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  1. Article ; Online: Early mobilisation during critical illness: good for the body and brain.

    Girard, Timothy D / Pandharipande, Pratik P

    The Lancet. Respiratory medicine

    2023  Volume 11, Issue 6, Page(s) 500–502

    MeSH term(s) Humans ; Early Ambulation ; Critical Illness/therapy ; Brain ; Intensive Care Units
    Language English
    Publishing date 2023-01-25
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(23)00011-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7041: Show issues Location:
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  2. Article ; Online: How does haloperidol influence the long-term outcomes of delirium?

    Devlin, John W / Duprey, Matthew S / Girard, Timothy D

    Intensive care medicine

    2024  Volume 50, Issue 2, Page(s) 269–271

    MeSH term(s) Humans ; Haloperidol/adverse effects ; Delirium/drug therapy
    Chemical Substances Haloperidol (J6292F8L3D)
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Editorial
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-024-07321-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1089: Show issues Location:
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  3. Article ; Online: Haloperidol and delirium: what is next?

    Andersen-Ranberg, Nina C / Girard, Timothy D / Perner, Anders

    Intensive care medicine

    2023  Volume 49, Issue 12, Page(s) 1535–1537

    MeSH term(s) Humans ; Haloperidol/adverse effects ; Antipsychotic Agents/adverse effects ; Delirium/chemically induced ; Delirium/drug therapy
    Chemical Substances Haloperidol (J6292F8L3D) ; Antipsychotic Agents
    Language English
    Publishing date 2023-10-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07232-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1089: Show issues Location:
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  4. Article ; Online: Ventilator-associated Brain Injury - VABI: A New Priority for Research in Mechanical Ventilation.

    Bassi, Thiago / Taran, Shaurya / Girard, Timothy D / Robba, Chiara / Goligher, Ewan C

    American journal of respiratory and critical care medicine

    2024  

    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202401-0069VP
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  5. Article ; Online: Haloperidol in the ICU: A Hammer Looking for a Nail?

    Prendergast, Niall T / Girard, Timothy D

    Critical care medicine

    2021  Volume 49, Issue 8, Page(s) 1363–1365

    MeSH term(s) Delirium ; Haloperidol/therapeutic use ; Humans ; Intensive Care Units
    Chemical Substances Haloperidol (J6292F8L3D)
    Language English
    Publishing date 2021-07-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000004995
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1261: Show issues Location:
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  6. Article ; Online: Advancing Telehealth-Based Screening for Postintensive Care Syndrome: A Coronavirus Disease 2019 Paradigm Shift.

    Scheunemann, Leslie P / Girard, Timothy D

    Critical care medicine

    2021  Volume 49, Issue 9, Page(s) 1569–1572

    MeSH term(s) COVID-19 ; Critical Illness ; Humans ; SARS-CoV-2 ; Telemedicine
    Language English
    Publishing date 2021-05-12
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1261: Show issues Location:
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  7. Article ; Online: Health Equity and Critical Care Survivorship: Where Do We Go From Here?

    Potter, Kelly M / Scheunemann, Leslie P / Girard, Timothy D

    Annals of internal medicine

    2022  Volume 175, Issue 5, Page(s) 749–750

    MeSH term(s) Critical Care ; Health Equity ; Humans ; Neoplasms ; Survivors ; Survivorship
    Language English
    Publishing date 2022-03-08
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M22-0726
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.178/2: Show issues Location:
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  8. Article ; Online: Sedation, Delirium, and Cognitive Function After Critical Illness.

    Girard, Timothy D

    Critical care clinics

    2018  Volume 34, Issue 4, Page(s) 585–598

    Abstract: Delirium has been consistently identified as a risk factor for critical illness brain injury, but ICU patients are exposed to a multitude of risk factors for delirium and it remains unclear which of these risk factors should be targeted to improve long- ... ...

