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  1. Article: Vascular smooth muscle cells in intimal hyperplasia, an update.

    Déglise, Sébastien / Bechelli, Clémence / Allagnat, Florent

    Frontiers in physiology

    2023  Volume 13, Page(s) 1081881

    Abstract: Arterial occlusive disease is the leading cause of death in Western countries. Core contemporary therapies for this disease include angioplasties, stents, endarterectomies and bypass surgery. However, these treatments suffer from high failure rates due ... ...

    Abstract Arterial occlusive disease is the leading cause of death in Western countries. Core contemporary therapies for this disease include angioplasties, stents, endarterectomies and bypass surgery. However, these treatments suffer from high failure rates due to re-occlusive vascular wall adaptations and restenosis. Restenosis following vascular surgery is largely due to intimal hyperplasia. Intimal hyperplasia develops in response to vessel injury, leading to inflammation, vascular smooth muscle cells dedifferentiation, migration, proliferation and secretion of extra-cellular matrix into the vessel's innermost layer or intima. In this review, we describe the current state of knowledge on the origin and mechanisms underlying the dysregulated proliferation of vascular smooth muscle cells in intimal hyperplasia, and we present the new avenues of research targeting VSMC phenotype and proliferation.
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.1081881
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clinical Potential of Hydrogen Sulfide in Peripheral Arterial Disease.

    Bechelli, Clémence / Macabrey, Diane / Deglise, Sebastien / Allagnat, Florent

    International journal of molecular sciences

    2023  Volume 24, Issue 12

    Abstract: Peripheral artery disease (PAD) affects more than 230 million people worldwide. PAD patients suffer from reduced quality of life and are at increased risk of vascular complications and all-cause mortality. Despite its prevalence, impact on quality of ... ...

    Abstract Peripheral artery disease (PAD) affects more than 230 million people worldwide. PAD patients suffer from reduced quality of life and are at increased risk of vascular complications and all-cause mortality. Despite its prevalence, impact on quality of life and poor long-term clinical outcomes, PAD remains underdiagnosed and undertreated compared to myocardial infarction and stroke. PAD is due to a combination of macrovascular atherosclerosis and calcification, combined with microvascular rarefaction, leading to chronic peripheral ischemia. Novel therapies are needed to address the increasing incidence of PAD and its difficult long-term pharmacological and surgical management. The cysteine-derived gasotransmitter hydrogen sulfide (H
    MeSH term(s) Humans ; Hydrogen Sulfide/therapeutic use ; Hydrogen Sulfide/pharmacology ; Quality of Life ; Peripheral Arterial Disease/drug therapy ; Peripheral Arterial Disease/diagnosis ; Atherosclerosis/epidemiology ; Myocardial Infarction
    Chemical Substances Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2023-06-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24129955
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  3. Article: Clinical Use of Hydrogen Sulfide to Protect Against Intimal Hyperplasia.

    Macabrey, Diane / Longchamp, Alban / Déglise, Sébastien / Allagnat, Florent

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 876639

    Abstract: Arterial occlusive disease is the narrowing of the ... ...

    Abstract Arterial occlusive disease is the narrowing of the arteries
    Language English
    Publishing date 2022-04-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.876639
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  4. Article: Cystathionine Gamma Lyase Is Regulated by Flow and Controls Smooth Muscle Migration in Human Saphenous Vein.

    Zhao, Shuang / Deslarzes-Dubuis, Céline / Urfer, Severine / Lambelet, Martine / Déglise, Sébastien / Allagnat, Florent

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 9

    Abstract: The saphenous vein is the conduit of choice for bypass grafting. Unfortunately, the hemodynamic stress associated with the arterial environment of the bypass vein graft leads to the development of intimal hyperplasia (IH), an excessive cellular growth ... ...

    Abstract The saphenous vein is the conduit of choice for bypass grafting. Unfortunately, the hemodynamic stress associated with the arterial environment of the bypass vein graft leads to the development of intimal hyperplasia (IH), an excessive cellular growth and collagen deposition that results in restenosis and secondary graft occlusion. Hydrogen sulfide (H
    Language English
    Publishing date 2023-09-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12091731
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  5. Article ; Online: Store-operated Ca2+ entry: a key component of the insulin secretion machinery.

