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Article ; Online: Association Between Parental BMI and Offspring’s Blood Pressure by Mediation Analysis

Hyowon Choi / Hunju Lee / Yeon-Soon Ahn

Journal of Preventive Medicine and Public Health, Vol 56, Iss 6, Pp 533-

A Study Using Data From the Korean National Health and Nutrition Examination Survey

2023 Volume 541

Abstract: Objectives This study analyzed the relationship between parental body mass index (BMI; BMI_p) and hypertension in their adolescent offspring (HTN_a), focusing on the mediating effect of adolescents’ BMI (BMI_a). Methods Utilizing data from the Korea ... ...

Abstract	Objectives This study analyzed the relationship between parental body mass index (BMI; BMI_p) and hypertension in their adolescent offspring (HTN_a), focusing on the mediating effect of adolescents’ BMI (BMI_a). Methods Utilizing data from the Korea National Health and Nutrition Examination Survey, including participants aged 12-18, we conducted a mediation analysis while controlling for confounding factors such as age, sex, physical activity, dietary habits, household income quartile, and parents’ alcohol and smoking habits. Results The study included a total of 5731 participants, of whom 3381 and 5455 participants had data on fathers’ and mothers’ BMI, respectively. For adolescent systolic blood pressure (SBP_a), the father’s BMI (BMI_f) had a significant total effect (β, 0.23; 95% confidence interval [CI], 0.12 to 0.34) and average controlled mediated effect (ACME) (β, 0.27; 95% CI, 0.23 to 0.32), but the average direct effect (ADE) was not significant. The mother’s BMI (BMI_m) had a significant total effect (β, 0.17; 95% CI, 0.09 to 0.25), ACME (β, 0.25; 95% CI, 0.22 to 0.28) and ADE (β, -0.08; 95% CI, -0.16 to 0.00). For adolescent diastolic blood pressure, both BMI_f and BMI_m had significant ACMEs (β, 0.10; 95% CI, 0.08 to 0.12 and β, 0.09; 95% CI, 0.07 to 0.12, respectively), BMI_m had a significant ADE (β, -0.09; 95% CI, -0.16 to -0.02) but BMI_f had an insignificant ADE and total effect. Conclusions The study found that parental BMI had a significant effect on SBP_a, mediated through BMI_a. Therefore, a high BMI in parents could be a risk factor, mediated through BMI_a, for systolic hypertension in adolescents, necessitating appropriate management.
Keywords	hypertension ; adolescent ; body mass index ; mediation analysis ; Medicine ; R ; Public aspects of medicine ; RA1-1270
Subject code	796
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Korean Society for Preventive Medicine
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association Between Parental BMI and Offspring's Blood Pressure by Mediation Analysis: A Study Using Data From the Korean National Health and Nutrition Examination Survey.

Choi, Hyowon / Lee, Hunju / Ahn, Yeon-Soon

Journal of preventive medicine and public health = Yebang Uihakhoe chi

2023 Volume 56, Issue 6, Page(s) 533–541

Abstract: Objectives: This study analyzed the relationship between parental body mass index (BMI; BMI_p) and hypertension in their adolescent offspring (HTN_a), focusing on the mediating effect of adolescents' BMI (BMI_a).: Methods: Utilizing data from the ... ...

Abstract	Objectives: This study analyzed the relationship between parental body mass index (BMI; BMI_p) and hypertension in their adolescent offspring (HTN_a), focusing on the mediating effect of adolescents' BMI (BMI_a). Methods: Utilizing data from the Korea National Health and Nutrition Examination Survey, including participants aged 12-18, we conducted a mediation analysis while controlling for confounding factors such as age, sex, physical activity, dietary habits, household income quartile, and parents' alcohol and smoking habits. Results: The study included a total of 5731 participants, of whom 3381 and 5455 participants had data on fathers' and mothers' BMI, respectively. For adolescent systolic blood pressure (SBP_a), the father's BMI (BMI_f) had a significant total effect (β, 0.23; 95% confidence interval [CI], 0.12 to 0.34) and average controlled mediated effect (ACME) (β, 0.27; 95% CI, 0.23 to 0.32), but the average direct effect (ADE) was not significant. The mother's BMI (BMI_m) had a significant total effect (β, 0.17; 95% CI, 0.09 to 0.25), ACME (β, 0.25; 95% CI, 0.22 to 0.28) and ADE (β, -0.08; 95% CI, -0.16 to 0.00). For adolescent diastolic blood pressure, both BMI_f and BMI_m had significant ACMEs (β, 0.10; 95% CI, 0.08 to 0.12 and β, 0.09; 95% CI, 0.07 to 0.12, respectively), BMI_m had a significant ADE (β, -0.09; 95% CI, -0.16 to -0.02) but BMI_f had an insignificant ADE and total effect. Conclusions: The study found that parental BMI had a significant effect on SBP_a, mediated through BMI_a. Therefore, a high BMI in parents could be a risk factor, mediated through BMI_a, for systolic hypertension in adolescents, necessitating appropriate management.
MeSH term(s)	Female ; Adolescent ; Humans ; Body Mass Index ; Blood Pressure ; Nutrition Surveys ; Parents ; Hypertension/epidemiology ; Republic of Korea/epidemiology
Language	English
Publishing date	2023-10-30
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2620879-9
ISSN	2233-4521 ; 2233-4521
ISSN (online)	2233-4521
ISSN	2233-4521
DOI	10.3961/jpmph.23.289
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Non-planar graphene directly synthesized on intracavity optical microresonators for GHz repetition rate mode-locked lasers

