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Article ; Online: Monitoring Pulse Rate in the Background Using Front Facing Cameras of Mobile Devices.

Savur, Celal / Dautov, Ruslan / Bukum, Kamil / Xia, Xiaojuan / Couderc, Jean-Philippe / Tsouri, Gill R

IEEE journal of biomedical and health informatics

2023 Volume 27, Issue 5, Page(s) 2208–2218

Abstract: We propose a novel framework to passively monitor pulse rate during the time spent by users on their personal mobile devices. Our framework is based on passively capturing the user's pulse signal using the front-facing camera. Signal capture is performed ...

Abstract	We propose a novel framework to passively monitor pulse rate during the time spent by users on their personal mobile devices. Our framework is based on passively capturing the user's pulse signal using the front-facing camera. Signal capture is performed in the background, while the user is interacting with the device as he/she normally would, e.g., watch movies, read emails, text, and play games. The framework does not require subject participation with the monitoring procedure, thereby addressing the well-known problem of low adherence with such procedures. We investigate various techniques to suppress the impact of spontaneous user motion and fluctuations in ambient light conditions expected in non-participatory environments. Techniques include traditional signal processing, machine learning classifiers, and deep learning methods. Our performance evaluation is based on a clinical study encompassing 113 patients with a history of atrial fibrillation (Afib) who are passively monitored at home using a tablet for a period of two weeks. Our results show that the proposed framework accurately monitors pulse rate, thereby providing a gateway for long-term monitoring without relying on subject participation or the use of a dedicated wearable device.
MeSH term(s)	Female ; Humans ; Heart Rate ; Atrial Fibrillation/diagnosis ; Monitoring, Physiologic ; Wearable Electronic Devices ; Pulse
Language	English
Publishing date	2023-05-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2695320-1
ISSN	2168-2208 ; 2168-2194
ISSN (online)	2168-2208
ISSN	2168-2194
DOI	10.1109/JBHI.2022.3197076
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Article ; Online: T-Wave Morphology in LQTS Patients: Challenges and Hopes.

Couderc, Jean-Philippe / Zareba, Wojciech

JACC. Clinical electrophysiology

2017 Volume 3, Issue 4, Page(s) 382–383

MeSH term(s)	Arrhythmias, Cardiac ; Electrocardiography ; Humans ; Long QT Syndrome
Language	English
Publishing date	2017-04-17
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	2846739-5
ISSN	2405-5018 ; 2405-500X ; 2405-500X
ISSN (online)	2405-5018 ; 2405-500X
ISSN	2405-500X
DOI	10.1016/j.jacep.2016.12.019
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Article ; Online: Challenges in implementing and obtaining acceptance for J-Tpeak assessment as the clinical component of CiPA.

Darpo, Borje / Couderc, Jean-Philippe

Journal of pharmacological and toxicological methods

2018 Volume 93, Page(s) 75–79

Abstract: Introduction: This paper is based on a presentation held at the Annual Safety Pharmacology Society meeting in September 2017, at which challenges for the clinical component of CiPA were presented. FDA has published an automated algorithm for measurement ...