    Abstract Delirium has been consistently identified as a risk factor for critical illness brain injury, but ICU patients are exposed to a multitude of risk factors for delirium and it remains unclear which of these risk factors should be targeted to improve long-term cognitive outcomes. Because exposure to sedating medications-which are frequently used to treat unwanted yet common symptoms during critical illness-is a risk factor for delirium that is directly controlled by clinicians, the relationship between sedation, delirium, and long-term cognition is of great interest to clinicians, researchers, and patients. This review describes theoretic relationships between sedation, delirium, and long-term cognition and reviews the evidence supporting these theoretic relationships.
    MeSH term(s) Cognition ; Critical Care ; Critical Illness/psychology ; Delirium/etiology ; Humans ; Hypnotics and Sedatives/adverse effects ; Hypnotics and Sedatives/therapeutic use
    Chemical Substances Hypnotics and Sedatives
    Language English
    Publishing date 2018-08-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1006423-0
    ISSN 1557-8232 ; 0749-0704
    ISSN (online) 1557-8232
    ISSN 0749-0704
    DOI 10.1016/j.ccc.2018.06.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Se 990: Show issues Location:
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  9. Article ; Online: Acute encephalopathy in the ICU: a practical approach.

    Kurtz, Pedro / van den Boogaard, Mark / Girard, Timothy D / Hermann, Bertrand

    Current opinion in critical care

    2024  Volume 30, Issue 2, Page(s) 106–120

    Abstract: Purpose of review: Acute encephalopathy (AE) - which frequently develops in critically ill patients with and without primary brain injury - is defined as an acute process that evolves rapidly and leads to changes in baseline cognitive status, ranging ... ...

    Abstract Purpose of review: Acute encephalopathy (AE) - which frequently develops in critically ill patients with and without primary brain injury - is defined as an acute process that evolves rapidly and leads to changes in baseline cognitive status, ranging from delirium to coma. The diagnosis, monitoring, and management of AE is challenging. Here, we discuss advances in definitions, diagnostic approaches, therapeutic options, and implications to outcomes of the clinical spectrum of AE in ICU patients without primary brain injury.
    Recent findings: Understanding and definitions of delirium and coma have evolved. Delirium is a neurocognitive disorder involving impairment of attention and cognition, usually fluctuating, and developing over hours to days. Coma is a state of unresponsiveness, with absence of command following, intelligible speech, or visual pursuit, with no imaging or neurophysiological evidence of cognitive motor dissociation. The CAM-ICU(-7) and the ICDSC are validated, guideline-recommended tools for clinical delirium assessment, with identification of clinical subtypes and stratification of severity. In comatose patients, the roles of continuous EEG monitoring and neuroimaging have grown for the early detection of secondary brain injury and treatment of reversible causes.
    Summary: Evidence-based pharmacologic treatments for delirium are limited. Dexmedetomidine is effective for mechanically ventilated patients with delirium, while haloperidol has minimal effect of delirium but may have other benefits. Specific treatments for coma in nonprimary brain injury are still lacking.
    MeSH term(s) Humans ; Delirium/diagnosis ; Delirium/therapy ; Coma/diagnosis ; Coma/therapy ; Intensive Care Units ; Haloperidol/therapeutic use ; Critical Illness/psychology ; Brain Injuries/complications
    Chemical Substances Haloperidol (J6292F8L3D)
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000001144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4999: Show issues Location:
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  10. Article ; Online: Selecting Intermediate Respiratory Support Following Extubation in the Pediatric Intensive Care Unit.

    Horvat, Christopher M / Curley, Martha A Q / Girard, Timothy D

    JAMA

    2022  Volume 327, Issue 16, Page(s) 1550–1552

    MeSH term(s) Airway Extubation ; Airway Management/methods ; Child ; Humans ; Intensive Care Units, Pediatric ; Respiratory Rate ; Respiratory System ; Respiratory Therapy/methods ; Ventilator Weaning
    Language English
    Publishing date 2022-04-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2022.4637
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