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Book: Anesthesia and perioperative care of the high risk patient

McConachie, Ian

2014

Title variant	Anesthesia and perioperative care of the high-risk patient
Author's details	ed. by Ian McConachie
Keywords	Anesthesia / adverse effects ; Anesthesia / methods ; Perioperative Care / methods ; Risk Factors
Language	English
Size	XX, 480 S. : Ill., graph. Darst.
Edition	3. ed.
Publisher	Cambridge Univ. Press
Publishing place	Cambridge
Publishing country	Great Britain
Document type	Book
Note	Includes bibliographical references and index
Old title	Frühere Aufl. u.d.T. Anesthesia for the high risk patient
HBZ-ID	HT018394919
ISBN	978-1-107-69057-8 ; 1-107-69057-9
Database	Catalogue ZB MED Medicine, Health

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2014 A 3578	available for loan (reading room)	Lesesaal EG

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Article ; Online: Learning where to trust unreliable models in an unstructured world for deformable object manipulation.

Mitrano, P / McConachie, D / Berenson, D

Science robotics

2021 Volume 6, Issue 54

Abstract: The world outside our laboratories seldom conforms to the assumptions of our models. This is especially true for dynamics models used in control and motion planning for complex high-degree of freedom systems like deformable objects. We must develop ... ...

Abstract	The world outside our laboratories seldom conforms to the assumptions of our models. This is especially true for dynamics models used in control and motion planning for complex high-degree of freedom systems like deformable objects. We must develop better models, but we must also consider that, no matter how powerful our simulators or how big our datasets, our models will sometimes be wrong. What is more, estimating how wrong models are can be difficult, because methods that predict uncertainty distributions based on training data do not account for unseen scenarios. To deploy robots in unstructured environments, we must address two key questions: When should we trust a model and what do we do if the robot is in a state where the model is unreliable. We tackle these questions in the context of planning for manipulating rope-like objects in clutter. Here, we report an approach that learns a model in an unconstrained setting and then learns a classifier to predict where that model is valid, given a limited dataset of rope-constraint interactions. We also propose a way to recover from states where our model prediction is unreliable. Our method statistically significantly outperforms learning a dynamics function and trusting it everywhere. We further demonstrate the practicality of our method on real-world mock-ups of several domestic and automotive tasks.
Language	English
Publishing date	2021-05-27
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ISSN	2470-9476
ISSN (online)	2470-9476
DOI	10.1126/scirobotics.abd8170
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mechanical thrombectomy for acute ischaemic stroke during the COVID-19 pandemic: changes to UK practice and lessons learned.

McConachie, D / McConachie, N / White, P / Crossley, R / Izzath, W

Clinical radiology

2020 Volume 75, Issue 10, Page(s) 795.e7–795.e13

Abstract: Aim: To describe evolving practices in the provision of mechanical thrombectomy (MT) services across the UK during the COVID-19 pandemic, the responses of and impact on MT teams, and the effects on training.: Materials and methods: The UK ... ...

Abstract	Aim: To describe evolving practices in the provision of mechanical thrombectomy (MT) services across the UK during the COVID-19 pandemic, the responses of and impact on MT teams, and the effects on training. Materials and methods: The UK Neurointerventional Group (UKNG) and the British Society of Neuroradiologists (BSNR) sent out a national survey on 1 May 2020 to all 28 UK neuroscience centres that have the potential capability to perform MT. Results: Responses were received from 27/28 MT-capable centres (96%). Three of the 27 centres do not currently provide MT services. There was a 27.7% reduction in MTs performed during April 2020 compared with the first 3 months of the year. All MT patients in 20/24 centres that responded were considered as COVID-19 suspicious/positive unless or until proven otherwise. Twenty-two of the 24 centres reported delays to the patient pathway. Seventeen of the 24 centres reported that the COVID-19 pandemic had reduced training opportunities for specialist registrars (SpR). Fourteen of the 24 centres reported that the pandemic had hampered their development plans for their local or regional MT service. Conclusion: The present survey has highlighted a trend of decreasing cases and delays in the patient pathway during the early stages of the COVID-19 pandemic across UK centres.
MeSH term(s)	Brain Ischemia/complications ; Brain Ischemia/surgery ; COVID-19 ; Clinical Protocols ; Coronavirus Infections/prevention & control ; Humans ; Mechanical Thrombolysis/statistics & numerical data ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Stroke/surgery ; United Kingdom
Keywords	covid19
Language	English
Publishing date	2020-07-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391227-9
ISSN	1365-229X ; 0009-9260
ISSN (online)	1365-229X
ISSN	0009-9260
DOI	10.1016/j.crad.2020.07.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: National Cancer Institute (NCI) Program for Natural Product Discovery: Exploring NCI-60 Screening Data of Natural Product Samples with Artificial Neural Networks.

