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  1. Article ; Online: Nicotine pouches: a review for the dental team.

    M Jackson, Joshua / Weke, Anthony / Holliday, Richard

    British dental journal

    2023  Volume 235, Issue 8, Page(s) 643–646

    Abstract: Nicotine pouches are tobacco-free products that are becoming increasingly popular in the UK. They are held between the user's lip and gum to provide a source of nicotine. This article describes the composition of nicotine pouches, the legality ... ...

    Abstract Nicotine pouches are tobacco-free products that are becoming increasingly popular in the UK. They are held between the user's lip and gum to provide a source of nicotine. This article describes the composition of nicotine pouches, the legality surrounding their production and sale, patterns of use and explores possible oral and general health effects of their usage.
    MeSH term(s) Nicotine/adverse effects ; Tobacco, Smokeless ; Commerce ; Electronic Nicotine Delivery Systems ; Tobacco Products
    Chemical Substances Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2023-10-27
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-023-6383-7
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    In stock of ZB MED Cologne/Königswinter

    Ul III Zs.143: Show issues Location:
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  2. Article: Spatial patterns of reproduction suggest marginal habitat limits continued range expansion of black bears at a forest-desert ecotone.

    Sultaire, Sean M / Montgomery, Robert A / Jackson, Patrick J / Millspaugh, Joshua J

    Ecology and evolution

    2023  Volume 13, Issue 11, Page(s) e10658

    Abstract: Investigating spatial patterns of animal occupancy and reproduction in peripheral populations can provide insight into factors that form species range boundaries. Following historical extirpation, American black bears ( ...

    Abstract Investigating spatial patterns of animal occupancy and reproduction in peripheral populations can provide insight into factors that form species range boundaries. Following historical extirpation, American black bears (
    Language English
    Publishing date 2023-10-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2635675-2
    ISSN 2045-7758
    ISSN 2045-7758
    DOI 10.1002/ece3.10658
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  3. Article: Effects of antiretroviral treatment on central and peripheral immune response in mice with EcoHIV infection.

    Xie, Qiaowei / Namba, Mark D / Buck, Lauren A / Park, Kyewon / Jackson, Joshua G / Barker, Jacqueline M

    bioRxiv : the preprint server for biology

    2024  

    Abstract: HIV infection is an ongoing global health issue despite increased access to antiretroviral therapy (ART). People living with HIV (PLWH) who are virally suppressed through ART still experience negative health outcomes, including neurocognitive impairment. ...

    Abstract HIV infection is an ongoing global health issue despite increased access to antiretroviral therapy (ART). People living with HIV (PLWH) who are virally suppressed through ART still experience negative health outcomes, including neurocognitive impairment. It is increasingly evident that ART may act independently or in combination with HIV infection to alter immune state, though this is difficult to disentangle in the clinical population. Thus, these experiments used multiplexed chemokine/cytokine arrays to assess peripheral (plasma) and brain (nucleus accumbens; NAc) expression of immune targets in the presence and absence of ART treatment in the EcoHIV mouse model. The findings identify effects of EcoHIV infection and of treatment with bictegravir (B), emtricitabine (F) and tenofovir alafenamide (TAF) on expression of numerous immune targets. In the NAc, this included EcoHIV-induced increases in IL-1α and IL-13 expression and B/F/TAF-induced reductions in KC/CXCL1. In the periphery, EcoHIV suppressed IL-6 and LIF expression, while B/F/TAF reduced IL-12p40 expression. In absence of ART, IBA-1 expression was negatively correlated with CX3CL1 expression in the NAc of EcoHIV-infected mice. These findings identify distinct effects of ART and EcoHIV infection on peripheral and central immune factors and emphasize the need to consider ART effects on neural and immune outcomes.
    Language English
    Publishing date 2024-04-14
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.04.11.589109
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  4. Article: EcoHIV Infection Modulates the Effects of Cocaine Exposure Pattern and Abstinence on Cocaine Seeking and Neuroimmune Protein Expression in Male Mice.

