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  1. Book ; Online: Fast Facts : Clinical Trials in Oncology

    Hackshaw, Allan

    The fundamentals of design, conduct and interpretation

    2021  

    Abstract: Written by leading experts, 'Fast Facts: Clinical Trials in Oncology' will enhance the reader’s ability to critically evaluate published evidence. Assuming little or no prior knowledge, the book sets out clearly the fundamental features of clinical ... ...

    Title variant Fast Facts
    Author's details Allan Hackshaw, Gavin C.E. Stuart
    Abstract Written by leading experts, 'Fast Facts: Clinical Trials in Oncology' will enhance the reader’s ability to critically evaluate published evidence. Assuming little or no prior knowledge, the book sets out clearly the fundamental features of clinical trials. The key attributes of Phase I–III trials of pharmaceutical products are described, as are trials of surgical procedures, radiation therapy and advanced therapies. The processes and documentation required to set up and conduct a trial are outlined, and the authors describe how trial data and real-world evidence are used to improve care. Although this concise colorful book focuses on oncology, the principles apply equally to interventions in other areas of practice. It will prove invaluable to medical, pharmaceutical and allied health professionals who want, or need, an overview of how contemporary clinical trials are designed and conducted. Contents: • Fundamental features of clinical trials • Phase I trials • Phase II trials • Phase III trials • Trials of non-drug interventions • Setting up and conducting trials • Publishing trial results, changing clinical practice, and supporting evidence
    Keywords Oncology
    Language English
    Size 1 online resource (120 pages) :, 24 figures, 24 in color, 23 tables
    Publisher S. Karger
    Publishing place Basel
    Document type Book ; Online
    ISBN 1-912776-74-X ; 1-912776-73-1 ; 978-1-912776-74-0 ; 978-1-912776-73-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: A concise guide to clinical trials

    Hackshaw, Allan

    2009  

    Author's details Allan Hackshaw
    Keywords Clinical Trials as Topic ; Clinical trials
    Subject code 615.50724
    Language English
    Size VII, 215 S. : Ill., graph. Darst., 23cm
    Publisher Wiley-Blackwell u.a.
    Publishing place Chichester
    Publishing country Great Britain
    Document type Article
    Note Includes bibliographical references and index. - Formerly CIP
    HBZ-ID HT016043895
    ISBN 1-4051-6774-2 ; 978-1-4051-6774-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 4094 order for loan Magazin

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  3. Article ; Online: The Risk-Screening Converter.

    Wald, Nicholas J / Duffy, Stephen W / Hackshaw, Allan

    Journal of medical screening

    2023  Volume 30, Issue 1, Page(s) 1–2

    MeSH term(s) Humans ; Early Detection of Cancer
    Language English
    Publishing date 2023-01-08
    Publishing country England
    Document type Editorial
    ZDB-ID 1235253-6
    ISSN 1475-5793 ; 0969-1413
    ISSN (online) 1475-5793
    ISSN 0969-1413
    DOI 10.1177/09691413221149640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4284: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: When alternatives to screening should be the priority.

    Wald, Nicholas J / Duffy, Stephen W / Hackshaw, Allan

    Journal of medical screening

    2022  Volume 29, Issue 3, Page(s) 137

    MeSH term(s) Humans ; Mass Screening
    Language English
    Publishing date 2022-06-23
    Publishing country England
    Document type Editorial
    ZDB-ID 1235253-6
    ISSN 1475-5793 ; 0969-1413
    ISSN (online) 1475-5793
    ISSN 0969-1413
    DOI 10.1177/09691413221102322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: An efficient randomised trial design for multi-cancer screening blood tests: nested enhanced mortality outcomes of screening trial.

    Hackshaw, Allan / Berg, Christine D

    The Lancet. Oncology

    2021  Volume 22, Issue 10, Page(s) 1360–1362

    MeSH term(s) Early Detection of Cancer ; Hematologic Tests ; Humans ; Mass Screening ; Neoplasms/blood ; Neoplasms/diagnosis ; Neoplasms/mortality ; Randomized Controlled Trials as Topic ; Research Design
    Language English
    Publishing date 2021-09-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(21)00204-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5696: Show issues Location:
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    Zs.MO 460: Show issues

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  6. Article ; Online: New genomic technologies for multi-cancer early detection: Rethinking the scope of cancer screening.

    Hackshaw, Allan / Clarke, Christina A / Hartman, Anne-Renee

    Cancer cell

    2022  Volume 40, Issue 2, Page(s) 109–113

    Abstract: Cancers other than breast, colorectal, cervical, and lung do not have guideline-recommended screening. New multi-cancer early detection (MCED) tests-using a single blood sample-have been developed based on circulating cell-free DNA (cfDNA) or other ... ...