    Sabourin, Jessica / Allagnat, Florent

    Journal of molecular endocrinology

    2016  Volume 57, Issue 3, Page(s) F35–F39

    Abstract: Normal plasma glucose level is ensured by the action of insulin, the major hypoglycemic hormone. Therefore, it is not surprising that insulin release from pancreatic β-cells of the islets of Langerhans is controlled by an array of balanced mechanisms in ... ...

    Abstract Normal plasma glucose level is ensured by the action of insulin, the major hypoglycemic hormone. Therefore, it is not surprising that insulin release from pancreatic β-cells of the islets of Langerhans is controlled by an array of balanced mechanisms in which glucose plays the leading role. Glucose triggers insulin secretion through the well-described pathway of ATP-driven closure of ATP-sensitive potassium channels (K
    Language English
    Publishing date 2016-10
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 645012-x
    ISSN 1479-6813 ; 0952-5041
    ISSN (online) 1479-6813
    ISSN 0952-5041
    DOI 10.1530/JME-16-0106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2406: Show issues Location:
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  6. Article ; Online: Sodium thiosulfate acts as a hydrogen sulfide mimetic to prevent intimal hyperplasia via inhibition of tubulin polymerisation.

    Macabrey, Diane / Longchamp, Alban / MacArthur, Michael R / Lambelet, Martine / Urfer, Severine / Deglise, Sebastien / Allagnat, Florent

    EBioMedicine

    2022  Volume 78, Page(s) 103954

    Abstract: Background: Intimal hyperplasia (IH) remains a major limitation in the long-term success of any type of revascularisation. IH is due to vascular smooth muscle cell (VSMC) dedifferentiation, proliferation and migration. The gasotransmitter Hydrogen ... ...

    Abstract Background: Intimal hyperplasia (IH) remains a major limitation in the long-term success of any type of revascularisation. IH is due to vascular smooth muscle cell (VSMC) dedifferentiation, proliferation and migration. The gasotransmitter Hydrogen Sulfide (H
    Methods: Low density lipoprotein receptor deleted (LDLR
    Findings: STS inhibited IH in WT mice, as well as in LDLR
    Interpretation: STS, a drug used for the treatment of cyanide poisoning and calciphylaxis, protects against IH in a mouse model of arterial restenosis and in human vein segments. STS acts as an H
    Funding: This work was supported by the Swiss National Science Foundation (grant FN-310030_176158 to FA and SD and PZ00P3-185927 to AL); the Novartis Foundation to FA; and the Union des Sociétés Suisses des Maladies Vasculaires to SD, and the Fondation pour la recherche en chirurgie vasculaire et thoracique.
    MeSH term(s) Animals ; Cell Proliferation ; Cystathionine gamma-Lyase/metabolism ; Humans ; Hydrogen Sulfide/metabolism ; Hydrogen Sulfide/pharmacology ; Hyperplasia/pathology ; Male ; Mice ; Myocytes, Smooth Muscle/metabolism ; Thiosulfates ; Tubulin/metabolism
    Chemical Substances Thiosulfates ; Tubulin ; Cystathionine gamma-Lyase (EC 4.4.1.1) ; sodium thiosulfate (HX1032V43M) ; Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2022-03-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2022.103954
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7090: Show issues Location:
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  7. Article ; Online: Short-term hypercaloric carbohydrate loading increases surgical stress resilience by inducing FGF21.

    Agius, Thomas / Emsley, Raffaella / Lyon, Arnaud / MacArthur, Michael R / Kiesworo, Kevin / Faivre, Anna / Stavart, Louis / Lambelet, Martine / Legouis, David / de Seigneux, Sophie / Golshayan, Déla / Lazeyras, Francois / Yeh, Heidi / Markmann, James F / Uygun, Korkut / Ocampo, Alejandro / Mitchell, Sarah J / Allagnat, Florent / Déglise, Sébastien /
    Longchamp, Alban

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1073

    Abstract: Dietary restriction promotes resistance to surgical stress in multiple organisms. Counterintuitively, current medical protocols recommend short-term carbohydrate-rich drinks (carbohydrate loading) prior to surgery, part of a multimodal perioperative care ...

