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Article ; Online: Vinylogous and stereoselective domino synthesis of pyrano[2,3-

Savchuk, Mariia / Vo-Thanh, Giang / Oudeyer, Sylvain / Beucher, Hélène / Brière, Jean-François

2024 Volume 22, Issue 15, Page(s) 2948–2952

Abstract: A domino Vinylogous aza-Michael-Aldol-Cyclocondensation (aza-VMAC) reaction was achieved with a series of alkylidene Meldrum's acid derivatives under simple operational conditions paving the way to novel pyrano[2,3- ...

Abstract	A domino Vinylogous aza-Michael-Aldol-Cyclocondensation (aza-VMAC) reaction was achieved with a series of alkylidene Meldrum's acid derivatives under simple operational conditions paving the way to novel pyrano[2,3-
Language	English
Publishing date	2024-04-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d4ob00233d
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prise en charge des fausses-couches spontanées du premier trimestre.

Beucher, G

Journal de gynecologie, obstetrique et biologie de la reproduction

2010 Volume 39, Issue 3 Suppl, Page(s) F3–10

Title translation	Management of spontaneous miscarriage in the first trimester.
MeSH term(s)	Abortifacient Agents, Nonsteroidal/therapeutic use ; Abortion, Spontaneous/diagnosis ; Abortion, Spontaneous/diagnostic imaging ; Abortion, Spontaneous/drug therapy ; Abortion, Spontaneous/surgery ; Education, Medical, Continuing ; Endosonography ; Female ; Humans ; Misoprostol/therapeutic use ; Pregnancy ; Pregnancy Trimester, First ; Treatment Outcome
Chemical Substances	Abortifacient Agents, Nonsteroidal ; Misoprostol (0E43V0BB57)
Language	French
Publishing date	2010-05
Publishing country	France
Document type	Journal Article
ZDB-ID	121670-3
ISSN	1773-0430 ; 0368-2315 ; 0150-9918
ISSN (online)	1773-0430
ISSN	0368-2315 ; 0150-9918
DOI	10.1016/j.jgyn.2010.02.010
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Article ; Online: An Organocatalytic and Stereoselective Vinylogous Domino Process towards Thiochromans.

Milbeo, Pierre / Lebrêne, Arthur / Savchuk, Mariia / Vo-Thanh, Giang / Oudeyer, Sylvain / Beucher, Hélène / Brière, Jean-François

Chemistry (Weinheim an der Bergstrasse, Germany)

2023 Volume 29, Issue 42, Page(s) e202301311

Abstract: A highly diastereoselective organocatalyzed domino vinylogous sulfa-Michael-aldol-cyclocondensation (VMAC) reaction has been developed using alkylidene Meldrum's acid as dienes highlighting two vinylogous steps, an unprecedented sulfa-1,6-conjugate ... ...

Abstract	A highly diastereoselective organocatalyzed domino vinylogous sulfa-Michael-aldol-cyclocondensation (VMAC) reaction has been developed using alkylidene Meldrum's acid as dienes highlighting two vinylogous steps, an unprecedented sulfa-1,6-conjugate addition and a diastereoselective aldol reaction triggering a formal (4+2) cycloaddition. This work opens a new route towards bio-relevant and original tricyclic thiochroman derivatives.
Language	English
Publishing date	2023-06-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202301311
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Article: Complications maternelles des extractions instrumentales.

Beucher, G

Journal de gynecologie, obstetrique et biologie de la reproduction

2008 Volume 37 Suppl 8, Page(s) S244–59

Abstract: Operative vaginal delivery significantly increases the risk of anal sphincter injury compared with spontaneous vaginal delivery, particularly when an instrumental application at high station, persistent occipital posterior presentation and/or macrosomia ... ...

