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Article: Comment on Mahajan, S.; Schmidt, M.H.H. Distinct Lineage of Slow-Cycling Cells Amidst the Prevailing Heterogeneity in Glioblastoma.

Yang, Changlin / Mitchell, Duane A / Deleyrolle, Loic P

2024 Volume 16, Issue 2

Abstract: We greatly appreciate the interest, careful reading, and appraisal by Mahajan and Schmidt [ ... ]. ...

Abstract	We greatly appreciate the interest, careful reading, and appraisal by Mahajan and Schmidt [...].
Language	English
Publishing date	2024-01-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16020277
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Article ; Online: Comparative Study of Pyloromyotomy and H-M Pyloroplasty in Proximal Gastrectomy for Adenocarcinoma of Esophageal-Gastric Junction.

Shi, Mengyao / Hu, Zunqi / Wu, Kaiming / Yang, Dejun / Fu, Hongbing / Zhang, Juanjuan / Li, Dong / Wang, Weimin / Wang, Weijun / Zhu, Zhenxin

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

2022 Volume 26, Issue 8, Page(s) 1585–1595

Abstract: ... the vagus nerve around the esophagus, so H-M pyloroplasty (Heineke-Mikulicz pyloroplasty) is often operated after ... PG-EG to prevent delayed gastric emptying. However, H-M pyloroplasty destroys anti-reflux structure ... of pylorus and leads to serious bile reflux. The present study was designed to compare pyloromyotomy and H-M ...

Abstract	Introduction: The incidence of adenocarcinoma of esophageal-gastric junction (AEJ) has been increasing in recent years. Esophagogastrostomy after proximal gastrectomy (PG-EG) is the most commonly used surgical method for this disease which causes a constant spasm of the pyloric sphincter by cutting the vagus nerve around the esophagus, so H-M pyloroplasty (Heineke-Mikulicz pyloroplasty) is often operated after PG-EG to prevent delayed gastric emptying. However, H-M pyloroplasty destroys anti-reflux structure of pylorus and leads to serious bile reflux. The present study was designed to compare pyloromyotomy and H-M pyloroplasty in proximal subtotal gastrectomy through clinical studies and animal experiments. Methods: We retrospectively evaluated the outcomes of 73 AEJ patients (39 underwent PG-EG with an H-M pyloroplasty and 34 underwent PG-EG with a pyloromyotomy) between January 2016 and August 2020, and perioperative variables were compared. In the animal experiment, 48 rats were randomly divided into four groups (n = 12): vagotomy group (V group), H-M pyloroplasty group (HM group), pyloromyotomy group (PM group), and control group (O group). Gastric emptying and bile reflux were evaluated in each group. Results: In the retrospective clinic study, pyloromyotomy and H-M pyloroplasty could all prevent delayed gastric emptying effectively, and the incidence of bile reflux found by electronic gastroscopy in the PM group was significantly lower than that in the HM group (HM, 14/39; PM, 4/34; P = 0.028). In the animal experiment, there was no significant between-group difference of gastric emptying rate (%) in the HM group and PM group (HM, 70.6 ± 16; PM, 72.3 ± 12; P = 0.68) while the gastric emptying rate (%) was significantly lower in the V group than in the HM, PM, and control group (P values were 0.037, 0.021, and 0.001 respectively). The gastric mucosa bile acid concentration was significantly higher in the HM group than other group (P values were all less than 0.001). Conclusions: The pyloromyotomy could prevent delayed gastric emptying effectively after PG-EG for types II and III AEJ and reduce bile reflux compared to Heineke-Mikulicz pyloroplasty.
MeSH term(s)	Adenocarcinoma/surgery ; Animals ; Bile Reflux ; Esophagus ; Gastrectomy ; Gastric Emptying ; Gastroparesis/surgery ; Pyloromyotomy ; Pylorus/surgery ; Rats ; Retrospective Studies
Language	English
Publishing date	2022-05-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2012365-6
ISSN	1873-4626 ; 1934-3213 ; 1091-255X
ISSN (online)	1873-4626 ; 1934-3213
ISSN	1091-255X
DOI	10.1007/s11605-022-05347-4
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Zs.A 5207: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Hydralazine derivative of aldehyde: A new type of [M - H]

Xiao, Hua-Ming / Wang, Xian / Yang, Xing / Zheng, Feng / Feng, Yu-Qi

Journal of mass spectrometry : JMS

2019 Volume 54, Issue 3, Page(s) 239–249

Abstract: ... ligands. In the present work, we reported a new type of dehydrogenated ion [M - H] ...

