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  1. Article ; Online: Technische Aspekte und Neuerungen in der nicht-invasiven und invasiven Beatmung.

    Dellweg, Dominic / Lepper, Philipp M

    Pneumologie (Stuttgart, Germany)

    2024  Volume 78, Issue 2, Page(s) 120–130

    Abstract: Non-invasive and invasive ventilation have become essential for therapy in acute and chronic respiratory failure. More than one-third of patients in intensive care units receive invasive ventilation, and the number of ventilated patients in out-of- ... ...

    Title translation Technical aspects and innovations in non-invasive and invasive ventilation.
    Abstract Non-invasive and invasive ventilation have become essential for therapy in acute and chronic respiratory failure. More than one-third of patients in intensive care units receive invasive ventilation, and the number of ventilated patients in out-of-hospital care is also steadily increasing. While normalization of blood gases was considered the most significant goal in past decades, and the idea that mechanical ventilation also poses dangers played little role, the dominant thought at present is the application of ventilation from the most protective point of view possible. Because fundamental change in equipment technology is likely to be difficult, improvement of protective ventilation and further development of understanding of pathophysiologic processes in acute and chronic respiratory failure will continue to be of great importance in the future. This article summarizes different aspects of the technical basis of noninvasive and invasive ventilation and their practical implementation.
    MeSH term(s) Humans ; Noninvasive Ventilation ; Respiratory Insufficiency/diagnosis ; Respiratory Insufficiency/therapy ; Respiratory Insufficiency/etiology ; Respiration, Artificial/adverse effects ; Lung ; Intensive Care Units
    Language German
    Publishing date 2024-02-16
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 607630-0
    ISSN 1438-8790 ; 0934-8387
    ISSN (online) 1438-8790
    ISSN 0934-8387
    DOI 10.1055/a-2229-3854
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Book: Modulation of toll like receptor signalling as a new therapeutic principle

    Lepper, Philipp M.

    (Mediators of inflammation ; 2010, Spec. iss.)

    2010  

    Title variant Modulation of toll-like receptor signalling as a new therapeutic principle
    Author's details guest ed.: Philipp M. Lepper
    Series title Mediators of inflammation ; 2010, Spec. iss.
    Collection
    Language English
    Size Getr. Zählung : Ill., graph. Darst.
    Publisher Hindawi
    Publishing place S.l.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT016752775
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3575 -2010,Spec.iss.- not available for loan Zeitschriften-Lesesaal

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  3. Article: Technische Aspekte und Neuerungen in der nicht-invasiven und invasiven Beatmung

    Dellweg, Dominic / Lepper, Philipp M.

    Pneumologie

    2024  Volume 78, Issue 02, Page(s) 120–130

    Abstract: Nicht-invasive und invasive Beatmung sind für die Therapie bei akuter und chronischer respiratorischer Insuffizienz unerlässlich geworden. Mehr als ein Drittel der Patienten auf Intensivstationen wird invasiv beatmet, und auch in der außerklinischen ... ...

    Abstract Nicht-invasive und invasive Beatmung sind für die Therapie bei akuter und chronischer respiratorischer Insuffizienz unerlässlich geworden. Mehr als ein Drittel der Patienten auf Intensivstationen wird invasiv beatmet, und auch in der außerklinischen Beatmung nimmt die Zahl beatmeter Patienten stetig zu. Während die Normalisierung der Blutgase in vergangenen Jahrzehnten als bedeutsamstes Ziel angesehen wurde und der Gedanke, dass mechanische Beatmung auch Gefahren birgt, kaum eine Rolle spielte, ist der dominierende Gedanke derzeit die Applikation von Beatmung unter möglichst protektiven Gesichtspunkten. Da eine grundlegende Änderung der Gerätetechnik schwierig sein dürfte, wird die Verbesserung protektiver Beatmung und eine Weiterentwicklung des Verständnisses der pathophysiologischen Vorgänge bei akutem und chronischem Lungenversagen auch in der Zukunft eine große Bedeutung haben. Der Artikel fasst unterschiedliche Aspekte der technischen Grundlagen der nicht-invasiven und invasiven Beatmung und deren praktische Umsetzung zusammen.
    Keywords Beatmung ; nicht-invasive Beatmung ; respiratorische Insuffizienz ; invasive Beatmung ; mechanical ventilation ; non-invasive ventilation ; respiratory failure ; invasive mechanical ventilation
    Language German
    Publishing date 2024-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 607630-0
    ISSN 1438-8790 ; 0934-8387
    ISSN (online) 1438-8790
    ISSN 0934-8387
    DOI 10.1055/a-2229-3854
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Wenn maschinelle Beatmung nicht mehr ausreicht – venovenöse extrakorporale Membranoxygenierung.

