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  1. Article: Adsorptive removal of azithromycin from aqueous solutions using raw and saponin-modified nano diatomite.

    Davoodi, Siavash / Dahrazma, Behnaz / Goudarzi, Nasser / Gorji, Hajar Ghasemian

    Water science and technology : a journal of the International Association on Water Pollution Research

    2019  Volume 80, Issue 5, Page(s) 939–949

    Abstract: This study aims to investigate the performance and mechanism of raw (R-ND) and saponin-modified nano diatomite (M-ND) in the removal of azithromycin from aqueous solutions. Adsorbent characterization was performed using X-ray fluorescence, Brunauer- ... ...

    Abstract This study aims to investigate the performance and mechanism of raw (R-ND) and saponin-modified nano diatomite (M-ND) in the removal of azithromycin from aqueous solutions. Adsorbent characterization was performed using X-ray fluorescence, Brunauer-Emmett-Teller (BET), scanning electron spectroscopy, dynamic light scattering and energy-dispersive X-ray analyses. It was shown that the specific surface area of R-ND was 119.5 m
    MeSH term(s) Adsorption ; Azithromycin ; Diatomaceous Earth ; Hydrogen-Ion Concentration ; Kinetics ; Saponins ; Solutions ; Spectroscopy, Fourier Transform Infrared ; Water Pollutants, Chemical
    Chemical Substances Saponins ; Solutions ; Water Pollutants, Chemical ; Diatomaceous Earth (61790-53-2) ; diatomite (68855-54-9) ; Azithromycin (83905-01-5)
    Language English
    Publishing date 2019-11-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 764273-8
    ISSN 1996-9732 ; 0273-1223
    ISSN (online) 1996-9732
    ISSN 0273-1223
    DOI 10.2166/wst.2019.337
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Diagnostic Accuracy of Pyrazinamide Susceptibility Testing in

    Bagheri, Mohammad / Pormohammad, Ali / Fardsanei, Fatemeh / Yadegari, Ali / Arshadi, Maniya / Deihim, Behnaz / Hajikhani, Bahareh / Turner, Ray J / Khalili, Farima / Mousavi, Seyyed Mohammad Javad / Dadashi, Masoud / Goudarzi, Mehdi / Dabiri, Hossein / Goudarzi, Hossein / Mirsaeidi, Mehdi / Nasiri, Mohammad Javad

    Microbial drug resistance (Larchmont, N.Y.)

    2021  Volume 28, Issue 1, Page(s) 87–98

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) Antitubercular Agents/pharmacology ; Humans ; Microbial Sensitivity Tests/methods ; Mycobacterium tuberculosis/drug effects ; Pyrazinamide/pharmacology ; Sensitivity and Specificity ; Sequence Analysis
    Chemical Substances Antitubercular Agents ; Pyrazinamide (2KNI5N06TI)
    Language English
    Publishing date 2021-09-28
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 1290490-9
    ISSN 1931-8448 ; 1076-6294
    ISSN (online) 1931-8448
    ISSN 1076-6294
    DOI 10.1089/mdr.2021.0048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Prevalence and Mechanisms of Carbapenem Resistance in

    Nasiri, Mohammad Javad / Mirsaeidi, Mehdi / Mousavi, Seyyed Mohammad Javad / Arshadi, Mania / Fardsanei, Fatemeh / Deihim, Behnaz / Davoudabadi, Sara / Zamani, Samin / Hajikhani, Bahareh / Goudarzi, Hossein / Goudarzi, Mehdi / Seghatoleslami, Zahra Sadat / Dabiri, Hossein / Tabarsi, Payam

    Microbial drug resistance (Larchmont, N.Y.)

