LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 423

Search options

  1. Article ; Online: Association Between Sleep Apnea and Tinnitus: A Meta-Analysis.

    Gao, Jing / Tan, Ping / Liu, Yunliang / Chen, Shoujian / Liu, Jianqing

    Ear, nose, & throat journal

    2024  , Page(s) 1455613241226853

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 750153-5
    ISSN 1942-7522 ; 0145-5613
    ISSN (online) 1942-7522
    ISSN 0145-5613
    DOI 10.1177/01455613241226853
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 107: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: The Tumorigenicity of Breast Cancer Cells Is Reduced upon Treatment with Small Extracellular Vesicles Isolated from Heparin Treated Cell Cultures

    Yunliang Chen / Michael Scully

    International Journal of Molecular Sciences, Vol 24, Iss 21, p

    2023  Volume 15736

    Abstract: As a member of the HPSG family, heparin is often used as a specific probe of their role in cell physiology; indeed, we have previously shown a reduction in the tumorigenicity of breast cancer cells when cultured in its presence. However, a partial ... ...

    Abstract As a member of the HPSG family, heparin is often used as a specific probe of their role in cell physiology; indeed, we have previously shown a reduction in the tumorigenicity of breast cancer cells when cultured in its presence. However, a partial reversal of the anti-tumorigenic effect occurred when the treated cells were cultured in fresh medium without heparin, which led us to consider whether a more persistent effect could be achieved by treatment of the cells with small extracellular vesicles (sEV) from heparin-treated cells. The tumorigenicity was analyzed using sEV isolated from the culture medium of heparin-treated MCF-7 and MDA-MB231 breast cancer cells (sEV-HT) or from conditioned medium following the termination of treatment (heparin discontinued, sEV-HD). Tumorigenicity was reduced in cells cultured in the presence of sEV-HT compared to that of cells cultured in the presence of sEV from untreated cells (sEV-Ctrl). sEV-HD were also observed to exert an anti-tumorigenic effect on the expression of pro-tumorigenic and cell cycle regulatory proteins, as well as signaling activities when added to fresh cultures of MCF-7 and MDA-MB231 cells. The anti-tumorigenic activity of the heparin-derived sEV may arise from observed changes in the miRNA content or from heparin, which was observed to be bound to the sEV. sEV may constitute a relatively stable reservoir of circulating heparin, allowing heparin activity to persist in the circulation even after therapy has been discontinued. These findings can be considered as a special additional pharmacological characteristic of heparin clinical therapy.
    Keywords breast cancer ; heparin ; small extracellular vesicles ; miRNA ; cytology profile ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 616
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: The Tumorigenicity of Breast Cancer Cells Is Reduced upon Treatment with Small Extracellular Vesicles Isolated from Heparin Treated Cell Cultures.

    Chen, Yunliang / Scully, Michael

    International journal of molecular sciences

    2023  Volume 24, Issue 21

    Abstract: As a member of the HPSG family, heparin is often used as a specific probe of their role in cell physiology; indeed, we have previously shown a reduction in the tumorigenicity of breast cancer cells when cultured in its presence. However, a partial ... ...

    Abstract As a member of the HPSG family, heparin is often used as a specific probe of their role in cell physiology; indeed, we have previously shown a reduction in the tumorigenicity of breast cancer cells when cultured in its presence. However, a partial reversal of the anti-tumorigenic effect occurred when the treated cells were cultured in fresh medium without heparin, which led us to consider whether a more persistent effect could be achieved by treatment of the cells with small extracellular vesicles (sEV) from heparin-treated cells. The tumorigenicity was analyzed using sEV isolated from the culture medium of heparin-treated MCF-7 and MDA-MB231 breast cancer cells (sEV-HT) or from conditioned medium following the termination of treatment (heparin discontinued, sEV-HD). Tumorigenicity was reduced in cells cultured in the presence of sEV-HT compared to that of cells cultured in the presence of sEV from untreated cells (sEV-Ctrl). sEV-HD were also observed to exert an anti-tumorigenic effect on the expression of pro-tumorigenic and cell cycle regulatory proteins, as well as signaling activities when added to fresh cultures of MCF-7 and MDA-MB231 cells. The anti-tumorigenic activity of the heparin-derived sEV may arise from observed changes in the miRNA content or from heparin, which was observed to be bound to the sEV. sEV may constitute a relatively stable reservoir of circulating heparin, allowing heparin activity to persist in the circulation even after therapy has been discontinued. These findings can be considered as a special additional pharmacological characteristic of heparin clinical therapy.
    MeSH term(s) Humans ; Heparin/pharmacology ; Extracellular Vesicles ; Cell Culture Techniques ; Carcinogenesis ; Cell Cycle Proteins
    Chemical Substances Heparin (9005-49-6) ; Cell Cycle Proteins
    Language English
    Publishing date 2023-10-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242115736
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Critical bloodstream infection caused by