Abstract	Introduction: This paper is based on a presentation held at the Annual Safety Pharmacology Society meeting in September 2017, at which challenges for the clinical component of CiPA were presented. FDA has published an automated algorithm for measurement of the J-Tpeak interval on a median beat from a vector magnitude lead derived from a 12-lead ECG. CiPA proposes that J-Tpeak prolongation < 10 ms can be used for drugs with a QTc effect < 20 ms to differentiate between safe and unsafe delayed repolarization and to reduce the level of ECG monitoring in late stage clinical trials. Methods: We applied FDA's algorithm, complemented with iCOMPAS, to moxifloxacin and dolasetron data from the IQ-CSRC study with 9 subjects on active and 6 on placebo. The effect on QTcF and corrected J-Tpeak (J-Tpeak_c) was analyzed using concentration-effect modeling. Results: There was a good correlation between QTcF and J-Tpeak_c prolongation after oral dosing of 400 mg moxifloxacin with placebo-adjusted, change-from-baseline (ΔΔ) J-Tpeak_c of ~12 ms at concentrations that caused ΔΔQTcF of ~20 ms. On dolasetron, J-Tpeak_c was highly variable, no prolongation was seen and an effect on ΔΔJ-Tpeak_c > 10 ms could be excluded across the observed plasma concentration range. Discussion: In this limited analysis performed on the IQ-CSRC study waveforms using FDA's automated algorithm, J-Tpeak prolongation was observed on moxifloxacin, but not on dolasetron, despite clinical observations of proarrhythmias with both drugs. Challenges for the implementation of the J-Tpeak interval as a replacement or complement to the QTc interval, include to demonstrate that the proposed clinical algorithm using a J-Tpeak threshold of 10 ms, can be used to categorize drugs with a QT effect up to ~20 ms as having low pro-arrhythmic risk.
MeSH term(s)	Algorithms ; Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/therapeutic use ; Arrhythmias, Cardiac/chemically induced ; Arrhythmias, Cardiac/physiopathology ; Berlin ; Congresses as Topic ; Dose-Response Relationship, Drug ; Electrocardiography/drug effects ; Electrocardiography/methods ; Heart Conduction System/drug effects ; Heart Conduction System/physiology ; Humans ; Long QT Syndrome/chemically induced ; Long QT Syndrome/physiopathology ; Moxifloxacin/adverse effects ; Moxifloxacin/therapeutic use ; Pharmacology/methods
Chemical Substances	Anti-Bacterial Agents ; Moxifloxacin (U188XYD42P)
Language	English
Publishing date	2018-06-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1105919-9
ISSN	1873-488X ; 1056-8719
ISSN (online)	1873-488X
ISSN	1056-8719
DOI	10.1016/j.vascn.2018.05.006
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Article ; Online: Arthur J. Moss, MD-A giant who changed cardiology.

Zareba, Wojciech / Kutyifa, Valentina / Couderc, Jean-Philippe

Heart rhythm

2018 Volume 15, Issue 5, Page(s) 639–640

Language	English
Publishing date	2018-04-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2018.03.017
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Article ; Online: The Telemetric and Holter ECG Warehouse (THEW): the first three years of development and research.

Couderc, Jean-Philippe

Journal of electrocardiology

2012 Volume 45, Issue 6, Page(s) 677–683

Abstract: The Telemetric and Holter ECG Warehouse (THEW) hosts more than 3700 digital 24-Holter ECG recordings from 13 independent studies. In addition to the ECGs, the repository includes patient information in separate clinical database with content varying ... ...

Abstract	The Telemetric and Holter ECG Warehouse (THEW) hosts more than 3700 digital 24-Holter ECG recordings from 13 independent studies. In addition to the ECGs, the repository includes patient information in separate clinical database with content varying according to the study focus. In its third year of activities, the THEW database has been accessed by researchers from 37 universities and 16 corporations located in 16 countries worldwide. Twenty publications were released primarily focusing on the development and validation of ECG-based technologies. This communication describes the content of the databases of the repository with brief summary of the research and development projects completed using these data.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Database Management Systems ; Databases, Factual/statistics & numerical data ; Electrocardiography, Ambulatory/statistics & numerical data ; Female ; Health Records, Personal ; Heart Diseases/diagnosis ; Heart Diseases/epidemiology ; Humans ; Male ; Middle Aged ; Prevalence ; Research/trends ; Telemetry/statistics & numerical data ; United States/epidemiology ; Young Adult
Language	English
Publishing date	2012-09-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	410286-1
ISSN	1532-8430 ; 0022-0736
ISSN (online)	1532-8430
ISSN	0022-0736
DOI	10.1016/j.jelectrocard.2012.08.001
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Article: Challenges in implementing and obtaining acceptance for J-Tpeak assessment as the clinical component of CiPA

Darpo, Borje / Couderc, Jean-Philippe

Journal of pharmacological and toxicological methods. 2018 Sept., Oct., v. 93

2018

Abstract: This paper is based on a presentation held at the Annual Safety Pharmacology Society meeting in September 2017, at which challenges for the clinical component of CiPA were presented. FDA has published an automated algorithm for measurement of the J-Tpeak ...