    2020  Volume 26, Issue 12, Page(s) 1491–1502

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Carbapenem-Resistant Enterobacteriaceae/drug effects ; Carbapenem-Resistant Enterobacteriaceae/genetics ; Cross-Sectional Studies ; Drug Resistance, Multiple, Bacterial/drug effects ; Drug Resistance, Multiple, Bacterial/genetics ; Escherichia coli/drug effects ; Escherichia coli/genetics ; Genes, Bacterial ; Humans ; Iran ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/genetics ; Microbial Sensitivity Tests
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-04-28
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 1290490-9
    ISSN 1931-8448 ; 1076-6294
    ISSN (online) 1931-8448
    ISSN 1076-6294
    DOI 10.1089/mdr.2019.0440
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Documenting water (fluid) from dewatering process as the most strategic product in drilling operations in order to make fluid and improve its rheological properties in line with environmental standards for reuse of wastewater

    Sara Karimi / Behnaz Goudarzi / Abdolamir Moezzi / Ebrahim RajabZadeh Qhatrami

    Environment Conservation Journal, Vol 16, Iss SE (2015)

    2015  

    Abstract: Drilling operations, like any other industrial activity, at the end of the operation employed dumps waste, wastewater to the environment, and if there is no planning for treatment and their elimination, in long-term this can have adverse effects on the ... ...

    Abstract Drilling operations, like any other industrial activity, at the end of the operation employed dumps waste, wastewater to the environment, and if there is no planning for treatment and their elimination, in long-term this can have adverse effects on the environment. Assessment and recognition of the effects of drilling fluids is an acceptable and logical method for making a suggestion to reduce the probable injuries and damages resulting from the disposal and the drilling to the environment. In addition, one of the most important factors in reducing the negative environmental effects of waste is correct management. So that sometimes the cost required for the removal of pollution or controlling emissions of waste significantly decreases with proper and innovative management, and all the waste caused by the washing of the reservoir, well reservoirs, adjacent area of pumps and equipment related to wells enter water run-off and after entering into the storage basin, the solid settles there and its liquid phase enters dewatering to do operations and water treatment units. Moreover, at a later stage to decide whether dewatering water is appropriate for dilution or making clay or not, depends on the results of rheological water mixture and drilling fluid (1). If the desired mixture had appropriate rheological properties after treatment, dewatering water can be used. (According to the environmental standards of water reuse and wastewater returned in accordance with the agenda of the Technical Office of the Executive Vice President of Strategic Planning and Monitoring, suitable Dewatering Water is the one that does not make rheological change properties more than 50% in the of the fluid). In this study, a number of drilling machines will be used in defined projects to the amount of waste in order to make use of the standards and to improve the rheological properties of the fluid examine (Islamic Republic of Iran Iran's vice president of strategic planning and monitoring, the Office of Strategic Technical Assistance ...
    Keywords Dewatering ; loss ; rheological properties ; fluid ; waste ; Environmental sciences ; GE1-350
    Subject code 660
    Language English
    Publishing date 2015-12-01T00:00:00Z
    Publisher Action for Sustainable Efficacious Development and Awareness
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Measuring the "unmeasurable": assessment of bone marrow response to therapy using FDG-PET in patients with lymphoma.

    Goudarzi, Behnaz / Jacene, Heather A / Wahl, Richard L

    Academic radiology

    2010  Volume 17, Issue 9, Page(s) 1175–1185

    Abstract: Rationale and objectives: To determine if anatomically "nonmeasurable" disease in bone marrow (BM) is assessable for response to therapy by [(18)F]-2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET)/computed tomography (CT).: ... ...

