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  1. Article: Precision strikes: PSMA-targeted radionuclide therapy in prostate cancer - a narrative review.

    Szponar, Paweł / Petrasz, Piotr / Brzeźniakiewicz-Janus, Katarzyna / Drewa, Tomasz / Zorga, Piotr / Adamowicz, Jan

    Frontiers in oncology

    2023  Volume 13, Page(s) 1239118

    Abstract: Introduction: Radio-ligand targeted therapy is a new and promising concept of treatment Castration resistant prostate cancer (CRPC). Only a few radio-pharmaceutics were approved for usage in treating prostate cancer, among the multiple others tested. We ...

    Abstract Introduction: Radio-ligand targeted therapy is a new and promising concept of treatment Castration resistant prostate cancer (CRPC). Only a few radio-pharmaceutics were approved for usage in treating prostate cancer, among the multiple others tested. We aimed to review and summarize the literature on the therapeutic isotopes specific for PSMA.
    Methods: We performed a scoping literature review of PubMed from January 1996 to December 2022.
    Results: 98 publications were selected for inclusion in this review. The studies contained in publications allowed to summarize the data on pharmacokinetics, therapeutic effects, side effects and the medical use of 225Ac and 177Lu radionuclides. The review also presents new research directions for specific PSMA radionuclides.
    Conclusion: Radioligand targeted therapy is a new and promising concept where Lu-177-PSMA-617 have promising outcomes in treatment according to standard of care.
    Language English
    Publishing date 2023-11-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1239118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Structure and Organization of Sport for People With Intellectual Disabilities Across Europe.

    Marin-Urquiza, Adriana / Burns, Jan / Morgulec-Adamowicz, Natalia / Van Biesen, Debbie

    Adapted physical activity quarterly : APAQ

    2023  Volume 41, Issue 1, Page(s) 126–152

    Abstract: Opportunities to participate and compete in sports for athletes with intellectual disability (ID) have increased; however, this group still encounters limitations in accessing a comprehensive range of sports. This study addressed the current knowledge on ...

    Abstract Opportunities to participate and compete in sports for athletes with intellectual disability (ID) have increased; however, this group still encounters limitations in accessing a comprehensive range of sports. This study addressed the current knowledge on how sport for people with ID is organized and the relationships between the major sport organizations for people with ID across 10 European countries. The participants were 29 national sport organizations for people with ID. Data were collected using semistructured interviews with representatives from the key organizations and analyzed thematically. From the results, two major themes emerged: (a) connection and networking between sport organizations and (b) organizational landscape of each nation (i.e., ID, multidisability, or mainstream). The results of this study contribute to understanding how sport for people with ID is organized across the participating nations, demonstrating different models of development and examples of good practice.
    MeSH term(s) Humans ; Intellectual Disability ; Sports ; Athletes ; Mainstreaming, Education ; Europe
    Language English
    Publishing date 2023-08-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 995992-0
    ISSN 1543-2777 ; 0736-5829
    ISSN (online) 1543-2777
    ISSN 0736-5829
    DOI 10.1123/apaq.2022-0212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3421: Show issues Location:
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  3. Article ; Online: Online in silico validation of disease and gene sets, clusterings or subnetworks with DIGEST.

    Adamowicz, Klaudia / Maier, Andreas / Baumbach, Jan / Blumenthal, David B

    Briefings in bioinformatics

    2022  Volume 23, Issue 4

    Abstract: As the development of new drugs reaches its physical and financial limits, drug repurposing has become more important than ever. For mechanistically grounded drug repurposing, it is crucial to uncover the disease mechanisms and to detect clusters of ... ...

    Abstract As the development of new drugs reaches its physical and financial limits, drug repurposing has become more important than ever. For mechanistically grounded drug repurposing, it is crucial to uncover the disease mechanisms and to detect clusters of mechanistically related diseases. Various methods for computing candidate disease mechanisms and disease clusters exist. However, in the absence of ground truth, in silico validation is challenging. This constitutes a major hurdle toward the adoption of in silico prediction tools by experimentalists who are often hesitant to carry out wet-lab validations for predicted candidate mechanisms without clearly quantified initial plausibility. To address this problem, we present DIGEST (in silico validation of disease and gene sets, clusterings or subnetworks), a Python-based validation tool available as a web interface (https://digest-validation.net), as a stand-alone package or over a REST API. DIGEST greatly facilitates in silico validation of gene and disease sets, clusterings or subnetworks via fully automated pipelines comprising disease and gene ID mapping, enrichment analysis, comparisons of shared genes and variants and background distribution estimation. Moreover, functionality is provided to automatically update the external databases used by the pipelines. DIGEST hence allows the user to assess the statistical significance of candidate mechanisms with regard to functional and genetic coherence and enables the computation of empirical $P$-values with just a few mouse clicks.
    MeSH term(s) Cluster Analysis ; Databases, Factual ; Software
    Language English
    Publishing date 2022-06-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2068142-2
    ISSN 1477-4054 ; 1467-5463
    ISSN (online) 1477-4054
    ISSN 1467-5463
    DOI 10.1093/bib/bbac247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6262: Show issues Location:
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  4. Article: Tissue Engineering and Its Potential to Reduce Prostate Cancer Treatment Sequelae-Narrative Review.