    Mang, Sebastian / Karagiannidis, Christian / Lepper, Philipp M

    Innere Medizin (Heidelberg, Germany)

    2023  Volume 64, Issue 10, Page(s) 922–931

    Abstract: Venovenous extracorporeal membrane oxygenation (VV-ECMO) is predominantly being used as a rescue strategy in patients with acute lung failure, suffering from severe oxygenation and/or decarboxylation impairment. Cannulas introduced into the central veins ...

    Title translation When mechanical ventilation fails-Venovenous extracorporeal membrane oxygenation.
    Abstract Venovenous extracorporeal membrane oxygenation (VV-ECMO) is predominantly being used as a rescue strategy in patients with acute lung failure, suffering from severe oxygenation and/or decarboxylation impairment. Cannulas introduced into the central veins lead blood through a membrane oxygenator in which it is oxygenated via sweep gas (pO
    MeSH term(s) Humans ; Respiration, Artificial/adverse effects ; Extracorporeal Membrane Oxygenation/adverse effects ; Respiratory Distress Syndrome/therapy ; Pandemics ; COVID-19/therapy
    Language German
    Publishing date 2023-09-18
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ISSN 2731-7099
    ISSN (online) 2731-7099
    DOI 10.1007/s00108-023-01586-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mechanical ventilation in early COVID-19 ARDS.

    Lepper, Philipp M / Muellenbach, Ralf M

    EClinicalMedicine

    2020  Volume 28, Page(s) 100616

    Keywords covid19
    Language English
    Publishing date 2020-11-06
    Publishing country England
    Document type Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2020.100616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Außerklinische Beatmung.

    Schwarz, Sarah B / Lepper, Philipp M / Schönhofer, Bernd

    Pneumologie (Stuttgart, Germany)

    2022  Volume 76, Issue 6, Page(s) 395–396

    Title translation Home Mechanical Ventilation.
    MeSH term(s) Home Care Services ; Humans ; Respiration, Artificial ; Respiratory Insufficiency
    Language German
    Publishing date 2022-06-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 607630-0
    ISSN 1438-8790 ; 0934-8387
    ISSN (online) 1438-8790
    ISSN 0934-8387
    DOI 10.1055/a-1803-1646
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.142: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MO 54: Show issues

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  7. Article ; Online: Two single lung transplantations from one donor: lung twinning in the LAS era.

    Langer, Frank / Lepper, Philipp M / Weingard, Bettina / Aliyev, Parviz / Bals, Robert / Wilkens, Heinrike

    Respiratory research

    2024  Volume 25, Issue 1, Page(s) 131

    Abstract: Objectives: The implementation of the Lung Allocation Score (LAS) in the Eurotransplant international collaborative framework decreased waiting list mortality, but organ shortage remains a significant problem. Transplantation of two single lungs from ... ...

