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Book: Dentale Volumentomographie

Fleiner, Jonathan / Weyer, Nils / Stricker, Adres

DVT-Diagnostik ; die wichtigsten Fälle im klinischen Alltag als Bildatlas ; systematisierte Befundung, Diagnostik, Therapie ; English-Deutsch

2013

Author's details	[Fleiner J. ; Weyer N. ; Stricker A.]
Subject code	617.60757220222
Language	German ; English
Size	231 S. : zahlr. Ill., 31 cm
Edition	2. Aufl.
Publisher	2einhalb
Publishing place	Biberach
Publishing country	Germany
Document type	Book
Note	Literaturangaben
HBZ-ID	HT018161370
ISBN	978-3-9815787-0-6 ; 978-3-9815787-1-3 ; 3-9815787-0-8 ; 3-9815787-1-6
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: How does team diversity relate to the willingness to collaborate with asylum seekers? It depends on the diversity dimensions investigated and boundary conditions.

Kotzur, Patrick F / Stricker, Johannes / Fricke, Ramona / McPhetres, Jonathan / Meyer, Bertolt

PloS one

2022 Volume 17, Issue 3, Page(s) e0266166

Abstract: The successful integration of asylum seekers into the labor market is among the most pressing issues of refugee-receiving countries. We construe co-workers' willingness to collaborate with asylum seekers as a crucial factor for integration and ... ...

Abstract	The successful integration of asylum seekers into the labor market is among the most pressing issues of refugee-receiving countries. We construe co-workers' willingness to collaborate with asylum seekers as a crucial factor for integration and investigate its antecedents. Linking Allport's contact theory with team diversity theories, we propose that a work team's diversity affects team members' willingness to collaborate with asylum seekers. We thus investigated the effects of different facets of objective (national, migration background, age, and gender) and perceived diversity in work teams on team members' willingness to collaborate with asylum seekers. In doing so, we also tested whether asylum seekers' status in the team hierarchy (superior vs. colleague), task interdependence, and pro-diversity team norms moderate these effects. Multi-level regression analyses based on 470 participants nested in 106 teams showed that, overall, team diversity played a small role in explaining the willingness to collaborate with asylum seekers. Age diversity was negatively associated with the willingness to collaborate with asylum seekers, especially when asylum seekers were considered to take a post as a superior rather than a colleague. In teams with high task interdependence, migration background diversity and willingness to collaborate with asylum seekers were positively associated. Pro-diversity norms did not moderate team diversity effects. Overall, our findings demonstrate that team diversity can have beneficial, harmful, and no substantial consequences for the willingness to work with asylum seekers, depending on the considered type of diversity and boundary conditions.
MeSH term(s)	Humans ; Refugees
Language	English
Publishing date	2022-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0266166
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: How does team diversity relate to the willingness to collaborate with asylum seekers? It depends on the diversity dimensions investigated and boundary conditions.

Patrick F Kotzur / Johannes Stricker / Ramona Fricke / Jonathan McPhetres / Bertolt Meyer

PLoS ONE, Vol 17, Iss 3, p e

2022 Volume 0266166

Abstract	The successful integration of asylum seekers into the labor market is among the most pressing issues of refugee-receiving countries. We construe co-workers' willingness to collaborate with asylum seekers as a crucial factor for integration and investigate its antecedents. Linking Allport's contact theory with team diversity theories, we propose that a work team's diversity affects team members' willingness to collaborate with asylum seekers. We thus investigated the effects of different facets of objective (national, migration background, age, and gender) and perceived diversity in work teams on team members' willingness to collaborate with asylum seekers. In doing so, we also tested whether asylum seekers' status in the team hierarchy (superior vs. colleague), task interdependence, and pro-diversity team norms moderate these effects. Multi-level regression analyses based on 470 participants nested in 106 teams showed that, overall, team diversity played a small role in explaining the willingness to collaborate with asylum seekers. Age diversity was negatively associated with the willingness to collaborate with asylum seekers, especially when asylum seekers were considered to take a post as a superior rather than a colleague. In teams with high task interdependence, migration background diversity and willingness to collaborate with asylum seekers were positively associated. Pro-diversity norms did not moderate team diversity effects. Overall, our findings demonstrate that team diversity can have beneficial, harmful, and no substantial consequences for the willingness to work with asylum seekers, depending on the considered type of diversity and boundary conditions.
Keywords	Medicine ; R ; Science ; Q
Subject code	941
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Resorption of retromolar bone grafts after alveolar ridge augmentation-volumetric changes after 12 months assessed by CBCT analysis.

