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Book ; Online: J.C. Steyn en Afrikaans

van Coller, H.P / Van Niekerk, Angelique / Odendaal, Bernard

n Viering

2019

Keywords	Afrikaans ; Behoedsame skaafwerk ; briefwisseling tussen Elize Botha en Jaap Steyn ; Die vergete Verlore vader van J.C. Steyn ; Twee terugblikgedigte ; Boekensteynfontein ; spitsberaad ; Toe die Derde Afrikaanse Woordelys en Spelreëls die eerste Afrikaanse woordelys en spelreëls was ; Onomastiek ; Afrikaanse spitse op die leksikografiese landskap ; Apokopoësie ; 'n Sosiolinguistiese bespreking van die taalgebruiksvergestalting van bejaardheid in Elsa Joubert se Spertyd ; Die emeritus en die gespreksgroep ; 'n Kortverhaal ; Institusionele taalbeleid en akademiese taalbeleid - versoenbaar binne taal-in-onderwysbeplanning ; klaarpraatgedigte ; Geskiedskrywing en beskrywing van Afrikaans: Wat is daar nog te sê ; Apophrades ; 'n Gedig ; Die identiteit van die verbeelde Afrikaanssprekende gemeenskap soos vergestalt in gedrukte advertensies uit kommersiële tydskrifte ; Representasie as strategiese posisionering: J.C. Steyn se biografieë ; Oorskryding van kultuurgrense: S.J. du Toit ; die koningin van Skeba en Egipte ; die evolusie van skryf ; 'n Argument vir verraad en verset ; dramatologies gelees
Language	Afrikaans
Size	1 electronic resource (332 pages)
Publisher	UJ Press
Publishing place	Bloemfontein
Document type	Book ; Online
Note	Afrikaans
HBZ-ID	HT030380296
ISBN	9781928424321 ; 1928424325
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: The elusive scleral cartilages: Comparative anatomy and development in teleosts and avians.

Franz-Odendaal, Tamara A

Anatomical record (Hoboken, N.J. : 2007)

2023

Abstract: The sclera of all vertebrate eyes is comprised of connective tissue, with some organisms developing cartilage within this tissue. A review of the cartilages that have been described in the vertebrate sclera and their anatomical relationships is discussed ...

Abstract	The sclera of all vertebrate eyes is comprised of connective tissue, with some organisms developing cartilage within this tissue. A review of the cartilages that have been described in the vertebrate sclera and their anatomical relationships is discussed together with their potential homology. Incorrect terminology erroneously implies similarity in location, development, morphology, and evolution, which may lead some scientists to assume all cartilages in orbit are the same elements when reading the literature. Therefore, new terminology to distinguish the different types of cartilage associated with the vertebrate eye is proposed. The scleral cartilages that are likely homologous to one another and which are situated in the sclera, should be termed scleral cartilages sensu stricto, while other cartilages in the sclera should be termed ocular cartilages. Some of the cartilages also ossify, and these bones should be distinguished from the scleral ossicles. The plasticity of the scleral tissue layer and its range of morphologies from fibrous to cartilaginous connective tissue across different vertebrate lineages are also described. This review also highlights several gaps in our understanding of the vertebrate scleral cartilages, in particular.
Language	English
Publishing date	2023-11-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2269667-2
ISSN	1932-8494 ; 1932-8486
ISSN (online)	1932-8494
ISSN	1932-8486
DOI	10.1002/ar.25345
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Article ; Online: Strong Association Between Placental Pathology and Second-trimester Miscarriage.

Odendaal, H J

Archives of obstetrics and gynaecology

2021 Volume 2, Issue 3, Page(s) 51–56

Language	English
Publishing date	2021-09-15
Publishing country	United States
Document type	Journal Article
ISSN	2692-787X
ISSN (online)	2692-787X
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Article ; Online: Selecting a birth weight standard for an indigenous population in a LMIC: A prospective comparative study.

