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  1. Article ; Online: B7-H3 and Prostate Cancer: New Therapeutic Dance Partners.

    Shenderov, Eugene / Antonarakis, Emmanuel S

    European urology

    2022  Volume 83, Issue 3, Page(s) 239–240

    MeSH term(s) Male ; Humans ; Dance Therapy ; Prostatic Neoplasms/therapy
    Language English
    Publishing date 2022-11-05
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2022.10.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Monitoring the Sea Surface Microlayer (SML) on Sentinel images.

    Nichol, Janet E / Antonarakis, Alexander S / Nazeer, Majid

    The Science of the total environment

    2023  Volume 872, Page(s) 162218

    Abstract: Slicks on the sea surface are usually related to oil spills, algal blooms or organic runoff around coastlines. An extensive network of slicks extending across the English Channel is seen on Sentinel 1 and Sentinel 2 images and are identified as ... ...

    Abstract Slicks on the sea surface are usually related to oil spills, algal blooms or organic runoff around coastlines. An extensive network of slicks extending across the English Channel is seen on Sentinel 1 and Sentinel 2 images and are identified as comprising a film of natural surfactant material within the sea surface microlayer (SML). As the SML represents the interface between ocean and atmosphere, controlling the vital exchange of gases and aerosols, identification of the slicks on images can add a new dimension to climate modelling. Current models use primary productivity often combined with wind speed, but quantifying the global extent of surface films spatially and temporally is difficult due to their patchy nature. The slicks are shown to be visible on Sentinel 2 optical images affected by sun glint, due to the wave dampening effect of the surfactants. On a Sentinel 1 SAR image of the same day, they can be identified using the VV polarised band. The paper investigates the nature and spectral properties of the slicks in relation to sun glint, and evaluates the performance of chlorophyll-a, floating algae and floating debris indices on the slick-affected areas. No index was able to distinguish slicks from non-slick areas as successfully as the original sun glint image. This image was used to devise a tentative Surfactant Index (SI) which indicates over 40 % of the study area covered by slicks. As ocean sensors have lower spatial resolution and are generally designed to avoid sun glint, Sentinel 1 SAR may offer a useful alternative for monitoring the global spatial extent of surface films, until dedicated sensors and algorithms can be developed.
    Language English
    Publishing date 2023-02-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.162218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Masseter muscle thickness and treatment outcomes in children with Class II division 1 malocclusion.

    Tentolouri, E / Antonarakis, G S / Georgiakaki, I / Kiliaridis, S

    European journal of paediatric dentistry

    2022  Volume 22, Issue 4, Page(s) 298–302

    Abstract: Aim: To investigate if treatment outcome in patients with Class II division 1 malocclusion treated by a variety of approaches is affected by masticatory muscle capacity.: Materials: Seventy-four children with Class II division 1 malocclusion were ... ...

    Abstract Aim: To investigate if treatment outcome in patients with Class II division 1 malocclusion treated by a variety of approaches is affected by masticatory muscle capacity.
    Materials: Seventy-four children with Class II division 1 malocclusion were included in the present study. These were divided into 54 children (10.4 ± 1.6 years of age) treated with fixed appliances including headgear and/or Class II intermaxillary elastics, 12 children (9.9 ± 1.9 years of age) treated with functional appliances and 8 children treated with fixed appliances and other means of treatment. Ultrasonographic masseter muscle thickness measurements were taken before treatment, while lateral cephalograms were taken before and after treatment.
    Statistics: Multivariate linear regression analysis was used to assess the association between masseter muscle thickness and treatment outcomes, as well as the gonial angle and treatment outcomes.
    Conclusion: In children with Class II division 1 malocclusion treated by means other than functional appliances, treatment outcome is not associated with masseter thickness. This may be the case since the application of intermaxillary forces and torque application may offset the functional component in tooth movement. Outcomes following functional appliance treatment may be partly determined by the masticatory muscles. During functional treatment, children with a weaker masticatory system show greater dentoalveolar compensation. This is however not maintained during the second phase of fixed appliance treatment.
    MeSH term(s) Cephalometry ; Child ; Humans ; Malocclusion, Angle Class II/diagnostic imaging ; Malocclusion, Angle Class II/therapy ; Mandible ; Masseter Muscle/diagnostic imaging ; Orthodontic Appliances, Functional ; Treatment Outcome
    Language English
    Publishing date 2022-01-15
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2035588-9
    ISSN 2035-648X ; 1591-996X
    ISSN (online) 2035-648X
    ISSN 1591-996X
    DOI 10.23804/ejpd.2021.22.04.7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Case report: Salivary duct carcinoma in a patient with a germline