Stricker, Andres / Jacobs, Reinhilde / Maes, Frederik / Fluegge, Tabea / Vach, Kirstin / Fleiner, Jonathan

International journal of implant dentistry

2021 Volume 7, Issue 1, Page(s) 7

Abstract: In this pilot study, a volumetric analysis of retromolar onlay bone grafts over a period of 12 months was conducted, using repeated CBCT imaging combined with automated image registration.Eleven patients being treated with 16 bone grafts taken from the ... ...

Abstract	In this pilot study, a volumetric analysis of retromolar onlay bone grafts over a period of 12 months was conducted, using repeated CBCT imaging combined with automated image registration.Eleven patients being treated with 16 bone grafts taken from the retromolar area were examined by CBCT scanning prior to bone augmentation (T0), immediately after bone augmentation (T1) and after a healing time of 12 months after augmentation (T2). Graft volumes were measured at each time point after automated image registration of consecutive CBCT scans.The mean volume of the augmented site was 372.2 ± 179.4 mm
MeSH term(s)	Alveolar Ridge Augmentation ; Bone Transplantation ; Humans ; Mandible/diagnostic imaging ; Pilot Projects ; Spiral Cone-Beam Computed Tomography
Language	English
Publishing date	2021-01-21
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2198-4034
ISSN	2198-4034
DOI	10.1186/s40729-020-00285-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Stricker Learning Span criterion validity: a remote self-administered multi-device compatible digital word list memory measure shows similar ability to differentiate amyloid and tau PET-defined biomarker groups as in-person Auditory Verbal Learning Test.

Stricker, Nikki H / Stricker, John L / Frank, Ryan D / Fan, Winnie Z / Christianson, Teresa J / Patel, Jay S / Karstens, Aimee J / Kremers, Walter K / Machulda, Mary M / Fields, Julie A / Graff-Radford, Jonathan / Jack, Clifford R / Knopman, David S / Mielke, Michelle M / Petersen, Ronald C

Journal of the International Neuropsychological Society : JINS

2023 Volume 30, Issue 2, Page(s) 138–151

Abstract: Objective: The Stricker Learning Span (SLS) is a computer-adaptive digital word list memory test ...

Abstract	Objective: The Stricker Learning Span (SLS) is a computer-adaptive digital word list memory test specifically designed for remote assessment and self-administration on a web-based multi-device platform (Mayo Test Drive). We aimed to establish criterion validity of the SLS by comparing its ability to differentiate biomarker-defined groups to the person-administered Rey's Auditory Verbal Learning Test (AVLT). Method: Participants ( Results: The SLS and AVLT showed similar ability to differentiate biomarker-defined groups when comparing AUROCs ( Conclusions: Remotely administered SLS performed similarly to in-person-administered AVLT in its ability to separate biomarker-defined groups, providing evidence of criterion validity. Results suggest the SLS may be sensitive to detecting subtle objective cognitive decline in preclinical AD.
MeSH term(s)	Humans ; Aged ; Learning ; Memory ; Verbal Learning ; Educational Status ; Alzheimer Disease/diagnostic imaging ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-06-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1230632-0
ISSN	1469-7661 ; 1355-6177
ISSN (online)	1469-7661
ISSN	1355-6177
DOI	10.1017/S1355617723000322
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Article ; Online: Supercoiling and looping promote DNA base accessibility and coordination among distant sites.

Fogg, Jonathan M / Judge, Allison K / Stricker, Erik / Chan, Hilda L / Zechiedrich, Lynn

Nature communications

2021 Volume 12, Issue 1, Page(s) 5683

Abstract: DNA in cells is supercoiled and constrained into loops and this supercoiling and looping influence every aspect of DNA activity. We show here that negative supercoiling transmits mechanical stress along the DNA backbone to disrupt base pairing at ... ...