    Wang, Xueqing / Tu, Yunliang / Chen, Yingqun / Yang, Huilin / Luo, Minghua / Li, Yanyan / Huang, Lei / Luo, Hua

    Frontiers in medicine

    2024  Volume 11, Page(s) 1342706

    Abstract: Chromobacterium ... ...

    Abstract Chromobacterium violaceum
    Language English
    Publishing date 2024-03-26
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2024.1342706
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Internet use, market transformation, and individual tolerance

    Yunliang Zhang / Xueli Chen / Zhiyang Shen

    Humanities & Social Sciences Communications, Vol 10, Iss 1, Pp 1-

    Evidence from China

    2023  Volume 12

    Abstract: Abstract Earlier literature studies the relationship between Internet use and individual tolerance, but little research explores these links in the context of China. This article analyzes the impact of Internet use on individuals’ tolerance using Chinese ...

    Abstract Abstract Earlier literature studies the relationship between Internet use and individual tolerance, but little research explores these links in the context of China. This article analyzes the impact of Internet use on individuals’ tolerance using Chinese national social survey data from 2015 to 2021. The results find that Internet use has a significant positive effect on individual social tolerance (ST) and moral tolerance (MT), and this effect is still valid after dealing with the endogenous problem by instrumental variables and the propensity score matching method. Moreover, the division of university education, unit system, and Hukou moderate the relationship between Internet use and individual social tolerance. Last, opportunity fairness and outcome fairness play the suppressing effects, not mediating effects. This article clarifies the role of digital technology in the development of high-quality economics and proposes that the government should pay more attention to changes in social attitudes.
    Keywords History of scholarship and learning. The humanities ; AZ20-999 ; Social Sciences ; H
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Springer Nature
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: A Hybrid Heuristic Algorithm for Maximizing the Resilience of Underground Logistics Network Planning

    Zhaojie Xue / Yunliang Fang / Wenxiang Peng / Xiangsheng Chen

    Applied Sciences, Vol 13, Iss 23, p

    2023  Volume 12588

    Abstract: In recent times, there has been a sharp increase in the congestion of ground transportation, the scarcity of land resources, and various disasters. Hence, there is an urgent need to find an effective and sustainable approach to transportation. The ... ...

    Abstract In recent times, there has been a sharp increase in the congestion of ground transportation, the scarcity of land resources, and various disasters. Hence, there is an urgent need to find an effective and sustainable approach to transportation. The construction of an underground logistics network, where transportation activities occur beneath the surface of the ground, is anticipated to emerge as a future trend. This study aims to formulate a resilient-maximizing plan for the underground logistics network, ensuring optimal meeting of transportation demands in the aftermath of ground disasters. Accordingly, a two-stage linear programming model is established to determine the layout plan for the most resilient underground logistics network. The first phase of the model is designed to generate viable layouts for the underground logistics network, while the second phase is dedicated to evaluating the resilience of the proposed layout plan. During the evaluation of network resilience, Monte Carlo simulations are used to simulate disaster scenarios. Given the inherent complexity of the model, the traditional solver cannot efficiently solve the problem. Thus, a new hybrid heuristic algorithm is designed to obtain solutions that maximize network resilience. The results show the effectiveness of the designed algorithm and the significant improvement in network resilience achieved by numerical experiments. Moreover, sensitivity analyses are conducted to reveal the relationships between resilience and budget, as well as resilience and the capacity of underground pipelines. It has a significant impact on sustainability when making decisions regarding network planning.
    Keywords underground logistics network ; network layout ; network resilience ; two-stage linear programming model ; heuristic algorithm ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 000
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article: Predicting mortality in acute kidney injury patients undergoing continuous renal replacement therapy using a visualization model: A retrospective study.

