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  1. Article ; Online: Implications of the healthcare pathway in infective endocarditis: beginning to see what we do not know.

    Cremer, Paul C

    European heart journal. Acute cardiovascular care

    2022  Volume 11, Issue 9, Page(s) 682–683

    MeSH term(s) Delivery of Health Care ; Endocarditis/diagnosis ; Endocarditis, Bacterial/diagnosis ; Health Facilities ; Humans
    Language English
    Publishing date 2022-08-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2663340-1
    ISSN 2048-8734 ; 2048-8726
    ISSN (online) 2048-8734
    ISSN 2048-8726
    DOI 10.1093/ehjacc/zuac101
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  2. Article ; Online: Acute Heart Valve Emergencies.

    Keane, Ryan R / Menon, Venu / Cremer, Paul C

    Cardiology clinics

    2024  Volume 42, Issue 2, Page(s) 237–252

    Abstract: Within the cardiac intensive care unit, prompt recognition of severe acute valvular lesions is essential because hemodynamic collapse can occur rapidly, especially when cardiac chambers have not had time for compensatory remodeling. Within this context, ... ...

    Abstract Within the cardiac intensive care unit, prompt recognition of severe acute valvular lesions is essential because hemodynamic collapse can occur rapidly, especially when cardiac chambers have not had time for compensatory remodeling. Within this context, optimal medical management, considerations for temporary mechanical circulatory support and decisive treatments strategies are addressed. Fundamental concepts include an appreciation for how sudden changes in flow and pressure gradients between cardiac chambers can impact hemodynamic and echocardiographic findings differently compared to similarly severe chronic lesions, as well as understanding the main causes for decompensated heart failure and cardiogenic shock for each valvular abnormality.
    MeSH term(s) Humans ; Heart Valve Diseases/therapy ; Emergencies ; Heart Valves ; Echocardiography ; Heart Failure ; Mitral Valve Insufficiency
    Language English
    Publishing date 2024-03-19
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1196385-2
    ISSN 1558-2264 ; 0733-8651
    ISSN (online) 1558-2264
    ISSN 0733-8651
    DOI 10.1016/j.ccl.2024.02.009
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  3. Article ; Online: Diagnostic Uncertainty in Prosthetic Valve Endocarditis: Value of

    Cremer, Paul C

    JACC. Cardiovascular imaging

    2020  Volume 13, Issue 12, Page(s) 2616–2618

    MeSH term(s) Endocarditis/diagnostic imaging ; Endocarditis, Bacterial ; Fluorodeoxyglucose F18 ; Heart Valve Prosthesis ; Humans ; Positron Emission Tomography Computed Tomography ; Predictive Value of Tests ; Reference Standards ; Uncertainty
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2020-08-19
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2491503-8
    ISSN 1876-7591 ; 1936-878X
    ISSN (online) 1876-7591
    ISSN 1936-878X
    DOI 10.1016/j.jcmg.2020.06.023
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  4. Article ; Online: SARS-CoV-2 and myocardial injury: Few answers, many questions.

    Cremer, Paul C

    Cleveland Clinic journal of medicine

    2020  Volume 87, Issue 9, Page(s) 521–525

    Abstract: Acute cardiac injury, defined as an elevated high-sensitivity troponin I or troponin T upon admission or during hospitalization, is common in patients with COVID-19, occurring in 10% to 35% of patients depending on the assay used and the population ... ...

    Abstract Acute cardiac injury, defined as an elevated high-sensitivity troponin I or troponin T upon admission or during hospitalization, is common in patients with COVID-19, occurring in 10% to 35% of patients depending on the assay used and the population studied. Even though the mechanisms of SARS-CoV-2 myocardial injury are not well defined, type 1 myocardial infarction and fulminant myocarditis are rare. Often, acute cardiac injury occurs in patients with elevated inflammatory markers, and both are associated with worse outcomes. However, the extent to which treatments should differ for patients with acute cardiac injury, heightened systemic inflammation, or both, is unknown.
    MeSH term(s) Acute Disease ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/therapy ; Hospitalization ; Humans ; Inflammation ; Myocardial Infarction/epidemiology ; Myocardial Infarction/therapy ; Myocardial Infarction/virology ; Myocarditis/epidemiology ; Myocarditis/therapy ; Myocarditis/virology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.87a.ccc001
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  5. Article ; Online: Recurrent Pericarditis: A Promising Future for IL-1 Blockers in Autoinflammatory Phenotypes.

    Klein, Allan L / Cremer, Paul C / Kafil, Tahir S

    Journal of the American College of Cardiology

    2023  Volume 82, Issue 1, Page(s) 41–45

    MeSH term(s) Interleukin-1
    Chemical Substances Interleukin-1
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2023.05.013
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    Zs.MO 196: Show issues

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  6. Article ; Online: Interleukin-1 Antagonists for the Treatment of Recurrent Pericarditis.