    Abstract Rationale and objectives: To determine if anatomically "nonmeasurable" disease in bone marrow (BM) is assessable for response to therapy by [(18)F]-2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET)/computed tomography (CT).
    Materials and methods: FDG PET/CT images of 27 patients with lymphoma, FDG-avid bone marrow (BM) lesions, and >or=1 FDG-avid, tumor-involved lymph node (LN) at baseline were retrospectively reviewed. FDG uptake in target LNs and BM foci was determined pre- and posttherapy using the standardized uptake value corrected for lean body mass (SUL(mean)). Size of the same target LNs was measured pre- and posttherapy on CT. Percentage decreases of LN size and LN and BM SUL were calculated. Response was classified according to revised International Workshop Criteria (IWC) with and without modification for metabolic evaluation of BM and correlated to overall survival. Statistical analyses were performed using paired t-tests, Pearson correlation coefficients, and z-tests.
    Results: LN size, LN SUL(mean), and BM SUL(mean) were significantly higher pre- versus posttherapy (2337 mm(2) +/- 1810 vs. 309 mm(2) +/- 323; 6.94 +/- 4.96 vs. 1.02 +/- 1.00; and 6.81 +/- 4.58 to 1.84 +/- 1.58, all P < .001, respectively). After therapy, significant correlation was found between percentage declines of LN size and SUL(mean) of LNs (r = 0.84, P < .001) or BM (r = 0.56, P = .002) and SUL(mean) of LN and BM (r = 0.76, P < .001). Including a metabolic assessment of BM correctly altered overall response assessment in 5/27 (19%) patients and better predicted overall survival than revised IWC.
    Conclusion: Anatomically "unmeasurable" BM infiltration with lymphoma behaves similarly to LN disease after therapy and is "measurable" by FDG PET/CT. FDG PET/CT is valuable for monitoring tumor response in "measurable" disease and BM, which was previously considered "unmeasurable" by anatomical imaging.
    MeSH term(s) Bone Marrow/diagnostic imaging ; Bone Marrow Neoplasms/diagnostic imaging ; Bone Marrow Neoplasms/therapy ; Female ; Fluorodeoxyglucose F18 ; Humans ; Lymphoma/diagnostic imaging ; Lymphoma/therapy ; Male ; Middle Aged ; Positron-Emission Tomography/methods ; Prognosis ; Radiopharmaceuticals ; Treatment Outcome
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2010-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1355509-1
    ISSN 1878-4046 ; 1076-6332
    ISSN (online) 1878-4046
    ISSN 1076-6332
    DOI 10.1016/j.acra.2010.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Diagnosis and differentiation of bronchioloalveolar carcinoma from adenocarcinoma with bronchioloalveolar components with metabolic and anatomic characteristics using PET/CT.

    Goudarzi, Behnaz / Jacene, Heather A / Wahl, Richard L

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2008  Volume 49, Issue 10, Page(s) 1585–1592

    Abstract: Unlabelled: (18)F-FDG PET has been reported to have reduced sensitivity in detecting bronchioloalveolar carcinoma (BAC) versus lung cancers with other histologies. However, there are CT characteristics that are suggestive of BAC, and potentially these ... ...

    Abstract Unlabelled: (18)F-FDG PET has been reported to have reduced sensitivity in detecting bronchioloalveolar carcinoma (BAC) versus lung cancers with other histologies. However, there are CT characteristics that are suggestive of BAC, and potentially these could be useful to refine diagnostic criteria so PET/CT can be more accurate in the diagnosis of BAC. We correlated tumor size and density obtained with CT and glucose metabolism obtained with (18)F-FDG PET in patients with BAC and adenocarcinoma with BAC components (Adeno+BAC) to determine the roles of both the anatomic and the functional components of the PET/CT examination in diagnosing this disease. Also, the correlation between tumor size and (18)F-FDG uptake or Hounsfield unit (HU) value was determined in these 2 groups.
    Methods: This was a retrospective study on a consecutive series of 53 patients with 57 pathology-proven lesions (26 BAC, 31 Adeno+BAC) who underwent (18)F-FDG PET/CT scans. The standardized uptake value (SUV) and average HUs reported were obtained for the tumors. The tumor size, (18)F-FDG uptake, and HU values in both groups were compared. The correlation between metabolic (SUV) and CT (HU) characteristics for the lesions and tumor size was assessed using the Pearson correlation coefficient.
    Results: A total of 26 lesions with pure BAC had a median SUVmax of 1.48 (range, 0.63-4.54). A total of 81% of patients with BAC (21/26 lesions) had SUVmax values of less than 2.5. Thirty-one lesions diagnosed as Adeno+BAC had a median SUVmax of 6.03 (range, 2.45-24) (P < 0.0001 vs. BAC). The mean SUVmax (1.77 +/- 0.99) of BAC was much lower than that of Adeno+BAC (6.55 +/- 4.33) (P < 0.0001). Maximum HU in BAC lesions (-111.96 +/- 123.92) was substantially lower than that in Adeno+BAC (82.03 +/- 33.77) lesions (P < 0.0001). The average maximum tumor dimension in the lung window was much smaller for BACs (17.63 +/- 5.5) than for Adeno+BACs (49.38 +/- 27.5) (P < 0.0001). A strong positive correlation between tumor size and HU was observed in the Adeno+BAC group (P = 0.0002).
    Conclusion: PET/CT can help differentiate between BAC and Adeno+BAC by using tumor size, CT density, and metabolic activity. Pure BAC exhibits smaller size, lower (18)F-FDG uptake, and lower tumor density than does Adeno+BAC. Many BACs have low SUVs (<2.0), but their low HU on CT aids in their proper identification.
    MeSH term(s) Adenocarcinoma/diagnosis ; Adenocarcinoma/diagnostic imaging ; Adult ; Aged ; Aged, 80 and over ; Bronchial Neoplasms/diagnosis ; Bronchial Neoplasms/diagnostic imaging ; Carcinoma/diagnosis ; Carcinoma/diagnostic imaging ; Diagnosis, Differential ; Female ; Humans ; Male ; Middle Aged ; Positron-Emission Tomography/methods ; Pulmonary Alveoli/pathology ; Radiopharmaceuticals ; Retrospective Studies ; Tomography, X-Ray Computed/methods
    Chemical Substances Radiopharmaceuticals
    Language English
    Publishing date 2008-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0161-5505 ; 0097-9058 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0161-5505 ; 0097-9058 ; 0022-3123
    DOI 10.2967/jnumed.108.052712
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Scalene muscle uptake: a potential pitfall in head and neck PET/CT.