Oleksiy Kovalchuk / Sungjae Lee / Hyowon Moon / Andrea M. Armani / Yong-Won Song

npj 2D Materials and Applications, Vol 8, Iss 1, Pp 1-

2024 Volume 9

Abstract: Abstract Generation of high-speed laser pulses is essential for sustaining today’s global, hyper-connected society. One approach for achieving high spectral and temporal purity is to combine optical nonlinear materials with spectral filtering devices. In ...

Abstract	Abstract Generation of high-speed laser pulses is essential for sustaining today’s global, hyper-connected society. One approach for achieving high spectral and temporal purity is to combine optical nonlinear materials with spectral filtering devices. In this work, a graphene-coated microresonator integrates a nonlinear material and a spectral filtering platform into a single device, creating a tunable GHz repetition rate mode-locked fiber laser. The graphene is directly synthesized on the non-planar surface of microresonator, resulting in a uniform, conformal coating with minimal optical loss in the device. The whispering gallery modes of the resonator filter the propagating modes, and the remaining modes from the interaction with graphene lock their relative phases to form short pulses at an elevated repetition rate relying on inter-modal spectral distance. Additionally, by leveraging the photo-thermal effect, all-optical tuning of the repetition rate is demonstrated. With optimized device parameters, repetition rates of 150 GHz and tuning of 6.1 GHz are achieved.
Keywords	Materials of engineering and construction. Mechanics of materials ; TA401-492 ; Chemistry ; QD1-999
Subject code	535
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A flexible, thin-film microchannel electrode array device for selective subdiaphragmatic vagus nerve recording.

Lim, Jongcheon / Zoss, Peter A / Powley, Terry L / Lee, Hyowon / Ward, Matthew P

Microsystems & nanoengineering

2024 Volume 10, Page(s) 16

Abstract: The vagus nerve (VN) plays an important role in regulating physiological conditions in the gastrointestinal (GI) tract by communicating via the parasympathetic pathway to the enteric nervous system (ENS). However, the lack of knowledge in the ... ...

Abstract	The vagus nerve (VN) plays an important role in regulating physiological conditions in the gastrointestinal (GI) tract by communicating via the parasympathetic pathway to the enteric nervous system (ENS). However, the lack of knowledge in the neurophysiology of the VN and GI tract limits the development of advanced treatments for autonomic dysfunctions related to the VN. To better understand the complicated underlying mechanisms of the VN-GI tract neurophysiology, it is necessary to use an advanced device enabled by microfabrication technologies. Among several candidates including intraneural probe array and extraneural cuff electrodes, microchannel electrode array devices can be used to interface with smaller numbers of nerve fibers by securing them in the separate channel structures. Previous microchannel electrode array devices to interface teased nerve structures are relatively bulky with thickness around 200 µm. The thick design can potentially harm the delicate tissue structures, including the nerve itself. In this paper, we present a flexible thin film based microchannel electrode array device (thickness: 11.5 µm) that can interface with one of the subdiaphragmatic nerve branches of the VN in a rat. We demonstrated recording evoked compound action potentials (ECAP) from a transected nerve ending that has multiple nerve fibers. Moreover, our analysis confirmed that the signals are from C-fibers that are critical in regulating autonomic neurophysiology in the GI tract.
Language	English
Publishing date	2024-01-23
Publishing country	England
Document type	Journal Article
ISSN	2055-7434
ISSN (online)	2055-7434
DOI	10.1038/s41378-023-00637-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A CRISPR/Cas12 trans-cleavage reporter enabling label-free colorimetric detection of SARS-CoV-2 and its variants.