    Desai, Nidhi / Racila, Emilian / Fujioka, Naomi / Gupta, Arjun / Antonarakis, Emmanuel S

    Frontiers in oncology

    2024  Volume 14, Page(s) 1372382

    Abstract: Introduction: Recently, an entity known as salivary duct carcinoma with rhabdoid features (SDC-RF) has been associated with somatic : Case discussion: A 67-year-old man presented with chest and back pain and was found to have osteolytic lesions in ... ...

    Abstract Introduction: Recently, an entity known as salivary duct carcinoma with rhabdoid features (SDC-RF) has been associated with somatic
    Case discussion: A 67-year-old man presented with chest and back pain and was found to have osteolytic lesions in the sternum and lumbar spine. Vertebral bone biopsies were positive for metastatic carcinoma of unknown primary. A molecular profiling assay consisting of both whole-exome next-generation sequencing (NGS) as well as immunohistochemistry (IHC) for select clinically-relevant proteins performed on the bone biopsy suggested a triple-negative (ER/PR/ERBB2 negative, by IHC), androgen receptor (AR IHC) positive tumor profile. Additionally, the assay uncovered a coding mutation in the
    Conclusion: Molecular testing revealed that our patient had bi-allelic inactivation of the
    Language English
    Publishing date 2024-04-08
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1372382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: An In Vitro Evaluation of the Effects of Air-Polishing Powders on Sound and Demineralised Enamel.

    Guma, Elton / Kiliaridis, Stavros / Scherrer, Susanne S / Antonarakis, Gregory S

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 13

    Abstract: ... to two groups (: Results: On sound enamel, the Ra was roughly 0.17 ± 0.07 μm. After 150 s of air ...

    Abstract Aim: To evaluate the effects of two air-polishing powders, during orthodontic treatment, on the surface roughness of sound and demineralised enamel.
    Materials and methods: Forty-two caries-free human molars were collected, and the enamel surfaces were flattened and polished. Teeth were assigned to two groups (
    Results: On sound enamel, the Ra was roughly 0.17 ± 0.07 μm. After 150 s of air polishing, the Ra increased with erythritol (by 0.28 μm), and even more so with bicarbonate treatment (by 0.68 μm) (
    Conclusions: On white spot lesions, one should be aware that enamel surface roughness will increase with both erythritol and bicarbonate air-polishing powders, especially with longer exposure times.
    Language English
    Publishing date 2023-07-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16134811
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: PARP Inhibitors in Metastatic Prostate Cancer: Evidence to Date.

    Nizialek, Emily / Antonarakis, Emmanuel S

    Cancer management and research

    2020  Volume 12, Page(s) 8105–8114

    Abstract: Poly (ADP-ribose) polymerase inhibitors (PARPi) are a unique class of antineoplastic agents that function by inducing synthetic lethality. Synthetic lethality occurs when PARPi and either another agent or an underlying genetic alteration together lead to ...

    Abstract Poly (ADP-ribose) polymerase inhibitors (PARPi) are a unique class of antineoplastic agents that function by inducing synthetic lethality. Synthetic lethality occurs when PARPi and either another agent or an underlying genetic alteration together lead to overwhelming DNA damage and ultimately cell death. PARPi first showed promise as a cancer therapy in patients with
    Language English
    Publishing date 2020-09-07
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2508013-1
    ISSN 1179-1322
    ISSN 1179-1322
    DOI 10.2147/CMAR.S227033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Reimagining Vaccines for Prostate Cancer: Back to the Future.

    Shenderov, Eugene / Antonarakis, Emmanuel S

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2020  Volume 26, Issue 19, Page(s) 5056–5058

    Abstract: Given the modest clinical benefits observed with immune checkpoint blockade in advanced prostate cancer, there is a renewed interest in exploring other forms of immunotherapy. Here, the authors report the use of a novel plasmid DNA vaccine encoding the ... ...

