post-lavage complications were observed. Four patients had complete resolution of inflammation events (44.4%), and the remaining 5 patients had a decrease in the number of events. The Wilcoxon signed-rank test showed a statistically significant difference between the number of inflammation events before and after the intervention (p = 0.009). Conclusions: Parotid irrigation with saline solution could be a safe and effective first-line technique for the treatment of JRP. Level-of-evidence: IV.
MeSH term(s)	Child ; Humans ; Inflammation ; Parotid Gland ; Parotitis/surgery ; Recurrence ; Retrospective Studies ; Saline Solution ; Therapeutic Irrigation
Chemical Substances	Saline Solution
Language	English
Publishing date	2022-02-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	604541-8
ISSN	1532-818X ; 0196-0709
ISSN (online)	1532-818X
ISSN	0196-0709
DOI	10.1016/j.amjoto.2022.103398
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Article: Drug Repurposing for Cancers With Limited Survival: Protocol for a Retrospective Cohort Study.

Rodríguez-Molinero, Alejandro / Pérez-López, Carlos / Salazar González, Jose L / Garcia-Lerma, Esther / Álvarez-García, Juan A / Soria Morillo, Luis M / Salas Fernández, Tomás

JMIR research protocols

2023 Volume 12, Page(s) e48925

Abstract: Background: Only 5% of the molecules tested in oncology phase 1 trials reach the market after an average of 7.5 years of waiting and at a cost of tens of millions of dollars. To reduce the cost and shorten the time of discovery of new treatments, "drug ... ...

Abstract	Background: Only 5% of the molecules tested in oncology phase 1 trials reach the market after an average of 7.5 years of waiting and at a cost of tens of millions of dollars. To reduce the cost and shorten the time of discovery of new treatments, "drug repurposing" (research with molecules already approved for another indication) and the use of secondary data (not collected for the purpose of research) have been proposed. Due to advances in informatics in clinical care, secondary data can, in some cases, be of equal quality to primary data generated through prospective studies. Objective: The objective of this study is to identify drugs currently marketed for other indications that may have an effect on the prognosis of patients with cancer. Methods: We plan to monitor a cohort of patients with high-lethality cancers treated in the public health system of Catalonia between 2006 and 2012, retrospectively, for survival for 5 years after diagnosis or until death. A control cohort, comprising people without cancer, will also be retrospectively monitored for 5 years. The following study variables will be extracted from different population databases: type of cancer (patients with cancer cohort), date and cause of death, pharmacological treatment, sex, age, and place of residence. During the first stage of statistical analysis of the patients with cancer cohort, the drugs consumed by the long-term survivors (alive at 5 years) will be compared with those consumed by nonsurvivors. In the second stage, the survival associated with the consumption of each relevant drug will be analyzed. For the analyses, groups will be matched for potentially confounding variables, and multivariate analyses will be performed to adjust for residual confounding variables if necessary. The control cohort will be used to verify whether the associations found are exclusive to patients with cancer or whether they also occur in patients without cancer. Results: We anticipate discovering multiple significant associations between commonly used drugs and the survival outcomes of patients with cancer. We expect to publish the initial results in the first half of 2024. Conclusions: This retrospective study may identify several commonly used drugs as candidates for repurposing in the treatment of various cancers. All analyses are considered exploratory; therefore, the results will have to be confirmed in subsequent clinical trials. However, the results of this study may accelerate drug discovery in oncology. International registered report identifier (irrid): DERR1-10.2196/48925.
Language	English
Publishing date	2023-11-14
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2719222-2
ISSN	1929-0748
ISSN	1929-0748
DOI	10.2196/48925
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Article ; Online: Machine learning for the development of diagnostic models of decompensated heart failure or exacerbation of chronic obstructive pulmonary disease.

Gálvez-Barrón, César / Pérez-López, Carlos / Villar-Álvarez, Felipe / Ribas, Jesús / Formiga, Francesc / Chivite, David / Boixeda, Ramón / Iborra, Cristian / Rodríguez-Molinero, Alejandro

Scientific reports

2023 Volume 13, Issue 1, Page(s) 12709

Abstract: Heart failure (HF) and chronic obstructive pulmonary disease (COPD) are two chronic diseases with the greatest adverse impact on the general population, and early detection of their decompensation is an important objective. However, very few diagnostic ... ...