    Abstract Dietary restriction promotes resistance to surgical stress in multiple organisms. Counterintuitively, current medical protocols recommend short-term carbohydrate-rich drinks (carbohydrate loading) prior to surgery, part of a multimodal perioperative care pathway designed to enhance surgical recovery. Despite widespread clinical use, preclinical and mechanistic studies on carbohydrate loading in surgical contexts are lacking. Here we demonstrate in ad libitum-fed mice that liquid carbohydrate loading for one week drives reductions in solid food intake, while nearly doubling total caloric intake. Similarly, in humans, simple carbohydrate intake is inversely correlated with dietary protein intake. Carbohydrate loading-induced protein dilution increases expression of hepatic fibroblast growth factor 21 (FGF21) independent of caloric intake, resulting in protection in two models of surgical stress: renal and hepatic ischemia-reperfusion injury. The protection is consistent across male, female, and aged mice. In vivo, amino acid add-back or genetic FGF21 deletion blocks carbohydrate loading-mediated protection from ischemia-reperfusion injury. Finally, carbohydrate loading induction of FGF21 is associated with the induction of the canonical integrated stress response (ATF3/4, NF-kB), and oxidative metabolism (PPARγ). Together, these data support carbohydrate loading drinks prior to surgery and reveal an essential role of protein dilution via FGF21.
    MeSH term(s) Animals ; Female ; Humans ; Male ; Mice ; Diet, Carbohydrate Loading ; Dietary Carbohydrates/metabolism ; Dietary Proteins/metabolism ; Fibroblast Growth Factors/metabolism ; Liver/surgery ; Liver/metabolism ; Mice, Inbred C57BL ; Reperfusion Injury/metabolism ; Surgical Procedures, Operative
    Chemical Substances Dietary Carbohydrates ; Dietary Proteins ; fibroblast growth factor 21 ; Fibroblast Growth Factors (62031-54-3)
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-44866-3
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  8. Article ; Online: Cystathionine-γ-lyase overexpression modulates oxidized nicotinamide adenine dinucleotide biosynthesis and enhances neovascularization.

    Kiesworo, Kevin / MacArthur, Michael R / Kip, Peter / Agius, Thomas / Macabrey, Diane / Lambelet, Martine / Hamard, Lauriane / Ozaki, C-Keith / Mitchell, James R / Déglise, Sébastien / Mitchell, Sarah J / Allagnat, Florent / Longchamp, Alban

    JVS-vascular science

    2023  Volume 4, Page(s) 100095

    Abstract: Objective: Hydrogen sulfide is a proangiogenic gas produced primarily by the transsulfuration enzyme cystathionine-γ-lyase (CGL). CGL-dependent hydrogen sulfide production is required for neovascularization in models of peripheral arterial disease. ... ...

    Abstract Objective: Hydrogen sulfide is a proangiogenic gas produced primarily by the transsulfuration enzyme cystathionine-γ-lyase (CGL). CGL-dependent hydrogen sulfide production is required for neovascularization in models of peripheral arterial disease. However, the benefits of increasing endogenous CGL and its mechanism of action have not yet been elucidated.
    Methods: Male whole body CGL-overexpressing transgenic (CGL
    Results: The restoration of blood flow occurred more rapidly in CGL
    Conclusions: Our results have demonstrated that CGL overexpression improves the neovascularization of skeletal muscle on hindlimb ischemia. These effects correlated with changes in the NAD pathway, which improved EC migration.
    Language English
    Publishing date 2023-01-13
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3503
    ISSN (online) 2666-3503
    DOI 10.1016/j.jvssci.2022.11.003
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  9. Article: Sodium Hydrosulfide Treatment During Porcine Kidney Ex Vivo Perfusion and Transplantation.

    Agius, Thomas / Songeon, Julien / Lyon, Arnaud / Longchamp, Justine / Ruttimann, Raphael / Allagnat, Florent / Déglise, Sébastien / Corpataux, Jean-Marc / Golshayan, Déla / Buhler, Léo / Meier, Raphael / Yeh, Heidi / Markmann, James F / Uygun, Korkut / Toso, Christian / Klauser, Antoine / Lazeyras, Francois / Longchamp, Alban

    Transplantation direct

    2023  Volume 9, Issue 11, Page(s) e1508

    Abstract: Background: In rodents, hydrogen sulfide (H: Methods: Adult porcine kidneys retrieved immediately or after 60 min of warm ischemia (WI) were exposed to 100 µM sodium hydrosulfide (NaHS) (1) during the hypothermic ex vivo perfusion only, (2) during WI ...