    Zeng, Zhenguo / Zou, Kang / Qing, Chen / Wang, Jiao / Tang, Yunliang

    Frontiers in physiology

    2022  Volume 13, Page(s) 964312

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-11-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.964312
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Drought risk analysis based on multivariate copula function in Henan Province, China

    Yunliang Wen / Liwei Zhou / Ling Kang / Hao Chen / Jinlei Guo

    Geomatics, Natural Hazards & Risk, Vol 14, Iss

    2023  Volume 1

    Abstract: AbstractGlobal droughts have become more frequent in recent years, posing a serious threat to human production and life. In order to overcome the limitations of traditional studies in quantifying drought risk, this study uses runs theory to extract ... ...

    Abstract AbstractGlobal droughts have become more frequent in recent years, posing a serious threat to human production and life. In order to overcome the limitations of traditional studies in quantifying drought risk, this study uses runs theory to extract drought duration, severity and kurtosis as drought characteristic variables from standardized precipitation index (SPI) in Henan Province. Drought risk analysis models based on multivariate copula function are constructed to reveal the response relationships between drought characteristic variables. The results show that the smaller the SPI scale, the higher the sensitivity to identify drought processes. In addition, the multivariate copula function shows good fitting performance for the optimal joint distribution of drought characteristic variables, with R2 values exceeding 0.9. Drought joint recurrence period is positively correlated with drought characteristic variables, and the recurrence period within the duration of 4–6 months occur frequently, indicating a higher probability of experiencing short-term droughts and cross-seasonal droughts. When the drought duration, severity and kurtosis are greater than 2.5, 2200 and 1300, respectively, the drought joint recurrence period reaches 20 months. The research results have provided new methods for drought risk analysis and data support for formulating drought mitigation strategies in Henan Province.
    Keywords Drought ; Standardized Precipitation Index (SPI) ; Runs theory ; multivariate copula function ; risk analysis ; Environmental technology. Sanitary engineering ; TD1-1066 ; Environmental sciences ; GE1-350 ; Risk in industry. Risk management ; HD61
    Subject code 910
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Drought driving mechanism and risk situation prediction based on machine learning models in the Yellow River Basin, China

    Ling Kang / Yunliang Wen / Liwei Zhou / Hao Chen / Jinwang Ye

    Geomatics, Natural Hazards & Risk, Vol 14, Iss

    2023  Volume 1

    Abstract: AbstractUnder global warming, the acceleration of the water cycle has increased the risk of drought in the Yellow River Basin. Revealing the drought driving mechanisms in the basin and understanding the risk situation of drought have become particularly ... ...

    Abstract AbstractUnder global warming, the acceleration of the water cycle has increased the risk of drought in the Yellow River Basin. Revealing the drought driving mechanisms in the basin and understanding the risk situation of drought have become particularly important. This paper uses wavelet analysis and transfer entropy to analyze the drought driving mechanisms. In addition, an Improved Particle Swarm Optimization (IPSO) coupled with Long Short-Term Memory (LSTM) is used for drought risk prediction. The results are as follows: (1) Hydrological drought lags behind meteorological drought by 2–3 months, and they show two main periods on different time scales, which are 5–6 months and 8–14 months, respectively. (2) Rainfall, runoff, temperature, humidity, and vapor pressure are the main drought driving factors, with rainfall and humidity having the most significant impact. (3) The IPSO-LSTM model has improved the process of selecting model parameters based on empirical experiences in the LSTM model, improving the prediction accuracy by an average of 3.1%. This paper provides a scientific basis for water resource management and drought risk assessment in the basin, to better cope with future climate challenges.
    Keywords Driving factors ; Drought risk prediction ; Transfer entropy ; Machine learning ; The yellow river basin ; Environmental technology. Sanitary engineering ; TD1-1066 ; Environmental sciences ; GE1-350 ; Risk in industry. Risk management ; HD61
    Subject code 910
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Retraction Note: Small Diameter Blood Vessels Bioengineered From Human Adipose-derived Stem Cells.

    Zhou, Renpeng / Zhu, Lei / Fu, Shibo / Qian, Yunliang / Wang, Danru / Wang, Chen

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 5669

    Language English
    Publishing date 2022-04-05
    Publishing country England
    Document type Journal Article ; Retraction of Publication
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-10006-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top