    Jacene, Heather A / Goudarzi, Behnaz / Wahl, Richard L

    European journal of nuclear medicine and molecular imaging

    2007  Volume 35, Issue 1, Page(s) 89–94

    Abstract: Purpose: To describe increased 2-deoxy-2-[(18)F] fluoro-D-glucose (FDG) uptake in the scalene muscles in a large population of patients referred for evaluation with FDG positron emission tomography/computed tomography (PET/CT) imaging.: Methods: The ... ...

    Abstract Purpose: To describe increased 2-deoxy-2-[(18)F] fluoro-D-glucose (FDG) uptake in the scalene muscles in a large population of patients referred for evaluation with FDG positron emission tomography/computed tomography (PET/CT) imaging.
    Methods: The study met criteria for institutional review board exemption. FDG PET/CT images from 410 patients (179 males; mean age 56.8 years, range 6-88) were retrospectively reviewed for the presence or absence of FDG uptake in the neck that corresponded to the scalene muscles on the concurrent CT scan. Medical records were reviewed and data including age, sex, smoking history, reason for referral, and history of obstructive airways disease, thoracotomy, and thoracic radiation were recorded and evaluated.
    Results: One hundred and forty-seven of the 410 scans (36%) demonstrated increased FDG uptake on PET that corresponded to the scalene muscles on the CT scan. The uptake was most often bilateral, symmetrical, and linear (n = 117). Other patterns of scalene muscle uptake included unilateral and linear uptake (n = 27) and unilateral and focal uptake (n = 3). Scalene muscle uptake was more common in patients referred for evaluation of lung carcinomas compared to other types of tumors (52% vs. 32%, p = 0.05).
    Conclusion: Linear FDG uptake in scalene muscles is a commonly seen pattern on PET/CT. This finding should be recognized as a distinct entity and not misinterpreted on transverse images as metastatic disease.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Artifacts ; Child ; Female ; Fluorodeoxyglucose F18/pharmacokinetics ; Head/diagnostic imaging ; Humans ; Male ; Middle Aged ; Neck/diagnostic imaging ; Neck Muscles/metabolism ; Positron-Emission Tomography ; Retrospective Studies ; Tomography, X-Ray Computed
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2007-10-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-007-0548-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Comparison of the myocardial blood flow response to regadenoson and dipyridamole: a quantitative analysis in patients referred for clinical 82Rb myocardial perfusion PET.

    Goudarzi, Behnaz / Fukushima, Kenji / Bravo, Paco / Merrill, Jennifer / Bengel, Frank M

    European journal of nuclear medicine and molecular imaging

    2011  Volume 38, Issue 10, Page(s) 1908–1916

    Abstract: Background: Regadenoson is a novel selective A2A adenosine receptor agonist, which is administered as an intravenous bolus at a fixed dose. It is currently not clear if the absolute flow increase in response to this fixed dose is a function of ... ...