Abstract	Hydralazine has been widely employed in the development of drugs, derivatization reagents, and ligands. In the present work, we reported a new type of dehydrogenated ion [M - H]
Language	English
Publishing date	2019-02-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1221763-3
ISSN	1096-9888 ; 1076-5174
ISSN (online)	1096-9888
ISSN	1076-5174
DOI	10.1002/jms.4330
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Zs.A 4254: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Asymmetric Total Syntheses of (-)-Fennebricin A, (-)-Renieramycin J, (-)-Renieramycin G, (-)-Renieramycin M, and (-)- Jorunnamycin A via C-H Activation.

Zheng, Yu / Li, Xue-Dan / Sheng, Peng-Zhen / Yang, Hong-Dou / Wei, Kun / Yang, Yu-Rong

Organic letters

2020 Volume 22, Issue 11, Page(s) 4489–4493

Abstract: ... unnatural amino acid building block rapidly and practically. The structure of synthetic (-)-renieramycin M ...

Abstract	Collective total synthesis of five tetrahydroisoquinoline alkaloids including the first total synthesis of (-)-fennebricin A and (-)-renieramycin J has been accomplished. The synthesis features employing a single common amino acid to symmetrically construct the pentacycle of title alkaloids. The palladium-catalyzed arylation of alanine-derived amide developed by Yu was tactically utilized to afford unnatural amino acid building block rapidly and practically. The structure of synthetic (-)-renieramycin M has been confirmed by single crystal X-ray analysis for the first time.
MeSH term(s)	Alkaloids/chemical synthesis ; Alkaloids/chemistry ; Crystallography, X-Ray ; Isoquinolines/chemical synthesis ; Isoquinolines/chemistry ; Models, Molecular ; Molecular Structure ; Quinolones/chemical synthesis ; Quinolones/chemistry ; Stereoisomerism ; Tetrahydroisoquinolines/chemical synthesis ; Tetrahydroisoquinolines/chemistry
Chemical Substances	Alkaloids ; Isoquinolines ; Quinolones ; Tetrahydroisoquinolines ; fennebricin A ; jorunnamycin A ; renieramycin G ; renieramycin J ; renieramycin M
Language	English
Publishing date	2020-05-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.0c01493
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Article: Phytochemical investigation of the flowers of Praxelis clematidea (Griseb.) R.M. King & H. Rob

Yang, Jian-Ni / Zhou, Xiu-Qiao / Nong, Xu-Hua / Cao, Jian / Hui, Yang / Wen, Mian / Chen, Wen-Hao

Natural product research. 2021 Sept. 23, v. 35, no. 20

2021

Abstract: Chemical investigations of the flowers of Praxelis clematidea resulted in the isolation of 12 known compounds (1–12). Their structures were elucidated by extensive spectroscopic studies and chemical evidence. The structure and absolute configuration of 1 ...

Abstract	Chemical investigations of the flowers of Praxelis clematidea resulted in the isolation of 12 known compounds (1–12). Their structures were elucidated by extensive spectroscopic studies and chemical evidence. The structure and absolute configuration of 1 was precisely determined by a combination of 2 D NMR and quantum chemical calculations of ECD spectra analysis. Compounds 1, 4, 11 were isolated from the genus Praxelis for the first time, while 1–6, 8–12 were isolated from P. clematidea for the first time. The antibacterial activity of compounds 1, 2, 7, 9 were evaluated.
Keywords	antibacterial properties ; phytochemicals ; quantum mechanics ; research
Language	English
Dates of publication	2021-0923
Size	p. 3504-3508.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2019.1709189
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Article: Over 11 kg m–² h–¹ Evaporation Rate Achieved by Cooling Metal–Organic Framework Foam with Pine Needle-Like Hierarchical Structures to Subambient Temperature

Wang, Hongqiang / Zhang, Chen / Ji, Xiujie / Yang, Jianming / Zhang, Zehui / Ma, Yi / Zhang, Zhihua / Zhou, Bin / Shen, Jun / Du, Ai

ACS applied materials & interfaces. 2022 Feb. 16, v. 14, no. 8

2022

Abstract: ... surface temperature and an evaporation rate of up to 3.27 kg m–² h–¹ under only one sun illumination. Furthermore ... when coupled with an air flow, the biface evaporator realizes an excellent evaporation rate of 11.58 kg m–² h ...

