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Article ; Online: Differential DNA methylation landscape of miRNAs genes in mice liver fibrosis.

Li, Deming / Yang, Wentong / Pang, Jiaojiao / Yu, Guoying

2024 Volume 51, Issue 1, Page(s) 475

Abstract: Background: Patients with chronic liver disease were found nearly all to have liver fibrosis, which is characterized by excess accumulation of extracellular matrix (ECM) proteins. While ECM accumulation can prevent liver infection and injury, it can ... ...

Abstract	Background: Patients with chronic liver disease were found nearly all to have liver fibrosis, which is characterized by excess accumulation of extracellular matrix (ECM) proteins. While ECM accumulation can prevent liver infection and injury, it can destroy normal liver function and architecture. miRNA's own regulation was involved in DNA methylation change. The purpose of this study is to detect DNA methylation landscape of miRNAs genes in mice liver fibrosis tissues. Methods: Male mice (10-12 weeks) were injected CCl Results: There are 769 differential methylation sites (DMS) in total between fibrotic liver tissue and normal mice liver tissue, which were related with 148 different miRNA genes. Chips array data were confirmed by bisulfite sequencing polymerase chain reaction (R = 0.953; P < 0.01). GO analysis of the target genes of 2 miRNA revealed that protein binding, cytoplasm and chromatin binding activity were commonly enriched; KEGG pathway enrichment analysis displayed that TGF-beta signaling pathway was commonly enriched. Conclusion: The DNA of 148 miRNA genes was found to have methylation change in liver fibrosis tissue. These discoveries in miRNA genes are beneficial to future miRNA function research in liver fibrosis.
MeSH term(s)	Humans ; Male ; Mice ; Animals ; DNA Methylation/genetics ; Liver Cirrhosis/genetics ; Liver Cirrhosis/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; DNA/metabolism ; Sulfites
Chemical Substances	hydrogen sulfite (OJ9787WBLU) ; MicroRNAs ; DNA (9007-49-2) ; Sulfites
Language	English
Publishing date	2024-03-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-024-09416-6
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Article ; Online: Repair and regeneration of the alveolar epithelium in lung injury.

Wang, Yaxuan / Wang, Lan / Ma, Shuaichen / Cheng, Lianhui / Yu, Guoying

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2024 Volume 38, Issue 8, Page(s) e23612

Abstract: Considerable progress has been made in understanding the function of alveolar epithelial cells in a quiescent state and regeneration mechanism after lung injury. Lung injury occurs commonly from severe viral and bacterial infections, inhalation lung ... ...

Abstract	Considerable progress has been made in understanding the function of alveolar epithelial cells in a quiescent state and regeneration mechanism after lung injury. Lung injury occurs commonly from severe viral and bacterial infections, inhalation lung injury, and indirect injury sepsis. A series of pathological mechanisms caused by excessive injury, such as apoptosis, autophagy, senescence, and ferroptosis, have been studied. Recovery from lung injury requires the integrity of the alveolar epithelial cell barrier and the realization of gas exchange function. Regeneration mechanisms include the participation of epithelial progenitor cells and various niche cells involving several signaling pathways and proteins. While alveoli are damaged, alveolar type II (AT2) cells proliferate and differentiate into alveolar type I (AT1) cells to repair the damaged alveolar epithelial layer. Alveolar epithelial cells are surrounded by various cells, such as fibroblasts, endothelial cells, and various immune cells, which affect the proliferation and differentiation of AT2 cells through paracrine during alveolar regeneration. Besides, airway epithelial cells also contribute to the repair and regeneration process of alveolar epithelium. In this review, we mainly discuss the participation of epithelial progenitor cells and various niche cells involving several signaling pathways and transcription factors.
MeSH term(s)	Humans ; Regeneration/physiology ; Animals ; Lung Injury/metabolism ; Lung Injury/pathology ; Alveolar Epithelial Cells/metabolism ; Alveolar Epithelial Cells/pathology ; Stem Cells/metabolism ; Stem Cells/physiology ; Pulmonary Alveoli/pathology ; Pulmonary Alveoli/metabolism ; Signal Transduction ; Cell Differentiation
Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.202400088R
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Article ; Online: Molecular Epidemiological Study of a Human Brucellosis Outbreak - Weihai City, Shandong Province, China, 2022.