    Namba, Mark D / Xie, Qiaowei / Park, Kyewon / Jackson, Joshua G / Barker, Jacqueline M

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Cocaine use disorders (CUDs) and human immunodeficiency virus (HIV) remain persistent public health dilemmas throughout the world. One major hurdle for treating CUD is the increase in cocaine craving and seeking behavior that occurs over a protracted ... ...

    Abstract Cocaine use disorders (CUDs) and human immunodeficiency virus (HIV) remain persistent public health dilemmas throughout the world. One major hurdle for treating CUD is the increase in cocaine craving and seeking behavior that occurs over a protracted period of abstinence, an effect known as the incubation of craving. Little is known about how HIV may modulate this process. Thus, we sought to examine the impact of chronic HIV infection on the incubation of cocaine craving and associated changes in the central and peripheral immune systems. Here, mice were inoculated with EcoHIV, which is a chimeric HIV-1 construct that produces chronic HIV infection in mice. EcoHIV- and sham-infected mice were conditioned with cocaine daily or intermittently in a conditioned place preference (CPP) paradigm, followed by 1 or 21 days of forced abstinence prior to assessing preference for the cocaine-paired chamber. Under both conditioning regimens, sham mice exhibited incubation of cocaine CPP after 21 days of abstinence. EcoHIV-infected mice conditioned daily with cocaine showed enhanced cocaine seeking at both abstinence timepoints, whereas infected mice conditioned intermittently showed a reversal of the incubation effect, with higher cocaine seeking after 1 day of abstinence compared to 21 days. Analysis of corticolimbic CX3CL1-CX3CR1 and glutamate receptor expression revealed alterations in medial prefrontal cortex (mPFC) CX3CL1 and nucleus accumbens (NAc) GluN2A receptors that correlated with cocaine seeking following daily cocaine exposure. Moreover, examination of peripheral immune markers showed that the effect of abstinence and EcoHIV infection on these measures depended on the cocaine exposure regimen. Altogether, these results highlight the importance of cocaine abstinence and exposure pattern as critical variables that modulate HIV-associated neuroimmune outcomes and relapse vulnerability.
    Language English
    Publishing date 2024-04-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.04.15.589615
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Algorithm-mediated social learning in online social networks.

    Brady, William J / Jackson, Joshua Conrad / Lindström, Björn / Crockett, M J

    Trends in cognitive sciences

    2023  Volume 27, Issue 10, Page(s) 947–960

    Abstract: Human social learning is increasingly occurring on online social platforms, such as Twitter, Facebook, and TikTok. On these platforms, algorithms exploit existing social-learning biases (i.e., towards prestigious, ingroup, moral, and emotional ... ...

    Abstract Human social learning is increasingly occurring on online social platforms, such as Twitter, Facebook, and TikTok. On these platforms, algorithms exploit existing social-learning biases (i.e., towards prestigious, ingroup, moral, and emotional information, or 'PRIME' information) to sustain users' attention and maximize engagement. Here, we synthesize emerging insights into 'algorithm-mediated social learning' and propose a framework that examines its consequences in terms of functional misalignment. We suggest that, when social-learning biases are exploited by algorithms, PRIME information becomes amplified via human-algorithm interactions in the digital social environment in ways that cause social misperceptions and conflict, and spread misinformation. We discuss solutions for reducing functional misalignment, including algorithms promoting bounded diversification and increasing transparency of algorithmic amplification.
    MeSH term(s) Humans ; Social Learning ; Social Media ; Social Networking ; Communication ; Algorithms
    Language English
    Publishing date 2023-08-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2010989-1
    ISSN 1879-307X ; 1364-6613
    ISSN (online) 1879-307X
    ISSN 1364-6613
    DOI 10.1016/j.tics.2023.06.008
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  6. Article: Cryptococcus neoformans

    Telzrow, Calla L / Esher Righi, Shannon / Cathey, Jackson M / Granek, Joshua A / Alspaugh, J Andrew

    Frontiers in physiology

    2023  Volume 14, Page(s) 1150272

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-03-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1150272
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  7. Article ; Online: Conflicts of interest and neurointerventional surgery.