    Adamowicz, Jan / Kluth, Luis Alex / Pokrywczynska, Marta / Drewa, Tomasz

    Frontiers in surgery

    2021  Volume 8, Page(s) 644057

    Abstract: Tissue engineering offers the possibility to overcome limitations of current management for postprostatectomy incontinence and ED. Developed in recent years biotechnological feasibility of mesenchymal stem cell isolation, ...

    Abstract Tissue engineering offers the possibility to overcome limitations of current management for postprostatectomy incontinence and ED. Developed in recent years biotechnological feasibility of mesenchymal stem cell isolation,
    Language English
    Publishing date 2021-10-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2021.644057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Leadless pacemaker implantation in a univentricular heart in a patient with a double-inlet left ventricle and L-transposition of the great arteries.

    Tajstra, Mateusz / Adamowicz-Czoch, Elżbieta / Kurek, Anna / Nowak, Jolanta / Głowacki, Jan / Miszalski-Jamka, Karol / Kalarus, Zbigniew / Gąsior, Mariusz / Kowalski, Oskar

    Kardiologia polska

    2023  Volume 81, Issue 5, Page(s) 528–529

    MeSH term(s) Humans ; Transposition of Great Vessels/surgery ; Univentricular Heart ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/surgery ; Bays ; Arteries ; Pacemaker, Artificial
    Language English
    Publishing date 2023-03-31
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 411492-9
    ISSN 1897-4279 ; 0022-9032
    ISSN (online) 1897-4279
    ISSN 0022-9032
    DOI 10.33963/KP.a2023.0082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 598: Show issues Location:
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    Zs.MO 474: Show issues

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  6. Article ; Online: May patients receiving 5-alpha-reductase inhibitors be in higher risk of COVID-19 complications?

    Adamowicz, Jan / Juszczak, Kajetan / Drewa, Tomasz

    Medical hypotheses

    2020  Volume 140, Page(s) 109751

    Abstract: COVID-19 pandemic is a major challenge for global and national healthcare providers. Number of new cases is continuously increasing with an emerging trend showing worse prognosis in males in comparison to females. Based on this observation, our proposed ... ...

    Abstract COVID-19 pandemic is a major challenge for global and national healthcare providers. Number of new cases is continuously increasing with an emerging trend showing worse prognosis in males in comparison to females. Based on this observation, our proposed hypothesis is that 5-alpha-reductase inhibitors, that are commonly used for BPH treatment, may be one of the factors contributing to poorer prognosis in males.
    MeSH term(s) 5-alpha Reductase Inhibitors/adverse effects ; Animals ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Finasteride/adverse effects ; Humans ; Lung/drug effects ; Lung/embryology ; Male ; Pandemics ; Pneumonia, Viral/complications ; Prognosis ; Prostatic Hyperplasia/complications ; Prostatic Hyperplasia/drug therapy ; Respiratory Mucosa/drug effects ; Respiratory Mucosa/embryology ; SARS-CoV-2 ; Sex Factors
    Chemical Substances 5-alpha Reductase Inhibitors ; Finasteride (57GNO57U7G)
    Keywords covid19
    Language English
    Publishing date 2020-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.109751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1132: Show issues Location:
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  7. Article ; Online: Treatment Success After Urethroplasty: The Ongoing Quest for a Pragmatic and Universal Definition.

    Verla, Wesley / Mantica, Guglielmo / Waterloos, Marjan / Adamowicz, Jan / Frankiewicz, Mikołaj / Cocci, Andrea / Rosenbaum, Clemens M / Campos-Juanatey, Felix / Vetterlein, Malte W

    European urology focus

    2023  Volume 9, Issue 4, Page(s) 617–620

    Abstract: There is no consensus on the ideal definition of success after urethroplasty, which makes research, quality control, and comparisons challenging. Ongoing research endeavors are focused on achieving consensus regarding the optimal battery of outcomes for ... ...

    Abstract There is no consensus on the ideal definition of success after urethroplasty, which makes research, quality control, and comparisons challenging. Ongoing research endeavors are focused on achieving consensus regarding the optimal battery of outcomes for evaluation of patients after urethroplasty.
    MeSH term(s) Humans ; Urethral Stricture/surgery ; Retrospective Studies ; Urethra/surgery ; Treatment Outcome
    Language English
    Publishing date 2023-02-13
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2405-4569
    ISSN (online) 2405-4569
    DOI 10.1016/j.euf.2023.01.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Shear Wave Elastography in the Evaluation of the Urethral Sphincter Complex after Radical Prostatectomy.