    Abstract Background: In rodents, hydrogen sulfide (H
    Methods: Adult porcine kidneys retrieved immediately or after 60 min of warm ischemia (WI) were exposed to 100 µM sodium hydrosulfide (NaHS) (1) during the hypothermic ex vivo perfusion only, (2) during WI only, and (3) during both WI and ex vivo perfusion. Kidney perfusion was evaluated with dynamic contrast-enhanced MRI. MRI spectroscopy was further employed to assess energy metabolites including ATP. Renal biopsies were collected at various time points for histopathological analysis.
    Results: Perfusion for 4 h pig kidneys with Belzer MPS UW + NaHS resulted in similar renal perfusion and ATP levels than perfusion with UW alone. Similarly, no difference was observed when NaHS was administered in the renal artery before ischemia. After autotransplantation, no improvement in histologic lesions or cortical/medullary kidney perfusion was observed upon H
    Conclusions: In conclusion, treatment of porcine kidney grafts using NaHS did not result in a significant reduction of ischemia-reperfusion injury or improvement of kidney metabolism. Future studies will need to define the benefits of H
    Language English
    Publishing date 2023-10-30
    Publishing country United States
    Document type Journal Article
    ISSN 2373-8731
    ISSN 2373-8731
    DOI 10.1097/TXD.0000000000001508
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  10. Article ; Online: Hydrogen Sulphide Release via the Angiotensin Converting Enzyme Inhibitor Zofenopril Prevents Intimal Hyperplasia in Human Vein Segments and in a Mouse Model of Carotid Artery Stenosis.

    Macabrey, Diane / Deslarzes-Dubuis, Céline / Longchamp, Alban / Lambelet, Martine / Ozaki, Charles K / Corpataux, Jean-Marc / Allagnat, Florent / Déglise, Sébastien

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

    2021  Volume 63, Issue 2, Page(s) 336–346

    Abstract: Objective: Hypertension is a major risk factor for intimal hyperplasia (IH) and re-stenosis following vascular and endovascular interventions. Preclinical studies suggest that hydrogen sulphide (H: Methods: Spontaneously hypertensive male Cx40 ... ...

    Abstract Objective: Hypertension is a major risk factor for intimal hyperplasia (IH) and re-stenosis following vascular and endovascular interventions. Preclinical studies suggest that hydrogen sulphide (H
    Methods: Spontaneously hypertensive male Cx40 deleted mice (Cx40
    Results: Compared with control animals (intima/media thickness 2.3 ± 0.33 μm), enalapril reduced IH in Cx40
    Conclusion: Zofenopril provides extra beneficial effects compared with non-sulfhydryl ACEi in reducing SMC proliferation and re-stenosis, even in normotensive animals. These findings may hold broad clinical implications for patients suffering from vascular occlusive diseases and hypertension.
    MeSH term(s) Angiotensin-Converting Enzyme Inhibitors/administration & dosage ; Animals ; Blood Pressure/drug effects ; Captopril/administration & dosage ; Captopril/analogs & derivatives ; Carotid Arteries/drug effects ; Carotid Arteries/pathology ; Carotid Stenosis/drug therapy ; Carotid Stenosis/etiology ; Carotid Stenosis/pathology ; Cells, Cultured ; Disease Models, Animal ; Humans ; Hydrogen Sulfide/metabolism ; Hyperplasia/drug therapy ; Hyperplasia/pathology ; Hypertension/complications ; Hypertension/drug therapy ; Male ; Mice ; Myocytes, Smooth Muscle ; Organ Culture Techniques ; Primary Cell Culture ; Tunica Intima/drug effects ; Tunica Intima/pathology ; Veins/drug effects ; Veins/pathology
    Chemical Substances Angiotensin-Converting Enzyme Inhibitors ; zofenopril (290ZY759PI) ; Captopril (9G64RSX1XD) ; Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2021-12-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1225869-6
    ISSN 1532-2165 ; 1078-5884
    ISSN (online) 1532-2165
    ISSN 1078-5884
    DOI 10.1016/j.ejvs.2021.09.032
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    Zs.A 2283: Show issues Location:
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    Zs.MO 381: Show issues

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