Abstract	Heart failure (HF) and chronic obstructive pulmonary disease (COPD) are two chronic diseases with the greatest adverse impact on the general population, and early detection of their decompensation is an important objective. However, very few diagnostic models have achieved adequate diagnostic performance. The aim of this trial was to develop diagnostic models of decompensated heart failure or COPD exacerbation with machine learning techniques based on physiological parameters. A total of 135 patients hospitalized for decompensated heart failure and/or COPD exacerbation were recruited. Each patient underwent three evaluations: one in the decompensated phase (during hospital admission) and two more consecutively in the compensated phase (at home, 30 days after discharge). In each evaluation, heart rate (HR) and oxygen saturation (Ox) were recorded continuously (with a pulse oximeter) during a period of walking for 6 min, followed by a recovery period of 4 min. To develop the diagnostic models, predictive characteristics related to HR and Ox were initially selected through classification algorithms. Potential predictors included age, sex and baseline disease (heart failure or COPD). Next, diagnostic classification models (compensated vs. decompensated phase) were developed through different machine learning techniques. The diagnostic performance of the developed models was evaluated according to sensitivity (S), specificity (E) and accuracy (A). Data from 22 patients with decompensated heart failure, 25 with COPD exacerbation and 13 with both decompensated pathologies were included in the analyses. Of the 96 characteristics of HR and Ox initially evaluated, 19 were selected. Age, sex and baseline disease did not provide greater discriminative power to the models. The techniques with S and E values above 80% were the logistic regression (S: 80.83%; E: 86.25%; A: 83.61%) and support vector machine (S: 81.67%; E: 85%; A: 82.78%) techniques. The diagnostic models developed achieved good diagnostic performance for decompensated HF or COPD exacerbation. To our knowledge, this study is the first to report diagnostic models of decompensation potentially applicable to both COPD and HF patients. However, these results are preliminary and warrant further investigation to be confirmed.
MeSH term(s)	Humans ; Chronic Disease ; Heart Failure/diagnosis ; Hospitalization ; Machine Learning ; Pulmonary Disease, Chronic Obstructive/diagnosis
Language	English
Publishing date	2023-08-05
Publishing country	England
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-39329-6
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Article: A New Paradigm in Parkinson's Disease Evaluation With Wearable Medical Devices: A Review of STAT-ON

Rodríguez-Martín, Daniel / Cabestany, Joan / Pérez-López, Carlos / Pie, Marti / Calvet, Joan / Samà, Albert / Capra, Chiara / Català, Andreu / Rodríguez-Molinero, Alejandro

Frontiers in neurology

2022 Volume 13, Page(s) 912343

Abstract: In the past decade, the use of wearable medical devices has been a great breakthrough in clinical practice, trials, and research. In the Parkinson's disease field, clinical evaluation is time limited, and healthcare professionals need to rely on ... ...

Abstract	In the past decade, the use of wearable medical devices has been a great breakthrough in clinical practice, trials, and research. In the Parkinson's disease field, clinical evaluation is time limited, and healthcare professionals need to rely on retrospective data collected through patients' self-filled diaries and administered questionnaires. As this often leads to inaccurate evaluations, a more objective system for symptom monitoring in a patient's daily life is claimed. In this regard, the use of wearable medical devices is crucial. This study aims at presenting a review on STAT-ON
Language	English
Publishing date	2022-06-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2022.912343
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Article ; Online: Plasma 3,3',5-Triiodo-L-thyronine [T3] level mirrors changes in tumor markers in two cases of metastatic cancer of the breast and pancreas treated with exogenous L-T3.

Rodríguez-Molinero, Alejandro / Hercbergs, Aleck / Sarrias, Manuel / Yuste, Antonio

Cancer biomarkers : section A of Disease markers

2017 Volume 21, Issue 2, Page(s) 433–438

Abstract: Preclinical studies have attributed 3,3',5-triiodo-L-thyronine (T3) a direct negative effect on tumor progression, as well as chemosensitizing, differentiating and immunomodulatory properties. On the other hand, L-thyroxine (T4), via a thyroid hormone ... ...