    Abstract Given the modest clinical benefits observed with immune checkpoint blockade in advanced prostate cancer, there is a renewed interest in exploring other forms of immunotherapy. Here, the authors report the use of a novel plasmid DNA vaccine encoding the androgen receptor, called pTVG-AR, in men with metastatic hormone-sensitive prostate cancer.
    MeSH term(s) Cancer Vaccines/therapeutic use ; Humans ; Ligands ; Male ; Prostatic Neoplasms/therapy ; Receptors, Androgen/genetics ; Vaccines, DNA
    Chemical Substances Cancer Vaccines ; Ligands ; Receptors, Androgen ; Vaccines, DNA
    Language English
    Publishing date 2020-07-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-20-2257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: MOOCs: la fin des facultés de médecine conventionnelles?

    Antonarakis, S E

    Revue medicale suisse

    2014  Volume 10, Issue 423, Page(s) 719–720

    Title translation MOOCs (Massive Open Online Courses): the end of conventional medical schools?.
    MeSH term(s) Accreditation/organization & administration ; Accreditation/trends ; Computer-Assisted Instruction ; Curriculum ; Education, Distance/organization & administration ; Education, Distance/trends ; Humans ; Internet ; Online Systems ; Schools, Medical/trends ; Switzerland
    Language French
    Publishing date 2014-03-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Masseter muscle thickness and vertical cephalometric characteristics in children with Class II malocclusion.

    Tentolouri, Eirini / Antonarakis, Gregory S / Georgiakaki, Ioanna / Kiliaridis, Stavros

    Clinical and experimental dental research

    2022  Volume 8, Issue 3, Page(s) 729–736

    Abstract: Background: Masseter muscle thickness and its relationship with vertical craniofacial morphology have been extensively studied in adults, but data on children are lacking.: Objective: To examine the association between masseter muscle thickness and ... ...

    Abstract Background: Masseter muscle thickness and its relationship with vertical craniofacial morphology have been extensively studied in adults, but data on children are lacking.
    Objective: To examine the association between masseter muscle thickness and vertical cephalometric parameters in a group of Class II malocclusion growing children.
    Methods: The current study design was retrospective and cross-sectional, looking at a sample of 211 growing children with Class II malocclusion between the ages of 6 and 15 derived from two centers. Ultrasonographic masseter muscle thickness measurements and vertical cephalometric variables, including the gonial angle, were evaluated before any orthodontic treatment had been carried out. Multiple linear regression analysis was used to examine the association between masseter muscle thickness and vertical cephalometric measurements, including age and patient origin as independent variables in the analysis.
    Results: In the present sample, masseter muscle thickness was found to be independent of sex, but correlated with age, with older children presenting thicker masseter muscles. In the total patient sample, using multiple regression analyses, children with thicker masseter muscles had significantly smaller intermaxillary and gonial angles. No other cephalometric vertical characteristics showed associations with masseter muscle thickness.
    Conclusion: In growing children with Class II malocclusion, those with thicker masseter muscles are more likely to display smaller intermaxillary and gonial angles respectively.
    MeSH term(s) Adolescent ; Adult ; Child ; Cross-Sectional Studies ; Humans ; Malocclusion, Angle Class II/diagnostic imaging ; Malocclusion, Angle Class II/therapy ; Masseter Muscle/anatomy & histology ; Masseter Muscle/diagnostic imaging ; Masseter Muscle/physiology ; Retrospective Studies ; Vertical Dimension
    Language English
    Publishing date 2022-02-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2829558-4
    ISSN 2057-4347 ; 2057-4347
    ISSN (online) 2057-4347
    ISSN 2057-4347
    DOI 10.1002/cre2.528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Correction: A multidisciplinary approach to address unmet needs in the management of patients with non-metastatic castration-resistant prostate cancer.

    Shore, Neal D / Antonarakis, Emmanuel S / Ross, Ashley E / Marshall, Catherine H / Stratton, Kelly L / Ayanambakkam, Adanma / Cookson, Michael S / McKay, Rana R / Bryce, Alan H / Kaymakcalan, Marina D

    Prostate cancer and prostatic diseases

    2024  

    Language English
    Publishing date 2024-04-20
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1419277-9
    ISSN 1476-5608 ; 1365-7852
    ISSN (online) 1476-5608
    ISSN 1365-7852
    DOI 10.1038/s41391-024-00835-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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