Geerts, Lut / Brink, Lucy T / Odendaal, Hein J

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

2024

Abstract: Objectives: The aim of the present study was to compare birth weight (BW) distribution and proportion of BWs below or above specified percentiles in low-risk singleton pregnancies in healthy South African (SA) women of mixed ancestry with expected ... ...

Abstract	Objectives: The aim of the present study was to compare birth weight (BW) distribution and proportion of BWs below or above specified percentiles in low-risk singleton pregnancies in healthy South African (SA) women of mixed ancestry with expected values according to four BW references and to determine the physiological factors affecting BW. Methods: This was an ancillary study of a prospective multinational cohort study, involving 7060 women recruited between August 2007 and January 2015 in two townships of Cape Town, characterized by low socioeconomic status, and high levels of drinking and smoking. Detailed information about maternal and pregnancy characteristics, including harmful exposures, was gathered prospectively, allowing us to select healthy women with uncomplicated pregnancies without any known harmful exposures. In this cohort we compared the median BW and the proportion of BWs <P3, 5 and 10 or >P90, 95 and 97 according to four reference standards (INTERGROWTH-21st, customized according to the method described by Mickolajczyk, Fetal Medicine Foundation and revised Fenton reference) with expected values. Appropriate parametric and nonparametric tests were used, and sensitivity analysis was performed for infant sex, first trimester bookings and women of normal body mass index (BMI). Multiple regression was used to explore effects of confounders. Written consent and ethics approval was obtained. Results: The cohort included 739 infants. The INTERGROWTH-21st standard was closest for the actual BW-distribution and categories. Below-expected BW was associated with boys, younger, shorter, leaner women, lower parity and gravidity. Actual BW was significantly influenced by maternal weight, BMI, parity and gestational age. Conclusion: Of the four references assessed in this study, the INTERGROWTH-21st standard was closest for the actual BW distribution. Maternal variables significantly influence BW.
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	80149-5
ISSN	1879-3479 ; 0020-7292
ISSN (online)	1879-3479
ISSN	0020-7292
DOI	10.1002/ijgo.15519
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Article: History Repeats Itself: The Relevance of Historical Pandemics to the Medical School Curriculum.

Jones, M / Quenby, S / Odendaal, J

Journal of medical education and curricular development

2023 Volume 10, Page(s) 23821205231210629

Abstract: Introduction: The dramatic global impact of the coronavirus pandemic has increased consideration on epidemiological progressions of pandemics. Measures implemented to reduce viral transmission have been largely historical, comparable in nature with the ... ...

Abstract	Introduction: The dramatic global impact of the coronavirus pandemic has increased consideration on epidemiological progressions of pandemics. Measures implemented to reduce viral transmission have been largely historical, comparable in nature with the 1918 and 2009 influenza pandemics, demonstrating the importance of clinicians' awareness on historical pandemics. Despite this, literature suggests medical students' knowledge on previous pandemics is poor. Objectives: This study aims to gather stakeholder information from UK medical students on the importance of including the history of pandemics in the medical school curriculum. Methods: A cross-sectional cohort study conducted via a mixed question type online survey was distributed to all UK medical schools to explore stakeholder views. Grounded theory emergent coding was used to generate themes to free-text answers and SPSS and Excel were used to analyse quantitative data using pivot tables and Fishers exact tests. Results: Two hundred and forty-one students consented to take part from eight medical schools in the UK with 98% of these students completing the questionnaire. 34% of students reported having teaching on pandemics with 78% of students stating it would be beneficial. Knowledge was poor with 5.7% of students achieving 100% on knowledge-based questions. 72% of students believed that learning about the history of medicine would be beneficial with 87% of these students referring to 'benefiting (the) future' in their answers. Additionally, 79% of students thought it would be beneficial to learn about historical pandemics with reference to the current COVID-19 pandemic. Conclusion: To date, this is the only UK based study assessing stakeholders' views on including the history of pandemics in the medical school curriculum. Our findings demonstrate that medical students wish to have more historical content included in their degree to better prepare tomorrow's doctors for situations that may occur when history repeats itself.
Language	English
Publishing date	2023-11-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2798123-X
ISSN	2382-1205
ISSN	2382-1205
DOI	10.1177/23821205231210629
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: An intrapartum cervical buttonhole tear: A case report and review of rare tear pathogenesis.

