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  1. Article ; Online: Current and emerging technologies for defining and validating tendon cell fate.

    Huang, Alice H / Galloway, Jenna L

    Journal of orthopaedic research : official publication of the Orthopaedic Research Society

    2023  Volume 41, Issue 10, Page(s) 2082–2092

    Abstract: The tendon field has been flourishing in recent years with the advent of new tools and model systems. The recent ORS 2022 Tendon Section Conference brought together researchers from diverse disciplines and backgrounds, showcasing studies in biomechanics ... ...

    Abstract The tendon field has been flourishing in recent years with the advent of new tools and model systems. The recent ORS 2022 Tendon Section Conference brought together researchers from diverse disciplines and backgrounds, showcasing studies in biomechanics and tissue engineering to cell and developmental biology and using models from zebrafish and mouse to humans. This perspective aims to summarize progress in tendon research as it pertains to understanding and studying tendon cell fate. The successful integration of new technologies and approaches have the potential to further propel tendon research into a new renaissance of discovery. However, there are also limitations with the current methodologies that are important to consider when tackling research questions. Altogether, we will highlight recent advances and technologies and propose new avenues to explore tendon biology.
    MeSH term(s) Humans ; Animals ; Mice ; Zebrafish ; Tendons ; Cell Differentiation ; Tissue Engineering/methods ; Biomechanical Phenomena
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 605542-4
    ISSN 1554-527X ; 0736-0266
    ISSN (online) 1554-527X
    ISSN 0736-0266
    DOI 10.1002/jor.25632
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Comparison of Plasma Metabolome Response to Diets Enriched in Soybean and Partially-Hydrogenated Soybean Oil in Moderately Hypercholesterolemic Adults-A Pilot Study.

    Huang, Neil K / Lichtenstein, Alice H / Matuszek, Gregory / Matthan, Nirupa R

    Metabolites

    2023  Volume 13, Issue 4

    Abstract: Partially-hydrogenated fat/ ...

    Abstract Partially-hydrogenated fat/
    Language English
    Publishing date 2023-03-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo13040474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The regenerative capacity of neonatal tissues.

    Montero, Angela M / Huang, Alice H

    Development (Cambridge, England)

    2022  Volume 149, Issue 12

    Abstract: It is well established that humans and other mammals are minimally regenerative compared with organisms such as zebrafish, salamander or amphibians. In recent years, however, the identification of regenerative potential in neonatal mouse tissues that ... ...

    Abstract It is well established that humans and other mammals are minimally regenerative compared with organisms such as zebrafish, salamander or amphibians. In recent years, however, the identification of regenerative potential in neonatal mouse tissues that normally heal poorly in adults has transformed our understanding of regenerative capacity in mammals. In this Review, we survey the mammalian tissues for which regenerative or improved neonatal healing has been established, including the heart, cochlear hair cells, the brain and spinal cord, and dense connective tissues. We also highlight common and/or tissue-specific mechanisms of neonatal regeneration, which involve cells, signaling pathways, extracellular matrix, immune cells and other factors. The identification of such common features across neonatal tissues may direct therapeutic strategies that will be broadly applicable to multiple adult tissues.
    MeSH term(s) Amphibians ; Animals ; Heart ; Mammals ; Mice ; Spinal Cord ; Zebrafish
    Language English
    Publishing date 2022-06-16
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.199819
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Conference proceedings: Airway Management After Radiation Therapy for Nasopharyngeal Carcinoma

    Huang, Alice E. / Hwang, Peter H. / Nekhendzy, Vladimir

    Journal of Neurological Surgery Part B: Skull Base

    2023  Volume 84, Issue S 01

    Event/congress 32nd Annual Meeting North American Skull Base Society, JW Marriott Tampa Water Street, Tampa, Florida, United States, 2023-02-17
    Language English
    Publishing date 2023-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2654269-9
    ISSN 2193-634X ; 2193-6331
    ISSN (online) 2193-634X
    ISSN 2193-6331
    DOI 10.1055/s-0043-1762166
    Database Thieme publisher's database

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  5. Article: Reparative and Maladaptive Inflammation in Tendon Healing.

