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Article ; Online: Synthesis and Expression of a Targeted, Ferritin-Based Tracer for PET Imaging of Kidney Glomeruli.

Baldelomar, Edwin J / Emoto, Kasey C / Jordan, Maria Veronica Clavijo / Charlton, Jennifer R / Reichert, David E / Parvin, Neda / Yokono, Courtnie / Hann, Bradley D / Bennett, Kevin M

Methods in molecular biology (Clifton, N.J.)

2023 Volume 2664, Page(s) 201–213

Abstract: Cationic ferritin (CF) has been developed as a multimodal, targeted imaging tracer to directly detect and map nephrons in the kidney in vivo. Direct detection of functional nephrons provides a unique, sensitive biomarker to predict or monitor kidney ... ...

Abstract	Cationic ferritin (CF) has been developed as a multimodal, targeted imaging tracer to directly detect and map nephrons in the kidney in vivo. Direct detection of functional nephrons provides a unique, sensitive biomarker to predict or monitor kidney disease progression. CF has been developed to map functional nephron number from magnetic resonance imaging (MRI) or positron emission tomography (PET). Previous preclinical imaging studies have used non-human-derived ferritin and commercial formulations that must still be developed for translation to clinical use. Here we describe the reproducible formulation of CF (either derived from horse or from human recombinant ferritin) optimized for intravenous injection and radiolabeling by PET. The human recombinant heteropolymer ferritin is spontaneously assembled in liquid culture (Escherichia coli, E. coli) and modified to form human recombinant cationic ferritin (HrCF) to mitigate potential immunologic reactions for use in humans.
MeSH term(s)	Animals ; Horses ; Ferritins ; Escherichia coli ; Kidney Glomerulus/pathology ; Kidney/diagnostic imaging ; Positron-Emission Tomography ; Magnetic Resonance Imaging/methods
Chemical Substances	Ferritins (9007-73-2)
Language	English
Publishing date	2023-07-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3179-9_15
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Article ; Online: Measuring the intrarenal distribution of glomerular volumes from histological sections.

Hann, Bradley D / Baldelomar, Edwin J / Charlton, Jennifer R / Bennett, Kevin M

American journal of physiology. Renal physiology

2016 Volume 310, Issue 11, Page(s) F1328–36

Abstract: Glomerular volume is an important metric reflecting glomerular filtration surface area within the kidney. Glomerular hypertrophy, or increased glomerular volume, may be an important marker for renal stress. Current stereological techniques report the ... ...

Abstract	Glomerular volume is an important metric reflecting glomerular filtration surface area within the kidney. Glomerular hypertrophy, or increased glomerular volume, may be an important marker for renal stress. Current stereological techniques report the average glomerular volume (AVglom) within the kidney. These techniques cannot assess the spatial or regional heterogeneity common in developing renal pathology. Here, we report a novel "unfolding" technique to measure the actual distribution of individual glomerular volumes in a kidney from the two-dimensional glomerulus profiles observed by optical microscopy. The unfolding technique was first developed and tested for accuracy with simulations and then applied to measure the number of glomeruli (Nglom), AVglom, and intrarenal distribution of individual glomerular volume (IVglom) in the oligosyndactyl (Os/(+)) mouse model compared with wild-type (WT) controls. The Os/(+) mice had fewer and larger glomeruli than WT mice: Nglom was 12,126 ± 1,658 (glomeruli/kidney) in the WT mice and 5,516 ± 899 in the Os/(+) mice; AVglom was 2.01 ± 0.28 × 10(-4) mm(3) for the WT mice and 3.47 ± 0.35 × 10(-4) mm(3) for the Os/(+) mice. Comparing the glomerular volume distributions in Os/(+) and WT kidneys, we observed that the Os/(+) distribution peaked at a higher value of IVglom than the WT distribution peak, and glomeruli with a radius greater than 55 μm were more prevalent in the Os/(+) mice (3.4 ± 1.6% of total glomeruli vs. 0.6 ± 1.2% in WT). Finally, the largest profiles were more commonly found in the juxtamedullary region. Unfolding is a novel stereological technique that provides a new quantitative view of glomerular volume distribution in the individual kidney.
MeSH term(s)	Algorithms ; Animals ; Kidney/pathology ; Kidney Diseases/pathology ; Kidney Glomerulus/pathology ; Mice ; Nephrons/pathology ; Organ Size/physiology
Language	English
Publishing date	2016-06-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	603837-2
ISSN	1522-1466 ; 0363-6127
ISSN (online)	1522-1466
ISSN	0363-6127
DOI	10.1152/ajprenal.00382.2015
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Article ; Online: How do organisational configuration and context influence the quantity and quality of NHS services provided by English community pharmacies? A qualitative investigation.