    Abadie, Bryan Q / Cremer, Paul C

    BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy

    2022  Volume 36, Issue 4, Page(s) 459–472

    Abstract: Although most patients with acute pericarditis will recover, a minority will have recurrent, debilitating episodes. In these patients, refractory symptoms result in high morbidity, and typically require a prolonged duration of anti-inflammatory treatment. ...

    Abstract Although most patients with acute pericarditis will recover, a minority will have recurrent, debilitating episodes. In these patients, refractory symptoms result in high morbidity, and typically require a prolonged duration of anti-inflammatory treatment. Initially, the efficacy of colchicine in both recurrent pericarditis and periodic fever syndromes suggested the central role of the inflammasome in pericarditis. Subsequently, the success of interleukin-1 antagonists in autoinflammatory diseases prompted further investigation in recurrent pericarditis. In current clinical practice, interleukin-1 antagonists include canakinumab, anakinra, and rilonacept. Both anakinra and rilonacept have demonstrated efficacy in randomized trials of patients with recurrent pericarditis. The aim of the current review is to explain the biological rationale for interleukin-1 antagonists in recurrent pericarditis, highlight supporting clinical evidence, and emphasizing future areas of investigation.
    MeSH term(s) Anti-Inflammatory Agents/therapeutic use ; Humans ; Interleukin 1 Receptor Antagonist Protein/therapeutic use ; Interleukin-1 ; Pericarditis/diagnosis ; Pericarditis/drug therapy
    Chemical Substances Anti-Inflammatory Agents ; Interleukin 1 Receptor Antagonist Protein ; Interleukin-1
    Language English
    Publishing date 2022-05-31
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 1364202-9
    ISSN 1179-190X ; 1173-8804
    ISSN (online) 1179-190X
    ISSN 1173-8804
    DOI 10.1007/s40259-022-00537-7
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    Zs.A 4112: Show issues Location:
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  7. Article ; Online: Pericardial Late Gadolinium Enhancement After Cardiac Surgery: Defining Disease Begins With Understanding Normal.

    Al-Kazaz, Mohamed / Cremer, Paul C

    Circulation. Cardiovascular imaging

    2023  Volume 16, Issue 11, Page(s) e016131

    MeSH term(s) Humans ; Contrast Media ; Gadolinium ; Pericardium/diagnostic imaging ; Pericardium/surgery ; Pericarditis ; Heart Defects, Congenital ; Cardiac Surgical Procedures/adverse effects ; Magnetic Resonance Imaging ; Pericarditis, Constrictive
    Chemical Substances Contrast Media ; Gadolinium (AU0V1LM3JT)
    Language English
    Publishing date 2023-11-21
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2435045-X
    ISSN 1942-0080 ; 1941-9651
    ISSN (online) 1942-0080
    ISSN 1941-9651
    DOI 10.1161/CIRCIMAGING.123.016131
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  8. Article ; Online: Compounding uncertainties with first-line computed tomography coronary angiography.

    Cremer, Paul C

    Heart (British Cardiac Society)

    2018  Volume 104, Issue 11, Page(s) 880–881

    MeSH term(s) Chest Pain ; Computed Tomography Angiography ; Coronary Angiography ; Heart ; Humans
    Language English
    Publishing date 2018-01-04
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2017-312472
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  9. Article ; Online: Response by Cremer and Jaber to Letter Regarding Article, "Incidence and Clinical Significance of Worsening Tricuspid Regurgitation Following Surgical or Transcatheter Aortic Valve Replacement: Analysis From the PARTNER IIA Trial".

    Cremer, Paul C / Jaber, Wael A

    Circulation. Cardiovascular interventions

    2021  Volume 14, Issue 11, Page(s) e011430

    MeSH term(s) Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Humans ; Incidence ; Transcatheter Aortic Valve Replacement/adverse effects ; Tricuspid Valve Insufficiency/diagnostic imaging ; Tricuspid Valve Insufficiency/epidemiology ; Tricuspid Valve Insufficiency/etiology
    Language English
    Publishing date 2021-11-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2450797-0
    ISSN 1941-7632 ; 1941-7640
    ISSN (online) 1941-7632
    ISSN 1941-7640
    DOI 10.1161/CIRCINTERVENTIONS.121.011430
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  10. Article ; Online: The evolving purpose of imaging for low risk patients with suspected acute coronary syndromes.

    Cremer, Paul C

    International journal of cardiology

    2017  Volume 249, Page(s) 494–495

    Language English
    Publishing date 2017-12-15
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2017.08.056
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