Abstract	DNA in cells is supercoiled and constrained into loops and this supercoiling and looping influence every aspect of DNA activity. We show here that negative supercoiling transmits mechanical stress along the DNA backbone to disrupt base pairing at specific distant sites. Cooperativity among distant sites localizes certain sequences to superhelical apices. Base pair disruption allows sharp bending at superhelical apices, which facilitates DNA writhing to relieve torsional strain. The coupling of these processes may help prevent extensive denaturation associated with genomic instability. Our results provide a model for how DNA can form short loops, which are required for many essential processes, and how cells may use DNA loops to position nicks to facilitate repair. Furthermore, our results reveal a complex interplay between site-specific disruptions to base pairing and the 3-D conformation of DNA, which influences how genomes are stored, replicated, transcribed, repaired, and many other aspects of DNA activity.
MeSH term(s)	Base Pairing ; DNA Cleavage ; DNA Repair ; DNA, Superhelical/chemistry ; DNA, Superhelical/metabolism ; Endodeoxyribonucleases/metabolism ; Genomic Instability ; Models, Chemical ; Models, Genetic ; Stress, Mechanical
Chemical Substances	DNA, Superhelical ; Endodeoxyribonucleases (EC 3.1.-) ; exonuclease Bal 31 (EC 3.1.11.-)
Language	English
Publishing date	2021-09-28
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-021-25936-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Small Molecule Regulators of microRNAs Identified by High-Throughput Screen Coupled with High-Throughput Sequencing.

Krichevsky, Anna / Nguyen, Lien / Wei, Zhiyun / Silva, M / Barberán-Soler, Sergio / Rabinovsky, Rosalia / Muratore, Christina / Stricker, Jonathan / Hortman, Colin / Young-Pearse, Tracy / Haggarty, Stephen

Research square

2023

Abstract: MicroRNAs (miRNAs) regulate fundamental biological processes by silencing mRNA targets and are dysregulated in many diseases. Therefore, miRNA replacement or inhibition can be harnessed as potential therapeutics. However, existing strategies for miRNA ... ...

Abstract	MicroRNAs (miRNAs) regulate fundamental biological processes by silencing mRNA targets and are dysregulated in many diseases. Therefore, miRNA replacement or inhibition can be harnessed as potential therapeutics. However, existing strategies for miRNA modulation using oligonucleotides and gene therapies are challenging, especially for neurological diseases, and none have yet gained clinical approval. We explore a different approach by screening a biodiverse library of small molecule compounds for their ability to modulate hundreds of miRNAs in human induced pluripotent stem cell-derived neurons. We demonstrate the utility of the screen by identifying cardiac glycosides as potent inducers of miR-132, a key miRNA downregulated in Alzheimer's disease and other tauopathies. Coordinately, cardiac glycosides downregulate known miR-132 targets, including Tau, and protect rodent and human neurons against various toxic insults. More generally, our dataset of 1370 drug-like compounds and their effects on the miRNome provide a valuable resource for further miRNA-based drug discovery.
Language	English
Publishing date	2023-03-14
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-2617979/v1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Supercoiling and looping promote DNA base accessibility and coordination among distant sites

Jonathan M. Fogg / Allison K. Judge / Erik Stricker / Hilda L. Chan / Lynn Zechiedrich

Nature Communications, Vol 12, Iss 1, Pp 1-

2021 Volume 16

Abstract: DNA supercoiling can result in underwinding with negative supercoiling or overwinding with positive supercoiling of the DNA double helix. Here the authors reveal insights into the dynamic relationship between DNA supercoiling-induced sequence-dependent ... ...

Abstract	DNA supercoiling can result in underwinding with negative supercoiling or overwinding with positive supercoiling of the DNA double helix. Here the authors reveal insights into the dynamic relationship between DNA supercoiling-induced sequence-dependent disruptions to base pairing, DNA looping, and the shape of the DNA molecule.
Keywords	Science ; Q
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing.