    Abstract Background: Regadenoson is a novel selective A2A adenosine receptor agonist, which is administered as an intravenous bolus at a fixed dose. It is currently not clear if the absolute flow increase in response to this fixed dose is a function of distribution volume in individual patients or if it is generally comparable to the previous standard agents dipyridamole or adenosine, which are dosed based on weight. We used quantitative analysis of clinical 82Rb PET/CT studies to obtain further insights.
    Methods: A total of 104 subjects with normal clinical rest/stress 82Rb perfusion PET/CT were included in a retrospective analysis. To rule out confounding factors, none had evidence of prior cardiac disease, ischaemia or infarction, cardiomyopathy, diabetes with insulin use, calcium score>400, renal disease or other significant systemic disease. A group of 52 patients stressed with regadenoson were compared with a group of 52 patients stressed with dipyridamole before regadenoson became available. The groups were matched for clinical characteristics, risk factors and baseline haemodynamics. Myocardial blood flow (MBF) and myocardial flow reserve (MFR) were quantified using a previously validated retention model, after resampling of dynamic studies from list-mode 82Rb datasets.
    Results: At rest, heart rate, blood pressure and MBF were comparable between the groups. Regadenoson resulted in a significantly higher heart rate (34±14 vs. 23±10 beats per minute increase from baseline; p<0.01) and rate-pressure product. Patients in the regadenoson group reported less severe symptoms and required less aminophylline. Stress MBF and MFR were not different between the groups (2.2±0.6 vs. 2.1±0.6 ml/min/g, p=0.39, and 2.9±0.8 vs. 2.8±0.7, p=0.31, respectively). In the regadenoson group, there was no correlation between stress flow or MFR and body weight or BMI.
    Conclusion: Despite its administration at a fixed dose, regadenoson results in an absolute increase in MBF which is comparable to that following dipyridamole administration and is independent of patient distribution volume. This further supports its usefulness as a clinical stress agent.
    MeSH term(s) Coronary Circulation/drug effects ; Dipyridamole/administration & dosage ; Dipyridamole/adverse effects ; Dipyridamole/pharmacology ; Female ; Hemodynamics/drug effects ; Humans ; Injections ; Male ; Middle Aged ; Myocardial Perfusion Imaging ; Positron-Emission Tomography ; Purinergic P1 Receptor Agonists/administration & dosage ; Purinergic P1 Receptor Agonists/adverse effects ; Purinergic P1 Receptor Agonists/pharmacology ; Purines/administration & dosage ; Purines/adverse effects ; Purines/pharmacology ; Pyrazoles/administration & dosage ; Pyrazoles/adverse effects ; Pyrazoles/pharmacology ; Retrospective Studies ; Rubidium Radioisotopes ; Stress, Physiological/drug effects
    Chemical Substances Purinergic P1 Receptor Agonists ; Purines ; Pyrazoles ; Rubidium Radioisotopes ; regadenoson (2XLN4Y044H) ; Dipyridamole (64ALC7F90C)
    Language English
    Publishing date 2011-06-09
    Publishing country Germany
    Document type Comparative Study ; Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-011-1853-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Detection of bone metastases using diffusion weighted magnetic resonance imaging: comparison with (11)C-methionine PET and bone scintigraphy.

    Goudarzi, Behnaz / Kishimoto, Riwa / Komatsu, Shuhei / Ishikawa, Hiroyuki / Yoshikawa, Kyosan / Kandatsu, Susumu / Obata, Takayuki

    Magnetic resonance imaging

    2010  Volume 28, Issue 3, Page(s) 372–379

    Abstract: Purpose: We evaluated the ability of diffusion-weighted imaging (DWI) to detect bone metastasis by comparing the results obtained using this modality with those obtained using (11)C-methionine (MET) positron emission tomography (PET) and bone ... ...