    Abstract Cancers other than breast, colorectal, cervical, and lung do not have guideline-recommended screening. New multi-cancer early detection (MCED) tests-using a single blood sample-have been developed based on circulating cell-free DNA (cfDNA) or other analytes. In this commentary, we review the current evidence on these tests, provide several major considerations for new MCED tests, and outline how their evaluation will need to differ from that established for traditional single-cancer screening tests.
    MeSH term(s) Biomarkers, Tumor ; Clinical Decision-Making ; Disease Management ; Disease Susceptibility ; Early Detection of Cancer/methods ; Early Detection of Cancer/standards ; Genomics/methods ; Genomics/standards ; Humans ; Neoplasms/diagnosis ; Neoplasms/genetics ; Organ Specificity
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2022-02-03
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2022.01.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5650: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 104: Show issues

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  7. Article ; Online: Reply to Comment(s) on "Nationwide randomised trial evaluating elective neck dissection for early stage oral cancer (SEND study) with meta-analysis and concurrent real-world cohort".

    Hutchison, Iain / Hackshaw, Allan

    British journal of cancer

    2020  Volume 123, Issue 7, Page(s) 1200–1201

    MeSH term(s) Cohort Studies ; Elective Surgical Procedures ; Humans ; Mouth Neoplasms/epidemiology ; Mouth Neoplasms/surgery ; Neck Dissection
    Language English
    Publishing date 2020-07-16
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-020-0983-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Uh III Zs.142: Show issues Location:
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  8. Book: Evidence based dentistry

    Hackshaw, Allan / Paul, Elizabeth A. / Davenport, Elizabeth S.

    an introduction

    2006  

    Title variant Evidence based dentistry
    Author's details Allan K. Hackshaw ; Elizabeth A. Paul ; Elizabeth S. Davenport
    Keywords Dental Research ; Evidence-Based Medicine
    Language English
    Size XII, 225 S. : graph. Darst.
    Publisher Blackwell Munksgaard
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT014469777
    ISBN 978-1-4051-2496-6 ; 1-4051-2496-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2006 A 4659 order for loan Magazin

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  9. Article ; Online: Sample size calculation in randomised phase II selection trials using a margin of practical equivalence.

    Dehbi, Hakim-Moulay / Hackshaw, Allan

    Trials

    2020  Volume 21, Issue 1, Page(s) 301

    Abstract: Background: In rare cancers or subtypes of common cancers, a comparison of multiple promising treatments may be required. The selected treatment can then be assessed against the standard of care (if it exists) or used as a backbone for combinations with ...

    Abstract Background: In rare cancers or subtypes of common cancers, a comparison of multiple promising treatments may be required. The selected treatment can then be assessed against the standard of care (if it exists) or used as a backbone for combinations with new, possibly targeted, agents. There could be different experimental therapies or different doses of the same therapy, and either can be done in combination with standard treatments. A 'pick-the-winner' design is often used, which focuses on efficacy to select the most promising treatment. However, a treatment with a slightly lower efficacy compared to another treatment may actually be preferred if it has a better toxicity or quality of life profile, is easier to administer, or cheaper.
    Methods: By pre-defining a margin of practical equivalence in order to calculate the sample size, a more flexible assessment can be made of whether the treatments have very different effects or are sufficiently close so that other factors can be used to choose between them. Using exact binomial probabilities, we calculated the sample size for two- and three-arm randomised selection trials including a margin of practical equivalence with a variety of input parameters.
    Results: We explain conceptually the margin of practical equivalence in this paper, and provide a free user-friendly web application to calculate the required sample size for a variety of input parameters.
    Conclusion: The web application should help promote the randomised selection design with a margin of practical equivalence, which provides greater flexibility than the 'pick-the-winner' approach in assessing the results of selection trials.
    MeSH term(s) Clinical Trials, Phase II as Topic/methods ; Humans ; Neoplasms/therapy ; Randomized Controlled Trials as Topic/methods ; Research Design/standards ; Sample Size ; Therapeutic Equivalency
    Language English
    Publishing date 2020-03-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1468-6708
    ISSN (online) 1745-6215 ; 1468-6694
    ISSN 1468-6708
    DOI 10.1186/s13063-020-04248-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Thyroid cancer recurrence in the HiLo trial - Authors' reply.

    Hackshaw, Allan / Dehbi, Hakim-Moulay

    The lancet. Diabetes & endocrinology

    2019  Volume 7, Issue 4, Page(s) 252–253

    MeSH term(s) Humans ; Iodine Radioisotopes ; Thyroid Neoplasms ; Thyrotropin
    Chemical Substances Iodine Radioisotopes ; Thyrotropin (9002-71-5)
    Language English
    Publishing date 2019-03-14
    Publishing country England
    Document type Letter ; Comment
    ISSN 2213-8595
    ISSN (online) 2213-8595
    DOI 10.1016/S2213-8587(19)30088-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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