Jacobs, Sally / Fegan, Tom / Bradley, Fay / Halsall, Devina / Hann, Mark / Schafheutle, Ellen I

PloS one

2018 Volume 13, Issue 9, Page(s) e0204304

Abstract: Community pharmacies are expanding their role into medicines-related healthcare and public health services, previously the domain of physicians and nurses, driven by policies to improve healthcare access for patients and to address problems of increasing ...

Abstract	Community pharmacies are expanding their role into medicines-related healthcare and public health services, previously the domain of physicians and nurses, driven by policies to improve healthcare access for patients and to address problems of increasing demands and rising costs in primary and urgent care services. Understanding the organisational context into which this expansion is taking place is necessary given concerns over the extent to which pharmacies prioritise service volume over the quality of service provision. As part of a larger programme of work, this paper aims to explore stakeholder perceptions of the organisational and extra-organisational factors associated with service quality and quantity in community pharmacy as an established exemplar of private sector organisations providing publicly-funded healthcare. With ethics committee approval, forty semi-structured interviews were conducted with service commissioners, superintendent and front-line pharmacists, purposively selected from across nine geographical areas and a range of community pharmacy organisational types in England. Interviews were audio-recorded, transcribed verbatim and thematically analysed. Findings highlight the perceived importance of appropriate staffing and skill-mix for promoting service quantity and quality in community pharmacy. Organisational cultures which supported team development were viewed as facilitatory whereas those prioritising business targets over service quality seen to be inhibitive. Older local populations and low patient expectations were thought to limit service uptake as was poor integration with wider primary care services. The contractual framework and commissioning processes were also seen as a barrier to increasing service quality, quantity and integration in this sector. These findings suggest that healthcare administrations should take account of organisational and extra-organisational drivers and barriers when commissioning services from private sector providers such as community pharmacies to ensure that the quality of service provision is incentivised in addition to service quantity. Additionally, collaborative working should be encouraged through integrated commissioning mechanisms.
MeSH term(s)	Attitude of Health Personnel ; Community Pharmacy Services/organization & administration ; Humans ; Pharmacists ; Professional Role ; Qualitative Research ; Quality of Health Care ; State Medicine ; United Kingdom
Language	English
Publishing date	2018-09-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0204304
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Article ; Online: Use of Cationized Ferritin Nanoparticles to Measure Renal Glomerular Microstructure with MRI.

Bennett, Kevin M / Beeman, Scott C / Baldelomar, Edwin J / Zhang, Min / Wu, Teresa / Hann, Bradley D / Bertram, John F / Charlton, Jennifer R

Methods in molecular biology (Clifton, N.J.)

2016 Volume 1397, Page(s) 67–79

Abstract: Magnetic resonance imaging (MRI) is becoming important for whole-kidney assessment of glomerular morphology, both in vivo and ex vivo. MRI-based renal morphological measurements can be made in intact organs and allow direct measurements of every perfused ...