Newnham-Hill, Amy / Odendaal, Joshua / Hillman, Catherine

Case reports in women's health

2023 Volume 38, Page(s) e00516

Abstract: Genital tract trauma and obstetric anal sphincter injuries are known complications of normal vaginal and assisted vaginal delivery. Cervical tears are an uncommon complication that can lead to significant postpartum haemorrhage and may have implications ... ...

Abstract	Genital tract trauma and obstetric anal sphincter injuries are known complications of normal vaginal and assisted vaginal delivery. Cervical tears are an uncommon complication that can lead to significant postpartum haemorrhage and may have implications for future pregnancies. Careful evaluation of the genital tract, including the cervix, along with adequate resuscitation are essential to reduce maternal morbidity and mortality. This is a case report of a 36-year-old primigravida woman at 41 + 6 weeks of gestation with delay in the second stage requiring Neville Barnes forceps delivery. She then went on to have a major postpartum haemorrhage, initially thought to be a result of uterine atony. However, inadequate response to uterotonics led to identification of a cervical buttonhole tear with an intact external os. She required repair under general anaesthesia. A rigid sigmoidoscope was utilised to ensure cervical canal patency during the repair. Previous reports have described annular cervical tears, thought to occur from the extension of a cervical buttonhole tear, but to the best of our knowledge the latter has not previously been reported. The case demonstrates the importance of awareness of such tears and proposes a novel technique for repair with the use of a rigid sigmoidoscope.
Language	English
Publishing date	2023-05-23
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2800286-6
ISSN	2214-9112 ; 2214-9112
ISSN (online)	2214-9112
ISSN	2214-9112
DOI	10.1016/j.crwh.2023.e00516
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Article ; Online: Immunological Testing in Assisted Reproductive Technology.

Odendaal, Joshua / Quenby, Siobhan

Seminars in reproductive medicine

2021 Volume 39, Issue 1-02, Page(s) 13–23

Abstract: Fetal implantation requires carefully orchestrated involvement of the maternal immune system. Aberrant function within implantation has been suggested as a cause of implantation failure. The emergence of immunological theories of miscarriage has led to ... ...

Abstract	Fetal implantation requires carefully orchestrated involvement of the maternal immune system. Aberrant function within implantation has been suggested as a cause of implantation failure. The emergence of immunological theories of miscarriage has led to immunological testing as an adjuvant treatment in assisted reproductive technology; however, it remains controversial, with mixed evidence both for immunological cause and the benefits of immunological testing. Literature on common methods of immunological testing within assisted reproductive technology is reviewed including those of peripheral and uterine natural killer cells, chronic endometritis, and T-helper cells cytokine ratio. There is little consensus in the evidence on immunological testing in the context of recurrent implantation failure. The field is limited by a lack of uniformity in approach to testing and heterogeneity of the pathophysiological cause. Nevertheless, the maternal immune system is heavily involved in implantation and the new era of personalized medicine ensures that a more defined approach to immunological testing will be achieved.
MeSH term(s)	Abortion, Habitual ; Abortion, Spontaneous ; Embryo Implantation ; Female ; Humans ; Killer Cells, Natural ; Pregnancy ; Reproductive Techniques, Assisted ; Uterus
Language	English
Publishing date	2021-06-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2042479-6
ISSN	1526-4564 ; 1526-8004
ISSN (online)	1526-4564
ISSN	1526-8004
DOI	10.1055/s-0041-1730908
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Article ; Online: Making miscarriage matter - Authors' reply.

Odendaal, Joshua / Quenby, Siobhan

Lancet (London, England)

2021 Volume 398, Issue 10302, Page(s) 745–746

MeSH term(s)	Abortion, Spontaneous ; Female ; Humans ; Pregnancy
Language	English
Publishing date	2021-08-28
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(21)01423-9
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Article ; Online: Intravitreal injection of FGF and TGF-β inhibitors disrupts cranial cartilage development.

