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  1. Book ; Online ; E-Book: Emerging infections

    Barrett, Ron / Zuckerman, Molly K. / Dudgeon, Matthew R. / Armelagos, George J.

    three epidemiological transitions from prehistory to the present

    2024  

    Abstract: This accessible textbook provides the first comprehensive synthesis of both the societal and environmental drivers of emerging infectious disease in humans, from prehistory to the present day. It discusses the applications of these ideas for global ... ...

    Author's details Ron Barrett, Molly K. Zuckerman, Matthew R. Dudgeon with George J. Armelagos
    Abstract This accessible textbook provides the first comprehensive synthesis of both the societal and environmental drivers of emerging infectious disease in humans, from prehistory to the present day. It discusses the applications of these ideas for global health policies and future research.
    Subject code 616.909
    Language English
    Size 1 Online-Ressource (xvi, 170 Seiten), Illustrationen, Diagramme
    Edition Second edition
    Publisher Oxford University Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030695335
    ISBN 978-0-19-265484-7 ; 9780192843142 ; 0-19-265484-5 ; 0192843141
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Some Improvements in Confidence Intervals for Standardized Regression Coefficients.

    Dudgeon, Paul

    Psychometrika

    2017  Volume 82, Issue 4, Page(s) 928–951

    Abstract: ... to circumstances where data are non-normal by examining confidence intervals based on Browne's (Br J Math Stat ... Psychol 37:62-83, 1984. doi: 10.1111/j.2044-8317.1984.tb00789.x ) asymptotic distribution-free (ADF ... Findings confirmed the superiority of the HC3 (MacKinnon and White, J Econ 35:305-325, 1985. doi: 10.1016 ...

    Abstract Yuan and Chan (Psychometrika 76:670-690, 2011. doi: 10.1007/S11336-011-9224-6 ) derived consistent confidence intervals for standardized regression coefficients under fixed and random score assumptions. Jones and Waller (Psychometrika 80:365-378, 2015. doi: 10.1007/S11336-013-9380-Y ) extended these developments to circumstances where data are non-normal by examining confidence intervals based on Browne's (Br J Math Stat Psychol 37:62-83, 1984. doi: 10.1111/j.2044-8317.1984.tb00789.x ) asymptotic distribution-free (ADF) theory. Seven different heteroscedastic-consistent (HC) estimators were investigated in the current study as potentially better solutions for constructing confidence intervals on standardized regression coefficients under non-normality. Normal theory, ADF, and HC estimators were evaluated in a Monte Carlo simulation. Findings confirmed the superiority of the HC3 (MacKinnon and White, J Econ 35:305-325, 1985. doi: 10.1016/0304-4076(85)90158-7 ) and HC5 (Cribari-Neto and Da Silva, Adv Stat Anal 95:129-146, 2011. doi: 10.1007/s10182-010-0141-2 ) interval estimators over Jones and Waller's ADF estimator under all conditions investigated, as well as over the normal theory method. The HC5 estimator was more robust in a restricted set of conditions over the HC3 estimator. Some possible extensions of HC estimators to other effect size measures are considered for future developments.
    MeSH term(s) Computer Simulation ; Data Interpretation, Statistical ; Humans ; Monte Carlo Method ; Regression Analysis
    Language English
    Publishing date 2017-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209479-4
    ISSN 1860-0980 ; 0033-3123
    ISSN (online) 1860-0980
    ISSN 0033-3123
    DOI 10.1007/s11336-017-9563-z
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1703: Show issues Location:
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  3. Article ; Online: Warming indirectly simplifies food webs through effects on apex predators.

    O'Gorman, Eoin J / Zhao, Lei / Kordas, Rebecca L / Dudgeon, Steve / Woodward, Guy

    Nature ecology & evolution

    2023  Volume 7, Issue 12, Page(s) 1983–1992

    Abstract: Warming alters ecosystems through direct physiological effects on organisms and indirect effects via biotic interactions, but their relative impacts in the wild are unknown due to the difficulty in warming natural environments. Here we bridge this gap by ...

    Abstract Warming alters ecosystems through direct physiological effects on organisms and indirect effects via biotic interactions, but their relative impacts in the wild are unknown due to the difficulty in warming natural environments. Here we bridge this gap by embedding manipulative field experiments within a natural stream temperature gradient to test whether warming and apex fish predators have interactive effects on freshwater ecosystems. Fish exerted cascading effects on algal production and microbial decomposition via both green and brown pathways in the food web, but only under warming. Neither temperature nor the presence of fish altered food web structure alone, but connectance and mean trophic level declined as consumer species were lost when both drivers acted together. A mechanistic model indicates that this temperature-induced trophic cascade is determined primarily by altered interactions, which cautions against extrapolating the impacts of warming from reductionist approaches that do not consider the wider food web.
    MeSH term(s) Animals ; Food Chain ; Ecosystem ; Temperature ; Rivers
    Language English
    Publishing date 2023-10-05
    Publishing country England
    Document type Journal Article
    ISSN 2397-334X
    ISSN (online) 2397-334X
    DOI 10.1038/s41559-023-02216-4
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  4. Article ; Online: From Data to Wisdom: Biomedical Knowledge Graphs for Real-World Data Insights.