    Abstract Objectives: The implementation of the Lung Allocation Score (LAS) in the Eurotransplant international collaborative framework decreased waiting list mortality, but organ shortage remains a significant problem. Transplantation of two single lungs from one donor into two recipients (lung twinning) may decrease waiting list mortality. We sought to analyze if this strategy can lead to an acceptable intermediate-term outcome.
    Methods: Since the LAS-implementation we performed 32 paired single-lung transplantations from 16 postmortal donors. Data and outcome were analyzed retrospectively comparing recipients receiving the first lung (first twins) with recipients receiving the second lung (second twins), left versus right transplantation and restrictive versus obstructive disease.
    Results: Survival at one year was 81% and 54% at five years. Veno-venous ECMO had been successfully used as bridge-to-transplant in three patients with ECMO-explantation immediately after surgery. Bronchial anastomotic complications were not observed in any patient. First twins and second twins exhibited similar survival (p = 0.82) despite higher LAS in first twins (median 45 versus 34, p < 0.001) and longer cold ischemic time in second twins (280 ± 83 vs. 478 ± 125 min, p < 0.001). Survival of left and right transplantation was similar (p = 0.45) with similar best post-transplant FEV1 (68 ± 15% versus 62 ± 14%, p = 0.26). Survival was similar in restrictive and obstructive disease (p = 0.28) with better post-transplant FEV1 (70 ± 15% versus 57 ± 11%, p = 0.02) in restrictive disease.
    Conclusions: Performing two single-lung transplantations from one donor can be performed safely with encouraging intermediate-term outcome and good functional capacity. Lung twinning maximizes the donor pool and may help to overcome severe organ shortage.
    Clinical trials: This research is not a clinical trial. Thus no registration details will be provided.
    MeSH term(s) Humans ; Retrospective Studies ; Lung Diseases ; Lung Transplantation ; Lung/surgery ; Tissue Donors
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041675-1
    ISSN 1465-993X ; 1465-993X
    ISSN (online) 1465-993X
    ISSN 1465-993X
    DOI 10.1186/s12931-024-02754-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Preserving the Membrane Lung Without Jeopardizing Patients' Safety.

    Mang, Sebastian / Omlor, Albert Joachim / Rixecker, Torben Millard / Lepper, Philipp M

    ASAIO journal (American Society for Artificial Internal Organs : 1992)

    2022  Volume 69, Issue 4, Page(s) e166

    MeSH term(s) Humans ; Lung
    Language English
    Publishing date 2022-10-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 759982-1
    ISSN 1538-943X ; 0162-1432 ; 1058-2916
    ISSN (online) 1538-943X
    ISSN 0162-1432 ; 1058-2916
    DOI 10.1097/MAT.0000000000001826
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Außerklinische Beatmung

    Schwarz, Sarah B. / Lepper, Philipp M. / Schönhofer, Bernd

    Pneumologie

    2022  Volume 76, Issue 06, Page(s) 395–396

    Language German
    Publishing date 2022-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 607630-0
    ISSN 1438-8790 ; 0934-8387
    ISSN (online) 1438-8790
    ISSN 0934-8387
    DOI 10.1055/a-1803-1646
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

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  10. Article: On the Use of Hemadsorption with CytoSorb in Patients with Septic Shock. Comment on Kogelmann et al. First Evaluation of a New Dynamic Scoring System Intended to Support Prescription of Adjuvant CytoSorb Hemoadsorption Therapy in Patients with Septic Shock.

    Supady, Alexander / Lepper, Philipp M / Duerschmied, Daniel / Wengenmayer, Tobias

    Journal of clinical medicine

    2022  Volume 11, Issue 2

    Abstract: With great interest we read the article by Klaus Kogelmann and co-authors on the "First Evaluation of a New Dynamic Scoring System Intended to Support Prescription of Adjuvant CytoSorb Hemoadsorption Therapy in Patients with Septic Shock" [ ... ]. ...

    Abstract With great interest we read the article by Klaus Kogelmann and co-authors on the "First Evaluation of a New Dynamic Scoring System Intended to Support Prescription of Adjuvant CytoSorb Hemoadsorption Therapy in Patients with Septic Shock" [...].
    Language English
    Publishing date 2022-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11020334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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