Zinck, Nicholas W / McInnis, Shea J L / Franz-Odendaal, Tamara A

Differentiation; research in biological diversity

2023 Volume 133, Page(s) 51–59

Abstract: Cartilage development is a tightly regulated process that requires the interaction of epithelial and mesenchymal tissues layers to initiate the aggregation of mesenchyme in a condensation. Several signaling molecules have been implicated in cartilage ... ...

Abstract	Cartilage development is a tightly regulated process that requires the interaction of epithelial and mesenchymal tissues layers to initiate the aggregation of mesenchyme in a condensation. Several signaling molecules have been implicated in cartilage formation including FGFs, WNTs, and members of the TGF-β super family. However, little is known about the earliest signals involved in these initial phases of development. Here we aimed to investigate whether direct intravitreal injection of pharmaceutical inhibitors for FGF and TGF-β signaling would perturb cranial cartilages in zebrafish. Via wholemount bone and cartilage staining, we found effects on multiple cranial cartilage elements. We found no effect on scleral cartilage development, however, the epiphyseal bar, basihyal, and basicapsular cartilages were disrupted. Interestingly, the epiphyseal bar arises from the same progenitor pool as the scleral cartilage, namely, the periocular ectomesenchyme. This study adds to the foundational knowledge about condensation induction of cranial cartilage development and provides insight into the timing and signaling involved in the early development of several craniofacial cartilage elements in zebrafish.
MeSH term(s)	Animals ; Zebrafish ; Transforming Growth Factor beta ; Intravitreal Injections ; Fibroblast Growth Factors/genetics ; Cartilage
Chemical Substances	Transforming Growth Factor beta ; Fibroblast Growth Factors (62031-54-3)
Language	English
Publishing date	2023-07-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	184540-8
ISSN	1432-0436 ; 0301-4681
ISSN (online)	1432-0436
ISSN	0301-4681
DOI	10.1016/j.diff.2023.07.003
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Article ; Online: The endometrial microbiota and early pregnancy loss.

Odendaal, Joshua / Black, Naomi / Bennett, Phillip R / Brosens, Jan / Quenby, Siobhan / MacIntyre, David A

Human reproduction (Oxford, England)

2024 Volume 39, Issue 4, Page(s) 638–646

Abstract: The human endometrium is a dynamic entity that plays a pivotal role in mediating the complex interplay between the mother and developing embryo. Endometrial disruption can lead to pregnancy loss, impacting both maternal physical and psychological health. ...

Abstract	The human endometrium is a dynamic entity that plays a pivotal role in mediating the complex interplay between the mother and developing embryo. Endometrial disruption can lead to pregnancy loss, impacting both maternal physical and psychological health. Recent research suggests that the endometrial microbiota may play a role in this, although the exact mechanisms are still being explored, aided by recent technological advancements and our growing understanding of host immune responses. Suboptimal or dysbiotic vaginal microbiota, characterized by increased microbial diversity and reduced Lactobacillus dominance, has been associated with various adverse reproductive events, including miscarriage. However, the mechanisms linking the lower reproductive tract microbiota with pregnancy loss remain unclear. Recent observational studies implicate a potential microbial continuum between the vaginal and endometrial niche in patients with pregnancy loss; however, transcervical sampling of the low biomass endometrium is highly prone to cross-contamination, which is often not controlled for. In this review, we explore emerging evidence supporting the theory that a dysbiotic endometrial microbiota may modulate key inflammatory pathways required for successful embryo implantation and pregnancy development. We also highlight that a greater understanding of the endometrial microbiota, its relationship with the local endometrial microenvironment, and potential interventions remain a focus for future research.
MeSH term(s)	Pregnancy ; Female ; Humans ; Abortion, Spontaneous ; Endometrium ; Embryo Implantation/physiology ; Microbiota/physiology ; Vagina
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	632776-x
ISSN	1460-2350 ; 0268-1161 ; 1477-741X
ISSN (online)	1460-2350
ISSN	0268-1161 ; 1477-741X
DOI	10.1093/humrep/dead274
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