Evans, Jason R / Akee, Rhone K / Chanana, Shaurya / McConachie, Grant D / Thornburg, Christopher C / Grkovic, Tanja / O'Keefe, Barry R

ACS omega

2023 Volume 8, Issue 10, Page(s) 9250–9256

Abstract: National Cancer Institute (NCI) Program for Natural Product Discovery is a new initiative aimed at creating new technologies for natural product-based drug discovery. Here, we present the development of a neural network-based bioinformatics platform for ... ...

Abstract	National Cancer Institute (NCI) Program for Natural Product Discovery is a new initiative aimed at creating new technologies for natural product-based drug discovery. Here, we present the development of a neural network-based bioinformatics platform for visualization and analysis of natural product high-throughput screening data using the NCI's 60 human tumor cell anticancer drug screen. We demonstrate how the tool enables visualization of similar patterns of response that can be parsed both chemically and taxonomically, grouping NCI-60 biological profiles in one easy-to-use bioinformatics interface.
Language	English
Publishing date	2023-03-01
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.2c07416
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Evaluation of adverse drug reaction formatting in drug information mobile phone applications.

McConachie, Sean M / Berri, Dena / Konja, Jewel / Giuliano, Christopher A

Journal of the Medical Library Association : JMLA

2021 Volume 110, Issue 1, Page(s) 81–86

Abstract: Objective: To evaluate the differences in presentation (formatting) of adverse drug reaction (ADR) information within drug monographs in commonly used drug information (DI) mobile device applications.: Methods: A cross-sectional analysis of ADR ... ...

Abstract	Objective: To evaluate the differences in presentation (formatting) of adverse drug reaction (ADR) information within drug monographs in commonly used drug information (DI) mobile device applications. Methods: A cross-sectional analysis of ADR formatting of twenty commonly prescribed oral medications within seven DI mobile applications was performed. Databases were assessed for ADR information, including presence of placebo comparisons, severity of ADR, onset of ADR, formatting of ADRs in percentile (quantitative) format or qualitative format, whether references were used to cite information, and whether ADRs are grouped by organ system. Data was collected by two study investigators and discrepancies were resolved via consensus. Results: The seven DI mobile applications varied significantly on every analyzed ADR variable with the exception of ADR onset, which was absent in all databases. Significant differences were found for variables known to impact clinical judgment such as placebo comparisons and qualitative versus quantitative formatting. Placebo comparisons were most common among monographs in Lexicomp (30%) but were absent among monographs within other applications. Quantitative information was commonly used in most databases but was absent in Epocrates. Qualitative formatting was present in all Epocrates and Micromedex applications but absent in the majority of other applications. Substantial variations were also found in severity and grouping information. Conclusion: Substantial variation in ADR formatting exists among the most common DI mobile applications. These differences may translate into alternative interpretations of medical information and thus impact clinical judgment. Health care librarians and clinicians should consider ADR formatting when choosing between DI applications.
MeSH term(s)	Cell Phone ; Cross-Sectional Studies ; Drug-Related Side Effects and Adverse Reactions ; Humans ; Mobile Applications ; Pharmaceutical Preparations
Chemical Substances	Pharmaceutical Preparations
Language	English
Publishing date	2021-06-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2072435-4
ISSN	1558-9439 ; 1536-5050
ISSN (online)	1558-9439
ISSN	1536-5050
DOI	10.5195/jmla.2022.1251
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Article ; Online: Mechanical thrombectomy for acute ischaemic stroke during the COVID-19 pandemic

McConachie, D. / McConachie, N. / White, P. / Crossley, R. / Izzath, W.