Li, Yan / Yu, Yifan / Zhao, Jian / Ding, Shujun / Zhang, Guoying / Yu, Xiaolin / Kou, Zengqiang

China CDC weekly

2024 Volume 6, Issue 12, Page(s) 230–234

Abstract: What is already known about this topic?: Brucellosis, mainly caused by : What is added by this report?: This was the initial report of a brucellosis outbreak in the last five years. Strains of : What are the implications for public health practice?! ...

Abstract	What is already known about this topic?: Brucellosis, mainly caused by What is added by this report?: This was the initial report of a brucellosis outbreak in the last five years. Strains of What are the implications for public health practice?: Epidemiological investigations depend on standardized and effective molecular typing methods and analysis tools for public health laboratories to identify and trace outbreaks. Understanding the circulation patterns of livestock in free-range households in heavily affected areas is essential for controlling the spread of brucellosis.
Language	English
Publishing date	2024-03-08
Publishing country	China
Document type	Journal Article
ISSN	2096-7071
ISSN (online)	2096-7071
DOI	10.46234/ccdcw2024.046
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Article: Circulating miR-4739 and IGFBP-4 Levels in Postmenopausal Women with Osteoporosis and Osteoporotic Vertebral Fracture.

Lei, Yisong / Yu, Li / Tang, Guoying / Liu, Anping

Alternative therapies in health and medicine

2023 Volume 29, Issue 7, Page(s) 204–209

Abstract: Objective: This study aimed to investigate the potential plasma miRNA-mRNA regulatory networks in postmenopausal women with osteoporosis (OP) and osteoporotic vertebral fracture (OVF).: Methods: The study employed a cross-sectional design, and the ... ...

Abstract	Objective: This study aimed to investigate the potential plasma miRNA-mRNA regulatory networks in postmenopausal women with osteoporosis (OP) and osteoporotic vertebral fracture (OVF). Methods: The study employed a cross-sectional design, and the microarray dataset GSE93883 was acquired from the Gene Expression Omnibus (GEO) to assess plasma miRNA profiles in postmenopausal women with osteoporosis (OP) and osteoporotic vertebral fracture (OVF). Subsequently, plasma microRNA-4739 (miR-4739) and Insulin-like Growth Factor Binding Protein-4 (IGFBP-4) levels were validated in a well-defined cohort comprising 210 postmenopausal women. This cohort consisted of three distinct groups: healthy controls (HC, n = 70), OP patients (n = 70), and OVF patients (n = 70). Results: Analysis of the GSE93883 dataset revealed a stepwise increase in four miRNAs (hsa-miR-4739, hsa-miR-4505, hsa-miR-4459, hsa-miR-665) in plasma samples from HC to OP patients to OVF patients. Conversely, plasma miR-4666a-3p showed a gradual decrease. We predicted six genes targeted by miR-4739 using six online databases. Plasma miR-4739 levels were significantly higher in OP and OVF patients compared to HC, especially in OVF patients. However, plasma IGFBP-4 exhibited an inverse pattern. Pearson analysis demonstrated a significant negative correlation between plasma miR-4739 and plasma IGFBP-4 in OP and OVF patients. Receiver operating characteristic (ROC) curve analysis of plasma miR-4739 yielded a sensitivity of 35.71% and specificity of 95.71% for predicting the presence of OP and a sensitivity of 71.43% and specificity of 95.71% for predicting OVF, with an AUC of 0.865. Moreover, the area under the curve (AUC) for IGFBP-4 was higher than that for plasma miR-4739 when differentiating OP patients from OVF patients. Conclusions: Circulating miR-4739 and IGFBP-4 demonstrated a negative correlation in OP and OVF patients, suggesting their potential as diagnostic biomarkers for OP and OVF in the future.
MeSH term(s)	Humans ; Female ; Circulating MicroRNA ; Spinal Fractures ; Postmenopause ; Cross-Sectional Studies ; Insulin-Like Growth Factor Binding Protein 4 ; Osteoporosis ; Osteoporotic Fractures ; MicroRNAs/genetics ; Biomarkers
Chemical Substances	Circulating MicroRNA ; Insulin-Like Growth Factor Binding Protein 4 ; MicroRNAs ; Biomarkers ; MIRN665 microRNA, human
Language	English
Publishing date	2023-07-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
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Article ; Online: A spreadsheet tool for designing statistical quality control programs based on patient risk parameters.