Title translation	Maternal morbidity after operative vaginal delivery.
Abstract	Operative vaginal delivery significantly increases the risk of anal sphincter injury compared with spontaneous vaginal delivery, particularly when an instrumental application at high station, persistent occipital posterior presentation and/or macrosomia are associated. Risks of vaginal tears, postpartum haemorrhage and urinary retention appear to be increased compared with spontaneous vaginal delivery. There is no evidence that one type of forceps is less safe than another. Different vacuum extractors (soft, rigid and single-use instruments) have similar maternal outcomes. A risk of anal incontinence in the first year postpartum is associated with operative vaginal delivery, particularly forceps. Operative vaginal delivery also appears to increase the risk of occult anal sphincter injury regardless of the instrument used, but does not appear to be associated with the risk of postpartum urinary incontinence and genital prolapse compared with spontaneous vaginal delivery. It does, however, increase the risks of perineal pain, postpartum dyspareunia and sexual disorders compared with spontaneous vaginal delivery, particularly in cases of perineal tears.
MeSH term(s)	Anal Canal/injuries ; Extraction, Obstetrical/adverse effects ; Fecal Incontinence/epidemiology ; Fecal Incontinence/etiology ; Female ; Humans ; MEDLINE ; Obstetrical Forceps/adverse effects ; Perineum/injuries ; Postpartum Hemorrhage/epidemiology ; Postpartum Hemorrhage/etiology ; Pregnancy ; Risk Factors ; Urinary Retention/epidemiology ; Urinary Retention/etiology ; Vagina/injuries
Language	French
Publishing date	2008-12
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	121670-3
ISSN	1773-0430 ; 0368-2315 ; 0150-9918
ISSN (online)	1773-0430
ISSN	0368-2315 ; 0150-9918
DOI	10.1016/S0368-2315(08)74762-8
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Article ; Online: Infection intra-utérine : diagnostic et traitement. RPC rupture prématurée des membranes avant terme CNGOF.

Beucher, G / Charlier, C / Cazanave, C

Gynecologie, obstetrique, fertilite & senologie

2018 Volume 46, Issue 12, Page(s) 1054–1067

Abstract: Objective: To determine the diagnosis criteria and management of intra-uterine inflammation or infection (Triple I, III).: Methods: PubMed and Cochrane Central databases search.: Results: III is defined as an infection of the fetal membranes, and/ ... ...

Title translation	Diagnosis and management of intra-uterine infection: CNGOF Preterm Premature Rupture of Membranes Guidelines.
Abstract	Objective: To determine the diagnosis criteria and management of intra-uterine inflammation or infection (Triple I, III). Methods: PubMed and Cochrane Central databases search. Results: III is defined as an infection of the fetal membranes, and/or other components like the decidua, fetus, amniotic fluid or placenta. This word should be preferred to the word chorioamnionitis that is less precise (Professional consensus). III clinical signs exhibit poor limited sensibility and specificity (EL3). The diagnosis of III is retained in case of maternal fever (defined by a body temperature≥38°C) with no alternative cause identified and at least 2 signs among the following: fetal tachycardia>160 bpm for 10min or longer, uterine pain of labor, purulent fluid from the cervical canal (Professional consensus). Maternal hyperleukocytosis>20 giga/L in the absence of corticosteroids treatment or increased plasmatic C-reactive protein also argue for III, despite their limited sensibility and specificity (EL3). III requires prompt delivery (Grade A). III is not by itself an indication for cesarean delivery (Professional consensus). Antibiotic treatment should cover Streptococcus agalactiae and Escherichia coli. Antibiotics should be started immediately and maintained all over delivery, to reduce neonatal and maternal morbidity (Grade B). Treatment should rely on a combination of betalactamin and aminoglycoside (Grade B). After vaginal delivery, one single dose of antibiotic is required. Antibiotic duration should be longer in case of bacteremia. Longer duration could be considered in case of persistent fever or of cesarean delivery (Professional consensus).
MeSH term(s)	Aminoglycosides/administration & dosage ; Anti-Bacterial Agents/therapeutic use ; Escherichia coli Infections/drug therapy ; Female ; Fetal Membranes, Premature Rupture/microbiology ; Fever ; France ; Humans ; Infection/diagnosis ; Infection/microbiology ; Infection/therapy ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Complications, Infectious/microbiology ; Pregnancy Complications, Infectious/therapy ; Streptococcal Infections/drug therapy ; Streptococcus agalactiae ; Uterine Diseases/diagnosis ; Uterine Diseases/microbiology ; Uterine Diseases/therapy ; beta-Lactams/administration & dosage
Chemical Substances	Aminoglycosides ; Anti-Bacterial Agents ; beta-Lactams
Language	French
Publishing date	2018-10-30
Publishing country	France
Document type	Journal Article ; Practice Guideline
ZDB-ID	2887456-0
ISSN	2468-7189
ISSN (online)	2468-7189
DOI	10.1016/j.gofs.2018.10.022
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Article ; Online: Mapping peat depth using a portable gamma-ray sensor and terrain attributes

Triven Koganti / Diana Vigah Adetsu / John Triantafilis / Mogens H. Greve / Amélie Marie Beucher

Geoderma, Vol 439, Iss , Pp 116672- (2023)

2023

Abstract: ... heavily altered (e.g., by draining the water table), increasing greenhouse gas (GHG) emissions. Restoring ...