Abstract	Magnetic resonance imaging (MRI) is becoming important for whole-kidney assessment of glomerular morphology, both in vivo and ex vivo. MRI-based renal morphological measurements can be made in intact organs and allow direct measurements of every perfused glomerulus. Cationic ferritin (CF) is used as a superparamagnetic contrast agent for MRI. CF binds to the glomerular basement membrane after intravenous injection, allowing direct, whole-kidney measurements of glomerular number, volume, and volume distribution. Here we describe the production, testing, and use of CF as an MRI contrast agent for quantitative glomerular morphology in intact mouse, rat, and human kidneys.
MeSH term(s)	Animals ; Ferritins/chemistry ; Humans ; Image Processing, Computer-Assisted ; Kidney Glomerulus/cytology ; Kidney Glomerulus/ultrastructure ; Magnetic Resonance Imaging/methods ; Metal Nanoparticles ; Mice ; Rats
Chemical Substances	polycationic ferritin ; Ferritins (9007-73-2)
Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-3353-2_7
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Article ; Online: Organisational factors associated with safety climate, patient satisfaction and self-reported medicines adherence in community pharmacies.

Jacobs, Sally / Hann, Mark / Bradley, Fay / Elvey, Rebecca / Fegan, Tom / Halsall, Devina / Hassell, Karen / Wagner, Andrew / Schafheutle, Ellen I

Research in social & administrative pharmacy : RSAP

2019 Volume 16, Issue 7, Page(s) 895–903

Abstract: Background: Evidence suggests that community pharmacy service quality varies, and that this may relate to pharmacy ownership. However little is known about wider organisational factors associated with quality.: Objective: To investigate ... ...

Abstract	Background: Evidence suggests that community pharmacy service quality varies, and that this may relate to pharmacy ownership. However little is known about wider organisational factors associated with quality. Objective: To investigate organisational factors associated with variation in safety climate, patient satisfaction and self-reported medicines adherence in English community pharmacies. Methods: Multivariable regressions were conducted using data from two cross-sectional surveys, of 817 pharmacies and 2124 patients visiting 39 responding pharmacies, across 9 diverse geographical areas. Outcomes measured were safety climate, patient satisfaction and self-reported medicines adherence. Independent variables included service volume (e.g. dispensing volume), pharmacy characteristics (e.g. pharmacy ownership), patient characteristics (e.g. age) and areal-specific demographic, socio-economic and health-needs variables. Results: Valid response rates were 277/800 (34.6%) and 971/2097 (46.5%) for pharmacy and patient surveys respectively. Safety climate was associated with pharmacy ownership (F Conclusions: This study characterised variation in the quality of English community pharmacy services identifying the importance of skill-mix, continuity of care, pharmacy ownership, organisational culture, and patient characteristics. Further research is needed into what constitutes and influences quality, including the development of validated quality measures.
MeSH term(s)	Community Pharmacy Services ; Cross-Sectional Studies ; Humans ; Organizational Culture ; Patient Satisfaction ; Pharmacies ; Pharmacists ; Self Report ; Surveys and Questionnaires
Language	English
Publishing date	2019-09-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2192059-X
ISSN	1934-8150 ; 1551-7411
ISSN (online)	1934-8150
ISSN	1551-7411
DOI	10.1016/j.sapharm.2019.09.058
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Article ; Online: Principles and emerging applications of nanomagnetic materials in medicine.

Clavijo-Jordan, Veronica / Kodibagkar, Vikram D / Beeman, Scott C / Hann, Bradley D / Bennett, Kevin M

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

2012 Volume 4, Issue 4, Page(s) 345–365

Abstract: The development of nanometer-scale magnetic materials for biomedical applications spans the interface between the physical sciences and biology. Applications of these materials are rapidly becoming important in medicine and enable targeted therapies and ... ...