Kim, Hansol / Jang, Hyowon / Song, Jayeon / Lee, Sang Mo / Lee, Seoyoung / Kwon, Hyung-Jun / Kim, Sunjoo / Kang, Taejoon / Park, Hyun Gyu

Biosensors & bioelectronics

2024 Volume 251, Page(s) 116102

Abstract: We present a label-free colorimetric CRISPR/Cas-based method enabling affordable molecular diagnostics for SARS-CoV-2. This technique utilizes 3,3'-diethylthiadicarbocyanine iodide ( ... ...

Abstract	We present a label-free colorimetric CRISPR/Cas-based method enabling affordable molecular diagnostics for SARS-CoV-2. This technique utilizes 3,3'-diethylthiadicarbocyanine iodide (DISC
MeSH term(s)	Humans ; SARS-CoV-2/genetics ; COVID-19/diagnosis ; CRISPR-Cas Systems/genetics ; Colorimetry ; RNA, Viral ; Biosensing Techniques ; Adenine ; Nucleic Acid Amplification Techniques
Chemical Substances	RNA, Viral ; Adenine (JAC85A2161)
Language	English
Publishing date	2024-02-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2024.116102
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Article ; Online: Complete genome sequence of tulip virus X, a Korean isolate from

Bak, Sangmin / Jeong, Hyowon / Son, Su-Jin / Kim, Minseok / Lim, Taegun / Lee, Su-Heon

Microbiology resource announcements

2023 Volume 13, Issue 1, Page(s) e0094823

Abstract: In this study, the presence of tulip virus X (TVX) in Korean tulips was confirmed through high-throughput RNA sequencing. Its complete genome sequence of 6,056 nucleotides was determined via Sanger sequencing, exhibiting a 99.24% nucleotide identity with ...

Abstract	In this study, the presence of tulip virus X (TVX) in Korean tulips was confirmed through high-throughput RNA sequencing. Its complete genome sequence of 6,056 nucleotides was determined via Sanger sequencing, exhibiting a 99.24% nucleotide identity with TVX-J isolate. This signifies a previously unreported presence of TVX outside Japan.
Language	English
Publishing date	2023-12-20
Publishing country	United States
Document type	Journal Article
ISSN	2576-098X
ISSN (online)	2576-098X
DOI	10.1128/mra.00948-23
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Article ; Online: Publisher Correction: Biporous silica nanostructure-induced nanovortex in microfluidics for nucleic acid enrichment, isolation, and PCR-free detection.

Jeon, Eunyoung / Koo, Bonhan / Kim, Suyeon / Kim, Jieun / Yu, Yeonuk / Jang, Hyowon / Lee, Minju / Kim, Sung-Han / Kang, Taejoon / Kim, Sang Kyung / Kwak, Rhokyun / Shin, Yong / Lee, Joonseok

Nature communications

2024 Volume 15, Issue 1, Page(s) 1993

Language	English
Publishing date	2024-03-05
Publishing country	England
Document type	Published Erratum
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-46401-w
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Article ; Online: Flow Analysis of PM/NO X Aftertreatment System for Emergency Generator

Giyoung Park / Hyowon Bang / Seangwock Lee

Applied Sciences, Vol 12, Iss 4404, p

2022 Volume 4404

Abstract: Emergency generators normally use diesel engines. The generators need to conduct weekly no-load operation inspections to ensure stable performance in emergency situations. In particular, the generators with large diesel engines mainly use rectangle-type ... ...

Abstract	Emergency generators normally use diesel engines. The generators need to conduct weekly no-load operation inspections to ensure stable performance in emergency situations. In particular, the generators with large diesel engines mainly use rectangle-type filter substrates. To minimize hazardous emissions generated by generators, optimizing the reduction efficiency through computational fluid dynamics (CFD) analysis of flow characteristics of particulate matter (PM)/NO X reduction system is important. In this study, we analyzed internal flow by CFD, which is difficult to confirm by experimental method. The main factors in our numerical study are the changes of flow uniformity and back pressure. As a result, the flow distribution characteristics according to the cross-sectional shape are similar at high engine loads. Spraying urea in the reverse direction increases static pressure, greatly improving flow uniformity. Raising the selective catalyst reduction (SCR) diffuser angle to 30 degrees improves both back pressure and flow uniformity characteristics, and when the porosity increases, both flow uniformity and back pressure decrease.
Keywords	emergency generator ; aftertreatment system ; CFD (computational fluid dynamics) ; uniformity index ; porosity ; DPF (diesel particulate filter) ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	532 ; 621
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Trends in the effects of socioeconomic position on physical activity levels and sedentary behavior among Korean adolescents.