    Midtlien, Jackson P / Iyer, Ankitha M / Jones, Brie S / Kittel, Carol / Hirsch, Joshua A / Fargen, Kyle M

    Journal of neurointerventional surgery

    2023  

    Language English
    Publishing date 2023-07-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2514982-9
    ISSN 1759-8486 ; 1759-8478
    ISSN (online) 1759-8486
    ISSN 1759-8478
    DOI 10.1136/jnis-2023-020646
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6845: Show issues Location:
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  8. Article ; Online: Measurement confounds in study on social media usage and adolescent life satisfaction.

    Foster, Joshua D / Jackson, M Hope

    Proceedings of the National Academy of Sciences of the United States of America

    2019  Volume 116, Issue 31, Page(s) 15333

    MeSH term(s) Adolescent ; Humans ; Personal Satisfaction ; Social Media
    Language English
    Publishing date 2019-07-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1908385116
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    Zs.A 1148: Show issues Location:
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  9. Article ; Online: Twelve tips for practical clinical skills coaching.

    Klig, Jean E / Stenson, Bryan A / Kivlehan, Sean M / Jackson, Agnieszka / Berwick, Jessica R / Kosowsky, Joshua M

    Medical teacher

    2023  Volume 45, Issue 12, Page(s) 1357–1363

    Abstract: Coaching is rapidly evolving in clinical medicine, including for clinical skills (CS) learning. Yet a schema is needed ... ...

    Abstract Coaching is rapidly evolving in clinical medicine, including for clinical skills (CS) learning. Yet a schema is needed for
    MeSH term(s) Humans ; Mentoring ; Clinical Competence ; Learning ; Medicine
    Language English
    Publishing date 2023-06-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 424426-6
    ISSN 1466-187X ; 0142-159X
    ISSN (online) 1466-187X
    ISSN 0142-159X
    DOI 10.1080/0142159X.2023.2220895
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    Zs.B 2176: Show issues Location:
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  10. Article ; Online: Quantifying endodermal strains during heart tube formation in the developing chicken embryo.

    Hack, Joshua M / Anwar, Nareen Z / Jackson, John G / Furth, Meagan E / Varner, Victor D

    Journal of biomechanics

    2023  Volume 149, Page(s) 111481

    Abstract: In the early avian embryo, the developing heart forms when bilateral fields of cardiac progenitor cells, which reside in the lateral plate mesoderm, move toward the embryonic midline, and fuse above the anterior intestinal portal (AIP) to form a straight, ...

    Abstract In the early avian embryo, the developing heart forms when bilateral fields of cardiac progenitor cells, which reside in the lateral plate mesoderm, move toward the embryonic midline, and fuse above the anterior intestinal portal (AIP) to form a straight, muscle-wrapped tube. During this process, the precardiac mesoderm remains in close contact with the underlying endoderm. Previous work has shown that the endoderm around the AIP actively contracts to pull the cardiac progenitors toward the midline. The morphogenetic deformations associated with this endodermal convergence, however, remain unclear, as do the signaling pathways that might regulate this process. Here, we fluorescently labeled populations of endodermal cells in early chicken embryos and tracked their motion during heart tube formation to compute time-varying strains along the anterior endoderm. We then determined how the computed endodermal strain distributions are affected by the pharmacological inhibition of either myosin II or fibroblast growth factor (FGF) signaling. Our data indicate that a mediolateral gradient in endodermal shortening is present around the AIP, as well as substantial convergence and extension movements both anterior and lateral to the AIP. These active endodermal deformations are disrupted if either actomyosin contractility or FGF signaling are inhibited pharmacologically. Taken together, these results demonstrate how active deformations along the anterior endoderm contribute to heart tube formation within the developing embryo.
    MeSH term(s) Animals ; Chick Embryo ; Chickens/metabolism ; Endoderm/metabolism ; Heart ; Morphogenesis ; Fibroblast Growth Factors/metabolism ; Fibroblast Growth Factors/pharmacology
    Chemical Substances Fibroblast Growth Factors (62031-54-3)
    Language English
    Publishing date 2023-02-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218076-5
    ISSN 1873-2380 ; 0021-9290
    ISSN (online) 1873-2380
    ISSN 0021-9290
    DOI 10.1016/j.jbiomech.2023.111481
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