Abstract	The development of nanometer-scale magnetic materials for biomedical applications spans the interface between the physical sciences and biology. Applications of these materials are rapidly becoming important in medicine and enable targeted therapies and diagnostics. At the same time, specific applications add focus to the development of novel magnetic materials and facilitate a deeper understanding of the physical mechanisms behind their function. This review presents a broad, nontechnical overview of the basis of magnetism in materials at the nanometer scale and describes how these materials are created, characterized, and used. Specific emerging applications in medical diagnostics and therapies are discussed, including cancer cell targeting for thermal ablation, tissue engineering, and three-dimensional noninvasive molecular imaging. Challenges in these fields are discussed, including the toxicity and delivery of magnetic nanomaterials and the sensitivity of imaging and therapeutic techniques. The development of novel nanomagnetic nanomaterials should continue to accelerate as new applications are identified and researchers uncover new mechanisms to increase and modulate magnetism at the nanometer scale.
MeSH term(s)	Animals ; Diagnostic Techniques and Procedures ; Drug Delivery Systems ; Humans ; Magnetics/methods ; Nanomedicine/methods ; Nanostructures/ultrastructure
Language	English
Publishing date	2012-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2502698-7
ISSN	1939-0041 ; 1939-5116
ISSN (online)	1939-0041
ISSN	1939-5116
DOI	10.1002/wnan.1169
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Article ; Online: A Randomized Double-Blind Phase II Study of the Seneca Valley Virus (NTX-010) versus Placebo for Patients with Extensive-Stage SCLC (ES SCLC) Who Were Stable or Responding after at Least Four Cycles of Platinum-Based Chemotherapy: North Central Cancer Treatment Group (Alliance) N0923 Study.

Schenk, Erin L / Mandrekar, Sumithra J / Dy, Grace K / Aubry, Marie Christine / Tan, Angelina D / Dakhil, Shaker R / Sachs, Bradley A / Nieva, Jorge J / Bertino, Erin / Lee Hann, Christine / Schild, Steven E / Wadsworth, Troy W / Adjei, Alex A / Molina, Julian R

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

2019 Volume 15, Issue 1, Page(s) 110–119

Abstract: Introduction: The Seneca Valley virus (NTX-010) is an oncolytic picornavirus with tropism for SCLC. This phase II double-blind, placebo-controlled trial evaluated NTX-010 in patients with extensive-stage (ES) SCLC after completion of first-line ... ...

Abstract	Introduction: The Seneca Valley virus (NTX-010) is an oncolytic picornavirus with tropism for SCLC. This phase II double-blind, placebo-controlled trial evaluated NTX-010 in patients with extensive-stage (ES) SCLC after completion of first-line chemotherapy. Methods: Patients with ES SCLC who did not progress after four or more cycles of platinum-based chemotherapy were randomized 1:1 to a single dose of NTX-010 or placebo within 12 weeks of chemotherapy. The primary end point was progression-free survival (PFS). A prespecified interim analysis for futility was performed after 40 events. Viral clearance and the development of neutralizing antibodies were followed. Results: From January 15, 2010, to January 10, 2013, a total of 50 patients were randomized and received therapy on study (26 received NTX-010 and 24 received placebo). At the specified interim analysis, the median PFS was 1.7 months (95% confidence interval [CI]: 1.4-3.1 months) for the NTX-010 group versus 1.7 months (95% CI: 1.4-4.3 months) for the placebo group (hazard ratio = 1.03, p = 0.92), and the trial was terminated owing to futility. In the NTX-010 group, PFS was shorter in patients with detectable virus at days 7 and 14 versus in those in whom it was not detected after treatment (1.0 month [95% CI: 0.4-1.5 months] versus 1.8 months [95% CI: 1.3-5.5 months, p = 0.008] and 0.9 months [95% CI: 0.4-2.6 months] versus 1.3 months [95% CI: 1.0-5.3 months], respectively [p = 0.04]). Conclusions: Patients with ES SCLC did not benefit from NTX-010 treatment after chemotherapy with a platinum doublet. Persistence of NTX-010 in the blood 1 or 2 weeks after treatment was associated with a shorter PFS.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carboplatin ; Cisplatin/therapeutic use ; Double-Blind Method ; Etoposide ; Humans ; Lung Neoplasms/drug therapy ; Picornaviridae ; Platinum/therapeutic use
Chemical Substances	Platinum (49DFR088MY) ; Etoposide (6PLQ3CP4P3) ; Carboplatin (BG3F62OND5) ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2019-10-09
Publishing country	United States
Document type	Clinical Trial, Phase II ; Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2432037-7
ISSN	1556-1380 ; 1556-0864
ISSN (online)	1556-1380
ISSN	1556-0864
DOI	10.1016/j.jtho.2019.09.083
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Zs.A 6664: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Organisational and extraorganisational determinants of volume of service delivery by English community pharmacies: a cross-sectional survey and secondary data analysis.