Clinical Radiology

changes to UK practice and lessons learned

2020 Volume 75, Issue 10, Page(s) 795.e7–795.e13

Keywords	Radiology Nuclear Medicine and imaging ; General Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	391227-9
ISSN	1365-229X ; 0009-9260
ISSN (online)	1365-229X
ISSN	0009-9260
DOI	10.1016/j.crad.2020.07.001
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Mechanical thrombectomy for acute ischaemic stroke during the COVID-19 pandemic: changes to UK practice and lessons learned

McConachie, D / McConachie, N / White, P / Crossley, R / Izzath, W

Clin Radiol

Abstract: AIM: To describe evolving practices in the provision of mechanical thrombectomy (MT) services across the UK during the COVID-19 pandemic, the responses of and impact on MT teams, and the effects on training. MATERIALS AND METHODS: The UK ... ...

Abstract	AIM: To describe evolving practices in the provision of mechanical thrombectomy (MT) services across the UK during the COVID-19 pandemic, the responses of and impact on MT teams, and the effects on training. MATERIALS AND METHODS: The UK Neurointerventional Group (UKNG) and the British Society of Neuroradiologists (BSNR) sent out a national survey on 1 May 2020 to all 28 UK neuroscience centres that have the potential capability to perform MT. RESULTS: Responses were received from 27/28 MT-capable centres (96%). Three of the 27 centres do not currently provide MT services. There was a 27.7% reduction in MTs performed during April 2020 compared with the first 3 months of the year. All MT patients in 20/24 centres that responded were considered as COVID-19 suspicious/positive unless or until proven otherwise. Twenty-two of the 24 centres reported delays to the patient pathway. Seventeen of the 24 centres reported that the COVID-19 pandemic had reduced training opportunities for specialist registrars (SpR). Fourteen of the 24 centres reported that the pandemic had hampered their development plans for their local or regional MT service. CONCLUSION: The present survey has highlighted a trend of decreasing cases and delays in the patient pathway during the early stages of the COVID-19 pandemic across UK centres.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #643322
Database	COVID19

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Article ; Online: Evaluation of adverse drug reaction formatting in drug information databases.

McConachie, Sean M / Volgyi, Derek / Moore, Hannah / Giuliano, Christopher A

Journal of the Medical Library Association : JMLA

2020 Volume 108, Issue 4, Page(s) 598–604

Abstract: Objective: The research evaluated the differences in formatting of adverse drug reaction (ADR) information in drug monographs in commonly used drug information (DI) databases.: Methods: A cross-sectional analysis of formatting of ADR information for ... ...

Abstract	Objective: The research evaluated the differences in formatting of adverse drug reaction (ADR) information in drug monographs in commonly used drug information (DI) databases. Methods: A cross-sectional analysis of formatting of ADR information for twenty commonly prescribed oral medications in seven commonly used DI databases was performed. Databases were assessed for presentation of ADR information, including presence of placebo comparisons, severity of ADR, onset of ADR, formatting of ADRs in percentile (quantitative) format or qualitative format, whether references were used to cite information, whether ADRs are grouped by organ system, and word count of the ADR section. Data were collected by two study investigators and discrepancies were resolved via consensus. Chi-square analyses and one-way analysis of variance (ANOVA) were used to evaluate for mean group differences in categorical and continuous data, respectively. Results: The seven DI databases varied significantly on each analyzed ADR variable, including variables known to impact interpretation such as placebo comparisons and qualitative versus quantitative formatting. Placebo comparisons were most common among monographs in Micromedex In-Depth Answers (70%) but were absent among monographs in Epocrates, Lexicomp, and Micromedex. Quantitative information was commonly used in most databases but was absent in Epocrates. Average word counts were higher in Clinical Pharmacology and Micromedex In-Depth answers compared to other databases. Conclusion: Substantial variation in ADR formatting exists between the most common DI databases. These differences may translate into alternative interpretations of medical information and, thus, impact clinical judgment. Further studies are needed to assess whether these differences impact clinical practice.
MeSH term(s)	Cross-Sectional Studies ; Databases, Factual ; Drug-Related Side Effects and Adverse Reactions ; Humans ; Information Storage and Retrieval/methods
Language	English
Publishing date	2020-10-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2072435-4
ISSN	1558-9439 ; 1536-5050
ISSN (online)	1558-9439
ISSN	1536-5050
DOI	10.5195/jmla.2020.983
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Impact of COVID-19 Restrictions on Psychological Distress in Family Caregivers of Children with Neurodevelopmental Disability in the UK.