    Tyloch, Dominik Janusz / Tyloch, Janusz Ferdynand / Adamowicz, Jan / Drewa, Tomasz

    Ultrasound in medicine & biology

    2021  Volume 47, Issue 7, Page(s) 1681–1691

    Abstract: Post-prostatectomy pelvic floor muscle rehabilitation has a significant impact on urinary continence recovery. The aim of our study was the evaluation of urethral sphincter complex using shear wave elastography in patients after radical prostatectomy, ... ...

    Abstract Post-prostatectomy pelvic floor muscle rehabilitation has a significant impact on urinary continence recovery. The aim of our study was the evaluation of urethral sphincter complex using shear wave elastography in patients after radical prostatectomy, with and without postsurgical pelvic floor muscle rehabilitation. Thirty-three patients were included in the study. The severity of urinary incontinence after radical prostatectomy was evaluated. Transrectal ultrasound examination was performed in all patients with shear wave elastography to visualize the urethral sphincter complex and estimate its length. Statistical analysis revealed that higher than average urethral sphincter complex stiffness correlates with a smaller number of pads used per day (p < 0,05) and better urine continence based on scales: subjective 0-10 (p < 0.05) and International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI SF) (p < 0.05). The post-prostatectomy pelvic floor muscle rehabilitation group had statistically significant higher stiffness of the urethral sphincter complex compared with the group without rehabilitation (p < 0.05). The study found that shear wave elastography is a valuable method in evaluation of the urethral sphincter complex.
    MeSH term(s) Aged ; Elasticity Imaging Techniques ; Humans ; Middle Aged ; Postoperative Complications/diagnostic imaging ; Prostatectomy/methods ; Urethra/diagnostic imaging ; Urinary Incontinence/diagnostic imaging
    Language English
    Publishing date 2021-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 186150-5
    ISSN 1879-291X ; 0301-5629
    ISSN (online) 1879-291X
    ISSN 0301-5629
    DOI 10.1016/j.ultrasmedbio.2021.02.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 963: Show issues Location:
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  9. Article: Quinolones as a Potential Drug in Genitourinary Cancer Treatment-A Literature Review.

    Kloskowski, Tomasz / Frąckowiak, Sylwia / Adamowicz, Jan / Szeliski, Kamil / Rasmus, Marta / Drewa, Tomasz / Pokrywczyńska, Marta

    Frontiers in oncology

    2022  Volume 12, Page(s) 890337

    Abstract: Quinolones, broad-spectrum antibiotics, are frequently prescribed by urologists for many urological disorders. The mechanism of their bactericidal activity is based on the inhibition of topoisomerase II or IV complex with DNA, which consequently leads to ...

    Abstract Quinolones, broad-spectrum antibiotics, are frequently prescribed by urologists for many urological disorders. The mechanism of their bactericidal activity is based on the inhibition of topoisomerase II or IV complex with DNA, which consequently leads to cell death. It has been observed that these antibiotics also act against the analogous enzymes present in eukaryotic cells. Due to their higher accumulation in urine and prostate tissue than in serum, these drugs seem to be ideal candidates for application in genitourinary cancer treatment. In this study, an extensive literature review has been performed to collect information about concentrations achievable in urine and prostate tissue together with information about anticancer properties of 15 quinolones. Special attention was paid to the application of cytotoxic properties of quinolones for bladder and prostate cancer cell lines. Data available in the literature showed promising properties of quinolones, especially in the case of urinary bladder cancer treatment. In the case of prostate cancer, due to low concentrations of quinolones achievable in prostate tissue, combination therapy with other chemotherapeutics or another method of drug administration is necessary.
    Language English
    Publishing date 2022-06-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.890337
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Tissue engineering in reconstructive urology-The current status and critical insights to set future directions-critical review.

    Ławkowska, Karolina / Rosenbaum, Clemens / Petrasz, Piotr / Kluth, Luis / Koper, Krzysztof / Drewa, Tomasz / Pokrywczynska, Marta / Adamowicz, Jan

    Frontiers in bioengineering and biotechnology

    2023  Volume 10, Page(s) 1040987

    Abstract: Advanced techniques of reconstructive urology are gradually reaching their limits in terms of their ability to restore urinary tract function and patients' quality of life. A tissue engineering-based approach to urinary tract reconstruction, utilizing ... ...

    Abstract Advanced techniques of reconstructive urology are gradually reaching their limits in terms of their ability to restore urinary tract function and patients' quality of life. A tissue engineering-based approach to urinary tract reconstruction, utilizing cells and biomaterials, offers an opportunity to overcome current limitations. Although tissue engineering studies have been heralding the imminent introduction of this method into clinics for over a decade, tissue engineering is only marginally applied. In this review, we discuss the role of tissue engineering in reconstructive urology and try to answer the question of why such a promising technology has not proven its clinical usability so far.
    Language English
    Publishing date 2023-03-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2022.1040987
    Database MEDical Literature Analysis and Retrieval System OnLINE

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