Lee, Hunju / Choi, Hyowon / Koh, Sang Baek / Kim, Hyeon Chang

Epidemiology and health

2023 Volume 45, Page(s) e2023085

Abstract: Objectives: We examined trends in physical activity and sedentary behavior in Korean adolescents, and their association with socioeconomic position (SEP).: Methods: We used data from the Korea Youth Risk Behavior Survey, a nationwide study involving ... ...

Abstract	Objectives: We examined trends in physical activity and sedentary behavior in Korean adolescents, and their association with socioeconomic position (SEP). Methods: We used data from the Korea Youth Risk Behavior Survey, a nationwide study involving students aged 12-19 conducted between 2009 and 2021. SEP was assessed based on economic status, parental education attainment, and urbanization. Physical activity was categorized into vigorous physical activity, moderate physical activity, and muscle training, and sedentary time was also measured. We conducted the log-binomial regression to calculate prevalence ratios (PRs) and prevalence differences. Results: Our analysis included a total of 593,896 students. We observed an increasing trend in physical activity, but a worsening trend in sedentary behavior. A positive association was found between an adolescent's physical activity and SEP indicators, except for urbanization. Adolescents with higher economic status engaged in more vigorous physical activity (high: PR, 1.26; 95% confidence interval [CI], 1.25 to 1.28; middle: PR, 1.03; 95% CI, 1.02 to 1.04). Similar associations were observed for father's education (tertiary or above: PR, 1.11; 95% CI, 1.09 to 1.13; upper secondary: PR, 1.05; 95% CI, 1.03 to 1.07) and mother's education (tertiary or above: PR, 1.17; 95% CI, 1.15 to 1.20; upper secondary: PR, 1.06; 95% CI, 1.04 to 1.08). Adolescents with higher economic status also showed a higher compliance rate with the guideline restricting sedentary time to 2 hours per day (high: PR, 1.28; 95% CI, 1.25 to 1.30; middle: PR, 1.03; 95% CI, 1.01 to 1.05). Conclusions: Adolescents with higher SEP exhibited more physical activity and less sedentary time than those with lower SEP.
MeSH term(s)	Humans ; Adolescent ; Sedentary Behavior ; Exercise ; Socioeconomic Factors ; Educational Status ; Republic of Korea/epidemiology
Language	English
Publishing date	2023-09-08
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2590698-7
ISSN	2092-7193 ; 2092-7193
ISSN (online)	2092-7193
ISSN	2092-7193
DOI	10.4178/epih.e2023085
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Article ; Online: Abdominal hernia as a rare manifestation of feline mammary gland carcinoma: a case report.

Kim, Hyowon / Lee, Seungjun / Cho, Seohyun / Kim, Kihoon / Eom, Kidong / Kim, Jaehwan

The Journal of veterinary medical science

2023 Volume 85, Issue 10, Page(s) 1116–1120

Abstract: A 15-year-old, spayed female, Scottish Straight cat without any traumatic history was presented with swollen abdomen and diagnosed as an abdominal wall hernia. Abdominal ultrasound revealed thickened, irregular, and hypoechoic change of abdominal wall ... ...

Abstract	A 15-year-old, spayed female, Scottish Straight cat without any traumatic history was presented with swollen abdomen and diagnosed as an abdominal wall hernia. Abdominal ultrasound revealed thickened, irregular, and hypoechoic change of abdominal wall muscle adjacent to defect. During the herniorrhaphy, multiple nodules were identified in the subcutaneous tissue around the defect. Histological examination of the nodular tissue was performed, and it was confirmed as mammary gland tumor. After the surgery, metastatic changes of the pancreas were identified, and pleural effusion and ascites were also confirmed. The patient deteriorated rapidly and died 78 days after the surgery. This is the first case presenting abdominal wall hernia induced by malignant tumor in veterinary medicine.
MeSH term(s)	Cats ; Animals ; Female ; Humans ; Mammary Glands, Human ; Hernia, Abdominal/diagnostic imaging ; Hernia, Abdominal/surgery ; Hernia, Abdominal/veterinary ; Hernia, Ventral/surgery ; Hernia, Ventral/veterinary ; Abdominal Wall/surgery ; Herniorrhaphy/veterinary ; Carcinoma/surgery ; Carcinoma/veterinary ; Cat Diseases/diagnostic imaging ; Cat Diseases/surgery
Language	English
Publishing date	2023-09-04
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	1071753-5
ISSN	1347-7439 ; 0916-7250
ISSN (online)	1347-7439
ISSN	0916-7250
DOI	10.1292/jvms.23-0224
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