Zhang, Yu / Ren, Biqiong / Zou, Guoying / Yang, Lihua

Clinical biochemistry

2023 Volume 116, Page(s) 52–58

Abstract: Background: Quality control (QC) in the laboratory aims to reduce the risk of harm to a patient due to erroneous results, as highlighted by the Clinical Laboratory Standards Institute (CLSI) guidance for Statistical Quality Control (SQC) (C24-Ed4). To ... ...

Abstract	Background: Quality control (QC) in the laboratory aims to reduce the risk of harm to a patient due to erroneous results, as highlighted by the Clinical Laboratory Standards Institute (CLSI) guidance for Statistical Quality Control (SQC) (C24-Ed4). To effectively reduce patient risk, a convenient spreadsheet tool was developed to assist laboratories in SQC design based on patient risk parameters. Methods: In accordance with Parvin's patient risk model and the mathematical formula for calculating the expected number of unreliable final patient results [E(N Results: A convenient spreadsheet tool is proposed in this study. After the quality requirements, performance parameters, practical run size, QC rules and the number of QC results of test items are input, the laboratory is enabled to quickly obtain MaxE(N Conclusions: Convenient spreadsheet tools can be adopted by laboratories to assess the risks of QC strategies and design appropriate risk-based SQC strategies to reduce patient risk to acceptable levels.
MeSH term(s)	Humans ; Laboratories ; Clinical Laboratory Services ; Quality Control ; Software ; Laboratories, Clinical
Language	English
Publishing date	2023-03-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	390372-2
ISSN	1873-2933 ; 0009-9120
ISSN (online)	1873-2933
ISSN	0009-9120
DOI	10.1016/j.clinbiochem.2023.03.009
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Article ; Online: Predictive value of PIVKA-II and AFP for the non-objective response of HBV-associated hepatocellular carcinoma after transarterial chemoembolization: a prospective study.

Wang, Lili / Yang, Xiulan / Wang, Jinhuan / Yu, Guoying

European journal of gastroenterology & hepatology

2023 Volume 35, Issue 12, Page(s) 1410–1415

Abstract: Background: To determine the predictive value of serum abnormal prothrombin (PIVKA-II) and alpha-fetoprotein (AFP) for the non-objective response of HBV-associated hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE).: Methods: ...

Abstract	Background: To determine the predictive value of serum abnormal prothrombin (PIVKA-II) and alpha-fetoprotein (AFP) for the non-objective response of HBV-associated hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE). Methods: This prospective study included HBV-associated HCC patients who underwent TACE at the Fourth People's Hospital of Qinghai Province between December 2021 and July 2022. According to contrast-enhanced ultrasound and upper abdomen contrast-enhanced MRI, the patients were divided into the objective response group and the non-objective response group 3 months after TACE. Results: There were 54 patients, of whom 31 experienced non-objective responses. The PIVKA-II levels in the objective response group were significantly lower than in the non-objective response group at 1 month [352.00 (142.16-722.54) vs. 528.58(241.32-1681.23) mAU/ml, P = 0.005] and 3 months [28.96 (20.01-42.49) vs. 2082.55 (52.63-10 057.30) mAU/ml, P = 0.016] after TACE. The Spearman rank correlation analysis showed no significant correlation between PIVKA-II and AFP (r = 0.315, P > 0.05). The areas under the curve (AUCs) of AFP and PIVKA-II before TACE were 0.632 and 0.529. One month after TACE, the AUC of PIVKA-II combined with AFP (AUC = 0.787) was higher than for PIVKA-II (AUC = 0.658) and AFP (AUC = 0.749). Conclusion: PIVKA-II does not outperform AFP in predicting non-objective response after TACE in HCC patients. The combination of PIVKA-II and AFP might improve the diagnosis of HCC non-objective response after TACE.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/diagnosis ; alpha-Fetoproteins/analysis ; Prothrombin ; Hepatitis B virus ; Prospective Studies ; Liver Neoplasms/diagnosis ; ROC Curve ; Chemoembolization, Therapeutic/adverse effects ; Biomarkers ; Biomarkers, Tumor
Chemical Substances	acarboxyprothrombin (53230-14-1) ; alpha-Fetoproteins ; Prothrombin (9001-26-7) ; Biomarkers ; Biomarkers, Tumor
Language	English
Publishing date	2023-10-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1034239-4
ISSN	1473-5687 ; 0954-691X
ISSN (online)	1473-5687
ISSN	0954-691X
DOI	10.1097/MEG.0000000000002663
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Article ; Online: Signaling pathways of liver regeneration