    Hänsel, Katrin / Dudgeon, Sarah N / Cheung, Kei-Hoi / Durant, Thomas J S / Schulz, Wade L

    Journal of medical systems

    2023  Volume 47, Issue 1, Page(s) 65

    Abstract: Graph data models are an emerging approach to structure clinical and biomedical information. These models offer intriguing opportunities for novel approaches in healthcare, such as disease phenotyping, risk prediction, and personalized precision care. ... ...

    Abstract Graph data models are an emerging approach to structure clinical and biomedical information. These models offer intriguing opportunities for novel approaches in healthcare, such as disease phenotyping, risk prediction, and personalized precision care. The combination of data and information in a graph model to create knowledge graphs has rapidly expanded in biomedical research, but the integration of real-world data from the electronic health record has been limited. To broadly apply knowledge graphs to EHR and other real-world data, a deeper understanding of how to represent these data in a standardized graph model is needed. We provide an overview of the state-of-the-art research for clinical and biomedical data integration and summarize the potential to accelerate healthcare and precision medicine research through insight generation from integrated knowledge graphs.
    MeSH term(s) Humans ; Algorithms ; Pattern Recognition, Automated ; Biomedical Research ; Phenotype ; Precision Medicine
    Language English
    Publishing date 2023-05-17
    Publishing country United States
    Document type Letter
    ZDB-ID 423488-1
    ISSN 1573-689X ; 0148-5598
    ISSN (online) 1573-689X
    ISSN 0148-5598
    DOI 10.1007/s10916-023-01951-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1426: Show issues Location:
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  5. Article ; Online: Creating more comparable cohorts in observational palliative care studies: A proposed framework to improve applicability and replicability of research.

    Kochovska, Slavica / Murtagh, Fliss Em / Agar, Meera / Phillips, Jane L / Dudgeon, Deborah / Lujic, Sanja / Johnson, Miriam J / Currow, David C

    Palliative medicine

    2024  , Page(s) 2692163241234227

    Abstract: Background: Palliative care is characterised by heterogeneous patient and caregiver populations who are provided care in different health systems and a research base including a large proportion of observational, mostly retrospective studies. The ... ...

    Abstract Background: Palliative care is characterised by heterogeneous patient and caregiver populations who are provided care in different health systems and a research base including a large proportion of observational, mostly retrospective studies. The inherent diversity of palliative care populations and the often inadequate study descriptions challenge the application of new knowledge into practice and reproducibility for confirmatory studies. Being able to define systematically study populations would significantly increase their generalisability and effective translation into practice.
    Proposal: Based on an informal consensus process by active palliative care researchers challenged by this problem and a review of the current evidence, we propose an approach to creating more comparable cohorts in observational (non-randomised) palliative care studies that relies on defining the study population in relation to a fixed, well-defined event from which analyses are built ('anchoring'). In addition to providing a detailed and complete description of the study population, anchoring is
    Discussion: Anchoring the cohort to reproducible data points will help create more comparable cohorts in palliative care whilst mitigating its inherent heterogeneity. This, in turn, will help optimise the generalisability, applicability and reproducibility of observational palliative care studies to strengthen the evidence base and improve practice.
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 639247-7
    ISSN 1477-030X ; 0269-2163
    ISSN (online) 1477-030X
    ISSN 0269-2163
    DOI 10.1177/02692163241234227
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    Zs.A 2285: Show issues Location:
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  6. Article ; Online: Conformational fingerprinting with Raman spectroscopy reveals protein structure as a translational biomarker of muscle pathology.

    Alix, James J P / Plesia, Maria / Dudgeon, Alexander P / Kendall, Catherine A / Hewamadduma, Channa / Hadjivassiliou, Marios / Gorman, Gráinne S / Taylor, Robert W / McDermott, Christopher J / Shaw, Pamela J / Mead, Richard J / Day, John C

    The Analyst

    2024  

    Abstract: Neuromuscular disorders are a group of conditions that can result in weakness of skeletal muscles. Examples include fatal diseases such as amyotrophic lateral sclerosis and conditions associated with high morbidity such as myopathies (muscle diseases). ... ...

    Abstract Neuromuscular disorders are a group of conditions that can result in weakness of skeletal muscles. Examples include fatal diseases such as amyotrophic lateral sclerosis and conditions associated with high morbidity such as myopathies (muscle diseases). Many of these disorders are known to have abnormal protein folding and protein aggregates. Thus, easy to apply methods for the detection of such changes may prove useful diagnostic biomarkers. Raman spectroscopy has shown early promise in the detection of muscle pathology in neuromuscular disorders and is well suited to characterising the conformational profiles relating to protein secondary structure. In this work, we assess if Raman spectroscopy can detect differences in protein structure in muscle in the setting of neuromuscular disease. We utilise
    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 210747-8
    ISSN 1364-5528 ; 0003-2654
    ISSN (online) 1364-5528
    ISSN 0003-2654
    DOI 10.1039/d4an00320a
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    Zs.A 2423: Show issues Location:
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  7. Book ; Article ; Online: Vacunas antisarampionosas

    Dudgeon, J. A

    2015  

    Keywords Sarampo ; Vacina contra Sarampo
    Publishing date 2015-12-08T02:50:19Z
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Flexibility for fuelling reproduction in a pelagic ray (Mobula eregoodoo) suggested by bioenergetic modelling.