Hann, Mark / Schafheutle, Ellen I / Bradley, Fay / Elvey, Rebecca / Wagner, Andrew / Halsall, Devina / Hassell, Karen / Jacobs, Sally

BMJ open

2017 Volume 7, Issue 10, Page(s) e017843

Abstract: Objectives: This study aimed to identify the organisational and extraorganisational factors associated with existing variation in the volume of services delivered by community pharmacies.: Design and setting: Linear and ordered logistic regression of ...

Abstract	Objectives: This study aimed to identify the organisational and extraorganisational factors associated with existing variation in the volume of services delivered by community pharmacies. Design and setting: Linear and ordered logistic regression of linked national data from secondary sources-community pharmacy activity, socioeconomic and health need datasets-and primary data from a questionnaire survey of community pharmacies in nine diverse geographical areas in England. Outcome measures: Annual dispensing volume; annual volume of medicines use reviews (MURs). Results: National dataset (n=10 454 pharmacies): greater dispensing volume was significantly associated with pharmacy ownership type (large chains>independents>supermarkets), greater deprivation, higher local prevalence of cardiovascular disease and depression, older people (aged >75 years) and infants (aged 0-4 years) but lower prevalence of mental health conditions. Greater volume of MURs was significantly associated with pharmacy ownership type (large chains/supermarkets>>independents), greater dispensing volume, and lower disease prevalence.Survey dataset (n=285 pharmacies; response=34.6%): greater dispensing volume was significantly associated with staffing, skill-mix, organisational culture, years open and greater deprivation. Greater MUR volume was significantly associated with pharmacy ownership type (large chains/supermarkets>>independents), greater dispensing volume, weekly opening hours and lower asthma prevalence. Conclusions: Organisational and extraorganisational factors were found to impact differently on dispensing volume and MUR activity, the latter being driven more by corporate ownership than population need. While levels of staffing and skill-mix were associated with dispensing volume, they did not influence MUR activity. Despite recent changes to the contractual framework, the existing fee-for-service reimbursement may therefore not be the most appropriate for the delivery of cognitive (rather than supply) services, still appearing to incentivise quantity over the quality (in terms of appropriate targeting) of services delivered. Future research should focus on the development of quality measures that could be incorporated into community pharmacy reimbursement mechanisms.
MeSH term(s)	Aged ; Aged, 80 and over ; Child, Preschool ; Commerce/statistics & numerical data ; Community Pharmacy Services/economics ; Community Pharmacy Services/organization & administration ; Community Pharmacy Services/statistics & numerical data ; Cross-Sectional Studies ; England ; Fee-for-Service Plans ; Female ; Health Services Needs and Demand ; Humans ; Infant ; Infant, Newborn ; Motivation ; Organizations/statistics & numerical data ; Ownership/statistics & numerical data ; Pharmacies/economics ; Pharmacies/organization & administration ; Pharmacies/statistics & numerical data ; Pharmacists ; Pharmacy/organization & administration ; Residence Characteristics ; Surveys and Questionnaires
Language	English
Publishing date	2017-10-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2017-017843
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Article ; Online: Phenotyping by magnetic resonance imaging nondestructively measures glomerular number and volume distribution in mice with and without nephron reduction.

Baldelomar, Edwin J / Charlton, Jennifer R / Beeman, Scott C / Hann, Bradley D / Cullen-McEwen, Luise / Pearl, Valeria M / Bertram, John F / Wu, Teresa / Zhang, Min / Bennett, Kevin M

Kidney international

2015 Volume 89, Issue 2, Page(s) 498–505

Abstract: Reduced nephron mass is strongly linked to susceptibility to chronic renal and cardiovascular diseases. There are currently no tools to identify nephropenia in clinical or preclinical diagnostics. Such new methods could uncover novel mechanisms and ... ...