Abstract	This paper is based on a presentation held at the Annual Safety Pharmacology Society meeting in September 2017, at which challenges for the clinical component of CiPA were presented. FDA has published an automated algorithm for measurement of the J-Tpeak interval on a median beat from a vector magnitude lead derived from a 12-lead ECG. CiPA proposes that J-Tpeak prolongation < 10 ms can be used for drugs with a QTc effect < 20 ms to differentiate between safe and unsafe delayed repolarization and to reduce the level of ECG monitoring in late stage clinical trials.We applied FDA's algorithm, complemented with iCOMPAS, to moxifloxacin and dolasetron data from the IQ-CSRC study with 9 subjects on active and 6 on placebo. The effect on QTcF and corrected J-Tpeak (J-Tpeak_c) was analyzed using concentration-effect modeling.There was a good correlation between QTcF and J-Tpeak_c prolongation after oral dosing of 400 mg moxifloxacin with placebo-adjusted, change-from-baseline (ΔΔ) J-Tpeak_c of ~12 ms at concentrations that caused ΔΔQTcF of ~20 ms. On dolasetron, J-Tpeak_c was highly variable, no prolongation was seen and an effect on ΔΔJ-Tpeak_c > 10 ms could be excluded across the observed plasma concentration range.In this limited analysis performed on the IQ-CSRC study waveforms using FDA's automated algorithm, J-Tpeak prolongation was observed on moxifloxacin, but not on dolasetron, despite clinical observations of proarrhythmias with both drugs. Challenges for the implementation of the J-Tpeak interval as a replacement or complement to the QTc interval, include to demonstrate that the proposed clinical algorithm using a J-Tpeak threshold of 10 ms, can be used to categorize drugs with a QT effect up to ~20 ms as having low pro-arrhythmic risk.
Keywords	algorithms ; automation ; complement ; lead ; moxifloxacin ; pharmacology ; placebos ; risk ; toxicology
Language	English
Dates of publication	2018-09
Size	p. 75-79.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	1105919-9
ISSN	1873-488X ; 1056-8719
ISSN (online)	1873-488X
ISSN	1056-8719
DOI	10.1016/j.vascn.2018.05.006
Database	NAL-Catalogue (AGRICOLA)

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Article: The telemetric and Holter ECG warehouse initiative (THEW): a data repository for the design, implementation and validation of ECG-related technologies.

Couderc, Jean-Philippe

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2010 Volume 2010, Page(s) 6252–6255

Abstract: we present an initiative supported by the National Heart Lung, and Blood Institute and the Food and Drug Administration for the development of a repository containing continuous electrocardiographic information to be shared with the worldwide scientific ... ...

Abstract	we present an initiative supported by the National Heart Lung, and Blood Institute and the Food and Drug Administration for the development of a repository containing continuous electrocardiographic information to be shared with the worldwide scientific community. We believe that sharing data reinforces open scientific inquiry. It encourages diversity of analysis and opinion while promoting new research and facilitating the education of new researchers.
MeSH term(s)	Access to Information/legislation & jurisprudence ; Biomedical Technology/instrumentation ; Databases as Topic/legislation & jurisprudence ; Electrocardiography, Ambulatory/instrumentation ; Equipment Design ; Health Plan Implementation ; Reproducibility of Results ; Telemetry/instrumentation
Language	English
Publishing date	2010-11-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2375-7477
ISSN	2375-7477
DOI	10.1109/IEMBS.2010.5628067
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Article ; Online: A scientific repository to support the research and development of technologies related to quantitative electrocardiography: the Telemetric and Holter ECG Warehouse (THEW).

Couderc, Jean-Philippe

Cardiology journal

2010 Volume 17, Issue 4, Page(s) 416–419

Abstract: We implemented an ECG data-warehousing project to promote cross-fertilization of scientific knowledge, resources and ideas that will advance the understanding of quantitative ECG and cardiac safety. While other open ECG databases are available, our ... ...

Abstract	We implemented an ECG data-warehousing project to promote cross-fertilization of scientific knowledge, resources and ideas that will advance the understanding of quantitative ECG and cardiac safety. While other open ECG databases are available, our Telemetric and Holter ECG Warehouse (THEW) proposes unique sets of continuous digital ECGs recorded in cardiac patients, healthy individuals and individuals exposed to non-cardiac and cardiac drugs. In this paper, we present briefly the content and the current research triggered by this initiative.
MeSH term(s)	Access to Information ; Cooperative Behavior ; Databases as Topic ; Electrocardiography, Ambulatory ; Heart Diseases/diagnosis ; Heart Diseases/physiopathology ; Humans ; Predictive Value of Tests ; Program Development ; Signal Processing, Computer-Assisted ; Telemetry
Language	English
Publishing date	2010-08-06
Publishing country	Poland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2488680-4
ISSN	1898-018X ; 1897-5593
ISSN (online)	1898-018X
ISSN	1897-5593
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Article ; Online: A unique digital electrocardiographic repository for the development of quantitative electrocardiography and cardiac safety: the Telemetric and Holter ECG Warehouse (THEW).