    Arvind, Varun / Huang, Alice H

    Frontiers in bioengineering and biotechnology

    2021  Volume 9, Page(s) 719047

    Abstract: Tendon injuries are common and debilitating, with non-regenerative healing often resulting in chronic disease. While there has been considerable progress in identifying the cellular and molecular regulators of tendon healing, the role of inflammation in ... ...

    Abstract Tendon injuries are common and debilitating, with non-regenerative healing often resulting in chronic disease. While there has been considerable progress in identifying the cellular and molecular regulators of tendon healing, the role of inflammation in tendon healing is less well understood. While inflammation underlies chronic tendinopathy, it also aids debris clearance and signals tissue repair. Here, we highlight recent findings in this area, focusing on the cells and cytokines involved in reparative inflammation. We also discuss findings from other model systems when research in tendon is minimal, and explore recent studies in the treatment of human tendinopathy to glean further insights into the immunobiology of tendon healing.
    Language English
    Publishing date 2021-07-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2021.719047
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  6. Article ; Online: Outcomes after liver transplantation in MPV17 deficiency: A rebuttal.

    Huang, Alice C / Ebel, Noelle H / Romero, Danielle / Enns, Gregory M / Esquivel, Carlos O / Bonham, Clark

    Pediatric transplantation

    2023  Volume 27, Issue 3, Page(s) e14472

    MeSH term(s) Humans ; Liver Transplantation ; Liver ; Mitochondrial Diseases ; Membrane Proteins ; Mitochondrial Proteins
    Chemical Substances MPV17 protein, human ; Membrane Proteins ; Mitochondrial Proteins
    Language English
    Publishing date 2023-03-05
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1390284-2
    ISSN 1399-3046 ; 1397-3142
    ISSN (online) 1399-3046
    ISSN 1397-3142
    DOI 10.1111/petr.14472
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    Zs.A 4947: Show issues Location:
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  7. Article ; Online: Difficult Tracheal Intubation and Airway Outcomes after Radiation for Nasopharyngeal Carcinoma.

    Huang, Alice E / Camiré, Daenis / Hwang, Peter H / Nekhendzy, Vladimir

    The Laryngoscope

    2023  Volume 134, Issue 1, Page(s) 120–126

    Abstract: Objective: The aim of the study was to characterize the incidence and management of difficult tracheal intubations (DTIs) in nasopharyngeal carcinoma (NPC) after primary radiation therapy (RT).: Methods: The study was a retrospective review of airway ...

    Abstract Objective: The aim of the study was to characterize the incidence and management of difficult tracheal intubations (DTIs) in nasopharyngeal carcinoma (NPC) after primary radiation therapy (RT).
    Methods: The study was a retrospective review of airway assessment and outcomes in post-RT NPC patients. Primary analysis was performed on patients who underwent post-RT procedures, who were split into non-DTI and DTI groups. Patients were classified as DTI if they (i) required >1 attempt to intubate, (ii) failed to be intubated, or (iii) experienced complications attributed to airway management. Secondary analysis was performed between patients who underwent post-RT procedures (procedure group) and those who did not (control group).
    Results: One-hundred and fifty patients were included, and 71.3% underwent post-RT procedures, with no differences in characteristics between the procedure and control groups. One-hundred and fifty procedures were identified, and 28.0% were categorized as DTI. There was no difference in patient characteristics or airway assessment measures between DTI and non-DTI groups. Regression analysis revealed concurrent cervical mobility restriction, and trismus increased DTI incidence by 7.1-fold (p = 0.011). Being non-White was an independent predictor of DTI. The incidence of high-grade intraoperative laryngoscopic view was lower in the non-DTI compared to the DTI group (20.4% vs. 64.3%, p < 0.0001). Failure to intubate occurred in 2.0% of cases, and 6.0% cases had perioperative complications. Based on preoperative assessment, sensitivity of predicting DTI was 54.8% and specificity was 63.9%.
    Conclusion: NPC patients frequently undergo post-RT procedures requiring complex airway management. Rates of DTI and failed intubation are significantly higher than those in the general surgical population, and the ability to predict DTI with standard preoperative airway measures is poor.
    Level of evidence: 4 Laryngoscope, 134:120-126, 2024.
    MeSH term(s) Humans ; Intubation, Intratracheal/adverse effects ; Intubation, Intratracheal/methods ; Nasopharyngeal Carcinoma/radiotherapy ; Airway Management ; Respiratory System ; Laryngoscopy/methods ; Nasopharyngeal Neoplasms/radiotherapy
    Language English
    Publishing date 2023-05-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.30767
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  8. Article ; Online: Coordinated development of the limb musculoskeletal system: Tendon and muscle patterning and integration with the skeleton.