    Abstract Purpose: We evaluated the ability of diffusion-weighted imaging (DWI) to detect bone metastasis by comparing the results obtained using this modality with those obtained using (11)C-methionine (MET) positron emission tomography (PET) and bone scintigraphy.
    Materials and methods: This retrospective study involved 29 patients with bone metastasis. DWI was obtained using a single-shot echo planar imaging (EPI) sequence with fat suppression using a short inversion time inversion recovery sequence. The detection capabilities of DWI for bone metastases were compared with those of whole body MET PET (in 19 patients) and 99mTc-methylene diphosphonate bone scintigraphy (in 15 patients).
    Results: Among the 19 patients who were diagnosed using DWI and PET, the PET identified 39 bone metastases, while the DWI identified 60 metastases out of 69 metastases revealed with conventional magnetic resonance imaging (MRI). Among the 15 patients who were diagnosed using DWI and bone scintigraphy, the bone scintigraphy identified 18 bone metastases, while the DWI identified 72 metastases out of 78 metastases revealed with conventional MRI. The overall bone metastasis detection rates were 56.5% for PET, 23.1% for bone scintigraphy and 92.3% for DWI.
    Conclusion: DWI is a very sensitive method for detecting bone metastasis and is superior to MET PET and bone scintigraphy in terms of its detection capabilities.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Bone Neoplasms/diagnosis ; Carcinoma/diagnosis ; Carcinoma/secondary ; Diffusion Magnetic Resonance Imaging/methods ; Female ; Humans ; Male ; Methionine/analogs & derivatives ; Middle Aged ; Positron-Emission Tomography/methods ; Radiopharmaceuticals ; Reproducibility of Results ; Sensitivity and Specificity
    Chemical Substances Radiopharmaceuticals ; Methionine (AE28F7PNPL) ; methionine methyl ester (BN630929UL)
    Language English
    Publishing date 2010-04
    Publishing country Netherlands
    Document type Comparative Study ; Evaluation Studies ; Journal Article
    ZDB-ID 604885-7
    ISSN 1873-5894 ; 0730-725X
    ISSN (online) 1873-5894
    ISSN 0730-725X
    DOI 10.1016/j.mri.2009.12.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Clinical significance of discordant findings between pre-therapy (123)I and post-therapy (131)I whole body scan in patients with thyroid cancer.

    Bravo, Paco E / Goudarzi, Behnaz / Rana, Uzma / Filho, Paulo Togni / Castillo, Raymond / Rababy, Christopher / Ewertz, Marjorie / Ziessman, Harvey A / Cooper, David S / Ladenson, Paul W / Wahl, Richard L

    International journal of clinical and experimental medicine

    2013  Volume 6, Issue 5, Page(s) 320–333

    Abstract: Radioactive therapy with (131)I (RAI) is commonly used during the management of patients with differentiated thyroid cancer (DTC). The aim of this study was to determine the clinical significance of discordant findings between pre-RAI whole body scan ( ... ...

    Abstract Radioactive therapy with (131)I (RAI) is commonly used during the management of patients with differentiated thyroid cancer (DTC). The aim of this study was to determine the clinical significance of discordant findings between pre-RAI whole body scan (WBS) with (123)I and post-RAI WBS in the management of DTC. We retrospectively evaluated 342 individuals between 2002 and 2008 who had a diagnosis of DTC and underwent RAI. All had WBS one day before RAI and WBS one week after RAI. Patients were divided into 3 groups: 1) RAI-naive subjects without known distant metastatic disease (M1); 2) patients with history of prior RAI and persistent disease (except M1); and 3) patients with known M1. In Group 1 (n=311), 7% of patients (n=22) had discordant scans, but in only 4 of these cases did this represent true disease (3 unsuspected lung and 1 mediastinal node metastasis). In the remaining 18 patients, discordant findings corresponded to physiologic or other benign causes. In group 2 (n=23), 7 subjects (30%) had discordant findings and all of the discrepant sites consisted of loco-regional nodal disease in the neck/upper mediastinum (n=6) and M1 in lung (n=1). In group 3 (n=8), 5 patients (62%) showed discordant uptake in lung and bone which corresponded to the locations of known M1. A total of 12 patients with iodine-avid M1 were identified on post-RAI WBS (3.5% of entire cohort). Pre-RAI WBS was only concordant in 3 of these cases (25%). In conclusion, the significance of pre and post-RAI WBS is highly influenced by the clinical setting. Unsuspected distant metastatic disease is infrequent in RAI-naive patients without known M1, where most discordant findings are usually due to benign explanations, and represent false positive findings in this group. In contrast, in patients with history of previous RAI or known M1, discordant results likely correspond to true disease. In our study, pre-RAI scans showed a low yield to detect iodine-avid distant metastatic disease when compared to post-RAI scans.
    Language English
    Publishing date 2013-05-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2418305-2
    ISSN 1940-5901
    ISSN 1940-5901
    Database MEDical Literature Analysis and Retrieval System OnLINE

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