Gillespie-Smith, Karri / McConachie, Doug / Ballantyne, Carrie / Auyeung, Bonnie / Goodall, Karen

Journal of autism and developmental disorders

2021 Volume 53, Issue 4, Page(s) 1573–1587

Abstract: Caregivers of a child with a neurodevelopmental disability are more vulnerable to mental health difficulties. These difficulties are influenced by the child's challenging behaviours, and the caregiver's coping strategies; factors impacted by the COVID-19 ...

Abstract	Caregivers of a child with a neurodevelopmental disability are more vulnerable to mental health difficulties. These difficulties are influenced by the child's challenging behaviours, and the caregiver's coping strategies; factors impacted by the COVID-19 pandemic. An online mixed methods survey was conducted on caregivers of children with neurodevelopmental disabilities (n = 43) and children who are typically developing (n = 67). The results showed that presence of challenging behaviours related to neurodevelopmental disability, and caregiver coping strategies predicted caregiver psychological distress during lockdown. Themes that emerged included 'confusing messages and guidance', 'loss of freedom' and 'unsupported and forgotten'. The results demonstrate the pressing need for the implementation of appropriate support to protect the mental health of caregivers across the UK.
MeSH term(s)	Humans ; Child ; Caregivers/psychology ; Pandemics ; Autism Spectrum Disorder ; COVID-19 ; Communicable Disease Control ; United Kingdom
Language	English
Publishing date	2021-07-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	391999-7
ISSN	1573-3432 ; 0162-3257
ISSN (online)	1573-3432
ISSN	0162-3257
DOI	10.1007/s10803-021-05132-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: "We couldn't think in the box if we tried. We can't even find the damn box": A qualitative study of the lived experiences of autistic adults and relatives of autistic adults.

Finch, Tracy L / Mackintosh, Joan / Petrou, Alex / McConachie, Helen / Le Couteur, Ann / Garland, Deborah / Parr, Jeremy R

PloS one

2022 Volume 17, Issue 3, Page(s) e0264932

Abstract: Autistic children grow to become autistic adults, and autism is increasingly diagnosed in adulthood and later life. This qualitative study aimed to understand experiences of autism throughout adulthood. A national cohort study of autistic adults and ... ...

Abstract	Autistic children grow to become autistic adults, and autism is increasingly diagnosed in adulthood and later life. This qualitative study aimed to understand experiences of autism throughout adulthood. A national cohort study of autistic adults and relatives of autistic adults (ASC-UK), enabled purposive recruitment of a diverse sample. Semi-structured interviews were conducted with 29 autistic adults (aged 20-71 years), mostly diagnosed in adulthood, and 16 relatives (aged 31-81 years) of autistic adults diagnosed across both childhood and adulthood (including some with learning disability). Interview topics included health, relationships, education, employment, quality of life and everyday experiences. Thematic analysis of the accounts of the autistic adults identified six key themes relating to their experiences: (1) diagnosis as validating yet limiting; (2) supportive and non-supportive social agents; (3) the "invisibility" of the needs of autistic adults; (4) health in the context of autism; (5) staying 'outside' the circle; and (6) multiple lives with autism. Data from relatives about autistic adult experiences gave additional perspectives on these themes. Experiences reported in other studies-of 'difference' from others, challenges of social engagement, and learning to 'conform' to society's expectations-were evident and relevant to male and female autistic adults, across all age groups, and unrelated to stage of life when diagnosed. Some expressed disappointment with their lives, but others were proud of their achievements. Education and employment, whilst challenging for many, were also rewarding for some. Health care and social services were often experienced as inaccessible, inappropriate, or lacking understanding of the individual's needs. We conclude that greater public understanding of autism as experienced in adulthood is needed. Key priorities are improving the availability of 'appropriate' health and social care services for autistic adults and families, and providing practical support to enable enhanced participation in life.
MeSH term(s)	Adult ; Autistic Disorder ; Child ; Cohort Studies ; Female ; Humans ; Male ; Palliative Care ; Qualitative Research ; Quality of Life
Language	English
Publishing date	2022-03-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0264932
Database	MEDical Literature Analysis and Retrieval System OnLINE

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