Abstract	Pristine peatlands being excellent storage for terrestrial Carbon (C) play a crucial role in regulating climate and water and provide several important ecosystem services. However, peatlands have been heavily altered (e.g., by draining the water table), increasing greenhouse gas (GHG) emissions. Restoring peatlands requires a comprehensive characterization, including knowledge of peat depth (PD; m). Traditionally, this requires the physical insertion of a push probe, which is time-consuming and labor-intensive. It has been shown that non-invasive proximal sensing techniques such as electromagnetic induction and ground penetrating radar can add value to PD data. In this research, we want to assess the potential of proximally sensed gamma-ray (γ-ray) spectrometry (i.e., potassium [K], thorium [Th], uranium [U], and the count rate [CR]) and terrain attributes data (i.e., elevation, slope, SAGAWI, and MRVBF) to map PD either alone or in combination across a small (10 ha) peatland area in ØBakker, Denmark. Here, the PD varies from 0.1 m in the south to 7.3 m in the north. We use various prediction models including ordinary kriging (OK) of PD, linear regression (LR), multiple LR (MLR), LR kriging (LRK), MLR kriging (MLRK) and empirical Bayesian kriging regression (EBKR). We also determine the minimum calibration sample size required by decreasing sample size in decrements (i.e., n = 100, 90, 80,…, 30). We compare these approaches using prediction agreement (Lin’s concordance correlation coefficient; LCCC) and accuracy (root mean square error; RMSE). The results show that OK using maximum calibration size (n = 108) had near perfect agreement (0.97) and accuracy (0.59 m), compared to LR (ln CR; 0.65 and 0.78 m, respectively) and MLR (ln K, Th, CR and elevation; 0.85 and 0.63 m). Improvements are achieved by adding residuals; LRK (0.95 and 0.71 m) and MLRK (0.96 and 0.51 m). The best results were obtained using EBKR (0.97 and 0.63 m) given all predictions were positive and no significant change in agreement and standard ...
Keywords	Proximal soil sensing ; Digital soil mapping ; Peat thickness ; Soil carbon ; Climate change ; Science ; Q
Subject code	333
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Gestational anaemia and severe acute maternal morbidity: a population-based study.

Guignard, J / Deneux-Tharaux, C / Seco, A / Beucher, G / Kayem, G / Bonnet, M-P

Anaesthesia

2020 Volume 76, Issue 1, Page(s) 61–71

Abstract: Anaemia is frequently diagnosed during pregnancy. However, there are few data regarding its incidence, and the association with severe maternal morbidity remains uncertain and potentially biased in high-resource countries. The purpose of this study was ... ...

Abstract	Anaemia is frequently diagnosed during pregnancy. However, there are few data regarding its incidence, and the association with severe maternal morbidity remains uncertain and potentially biased in high-resource countries. The purpose of this study was to explore the association between gestational anaemia and severe acute maternal morbidity during and after delivery. We performed a cohort-nested case-control analysis from the epidemiology of severe maternal mortality (EPIMOMS) prospective study conducted in six French regions (2012-2013, n = 182,309 deliveries). There were 1669 women with severe acute maternal morbidity during or after delivery, according to a standardised definition obtained by expert consensus. The control group were randomly selected among women without severe morbidity who delivered in the same health centres (n = 3234). We studied the association between gestational anaemia and severe acute maternal morbidity during or after delivery overall, by cause, and by mode of delivery, using multivariable logistic regression and multiple imputation. Gestational anaemia was significantly more frequent in women with severe acute maternal morbidity (25.3%) than in controls (16.3%), p < 0.001, and mostly mild in both groups. After adjustment for confounders, women with gestational anaemia were at increased risk of overall severe acute maternal morbidity during and after delivery (adjusted OR (95%CI) 1.8 (1.5-2.1)). This association was also found for severe postpartum haemorrhage (adjusted OR (95%CI) 1.7 (1.5-2.0)), even after omitting the transfusion criterion (adjusted OR (95%CI) 1.9 (1.6-2.3)), and for severe acute maternal morbidity secondary to causes other than haemorrhage or pregnancy-related hypertensive disorders (adjusted OR (95%CI) 2.7 (1.9-4.0)). These results highlight the importance of optimising the diagnosis and management of anaemia during pregnancy.
MeSH term(s)	Adolescent ; Adult ; Anemia/diagnosis ; Anemia/epidemiology ; Case-Control Studies ; Causality ; Female ; France/epidemiology ; Humans ; Incidence ; Maternal Mortality ; Postpartum Period ; Pregnancy ; Pregnancy Complications/epidemiology ; Pregnancy Complications, Hematologic/epidemiology ; Prevalence ; Young Adult
Language	English
Publishing date	2020-08-26
Publishing country	England
Document type	Journal Article
ZDB-ID	80033-8
ISSN	1365-2044 ; 0003-2409
ISSN (online)	1365-2044
ISSN	0003-2409
DOI	10.1111/anae.15222
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Article: Distinction between clonal and paraclonal cutaneous involvements in VEXAS syndrome.