    Huang, Alice H

    Developmental biology

    2017  Volume 429, Issue 2, Page(s) 420–428

    Abstract: Functional movement and stability of the limb depends on an organized and fully integrated musculoskeletal system composed of skeleton, muscle, and tendon. Much of our current understanding of musculoskeletal development is based on studies that focused ... ...

    Abstract Functional movement and stability of the limb depends on an organized and fully integrated musculoskeletal system composed of skeleton, muscle, and tendon. Much of our current understanding of musculoskeletal development is based on studies that focused on the development and differentiation of individual tissues. Likewise, research on patterning events have been largely limited to the primary skeletal elements and the mechanisms that regulate soft tissue patterning, the development of the connections between tissues, and their interdependent development are only beginning to be elucidated. This review will therefore highlight recent exciting discoveries in this field, with an emphasis on tendon and muscle patterning and their integrated development with the skeleton and skeletal attachments.
    MeSH term(s) Animals ; Body Patterning ; Bone and Bones/embryology ; Extremities/embryology ; Muscle, Skeletal/embryology ; Tendons/embryology ; Transcription Factors/metabolism
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2017-03-28
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1114-9
    ISSN 1095-564X ; 0012-1606
    ISSN (online) 1095-564X
    ISSN 0012-1606
    DOI 10.1016/j.ydbio.2017.03.028
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  9. Article: Plasma Metabolite Response to Simple, Refined and Unrefined Carbohydrate-Enriched Diets in Older Adults-Randomized Controlled Crossover Trial.

    Huang, Neil K / Matthan, Nirupa R / Matuszek, Gregory / Lichtenstein, Alice H

    Metabolites

    2022  Volume 12, Issue 6

    Abstract: Food intake data collected using subjective tools are prone to inaccuracies and biases. An objective assessment of food intake, such as metabolomic profiling, may offer a more accurate method if unique metabolites can be identified. To explore this ... ...

    Abstract Food intake data collected using subjective tools are prone to inaccuracies and biases. An objective assessment of food intake, such as metabolomic profiling, may offer a more accurate method if unique metabolites can be identified. To explore this option, we used samples generated from a randomized and controlled cross-over trial during which participants (
    Language English
    Publishing date 2022-06-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo12060547
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  10. Article: Plasma Metabolite Profiles Following Consumption of Animal Protein and Soybean-Based Diet in Hypercholesterolemic Postmenopausal Women.

    Huang, Neil K / Matthan, Nirupa R / Matuszek, Gregory / Lichtenstein, Alice H

    Metabolites

    2022  Volume 12, Issue 3

    Abstract: Subjective reporting of food intake can be unreliable. No objective method is available to distinguish between diets differing in protein type. To address this gap, a secondary analysis of a randomized controlled cross-over feeding trial was conducted. ... ...

    Abstract Subjective reporting of food intake can be unreliable. No objective method is available to distinguish between diets differing in protein type. To address this gap, a secondary analysis of a randomized controlled cross-over feeding trial was conducted. Assessed were fasting plasma metabolite profiles and their associations with cardiometabolic risk factors (CMRFs). Hypercholesterolemic post-menopausal women (N = 11) were provided with diets containing predominantly animal protein (AP) and soy protein (SP). Untargeted metabolomics were used to determine the plasma metabolite profiles at the end of each diet phase. Concentrations of identified metabolites (N = 829) were compared using paired
    Language English
    Publishing date 2022-02-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo12030209
    Database MEDical Literature Analysis and Retrieval System OnLINE

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