Abstract	Solar steam generation has become a hot research topic because of its great potential to alleviate the drinking water crisis without extra energy input. Although some efforts focusing on designing spatial geometry have been made to multiply the evaporation performances of up-to-date three-dimensional evaporators, they still have some shortcomings, such as low material and space utilization efficiencies, complex spatial geometry, energy loss due to the hot solar absorption surface, and salt crystallization due to inefficient water supply. Herein, a biomimetic copper-based metal–organic framework (Cu–Cu(OH)₂-MOF) foam sheet with interconnected pores and pine needle-like hierarchical structures consisting of Cu(OH)₂ nanowires and MOF nanowhiskers is fabricated. The pine needle-like hierarchical structures of Cu–Cu(OH)₂-MOF foam contribute to absorbing solar energy and supplying sufficient water by trapping incident light and enhancing the capillary force, respectively. Inspired by drying clothes outside under solar irradiation, through exposing one end of the Cu–Cu(OH)₂-MOF foam to air, the biface evaporator achieves a subambient evaporation surface temperature and an evaporation rate of up to 3.27 kg m–² h–¹ under only one sun illumination. Furthermore, when coupled with an air flow, the biface evaporator realizes an excellent evaporation rate of 11.58 kg m–² h–¹ with an energy efficiency of 160.07% even in seawater, ensuring its great application prospect to be used in drinking water production and seawater desalination.
Keywords	absorption ; air ; air flow ; biomimetics ; clothing ; coordination polymers ; copper ; crystallization ; desalination ; energy efficiency ; evaporation rate ; foams ; geometry ; lighting ; nanocrystals ; nanowires ; seawater ; solar energy ; solar radiation ; steam ; surface temperature ; water supply
Language	English
Dates of publication	2022-0216
Size	p. 10257-10266.
Publishing place	American Chemical Society
Document type	Article
ISSN	1944-8252
DOI	10.1021/acsami.1c20769
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Article ; Online: Iridium-induced regioselective B-H and C-H activations at azo-substituted m-carboranes: facile access to polynuclear complexes.

Gao, Yang / Guo, Shu-Ting / Cui, Peng-Fei / Aznarez, Francisco / Jin, Guo-Xin

Chemical communications (Cambridge, England)

2018 Volume 55, Issue 2, Page(s) 210–213

Abstract: Iridium(iii)-induced selective B(2,3)-H and C-H bond activations at mono- and bi-p ... methoxybenzeneazo-substituted m-carboranes have been investigated. A powerful methodology is introduced ... for the preparation of unique polynuclear complexes featuring m-carboranyl ligands in a single step. The experimental ...

Abstract	Iridium(iii)-induced selective B(2,3)-H and C-H bond activations at mono- and bi-p-methoxybenzeneazo-substituted m-carboranes have been investigated. A powerful methodology is introduced for the preparation of unique polynuclear complexes featuring m-carboranyl ligands in a single step. The experimental results highlight that the base employed in the reaction plays a key role in the formation and the structures of the complexes.
Language	English
Publishing date	2018-12-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/c8cc09084j
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Article ; Online: Hyperisampsins H-M, Cytotoxic Polycyclic Polyprenylated Acylphloroglucinols from Hypericum sampsonii.

Zhu, Hucheng / Chen, Chunmei / Tong, Qingyi / Chen, Xintao / Yang, Jing / Liu, Junjun / Sun, Bin / Wang, Jianping / Yao, Guangmin / Luo, Zengwei / Xue, Yongbo / Zhang, Yonghui

Scientific reports

2015 Volume 5, Page(s) 14772

Abstract: Six new polycyclic polyprenylated acylphloroglucinols (PPAPs), named hyperisampsins H-M (1-6), were ...