Abstract	Preclinical studies have attributed 3,3',5-triiodo-L-thyronine (T3) a direct negative effect on tumor progression, as well as chemosensitizing, differentiating and immunomodulatory properties. On the other hand, L-thyroxine (T4), via a thyroid hormone receptor on plasma membrane integrin αvβ3, promotes solid tumor growth and neoangiogenesis, therefore lowering endogenous T4 reduces tumor growth rate. We present the case of two patients with metastatic triple negative breast cancer and metastatic pancreatic cancer respectively, who benefit of the sole treatment with antithyroid drugs and exogenous administration of T3 (liothyronine). In these cases tumor growth was accompanied by T3 depletion in plasma, which may represent a novel marker for progression.
MeSH term(s)	Aged ; Aged, 80 and over ; Biomarkers, Tumor/blood ; Female ; Humans ; Neoplasm Metastasis ; Pancreatic Neoplasms/blood ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/pathology ; Triiodothyronine/administration & dosage ; Triiodothyronine/blood ; Triple Negative Breast Neoplasms/blood ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/pathology
Chemical Substances	Biomarkers, Tumor ; Triiodothyronine (06LU7C9H1V)
Language	English
Publishing date	2017-11-29
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	2203517-5
ISSN	1875-8592 ; 1574-0153 ; 1875-8592
ISSN (online)	1875-8592 ; 1574-0153
ISSN	1875-8592
DOI	10.3233/CBM-170668
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Article: Characteristics and Outcomes by Ceiling of Care of Subjects Hospitalized with COVID-19 During Four Waves of the Pandemic in a Metropolitan Area: A Multicenter Cohort Study.

Pallarès, Natàlia / Tebé, Cristian / Abelenda-Alonso, Gabriela / Rombauts, Alexander / Oriol, Isabel / Simonetti, Antonella F / Rodríguez-Molinero, Alejandro / Izquierdo, Elisenda / Díaz-Brito, Vicens / Molist, Gemma / Gómez Melis, Guadalupe / Carratalà, Jordi / Videla, Sebastián

Infectious diseases and therapy

2022 Volume 12, Issue 1, Page(s) 273–289

Abstract: Introduction: The profiles of patients with COVID-19 have been widely studied, but little is known about differences in baseline characteristics and in outcomes between subjects with a ceiling of care assigned at hospital admission and subjects without ... ...

Abstract	Introduction: The profiles of patients with COVID-19 have been widely studied, but little is known about differences in baseline characteristics and in outcomes between subjects with a ceiling of care assigned at hospital admission and subjects without a ceiling of care. The aim of this study is to compare, by ceiling of care, clinical features and outcomes of hospitalized subjects during four waves of COVID-19 in a metropolitan area in Catalonia. Methods: Observational study conducted during the first (March-April 2020), second (October-November 2020), third (January-February 2021), and fourth wave (July-August 2021) of COVID-19 in five centers of Catalonia. All subjects were adults (> 18 years old) hospitalized with a proven SARS-CoV-2 infection and with therapeutic ceiling of care assessed by the attending physician at hospital admission. Results: A total of 5813 subjects were analyzed. Subjects with a ceiling of care were mainly older (difference in median age of 20 years), with more comorbidities (Charlson index 3 points higher) and with fewer clinical signs at baseline than patients without a ceiling of care. Some features of their clinical profiles changed among waves. There were differences in treatments received during hospital admission across waves, but not between subjects with and without a ceiling of care. Subjects with a ceiling of care had a death incidence more than four times the death incidence of subjects a without a ceiling of care (risk ratio (RR) ranging from 3.5 in the first wave to almost 6 in the third and fourth). Incidence of severe pneumonia and complications for subjects with a ceiling of care was around 1.5 times the incidence in subjects without a ceiling of care. Discussion: Analysis of hospitalized subjects with SARS-CoV-2 infection should be stratified according to therapeutic ceiling of care to avoid bias and outcome misestimation.
Language	English
Publishing date	2022-12-10
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2701611-0
ISSN	2193-6382 ; 2193-8229
ISSN (online)	2193-6382
ISSN	2193-8229
DOI	10.1007/s40121-022-00705-w
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