Lacombe, Valentin / Beucher, Annaelle / Urbanski, Geoffrey / Le Corre, Yannick / Cottin, Laurane / Croué, Anne / Bouvier, Anne

Experimental hematology & oncology

2022 Volume 11, Issue 1, Page(s) 6

Abstract: VEXAS (vacuoles, E1 enzyme, X-linked, auto-inflammatory, somatic) syndrome is an inflammatory disorder with hematological and systemic features. A recent study demonstrated that the dermal infiltrate in neutrophilic dermatosis from VEXAS patients is ... ...

Abstract	VEXAS (vacuoles, E1 enzyme, X-linked, auto-inflammatory, somatic) syndrome is an inflammatory disorder with hematological and systemic features. A recent study demonstrated that the dermal infiltrate in neutrophilic dermatosis from VEXAS patients is derived from the pathological UBA1-mutated myeloid clone. Neutrophilic dermatosis is, however, only one of the various skin involvements observed in VEXAS syndrome. We analyzed 10 formalin-fixed paraffin-embedded skin biopsies from genetically confirmed VEXAS syndrome. UBA1 mutation was found in the biopsies related to neutrophilic dermatitis but in none of the other histological patterns (leukocytoclastic vasculitis and septal panniculitis). This could lead to a distinction between clonal and paraclonal cutaneous involvements in VEXAS syndrome, which could in turn improve therapeutic outcomes.
Language	English
Publishing date	2022-02-16
Publishing country	England
Document type	Letter
ZDB-ID	2669066-4
ISSN	2162-3619
ISSN	2162-3619
DOI	10.1186/s40164-022-00262-5
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Article ; Online: Experimental Evidence for Seed Metabolic Allometry in Barrel Medic (

Domergue, Jean-Baptiste / Lalande, Julie / Beucher, Daniel / Satour, Pascale / Abadie, Cyril / Limami, Anis M / Tcherkez, Guillaume

International journal of molecular sciences

2022 Volume 23, Issue 15

Abstract: Seed size is often considered to be an important trait for seed quality, i.e., vigour and germination performance. It is believed that seed size reflects the quantity of reserve material and thus the C and N sources available for post-germinative ... ...

Abstract	Seed size is often considered to be an important trait for seed quality, i.e., vigour and germination performance. It is believed that seed size reflects the quantity of reserve material and thus the C and N sources available for post-germinative processes. However, mechanisms linking seed size and quality are poorly documented. In particular, specific metabolic changes when seed size varies are not well-known. To gain insight into this aspect, we examined seed size and composition across different accessions of barrel medic (
MeSH term(s)	Amino Acids/metabolism ; Lipids ; Medicago truncatula/genetics ; Seeds/metabolism
Chemical Substances	Amino Acids ; Lipids
Language	English
Publishing date	2022-07-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23158484
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Article ; Online: GEODESIC RECONSTRUCTION, SADDLE ZONES & HIERARCHICAL SEGMENTATION

Serge Beucher

Image Analysis and Stereology, Vol 20, Iss 3, Pp 137-

2011 Volume 141

Abstract: ... not necessarily related to the function g to be built. However, this paper deals with operations ...

Abstract	The morphological reconstruction based on geodesic operators, is a powerful tool in mathematical morphology. The general definition of this reconstruction supposes the use of a marker function f which is not necessarily related to the function g to be built. However, this paper deals with operations where the marker function is defined from given characteristic regions of the initial function f, as it is the case, for instance, for the extrema (maxima or minima) but also for the saddle zones. Firstly, we show that the intuitive definition of a saddle zone is not easy to handle, especially when digitised images are involved. However, some of these saddle zones (regional ones also called overflow zones) can be defined, this definition providing a simple algorithm to extract them. The second part of the paper is devoted to the use of these overflow zones as markers in image reconstruction. This reconstruction provides a new function which exhibits a new hierarchy of extrema. This hierarchy is equivalent to the hierarchy produced by the so-called waterfall algorithm. We explain why the waterfall algorithm can be achieved by performing a watershed transform of the function reconstructed by its initial watershed lines. Finally, some examples of use of this hierarchical segmentation are described.
Keywords	geodesic reconstruction ; hierarchy ; saddles ; segmentation ; waterfall algorithm ; watersheds ; Medicine (General) ; R5-920 ; Mathematics ; QA1-939
Subject code	000
Language	English
Publishing date	2011-05-01T00:00:00Z
Publisher	Slovenian Society for Stereology and Quantitative Image Analysis
Document type	Article ; Online
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