    Lawson, Christopher L / Dudgeon, Christine L / Richardson, Anthony J / Broadhurst, Matt K / Bennett, Michael B

    Journal of fish biology

    2022  Volume 100, Issue 3, Page(s) 783–792

    Abstract: This study investigated the measurements of energy density and bioenergetic modelling for a pelagic ray, Mobula eregoodoo, to estimate its relative allocation to various bodily processes and especially reproduction. The data revealed M. eregoodoo uses up ...

    Abstract This study investigated the measurements of energy density and bioenergetic modelling for a pelagic ray, Mobula eregoodoo, to estimate its relative allocation to various bodily processes and especially reproduction. The data revealed M. eregoodoo uses up to 21.0% and 2.5% of its annual energy budget on growth and reproduction, respectively. During pregnancy, females depleted energy reserves in the liver, which, along with their biennial reproductive cycle, aligns with general theory that ectotherms are capital breeders and thus build energy reserves before reproduction. Nonetheless, the reduction in energy reserves did not account for all reproductive costs, and therefore, gravid females supplement reproductive costs through energy derived from the diet, according to an income-breeding strategy. These characteristics imply that M. eregoodoo exhibits some flexibility in fuelling reproduction depending on energy availability throughout the reproductive cycle, which may be prevalent in other elasmobranchs. The data represent the first estimates of both the metabolic costs of gestation in elasmobranchs and the relative cost of reproduction in rays. Energy costs and plasticity associated with highly variable reproductive strategies in elasmobranchs may influence long-term population viability under a rapidly changing environment.
    MeSH term(s) Animals ; Diet/veterinary ; Elasmobranchii ; Energy Metabolism ; Female ; Reproduction
    Language English
    Publishing date 2022-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 410564-3
    ISSN 1095-8649 ; 0022-1112
    ISSN (online) 1095-8649
    ISSN 0022-1112
    DOI 10.1111/jfb.14995
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4814: Show issues
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  9. Article ; Online: Structural Analysis of Cancer-relevant TCR-CD3 and Peptide-MHC Complexes by CryoEM.

    Saotome, Kei / Dudgeon, Drew / Colotti, Kiersten / Moore, Michael J / Jones, Jennifer / Zhou, Yi / Rafique, Ashique / Yancopoulos, George D / Murphy, Andrew J / Lin, John C / Olson, William C / Franklin, Matthew C

    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

    2023  Volume 29, Issue 29 Suppl 1, Page(s) 892

    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1385710-1
    ISSN 1435-8115 ; 1431-9276
    ISSN (online) 1435-8115
    ISSN 1431-9276
    DOI 10.1093/micmic/ozad067.440
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  10. Article ; Online: Structural analysis of cancer-relevant TCR-CD3 and peptide-MHC complexes by cryoEM.

    Saotome, Kei / Dudgeon, Drew / Colotti, Kiersten / Moore, Michael J / Jones, Jennifer / Zhou, Yi / Rafique, Ashique / Yancopoulos, George D / Murphy, Andrew J / Lin, John C / Olson, William C / Franklin, Matthew C

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 2401

    Abstract: The recognition of antigenic peptide-MHC (pMHC) molecules by T-cell receptors (TCR) initiates the T-cell mediated immune response. Structural characterization is key for understanding the specificity of TCR-pMHC interactions and informing the development ...

    Abstract The recognition of antigenic peptide-MHC (pMHC) molecules by T-cell receptors (TCR) initiates the T-cell mediated immune response. Structural characterization is key for understanding the specificity of TCR-pMHC interactions and informing the development of therapeutics. Despite the rapid rise of single particle cryoelectron microscopy (cryoEM), x-ray crystallography has remained the preferred method for structure determination of TCR-pMHC complexes. Here, we report cryoEM structures of two distinct full-length α/β TCR-CD3 complexes bound to their pMHC ligand, the cancer-testis antigen HLA-A2/MAGEA4 (230-239). We also determined cryoEM structures of pMHCs containing MAGEA4 (230-239) peptide and the closely related MAGEA8 (232-241) peptide in the absence of TCR, which provided a structural explanation for the MAGEA4 preference displayed by the TCRs. These findings provide insights into the TCR recognition of a clinically relevant cancer antigen and demonstrate the utility of cryoEM for high-resolution structural analysis of TCR-pMHC interactions.
    MeSH term(s) Humans ; Cryoelectron Microscopy ; Protein Binding ; Receptors, Antigen, T-Cell/metabolism ; Peptides/chemistry ; Histocompatibility Antigens/metabolism ; Neoplasms ; Major Histocompatibility Complex
    Chemical Substances Receptors, Antigen, T-Cell ; Peptides ; Histocompatibility Antigens
    Language English
    Publishing date 2023-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-37532-7
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