Chunyan Zhang / Caifang Sun / Yabin Zhao / Bingyu Ye / GuoYing Yu

iScience, Vol 27, Iss 1, Pp 108683- (2024)

Biological mechanisms and implications

1481

Abstract: Summary: The liver possesses a unique regenerative ability to restore its original mass, in this regard, partial hepatectomy (PHx) and partial liver transplantation (PLTx) can be executed smoothly and safely, which has important implications for the ... ...

Abstract	Summary: The liver possesses a unique regenerative ability to restore its original mass, in this regard, partial hepatectomy (PHx) and partial liver transplantation (PLTx) can be executed smoothly and safely, which has important implications for the treatment of liver disease. Liver regeneration (LR) can be the very complicated procedure that involves multiple cytokines and transcription factors that interact with each other to activate different signaling pathways. Activation of these pathways can drive the LR process, which can be divided into three stages, namely, the initiation, progression, and termination stages. Therefore, it is important to investigate the pathways involved in LR to elucidate the mechanism of LR. This study reviews the latest research on the key signaling pathways in the different stages of LR.
Keywords	Health sciences ; Biological sciences ; Science ; Q
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pharmacokinetics and safety of EVER206, a novel polymyxin antimicrobial, in healthy Chinese subjects.

Li, Size / Zhu, Xu / Cao, Guoying / Shen, Jufang / Yu, Jicheng / Wu, Xiaojie / Wu, Jufang / Yang, Haijing / Li, Nanyang / Hu, Yingying / Wang, Jingjing / Huang, Haihui / Zhang, Jing

Antimicrobial agents and chemotherapy

2024 , Page(s) e0156323

Abstract: EVER206 (also known as SPR206) is a novel polymyxin analog that has ... ...

Abstract	EVER206 (also known as SPR206) is a novel polymyxin analog that has shown
Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/aac.01563-23
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Einzelsignatur: Show issues

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Article: Clinical and Molecular Characterization of a Patient with Generalized Arterial Calcification of Infancy Caused by Rare

Yao, Ruen / Yang, Fan / Zhang, Qianwen / Yu, Tingting / Yu, Ying / Chang, Guoying / Wang, Xiumin

Journal of personalized medicine

2023 Volume 14, Issue 1

Abstract: Generalized arterial calcification of infancy (GACI) is a rare autosomal-recessive disease characterized by extensive arterial calcification in infancy, with clinical manifestations such as arterial stenoses and heart failure. The ENPP1 inactivation ... ...

Abstract	Generalized arterial calcification of infancy (GACI) is a rare autosomal-recessive disease characterized by extensive arterial calcification in infancy, with clinical manifestations such as arterial stenoses and heart failure. The ENPP1 inactivation mutation has been identified as a potential defect in most of the cases of GACI, while mutations in
Language	English
Publishing date	2023-12-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm14010054
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Article: Heat Shock Protein 20 Gene Superfamilies in Red Algae: Evolutionary and Functional Diversities.

Gao, Tian / Mo, Zhaolan / Tang, Lei / Yu, Xinzi / Du, Guoying / Mao, Yunxiang

Frontiers in plant science

2022 Volume 13, Page(s) 817852

Abstract: Heat shock protein 20 ( ...

Abstract	Heat shock protein 20 (
Language	English
Publishing date	2022-03-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2022.817852
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