Couderc, Jean-Philippe

Journal of electrocardiology

2010 Volume 43, Issue 6, Page(s) 595–600

Abstract: The sharing of scientific data reinforces open scientific inquiry; it encourages diversity of analysis and opinion while promoting new research and facilitating the education of next generations of scientists. In this article, we present an initiative ... ...

Abstract	The sharing of scientific data reinforces open scientific inquiry; it encourages diversity of analysis and opinion while promoting new research and facilitating the education of next generations of scientists. In this article, we present an initiative for the development of a repository containing continuous electrocardiographic information and their associated clinical information. This information is shared with the worldwide scientific community to improve quantitative electrocardiology and cardiac safety. First, we present the objectives of the initiative and its mission. Then, we describe the resources available in this initiative following 3 components: data, expertise, and tools. The data available in the Telemetric and Holter ECG Warehouse (THEW) includes continuous electrocardiogram signals and associated clinical information. The initiative attracted various academic and private partners whom expertise covers a large list of research arenas related to quantitative electrocardiography; their contribution to the THEW promotes cross-fertilization of scientific knowledge, resources, and ideas that will advance the field of quantitative electrocardiography. Finally, the tools of the THEW include software and servers to access and review the data available in the repository. To conclude, the THEW is an initiative developed to benefit the scientific community and to advance the field of quantitative electrocardiography and cardiac safety. It is a new repository designed to complement the existing ones such as Physionet, the American Heart Association - Beth Israel Hospital (AHA-BIH) arrhythmia database, and the Common Standard for Electrocardiography (CSE) database. The THEW hosts unique datasets from clinical trials and drug safety studies that, so far, were not available.
MeSH term(s)	Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/epidemiology ; Data Mining/methods ; Databases, Factual ; Electrocardiography, Ambulatory/statistics & numerical data ; Humans ; Information Dissemination/methods ; Internet ; Telemetry/statistics & numerical data ; User-Computer Interface
Language	English
Publishing date	2010-09-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	410286-1
ISSN	1532-8430 ; 0022-0736
ISSN (online)	1532-8430
ISSN	0022-0736
DOI	10.1016/j.jelectrocard.2010.07.015
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Article ; Online: Plasma tissue factor activity in lung cancer patients predicts venous thromboembolism and poor overall survival.

Doubre, Helene / Monnet, Isabelle / Azarian, Reza / Girard, Philippe / Meyer, Guy / Trichereau, Julie / Devillier, Philippe / Van Dreden, Patrick / Couderc, Louis-Jean / Chouaid, Christos / Vasse, Marc

Research and practice in thrombosis and haemostasis

2024 Volume 8, Issue 2, Page(s) 102359

Abstract: Background: Biomarkers to identify lung cancer (LC) patients with high risk of venous thromboembolism (VTE) are needed.: Objectives: To evaluate the usefulness of plasma tissue factor activity (TFA) and D-dimer levels for the prediction of VTE and ... ...

Abstract	Background: Biomarkers to identify lung cancer (LC) patients with high risk of venous thromboembolism (VTE) are needed. Objectives: To evaluate the usefulness of plasma tissue factor activity (TFA) and D-dimer levels for the prediction of VTE and overall survival in patients with LC. Methods: In a prospective multicenter observational cohort of consecutive LC patients, TFA and D-dimer levels were measured at diagnosis before any cancer treatment (V1) and between 8 and 12 weeks after diagnosis (V2). Results: Among 302 patients, 38 (12.6%) experienced VTE within the first year after diagnosis. V1-TFA and V1-D-dimer levels were significantly ( Conclusion: High plasma TFA levels are associated with the occurrence of VTE within the next 3 months after each visit (V1 or V2) and poor survival.
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ISSN	2475-0379
ISSN (online)	2475-0379
DOI	10.1016/j.rpth.2024.102359
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