Abstract	Reduced nephron mass is strongly linked to susceptibility to chronic renal and cardiovascular diseases. There are currently no tools to identify nephropenia in clinical or preclinical diagnostics. Such new methods could uncover novel mechanisms and therapies for chronic kidney disease (CKD) and reveal how variation among traits can affect renal function and morphology. Here we used cationized ferritin (CF)–enhanced MRI (CFE-MRI) to investigate the relationship between glomerular number (Nglom) and volume (Vglom) in kidneys of healthy wild-type mice and mice with oligosyndactylism (Os/+), a model of congenital nephron reduction. Mice were injected with CF and perfused, and the resected kidneys were imaged with 7T MRI to detect CF-labeled glomeruli. CFE-MRI was used to measure the intrarenal distribution of individual glomerular volumes and revealed two major populations of glomeruli distinguished by size. Spatial mapping revealed that the largest glomeruli were located in the juxtamedullary region in both wild-type and Os/+ mice and the smallest population located in the cortex. Os/+ mice had about a 50% reduction and 35% increase of Nglom and Vglom, respectively, in both glomerular populations compared with wild type, consistent with glomerular hypertrophy in the Os/+ mice. Thus, we provide a foundation for whole-kidney, MRI-based phenotyping of mouse renal glomerular morphology and provide new potential for quantitative human renal diagnostics.
MeSH term(s)	Animals ; Disease Models, Animal ; Kidney/abnormalities ; Magnetic Resonance Imaging/methods ; Male ; Mice ; Mice, Inbred C57BL
Language	English
Publishing date	2015-06-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1038/ki.2015.316
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Article ; Online: On the use of micron-sized iron oxide particles (MPIOS) to label resting monocytes in bone marrow.

Tang, Kevin S / Hann, Bradley / Shapiro, Erik M

Molecular imaging and biology

2010 Volume 13, Issue 5, Page(s) 819–824

Abstract: ... resolution 3-D MRI was performed on mouse legs, and signal changes were quantified. Flow cytometry and ...

Abstract	Purpose: The use of MRI to monitor immune cell infiltration into various pathologies is well established. In an effort to boost the magnetic material within immune cells, this work attempted to label resting monocytes within bone marrow, in mice, by intravenous administration of micron-sized iron oxide particles (MPIOs), similar in fashion to the administration of (U)SPIO. Procedures: MPIOs were incubated with various immune cells both in culture, and in whole blood. Flow cytometry and histology were used to analyze magnetic cell labeling. Also, MPIOs were injected intravenously into mice. In vivo, high-resolution 3-D MRI was performed on mouse legs, and signal changes were quantified. Flow cytometry and histology were used to analyze magnetic cell labeling of bone marrow resident cells. Results: It is demonstrated here that monocytes and neutrophils can indeed endocytose MPIOs both in cell culture and ex vivo in whole blood. However, despite rapid accumulation of MPIOs within the bone marrow following injection, MPIOs did not label monocytes or any other hematopoietic cell type in the marrow. Hypotheses are drawn to explain these results in light of recent usage of MPIOs for immune cell tracking. Conclusions: Systemic administration of various MPIO formulations showed that MPIOs arrive in bone marrow rapidly following injection and remain there for at least 7 days. Data also shows slow clearance of some particles from the tissue over this period. While MPIOs can efficiently label monocytes in culture and in whole blood ex vivo, they were not found to label bone marrow resident monocytes.
MeSH term(s)	Animals ; Bone Marrow Cells/cytology ; Ferric Compounds/administration & dosage ; Ferric Compounds/chemistry ; Flow Cytometry ; Magnetic Resonance Imaging ; Mice ; Microscopy, Fluorescence ; Monocytes ; Particle Size
Chemical Substances	Ferric Compounds ; ferric oxide (1K09F3G675)
Language	English
Publishing date	2010-10-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2079160-4
ISSN	1860-2002 ; 1536-1632
ISSN (online)	1860-2002
ISSN	1536-1632
DOI	10.1007/s11307-010-0437-3
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