Nguyen, Lien D / Wei, Zhiyun / Silva, M Catarina / Barberán-Soler, Sergio / Zhang, Jiarui / Rabinovsky, Rosalia / Muratore, Christina R / Stricker, Jonathan M S / Hortman, Colin / Young-Pearse, Tracy L / Haggarty, Stephen J / Krichevsky, Anna M

Nature communications

2023 Volume 14, Issue 1, Page(s) 7575

Abstract	MicroRNAs (miRNAs) regulate fundamental biological processes by silencing mRNA targets and are dysregulated in many diseases. Therefore, miRNA replacement or inhibition can be harnessed as potential therapeutics. However, existing strategies for miRNA modulation using oligonucleotides and gene therapies are challenging, especially for neurological diseases, and none have yet gained clinical approval. We explore a different approach by screening a biodiverse library of small molecule compounds for their ability to modulate hundreds of miRNAs in human induced pluripotent stem cell-derived neurons. We demonstrate the utility of the screen by identifying cardiac glycosides as potent inducers of miR-132, a key neuroprotective miRNA downregulated in Alzheimer's disease and other tauopathies. Coordinately, cardiac glycosides downregulate known miR-132 targets, including Tau, and protect rodent and human neurons against various toxic insults. More generally, our dataset of 1370 drug-like compounds and their effects on the miRNome provides a valuable resource for further miRNA-based drug discovery.
MeSH term(s)	Humans ; MicroRNAs/genetics ; Induced Pluripotent Stem Cells ; RNA, Messenger/genetics ; High-Throughput Nucleotide Sequencing ; Cardiac Glycosides
Chemical Substances	MicroRNAs ; RNA, Messenger ; Cardiac Glycosides
Language	English
Publishing date	2023-11-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-43293-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Surgical neonates: A retrospective review of procedures and postoperative outcomes at a quaternary children's hospital.

Nelson, Olivia / Rintoul, Natalie E / Tan, Jonathan M / Simpao, Allan F / Chuo, John / Hedrick, Holly L / Duran, Melissa S / Makeneni, Spandana / Devine, Matthew / Cao, Lusha / Stricker, Paul A

Paediatric anaesthesia

2023 Volume 34, Issue 4, Page(s) 354–365

Abstract: Introduction: Neonates have a high incidence of respiratory and cardiac perioperative events. Disease severity and indications for surgical intervention often dovetail with an overall complex clinical course and predispose these infants to adverse long- ... ...

Abstract	Introduction: Neonates have a high incidence of respiratory and cardiac perioperative events. Disease severity and indications for surgical intervention often dovetail with an overall complex clinical course and predispose these infants to adverse long-term neurodevelopmental outcomes and increased length of stay. Our aims were to describe severe and nonsevere early postoperative complications to establish a baseline of care outcomes and to identify subgroups of surgical neonates and procedures for future prospective studies. Methods: Electronic health record data were examined retrospectively for a cohort of patients who had general anesthesia from January 26, 2015 to August 31, 2018. Inclusion criteria were full-term infants with postmenstrual age less than 44 weeks or premature infants less than 60 weeks postmenstrual age undergoing nonimaging, noncardiac surgery. Severe postoperative complications were defined as mortality, reintubation, positive blood culture, and surgical site infection. Nonsevere early postoperative outcomes were defined as hypoglycemia, hyperglycemia, hypothermia, hyperthermia, and readmission within 30 days. Results: About 2569 procedures were performed in 1842 neonates of which 10.9% were emergency surgeries. There were 120 postoperative severe complications and 965 nonsevere postoperative outcomes. Overall, 30-day mortality was 1.8% for the first procedure performed, with higher mortality seen on subgroup analysis for patients who underwent exploratory laparotomy (10.3%) and congenital lung lesion resection (4.9%). Postoperative areas for improvement included hyperglycemia (13.9%) and hypothermia (7.9%). Discussion: The mortality rate in our study was comparable to other studies of neonatal surgery despite a high rate of emergency surgery and a high prevalence of prematurity in our cohort. The early outcomes data identified areas for improvement, including prevention of postoperative glucose and temperature derangements. Conclusions: Neonates in this cohort were at risk for severe and nonsevere adverse postoperative outcomes. Future studies are suggested to improve mortality and adverse event rates.
MeSH term(s)	Infant, Newborn ; Infant ; Child ; Humans ; Retrospective Studies ; Hypothermia ; Prospective Studies ; Postoperative Complications/epidemiology ; Hyperglycemia ; Hospitals
Language	English
Publishing date	2023-12-25
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1086049-6
ISSN	1460-9592 ; 1155-5645
ISSN (online)	1460-9592
ISSN	1155-5645
DOI	10.1111/pan.14827
Database	MEDical Literature Analysis and Retrieval System OnLINE

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