Abstract	Six new polycyclic polyprenylated acylphloroglucinols (PPAPs), named hyperisampsins H-M (1-6), were isolated from the aerial parts of Hypericum sampsonii, together with five known analogs (7-11). The structures of 1-6 were established by extensive spectroscopic analyses, including HRESIMS and NMR. In addition, the absolute configurations of these new compounds were determined by electronic circular dichroism (ECD) calculations. Compounds 1 and 2 represent the first examples of PPAPs possessing a unique γ-lactone ring at C-23, while 3-6 differed from normal PPAPs with an unprecedented 1,2-dioxane ring. Compounds 1-7 were evaluated for their cytotoxic activities against a panel of human cancer cell lines in vitro, of which 3, 4, and 6 exhibited significant cytotoxic activities with IC50 values ranging from 0.56 to 3.00 μM. Moreover, compound 3 induces leukemia cell apoptotic death, evidenced by activation of caspase-3, degradation of PARP, up-regulation of Bax, and down-regulation of Bcl-2 and Bcl-xl.
MeSH term(s)	Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis/drug effects ; Apoptosis Regulatory Proteins/metabolism ; Benzofurans/chemistry ; Benzofurans/pharmacology ; Cell Line, Tumor ; Circular Dichroism ; Drug Screening Assays, Antitumor ; Flow Cytometry/methods ; Humans ; Hypericum/chemistry ; Inhibitory Concentration 50 ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Phloroglucinol/chemistry ; Quinones/chemistry ; Quinones/pharmacology
Chemical Substances	Antineoplastic Agents, Phytogenic ; Apoptosis Regulatory Proteins ; Benzofurans ; Quinones ; Phloroglucinol (DHD7FFG6YS)
Language	English
Publishing date	2015-10-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep14772
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Article: Asymmetric Total Syntheses of (−)-Fennebricin A, (−)-Renieramycin J, (−)-Renieramycin G, (−)-Renieramycin M, and (−)- Jorunnamycin A via C–H Activation

Zheng, Yu / Li, Xue-Dan / Sheng, Peng-Zhen / Yang, Hong-Dou / Wei, Kun / Yang, Yu-Rong

Organic letters. 2020 May 21, v. 22, no. 11

2020

Abstract: ... unnatural amino acid building block rapidly and practically. The structure of synthetic (−)-renieramycin M ...

Abstract	Collective total synthesis of five tetrahydroisoquinoline alkaloids including the first total synthesis of (−)-fennebricin A and (−)-renieramycin J has been accomplished. The synthesis features employing a single common amino acid to symmetrically construct the pentacycle of title alkaloids. The palladium-catalyzed arylation of alanine-derived amide developed by Yu was tactically utilized to afford unnatural amino acid building block rapidly and practically. The structure of synthetic (−)-renieramycin M has been confirmed by single crystal X-ray analysis for the first time.
Keywords	X-ray diffraction ; amino acids ; arylation ; carbon-hydrogen bond activation
Language	English
Dates of publication	2020-0521
Size	p. 4489-4493.
Publishing place	American Chemical Society
Document type	Article
Note	NAL-AP-2-clean
ISSN	1523-7052
DOI	10.1021/acs.orglett.0c01493
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Article: m-CAᵣ–H Bond Alkylations and Difluoromethylation of Tertiary Phosphines Using a Ruthenium Catalyst

Li, Gang / An, Jiangzhen / Jia, Chunqi / Yan, Bingxu / Zhong, Lei / Wang, Junjie / Yang, Suling

Organic letters. 2020 Nov. 24, v. 22, no. 24

2020

Abstract: m-CAᵣ–H bond functionalization of tertiary phosphines was developed using [Ru(p-cymene)Cl₂ ... experiments indicated that m-CAᵣ–H bond functionalization was a radical reaction and that a hexagonal ...

Abstract	m-CAᵣ–H bond functionalization of tertiary phosphines was developed using [Ru(p-cymene)Cl₂]₂ as a catalyst. Desired product structures were confirmed by single-crystal X-ray diffraction. Mechanistic experiments indicated that m-CAᵣ–H bond functionalization was a radical reaction and that a hexagonal ruthenacycle complex was a crucial intermediate in the process. Therefore, this study provides a novel method for the late-stage meta-position modification of biphenyl monophosphine ligands.
Keywords	X-ray diffraction ; alkylation ; biphenyl ; catalysts ; ligands ; p-cymene ; ruthenium
Language	English
Dates of publication	2020-1124
Size	p. 9450-9455.
Publishing place	American Chemical Society
Document type	Article
Note	NAL-AP-2-clean
ISSN	1523-7052
DOI	10.1021/acs.orglett.0c03377
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